Cited by 86Fatty Acid Research and HealthNutritional Studies and DietDementia and Cognitive Impairment Research

Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study

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Nilsson, Anne, Radeborg, Karl, Salo, Ilkka, Björck, Inger·2012·Nutrition Journal

Abstract

BACKGROUND: Higher plasma n-3 polyunsaturated fatty acids (PUFA) have been associated with a lower risk of age related cognitive decline, and to beneficially affect cardiometabolic risk factors. A relation exists between metabolic disorders such as diabetes type 2 and cognitive decline. Results regarding the potential effects of n-3 PUFA on risk factors in healthy subjects are divergent, and studies regarding the possible relation between cardiometabolic parameters and cognitive performance are scarce. The objective was to evaluate the effects of five weeks intake of long chain n-3 PUFA on cognitive performance in healthy individuals, and to exploit the possible relation between outcomes in cognitive tests to cardiometabolic risk parameters. METHODS: Fish oil n-3 PUFA (3g daily) were consumed during 5 weeks separated by a 5 week washout period in a cross-over placebo controlled study, including 40 healthy middle aged to elderly subjects. Cognitive performance was determined by tests measuring working memory (WM) and selective attention. RESULTS: Supplementation with n-3 PUFA resulted in better performance in the WM-test compared with placebo (p < 0.05). In contrast to placebo, n-3 PUFA lowered plasma triacylglycerides (P < 0.05) and systolic blood pressure (p < 0.0001). Systolic blood pressure (p < 0.05), f-glucose (p = 0.05), and s-TNF-α (p = 0.05), were inversely related to the performance in cognitive tests. CONCLUSIONS: Intake of n-3 PUFA improved cognitive performance in healthy subjects after five weeks compared with placebo. In addition, inverse relations were obtained between cardiometabolic risk factors and cognitive performance, indicating a potential of dietary prevention strategies to delay onset of metabolic disorders and associated cognitive decline.

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  • An inverse relationship was observed between cardiometabolic risk factors and cognitive performance, suggesting that dietary prevention strategies may delay the onset of metabolic disorders and associated cognitive decline.

    “In addition, an inverse relationship was observed between cardiometabolic risk factors and cognitive performance, suggesting that dietary prevention strategies may delay the onset of metabolic disorders and associated cognitive decline.”
  • In middle-aged to elderly healthy individuals (n = 40), n-3 polyunsaturated fatty acid supplementation (3 mg/day) significantly improved cognitive performance (working memory and attention) compared with a placebo group in a 5-week RCT.

    “In middle-aged to elderly healthy individuals (n = 40), n-3 PUFA supplementation (3 mg/day) significantly improved cognitive performance (i.e. working memory and attention) compared with that of a placebo group in a 5-week RCT [137].”

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Authors
Nilsson, A., Radeborg, K., Salo, I., & Björck, I.
Affiliations
Lund University (SE)
Corresponding author
Nilsson, Anne
Venue
Nutrition Journal
Published
2012-11-22
Volume
11
Issue
1
Pages
99-99
ISSN
1475-2891 (ISSN-L)
OpenAlex
W2154321205
Cited by
86
References
52
Citations by year
2026: 5 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 8 · 2015: 11 · 2014: 11 · 2013: 3
FWCI
7.47
Type
journal article
Language
en
Open access
Locations
  • Nutrition Journal (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
VINNOVA
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
omega-3 fatty acids, fish oil supplementation, cognitive performance, working memory, selective attention, cardiometabolic risk factors, systolic blood pressure, fasting blood glucose, serum TNF-alpha, age-related cognitive decline
MeSH terms
Aged, Blood Glucose, Blood Pressure, Cardiovascular Diseases, Cognition, Cognition Disorders, Double-Blind Method, Female, Humans, Male, Middle Aged, Risk Factors, Triglycerides, Tumor Necrosis Factor-alpha, Biomarkers, Fatty Acids, Omega-3, Body Mass Index, Cross-Over Studies, Dietary Supplements

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