Fish consumption, n−3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study
Open accessAbstract
Background Indications have been seen of a protective effect of fish consumption and the intake of n-3 fatty acids on cognitive decline. However, studies are scarce and results inconsistent.Objective The objective of the study was to examine the associations between fish consumption, the intake of the n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from fish and other foods, and subsequent 5-y cognitive decline.Design Data on fish consumption of 210 participants in the Zutphen Elderly Study, who were aged 70-89 y in 1990, and data on cognitive functioning collected in 1990 and 1995 were used in the study. The intake of EPA and DHA (EPA+DHA) was calculated for each participant. Multivariate linear regression analysis with multiple adjustments was used to assess associations.Results Fish consumers had significantly (P = 0.01) less 5-y subsequent cognitive decline than did nonconsumers. A linear trend was observed for the relation between the intake of EPA+DHA and cognitive decline (P = 0.01). An average difference of approximately 380 mg/d in EPA+DHA intake was associated with a 1.1-point difference in cognitive decline (P = 0.01).Conclusions A moderate intake of EPA+DHA may postpone cognitive decline in elderly men. Results from other studies are needed before definite conclusions about this association can be drawn.
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Fish consumption is associated with less cognitive decline at a 5-year follow-up in a prospective cohort study involving 210 healthy men aged 70-89 years.
“Fish consumption has been associated with less cognitive decline at a 5-year follow-up in a prospective cohort study involving 210 healthy men aged 70–89 years [77].”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [77]
There is a dose-response relationship between tertiles of dietary EPA + DHA intake and subsequent 5-year cognitive decline.
“The study also reported a dose-response relationship between tertiles of dietary EPA + DHA intake and subsequent 5-year cognitive decline.”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [77]
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- Authors
- van Gelder, B. M., Tijhuis, M., Kalmijn, S., & Kromhout, D.
- Affiliations
- University Medical Center Utrecht (NL)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 85
- Issue
- 4
- Pages
- 1142-1147
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2167606917
- Cited by
- 346
- References
- 33
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 14 · 2020: 14 · 2019: 14 · 2018: 15 · 2017: 13 · 2016: 19 · 2015: 16 · 2014: 27 · 2013: 19 · 2012: 26
- FWCI
- 34.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- European Commission
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- fish consumption, omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, cognitive decline, older men, dietary intake, Zutphen Elderly Study, cognitive aging
- MeSH terms
- Aged, Aged, 80 and over, Cognition, Cognition Disorders, Diet Surveys, Docosahexaenoic Acids, Geriatric Psychiatry, Humans, Longitudinal Studies, Male, Netherlands, Prospective Studies, Psychometrics, Eicosapentaenoic Acid, Cohort Studies, Fatty Acids, Omega-3, Geriatric Assessment, Linear Models, Seafood
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