Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study
Open accessAbstract
BACKGROUND: Higher plasma n-3 polyunsaturated fatty acids (PUFA) have been associated with a lower risk of age related cognitive decline, and to beneficially affect cardiometabolic risk factors. A relation exists between metabolic disorders such as diabetes type 2 and cognitive decline. Results regarding the potential effects of n-3 PUFA on risk factors in healthy subjects are divergent, and studies regarding the possible relation between cardiometabolic parameters and cognitive performance are scarce. The objective was to evaluate the effects of five weeks intake of long chain n-3 PUFA on cognitive performance in healthy individuals, and to exploit the possible relation between outcomes in cognitive tests to cardiometabolic risk parameters. METHODS: Fish oil n-3 PUFA (3g daily) were consumed during 5 weeks separated by a 5 week washout period in a cross-over placebo controlled study, including 40 healthy middle aged to elderly subjects. Cognitive performance was determined by tests measuring working memory (WM) and selective attention. RESULTS: Supplementation with n-3 PUFA resulted in better performance in the WM-test compared with placebo (p < 0.05). In contrast to placebo, n-3 PUFA lowered plasma triacylglycerides (P < 0.05) and systolic blood pressure (p < 0.0001). Systolic blood pressure (p < 0.05), f-glucose (p = 0.05), and s-TNF-α (p = 0.05), were inversely related to the performance in cognitive tests. CONCLUSIONS: Intake of n-3 PUFA improved cognitive performance in healthy subjects after five weeks compared with placebo. In addition, inverse relations were obtained between cardiometabolic risk factors and cognitive performance, indicating a potential of dietary prevention strategies to delay onset of metabolic disorders and associated cognitive decline.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
An inverse relationship was observed between cardiometabolic risk factors and cognitive performance, suggesting that dietary prevention strategies may delay the onset of metabolic disorders and associated cognitive decline.
“In addition, an inverse relationship was observed between cardiometabolic risk factors and cognitive performance, suggesting that dietary prevention strategies may delay the onset of metabolic disorders and associated cognitive decline.”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [137]
In middle-aged to elderly healthy individuals (n = 40), n-3 polyunsaturated fatty acid supplementation (3 mg/day) significantly improved cognitive performance (working memory and attention) compared with a placebo group in a 5-week RCT.
“In middle-aged to elderly healthy individuals (n = 40), n-3 PUFA supplementation (3 mg/day) significantly improved cognitive performance (i.e. working memory and attention) compared with that of a placebo group in a 5-week RCT [137].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [137]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cohen, J. (1992) · Psychological Bulletin · doi:10.1037//0033-2909.112.1.155 · Cited by 8,771 · see citing works
Individual differences in working memory and reading
Daneman, M., & Carpenter, P. A. (1980) · Journal of Verbal Learning and Verbal Behavior · doi:10.1016/s0022-5371(80)90312-6 · Cited by 6,336 · see citing works
n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525 · see citing works
Models of Working Memory: Mechanisms of Active Maintenance and Executive Control
Miyake, A., & Shah, P. (1999) · Cited by 2,404 · see citing works
Reasoning ability is (little more than) working-memory capacity?!
Kyllonen, P. C., & Christal, R. E. (1990) · Intelligence · doi:10.1016/s0160-2896(05)80012-1 · Cited by 1,810 · see citing works
Optimal Diets for Prevention of Coronary Heart Disease
Hu, F. B. (2002) · JAMA · doi:10.1001/jama.288.20.2569 · Cited by 1,503 · see citing works
Engle, R. W., Kane, M. J., & Tuholski, S. W. (1999) · Models of Working Memory · doi:10.1017/cbo9781139174909.007 · Cited by 1,195 · see citing works
McKeown, N. M., Meigs, J. B., Liu, S., Saltzman, E., Wilson, P. W. F., & Jacques, P. F. (2004) · Diabetes Care · doi:10.2337/diacare.27.2.538 · Cited by 786 · see citing works
Beneficial effects of docosahexaenoic acid on cognition in age‐related cognitive decline
Yurko‐Mauro, K., McCarthy, D., Rom, D., Nelson, E. B., Ryan, A. S., Blackwell, A. D., Salem, N., Stedman, M., & MIDAS Investigators (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.01.013 · Cited by 583 · see citing works
McKeown, N. M., Meigs, J. B., Liu, S., Wilson, P. W., & Jacques, P. F. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.2.390 · Cited by 574 · see citing works
Strachan, M. W. J., Deary, I. J., Ewing, F. M. E., & Frier, B. M. (1997) · Diabetes Care · doi:10.2337/diacare.20.3.438 · Cited by 529 · cited 1× · see citing works
“conditions that predispose for cognitive decline [14,40-42]).”
Fish Consumption and Cognitive Decline With Age in a Large Community Study
Morris, M. C., Evans, D. A., Tangney, C. C., Bienias, J. L., & Wilson, R. S. (2005) · Archives of Neurology · doi:10.1001/archneur.62.12.noc50161 · Cited by 428 · see citing works
Effect of fish oil on cognitive performance in older subjects
van de Rest, O., Geleijnse, J. M., Kok, F. J., van Staveren, W. A., Dullemeijer, C., Olde-Rikkert, M. G. M., Beekman, A. T. F., & de Groot, C. P. G. M. (2008) · Neurology · doi:10.1212/01.wnl.0000324268.45138.86 · Cited by 380 · see citing works
van Gelder, B. M., Tijhuis, M., Kalmijn, S., & Kromhout, D. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1142 · Cited by 346 · see citing works
Fat intake at midlife and cognitive impairment later in life: a population‐based CAIDE study
Eskelinen, M. H., Ngandu, T., Helkala, E., Tuomilehto, J., Nissinen, A., Soininen, H., & Kivipelto, M. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1969 · Cited by 321 · see citing works
Neurological Benefits of Omega-3 Fatty Acids
Dyall, S. C., & Michael-Titus, A. T. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8036-z · Cited by 307 · see citing works
Nilsson, A. C., Östman, E. M., Holst, J. J., & Björck, I. (2008) · Journal of Nutrition · doi:10.1093/jn/138.4.732 · Cited by 299 · see citing works
Self-citationFontani, G., Corradeschi, F., Felici, A., Alfatti, F., Migliorini, S., & Lodi, L. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01570.x · Cited by 284 · see citing works
Beydoun, M. A., Kaufman, J. S., Satia, J. A., Rosamond, W., & Folsom, A. R. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1103 · Cited by 253 · see citing works
Individual Differences in Working Memory for Comprehension and Following Directions
Engle, R. W., Carullo, J. J., & Collins, K. W. (1991) · The Journal of Educational Research · doi:10.1080/00220671.1991.10886025 · Cited by 224 · see citing works
The Metabolic Syndrome and Development of Cognitive Impairment Among Older Women
Yaffe, K., Weston, A. L., Blackwell, T., & Krueger, K. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.566 · Cited by 220 · see citing works
Inflammation and the Incidence of Type 2 Diabetes
Bertoni, A. G., Burke, G. L., Owusu, J. A., Carnethon, M. R., Vaidya, D. M., Barr, R. G., Jenny, N. S., Ouyang, P., & Rotter, J. I. (2010) · Diabetes Care · doi:10.2337/dc09-1679 · Cited by 201 · see citing works
Ryan, A. S., Astwood, J. D., Gautier, S., Kuratko, C. N., Nelson, E. B., & Salem, N. (2010) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2010.02.007 · Cited by 192 · see citing works
The relationship between information-processing ability and notetaking
Kiewra, K. A., & Benton, S. L. (1988) · Contemporary Educational Psychology · doi:10.1016/0361-476x(88)90004-5 · Cited by 191 · see citing works
Interleukin-6 Covaries Inversely With Cognitive Performance Among Middle-Aged Community Volunteers
Marsland, A. L., Petersen, K. L., Sathanoori, R., Muldoon, M. F., Neumann, S. A., Ryan, C. M., Flory, J. D., & Manuck, S. B. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000238451.22174.92 · Cited by 179 · see citing works
Cognition in the Early Stage of Type 2 Diabetes
Ruis, C., Biessels, G. J., Gorter, K. J., van den Donk, M., Kappelle, L. J., & Rutten, G. E. H. M. (2009) · Diabetes Care · doi:10.2337/dc08-2143 · Cited by 164 · see citing works
Rosén, L. A. H., Silva, L. B., Andersson, U. K., Holm, C., Östman, E. M., & Björck, I. (2009) · Nutrition Journal · doi:10.1186/1475-2891-8-42 · Cited by 162 · see citing works
Self-citationMicallef, M. A., & Garg, M. L. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.09.020 · Cited by 157 · see citing works
Lamport, D. J., Lawton, C. L., Mansfield, M. W., & Dye, L. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.008 · Cited by 150 · see citing works
n−3 Fatty acid proportions in plasma and cognitive performance in older adults
Dullemeijer, C., Durga, J., Brouwer, I. A., van de Rest, O., Kok, F. J., Brummer, R.-J. M., van Boxtel, M. P., & Verhoef, P. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1479 · Cited by 148 · see citing works
Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study
Nurk, E., Drevon, C. A., Refsum, H., Solvoll, K., Vollset, S. E., Nygard, O. K., Nygaard, H. A., Engedal, K., Tell, G. S., & Smith, A. D. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1470 · Cited by 147 · see citing works
Dietary fatty acids intake: possible role in cognitive decline and dementia
Solfrizzi, V., D’Introno, A., Colacicco, A. M., Capurso, C. A., DelParigi, A., Capurso, S. A., Gadaleta, A., Capurso, A., & Panza, F. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.01.001 · Cited by 132 · see citing works
Cognitive abilities as determinants of success in acquiring logic skill
Kyllonen, P. C., & Stephens, D. L. (1990) · Learning and Individual Differences · doi:10.1016/1041-6080(90)90020-h · Cited by 126 · see citing works
Metabolic syndrome and cognitive decline in French elders
Raffaitin, C., Féart, C., Goff, M. L., Amieva, H., Helmer, C., Akbaraly, T. N., Tzourio, C., Gin, H., & Barberger‐Gateau, P. (2011) · Neurology · doi:10.1212/wnl.0b013e31820b7656 · Cited by 125 · see citing works
Is working memory capacity Spearman's g?
Kyllonen, P. C. (1996) · Cited by 120 · see citing works
Barceló‐Coblijn, G., Kitajka, K., Puskás, L. G., Hőgyes, E., Zvara, Á., Hackler, L., & Farkas, T. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(03)00064-7 · Cited by 103 · see citing works
Cognitive dysfunction associated with metabolic syndrome
Taylor, V. H., & MacQUEEN, G. M. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2007.00401.x · Cited by 102 · see citing works
van den Berg, E., Dekker, J. M., Nijpels, G., Kessels, R. P. C., Kappelle, L. J., de Haan, E. H. F., Heine, R. J., Stehouwer, C. D. A., & Biessels, G. J. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000160959 · Cited by 102 · see citing works
Metabolic Syndrome, Brain Magnetic Resonance Imaging, and Cognition
Cavalieri, M., Ropele, S., Petrovic, K., Pluta-Fuerst, A., Homayoon, N., Enzinger, C., Grazer, A., Katschnig, P., Schwingenschuh, P., Berghold, A., et al. (2010) · Diabetes Care · doi:10.2337/dc10-0851 · Cited by 92 · see citing works
Omega-3 fatty acids (fish-oil) and depression-related cognition in healthy volunteers
Antypa, N., van der Does, W. A. J., Smelt, A., & Rogers, R. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108092120 · Cited by 92 · see citing works
Dangour, A. D., Allen, E., Elbourne, D. R., FLETCHER, A. E., Richards, M., & Uauy, R. D. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0057-2 · Cited by 91 · see citing works
Dennis, I. (2013) · Psychology Press eBooks · doi:10.4324/9780203774007 · Cited by 79 · see citing works
Metabolic Syndrome Is Associated with Learning and Recall Impairment in Middle Age
Hassenstab, J. J., Sweat, V., Bruehl, H., & Convit, A. J. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000296071 · Cited by 71 · see citing works
Mann, N. J., O’Connell, S. L., Baldwin, K. M., Singh, I., & Meyer, B. J. (2010) · Lipids · doi:10.1007/s11745-010-3450-z · Cited by 60 · see citing works
Nilsson, A. C., Radeborg, K., & Björck, I. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602900 · Cited by 55 · see citing works
Self-citationNavas‐Carretero, S., Pérez-Granados, A. M., Schoppen, S., & Vaquero, M. P. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509220794 · Cited by 54 · see citing works
Chiou, J., & Hu, M. (1999) · Clinical Biochemistry · doi:10.1016/s0009-9120(98)00110-6 · Cited by 53 · see citing works
The effect of concurrent task difficulty on working memory during simulated driving
Radeborg, K., Briem, V., & Hedman, L. (1999) · Ergonomics · doi:10.1080/001401399185441 · Cited by 49 · see citing works
Self-citationMeyer, B. J., Lane, A., & Mann, N. J. (2009) · Lipids · doi:10.1007/s11745-009-3333-3 · Cited by 36 · see citing works
Segarra, A. B., Ruiz-Sanz, J. I., Ruiz‐Larrea, M. B., Ramírez‐Sánchez, M., de Gasparo, M., Banegas, I., Martínez‐Cañamero, M., Vives, F., & Prieto, I. (2010) · Hormone and Metabolic Research · doi:10.1055/s-0030-1269855 · Cited by 24 · see citing works
Clinical Significance of High-Sensitivity C-Reactive Protein in Cardiovascular Disease
Conen, D., & Ridker, P. M. (2007) · Biomarkers in Medicine · doi:10.2217/17520363.1.2.229 · Cited by 15 · see citing works
Sartorelli, D. S., Damião, R., Chaim, R., Hirai, A. T., Gimeno, S. G. A., & Ferreira, S. R. G. (2009) · Nutrition · doi:10.1016/j.nut.2009.03.013 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Janssen, C. I. F., & Kiliaan, A. J. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.10.002 · Cited by 515 · see citing works
Docosahexaenoic Acid and Cognition throughout the Lifespan
Weiser, M., Butt, C., & Mohajeri, M. (2016) · Nutrients · doi:10.3390/nu8020099 · Cited by 400 · see citing works
Emerging Risk Biomarkers in Cardiovascular Diseases and Disorders
Upadhyay, R. K. (2015) · Journal of Lipids · doi:10.1155/2015/971453 · Cited by 362 · see citing works
Cognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works
Beilharz, J. E., Maniam, J., & Morris, M. J. (2015) · Nutrients · doi:10.3390/nu7085307 · Cited by 214 · see citing works
Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap
Murphy, T., Dias, G. P., & Thuret, S. (2014) · Neural Plasticity · doi:10.1155/2014/563160 · Cited by 209 · see citing works
Impact of dietary fats on brain functions
Chianese, R., Coccurello, R., Viggiano, A., Scafuro, M., Fiore, M., Coppola, G., Operto, F. F., Fasano, S., Laye, S., Pierantoni, R., et al. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666171017102547 · Cited by 159 · see citing works
Leslie, M. A., Cohen, D. J. A., Liddle, D. M., Robinson, L. E., & Ma, D. W. L. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0049-7 · Cited by 143 · see citing works
Impact of Omega-3 Fatty Acid Supplementation on Memory Functions in Healthy Older Adults
Külzow, N., Witte, A. V., Kerti, L., Grittner, U., Schuchardt, J. P., Hahn, A., & Flöel, A. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150886 · Cited by 144 · see citing works
The Role for Dietary Omega-3 Fatty Acids Supplementation in Older Adults
Molfino, A., Gioia, G., Fanelli, F. R., & Muscaritoli, M. (2014) · Nutrients · doi:10.3390/nu6104058 · Cited by 122 · see citing works
Afshordel, S., Hagl, S., Werner, D., Röhner, N., Kögel, D., Bazan, N. G., & Eckert, G. P. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.05.008 · Cited by 106 · see citing works
Stonehouse, W. (2014) · Nutrients · doi:10.3390/nu6072730 · Cited by 105 · see citing works
Nutrition and Dementia: Evidence for Preventive Approaches?
Canevelli, M., Lucchini, F., Quarata, F., Bruno, G., & Cesari, M. (2016) · Nutrients · doi:10.3390/nu8030144 · Cited by 79 · see citing works
Kemse, N. G., Kale, A. A., & Joshi, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111902 · Cited by 78 · see citing works
Iolascon, G., Gimigliano, R., Bianco, M., Alessandro de, S. I. R. E., Moretti, A., Giusti, A., Malavolta, N., Migliaccio, S., Migliore, A., Napoli, N., et al. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0823-x · Cited by 79 · see citing works
de Jager, C. A., Dye, L., de Bruin, E. A., Butler, L. T., Fletcher, J., Lamport, D. J., Latulippe, M. E., Spencer, J. P. E., & Wesnes, K. A. (2014) · Nutrition Reviews · doi:10.1111/nure.12094 · Cited by 71 · see citing works
N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology
Pusceddu, M. M., Kelly, P., Stanton, C., Cryan, J. F., & Dinan, T. G. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw078 · Cited by 70 · see citing works
Alex, A., Abbott, K. A., McEvoy, M., Schofield, P. W., & Garg, M. L. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz073 · Cited by 63 · see citing works
Danthiir, V., Hosking, D. E., Nettelbeck, T., Vincent, A. D., Wilson, C. J., O’Callaghan, N. J., Calvaresi, E., Clifton, P. M., & Wittert, G. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqx077 · Cited by 61 · see citing works
Baleztena, J., Ruiz‐Canela, M., Sayón-Orea, C., Pardo, M., Añorbe, T., Gost, J. I., Gomez, C., Ilarregui, B., & Bes‐Rastrollo, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193568 · Cited by 58 · see citing works
HAMMOUDA, S., GHZAIEL, I., KHAMLAOUI, W., HAMMAMI, S., MHENNI, S. Y., SAMET, S., HAMMAMI, M., & ZARROUK, A. (2020) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2020.102159 · Cited by 50 · see citing works
Macaron, T., Giudici, K. V., Bowman, G. L., Sinclair, A. J., Stephan, E., Vellas, B. J., & Barreto, P. D. S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101300 · Cited by 49 · see citing works
Inflammation and neurodegenerative disorders
Baune, B. T. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000140 · Cited by 48 · see citing works
Rangel-Huerta, Ó. D., & Gil, Á. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux064 · Cited by 47 · see citing works
Wade, A. T., Davis, C. R., Dyer, K. A., Hodgson, J. M., Woodman, R. J., Keage, H. A. D., & Murphy, K. J. (2017) · Nutrients · doi:10.3390/nu9020145 · Cited by 46 · see citing works
Andriambelo, B., Stiffel, M., Roke, K., & Plourde, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101835 · Cited by 43 · see citing works
Jia, D., Heng, L., Yang, R.-H., & Gao, G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.016 · Cited by 43 · see citing works
Effects of Dietary Food Components on Cognitive Functions in Older Adults
Ozawa, H., Miyazawa, T., & Miyazawa, T. (2021) · Nutrients · doi:10.3390/nu13082804 · Cited by 44 · see citing works
Manuelli, M. C., Guardia, L. D., & Cena, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071552 · Cited by 42 · see citing works
A diet based on multiple functional concepts improves cognitive performance in healthy subjects
Nilsson, A. C., Tovar, J., Johansson, M., Radeborg, K., & Björck, I. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-49 · Cited by 41 · see citing works
Self-citationRuxton, C. H. S., Derbyshire, E. J., & Toribio-Mateas, M. A. (2015) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12335 · Cited by 39 · see citing works
Tokuda, H., Sueyasu, T., Kontani, M., Kawashima, H., Shibata, H., & Koga, Y. (2015) · Journal of Oleo Science · doi:10.5650/jos.ess15009 · Cited by 38 · see citing works
Rangel-Huerta, Ó. D., & Gil, Á. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.05.015 · Cited by 38 · see citing works
Omega-3 Fatty Acids, Cognition, and Brain Volume in Older Adults
Loong, S., Barnes, S. R., Gatto, N. M., Chowdhury, S., & Lee, G. J. (2023) · Brain Sciences · doi:10.3390/brainsci13091278 · Cited by 39 · see citing works
Kuszewski, J. C., Wong, R. H. X., & Howe, P. R. C. (2017) · Nutrients · doi:10.3390/nu9050487 · Cited by 37 · see citing works
Singh, J. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00329-x · Cited by 36 · see citing works
Mengelberg, A., LEATHEM, J. M., Podd, J., Hill, S., & Conlon, C. A. (2022) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5707 · Cited by 36 · see citing works
Microglia and modifiable life factors: Potential contributions to cognitive resilience in aging
Duggan, M. R., & Parikh, V. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113207 · Cited by 36 · see citing works
Ahmad, M. Z., Ahmad, J., Zafar, S., Warsi, M. H., Abdel‐Wahab, B. A., Akhter, S., & Alam, M. A. (2019) · Therapeutic Delivery · doi:10.4155/tde-2019-0072 · Cited by 35 · see citing works
Tovar, J., Johansson, M., & Björck, I. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-1039-2 · Cited by 33 · see citing works
Self-citationSandberg, J. C., Björck, I., & Nilsson, A. C. (2018) · Nutrition Journal · doi:10.1186/s12937-018-0412-4 · Cited by 31 · see citing works
Self-citationDietary Interventions to Prevent or Delay Alzheimer’s Disease: What the Evidence Shows
Bartochowski, Z., Conway, J., Wallach, Y., Chakkamparambil, B., Alakkassery, S., & Grossberg, G. T. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00333-1 · Cited by 30 · see citing works
Fish oil supplement use in New Zealand: A cross-sectional survey
Mengelberg, A., LEATHEM, J. M., & Podd, J. (2018) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2018.09.005 · Cited by 29 · see citing works
Wade, A. T., Davis, C. R., Dyer, K. A., Hodgson, J. M., Woodman, R. J., & Murphy, K. J. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519001168 · Cited by 32 · see citing works
N-of-1 Clinical Trials in Nutritional Interventions Directed at Improving Cognitive Function
Soldevila‐Domenech, N., Boronat, A., Langohr, K., & de la Torre, R. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00110 · Cited by 27 · see citing works
Asama, T., Hiraoka, T., Ohkuma, A., Okumura, N., Yamaki, A., & Urakami, K. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6664217 · Cited by 28 · see citing works
Controversies in omega-3 efficacy and novel concepts for application
Radcliffe, J., Thomas, J., Bramley, A. L., Kouris‐Blazos, A., Radford, B. E., Scholey, A. B., Pipingas, A., Thomas, C., & Itsiopoulos, C. (2016) · Journal of Nutrition & Intermediary Metabolism · doi:10.1016/j.jnim.2016.05.002 · Cited by 27 · see citing works
Yokoi, K., Yanagimoto, K., & Hayamizu, K. (2022) · Nutrients · doi:10.3390/nu14194136 · Cited by 27 · see citing works
An evidence-based method for examining and reporting cognitive processes in nutrition research
Pase, M. P., & Stough, C. K. K. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000158 · Cited by 27 · see citing works
Dietary Long-Chain Fatty Acids and Cognitive Performance in Older Australian Adults
MacDonald‐Wicks, L. K., McEvoy, M., Magennis, E., Schofield, P. W., Patterson, A. J., & Zacharia, K. (2019) · Nutrients · doi:10.3390/nu11040711 · Cited by 26 · see citing works
Schättin, A., Baier, C., Mai, D., Klamroth-Marganska, V., Herter‐Aeberli, I., & de Bruin, E. D. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1084-4 · Cited by 24 · see citing works
Maltais, M. L., Lorrain, D., Léveillé, P., Viens, I., Vachon, A., Houeto, A., Presse, N., & Plourde, M. (2022) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2022.102415 · Cited by 23 · see citing works
Sun, L., Hou, X.-H., Xue, S., Yan, F., Dai, Y., Zhao, C., Wang, F., & Yang, R. (2014) · Brain Research · doi:10.1016/j.brainres.2014.05.050 · Cited by 23 · see citing works
Teo, L., Crawford, C. C., Yehuda, R., Jaghab, D., Bingham, J. J., Chittum, H. K., Gallon, M. D., O’Connell, M. L., Arzola, S. M., & Berry, K. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux008 · Cited by 19 · see citing works
A Systematic Review of Omega-3 Consumption and Neuroprotective Cognitive Outcomes
Sherzai, A. Z., Sherzai, D., & Sherzai, D. (2022) · American Journal of Lifestyle Medicine · doi:10.1177/15598276221117102 · Cited by 19 · see citing works
Nutrition and Cognition in Older Adults With Heart Failure: A Systematic Review
Stewart, M. W., Traylor, A. C., & Bratzke, L. C. (2015) · Journal of Gerontological Nursing · doi:10.3928/00989134-20151015-06 · Cited by 18 · see citing works
Shimizu, K., Kuramochi, Y., & Hayamizu, K. (2024) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.24-36 · Cited by 13 · see citing works
Matura, S., Prvulovic, D., Mohadjer, N., Fußer, F., Oertel, V., Reif, A., Pantel, J., & Karakaya, T. (2021) · Acta Neuropsychiatrica · doi:10.1017/neu.2021.1 · Cited by 12 · see citing works
Blood–Brain Barrier Disruption Mediated by FFA1 Receptor—Evidence Using Miniscope
Lindenau, K. L., Barr, J. L., Higgins, C. R., Sporici, K. T., Brailoiu, E., & Brailoiu, G. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042258 · Cited by 12 · see citing works
Omega-3 Long-Chain Polyunsaturated Fatty Acids in the Elderly: A Review
Gareri, P. (2022) · OBM Geriatrics · doi:10.21926/obm.geriatr.2202198 · Cited by 11 · see citing works
Carvajal, F., Sánchez-Gil, A., Cardona, D., Rincón‐Cervera, M. Á., & Lerma-Cabrera, J. M. (2023) · Nutrients · doi:10.3390/nu15132993 · Cited by 11 · see citing works
Wade, A. T., Davis, C. R., Dyer, K. A., Hodgson, J. M., Woodman, R. J., Keage, H. A. D., & Murphy, K. J. (2017) · Nutrition Journal · doi:10.1186/s12937-017-0306-x · Cited by 10 · see citing works
Wesselman, L. M. P., Schild, A., Hooghiemstra, A. M., Meiberth, D. U., Drijver, A. J., van Leeuwenstijn‐Koopman, M., Prins, N. D., Brennan, S., Scheltens, P., Jessen, F., et al. (2020) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2020.9 · Cited by 9 · see citing works
Evidence Report: Risk Factor of Inadequate Nutrition
Smith, S. M., Zwart, S. R., & Heer, M. A. (2015) · NASA STI Repository (National Aeronautics and Space Administration) · Cited by 8 · see citing works
Tree-Borne Edible Oilseeds as Sources of Essential Omega Fatty Acids for Human Health
Chaliha, B., Saikia, D., & Saikia, S. P. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.89896 · Cited by 8 · see citing works
Choneva, M., Shishmanova-Doseva, M., Dimov, I., Boyanov, K., Dimitrov, I. V., Vlaykova, T. I., Georgieva, K. N., Hrischev, P., & Bivolarska, A. V. (2022) · Open Medicine · doi:10.1515/med-2022-0579 · Cited by 6 · see citing works
The relationship between omega‐3 fatty acids and blood pressure
Abraham, C., & Speth, R. C. (2018) · Journal of Pharmaceutical Health Services Research · doi:10.1111/jphs.12227 · Cited by 6 · see citing works
Oliveira, D., & Nilsson, A. C. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.08.010 · Cited by 5 · see citing works
Self-citationBianconi, S., Cantarelli, V. I., Almonacid, J. E. R., Zingerling, E., Weigandt, D. M., Báez, M. D. C., Ponzio, M. F., Williams, M. J., Schiöth, H. B., Santillán, M. E., et al. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111581 · Cited by 3 · see citing works
Fish Oil Supplementation Prevents Age-Related Memory Decline
Alfos, S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410527-0.00013-2 · Cited by 3 · see citing works
Krill Oil Supplementation and Cognitive Function
Burri, L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407824-6.00096-3 · Cited by 3 · see citing works
Plasma Phospholipid Polyunsaturated Fatty Acid Associations with Neurocognition
Ling, J., Keilp, J. G., Galfalvy, H., Cardino, V. N., Ahmed, A., Burke, A. K., Fenton, J. I., Mann, J. J., & Sublette, M. E. (2023) · Nutrients · doi:10.3390/nu15214542 · Cited by 2 · see citing works
"Cognition and Omega-3 Fatty Acids: A Narrative Review of the Literature"
Javier, G. (2021) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2021.40.006488 · Cited by 2 · see citing works
Esteves, E. A. (2017) · Food and Nutrition Report · doi:10.24218/fnr.2017.16 · Cited by 2 · see citing works
Dimopoulou, M., Madesis, P. B., Dimopoulou, A. M., & Gortzi, O. (2026) · Foods · doi:10.3390/foods15061079 · Cited by 1 · see citing works
Dietary and Nutritional Regulation
Murphy, T., & Thuret, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801977-1.00006-4 · Cited by 1 · see citing works
Plants based rich sources of polyunsaturated fatty acids: A comprehensive review
Prakash, S., & Sharma, S. (2023) · The Pharma Innovation · doi:10.22271/tpi.2023.v12.i5af.20250 · Cited by 1 · see citing works
Omega-3 fatty acids and brain function
Smollich, M. (2015) · Cited by 1 · see citing works
The effects of midlife diet on late-life cognition : an epidemiological approach
Eskelinen, M. H. (2014) · UEF eRepo (University of Eastern Finland) · Cited by 1 · see citing works
Meyer, B. J. (2018) · MDPI eBooks · doi:10.3390/books978-3-03842-972-2
Cognitive Performance and Nutrition in Esports
Sharpe, B. T., Rogers, E. J., & Montanari, S. (2025) · Springer eBooks · doi:10.1007/978-3-031-99625-2_2
Antioxidant- and omega-3 fatty acid-rich functional foods
Murali, S., Sruthi, T., Maurya, A. K., Yadav, A. K., Ronya, N., Samyor, D., Gupta, A., Mahato, D. K., Kamle, M., & Kumar, P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33853-3.00002-8
Market trends and opportunities in the polyunsaturated fatty acid food industry
Rajan, D., Rajan, S., Sundaravadivelu, K., & Gupta, R. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-43810-3.00009-9
Li, X., Jin, Y., Li, X., Chen, M., Kang, C., Lu, H., Gao, H., & Jiang, X. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108479
横井, 香., Kim, H., 綾華, 加., Hayamizu, K., Yamada, Y., & Momma, H. (2026) · European Journal of Clinical Nutrition · doi:10.1038/s41430-026-01832-0
- Authors
- Nilsson, A., Radeborg, K., Salo, I., & Björck, I.
- Affiliations
- Lund University (SE)
- Corresponding author
- Nilsson, Anne
- Venue
- Nutrition Journal
- Published
- 2012-11-22
- Volume
- 11
- Issue
- 1
- Pages
- 99-99
- ISSN
- 1475-2891 (ISSN-L)
- PMC
- PMC3564898
- OpenAlex
- W2154321205
- Cited by
- 86
- References
- 52
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 8 · 2015: 11 · 2014: 11 · 2013: 3
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrition Journal (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- VINNOVA
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- omega-3 fatty acids, fish oil supplementation, cognitive performance, working memory, selective attention, cardiometabolic risk factors, systolic blood pressure, fasting blood glucose, serum TNF-alpha, age-related cognitive decline
- MeSH terms
- Aged, Blood Glucose, Blood Pressure, Cardiovascular Diseases, Cognition, Cognition Disorders, Double-Blind Method, Female, Humans, Male, Middle Aged, Risk Factors, Triglycerides, Tumor Necrosis Factor-alpha, Biomarkers, Fatty Acids, Omega-3, Body Mass Index, Cross-Over Studies, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review