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Cited by 161Malaria Research and ControlPregnancy and preeclampsia studiesReproductive System and Pregnancy

Changes in the Levels of Chemokines and Cytokines in the Placentas of Women with Plasmodium falciparum Malaria

Suguitan, Jr., Amorsolo L., Leke, Rose G. F., Fouda, Genevieve, Zhou, Ainong, Thuita, Lucy, Metenou, Simon, Fogako, Josephine, Megnekou, Rosette +1 more·2003·The Journal of Infectious Diseases
DOI 10.1086/378500
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Abstract

Plasmodium falciparum-infected erythrocytes often are sequestered in the placenta and stimulate the accumulation of maternal mononuclear cells. In this study, the role that chemokines and cytokines play in mediating the inflammatory response was investigated. Placental parasites elicited a statistically significant increase in the levels of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-10, in plasma collected from the intervillous space. Explants of fetal tissue from malaria-positive placentas also secreted significantly enhanced amounts of IFN-gamma. Culture supernatant of maternal intervillous leukocytes obtained from infected placentas contained significantly higher levels of TNF-alpha, IL-10, monocyte chemotactic protein-1, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and IFN-gamma inducible protein-10 than did cultures of white blood cells obtained from uninfected placentas. Taken together, these results show that both fetal and maternal cells secrete inflammatory and immunoregulatory cytokines in response to P. falciparum and suggest that beta-chemokines produced by maternal cells contribute to the accumulation of macrophages in the intervillous space.

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Crossref · 10.1086/378500

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  • Activation of immune cells with upregulation of markers such as CD4+, CD8+ and CD68+ can be observed.

    “In addition, activation of immune cells with upregulation of markers such as CD4 + , CD8 + and CD68 + can be observed [121, 123, 124].”

    From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [123]

  • PM is associated with inflammatory immune responses, with increased levels of soluble mediators like TNF-α, TNF receptor I, TNF receptor II and IL-10 in peripheral blood.

    “PM is associated with inflammatory immune responses [75–79], with increased levels of soluble mediators like TNF-α, TNF receptor I, TNF receptor II and IL-10 in peripheral blood [80,81].”

    From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [76]

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Authors
Suguitan, Jr., Leke, R. G. F., Fouda, G., Zhou, A., Thuita, L., Metenou, S., Fogako, J., Megnekou, R., & Taylor, D. W.
Affiliations
  • Université de Yaoundé I (CM)
  • Georgetown University (US)
ORCID
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2003-10
Volume
188
Issue
7
Pages
1074-7082
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1086/378500
OpenAlex
W2096731679
Cited by
161
References
44
Citations by year
2026: 4 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 13
FWCI
8.12
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Public Health Service (U01A1 43888)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords
Plasmodium falciparum, malaria in pregnancy, placenta, chemokines, cytokines, interferon-gamma, TNF-α, IL-10, MCP-1, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1β, CXCL10, fetal tissue, placental inflammation, macrophage accumulation, immune regulation
MeSH terms
Adult, Animals, Cameroon, Enzyme-Linked Immunosorbent Assay, Female, Fetus, Hematocrit, Humans, Immunohistochemistry, Leukocyte Count, Placenta, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Parasitic, Cytokines, Malaria, Falciparum, Parasitemia, Chemokines

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