N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology

Pusceddu, Matteo M.; Kelly, Philip; Stanton, Catherine; Cryan, John F.; Dinan, Timothy G.

doi:10.1093/ijnp/pyw078

Cited by 70Fatty Acid Research and HealthNutritional Studies and DietAquaculture Nutrition and Growth

N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology

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Pusceddu, Matteo M., Kelly, Philip, Stanton, Catherine, Cryan, John F., Dinan, Timothy G.·2016·International Journal of Neuropsychopharmacology

DOI 10.1093/ijnp/pyw078PMC PMC5203760

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Abstract

OBJECTIVE: The impact of lifetime dietary habits and their role in physical, mental, and social well-being has been the focus of considerable recent research. Omega-3 polyunsaturated fatty acids as a dietary constituent have been under the spotlight for decades. Omega-3 polyunsaturated fatty acids constitute key regulating factors of neurotransmission, neurogenesis, and neuroinflammation and are thereby fundamental for development, functioning, and aging of the CNS. Of note is the fact that these processes are altered in various psychiatric disorders, including attention deficit hyperactivity disorder, depression, and Alzheimer's disease. DESIGN: Relevant literature was identified through a search of MEDLINE via PubMed using the following words, "n-3 PUFAs," "EPA," and "DHA" in combination with "stress," "cognition," "ADHD," "anxiety," "depression," "bipolar disorder," "schizophrenia," and "Alzheimer." The principal focus was on the role of omega-3 polyunsaturated fatty acids throughout the lifespan and their implication for psychopathologies. Recommendations for future investigation on the potential clinical value of omega-3 polyunsaturated fatty acids were examined. RESULTS: The inconsistent and inconclusive results from randomized clinical trials limits the usage of omega-3 polyunsaturated fatty acids in clinical practice. However, a body of literature demonstrates an inverse correlation between omega-3 polyunsaturated fatty acid levels and quality of life/ psychiatric diseases. Specifically, older healthy adults showing low habitual intake of omega-3 polyunsaturated fatty acids benefit most from consuming them, showing improved age-related cognitive decline. CONCLUSIONS: Although further studies are required, there is an exciting and growing body of research suggesting that omega-3 polyunsaturated fatty acids may have a potential clinical value in the prevention and treatment of psychopathologies.

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Lifetime omega-3 fatty acid, vitamin, sulforaphane, and prebiotic supplementation are effective universal prevention interventions to support good mental health by reducing neuroinflammation, oxidative stress, and microbiota dysbiosis.
“lifetime omega-3 fatty acid [56–58], vitamin [57–59], sulforaphane [60], and prebiotic [61] supplementation to support good mental health by reducing neuroinflammation, oxidative stress, and microbiota dysbiosis”
From Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care? (2020) · cites this paper as [56]

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n-3 Polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism
Rao, J. S., Ertley, R. N., Lee, H.-J., DeMar, J. C., Arnold, J. T., Rapoport, S. I., & Bazinet, R. P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001888 · Cited by 280 · see citing works
Retracted
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 4,981 · cited 1× · see citing works
“This evidence acquires more interest, since stress can exert a pivotal role in memory and cognition (McEwen, 2007).”
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works
Self-citation
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works
Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease
Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Wilson, R. S., Aggarwal, N., & Schneider, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.940 · Cited by 1,135 · see citing works
Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota
Stecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050244 · Cited by 1,048 · see citing works
Maternal Supplementation With Very-Long-Chain n-3 Fatty Acids During Pregnancy and Lactation Augments Children’s IQ at 4 Years of Age
Helland, I. B., Smith, L., Saarem, K., Saugstad, O. D., & Drevon, C. A. (2003) · PEDIATRICS · doi:10.1542/peds.111.1.e39 · Cited by 928 · see citing works
Dietary (n-3) Fatty Acids and Brain Development1
Innis, S. M. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.4.855 · Cited by 906 · see citing works
Fish consumption and major depression
Hibbeln, J. R. (1998) · The Lancet · doi:10.1016/s0140-6736(05)79168-6 · Cited by 897 · see citing works
Long-Chain ω-3 Fatty Acids for Indicated Prevention of Psychotic Disorders: A Randomized, Placebo-Controlled Trial
Amminger, G. P., Schäfer, M. R., Papageorgiou, K., Klier, C. M., Cotton, S. M., Harrigan, S. M., Mackinnon, A., McGorry, P. D., & Berger, G. E. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.192 · Cited by 896 · see citing works
Omega 3 Fatty Acids in Bipolar Disorder: A Preliminary Double-blind, Placebo-Controlled Trial
Stoll, A. L., Severus, W. E., Freeman, M. P., Rueter, S., Zboyan, H. A., Diamond, E., Cress, K. K., & Marangell, L. B. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.5.407 · Cited by 814 · see citing works
Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements
Clandinin, M. T., Chappell, J. E., Leong, S. F., Heim, T. F., Swyer, P. R., & CHANCE, G. W. (1980) · Early Human Development · doi:10.1016/0378-3782(80)90015-8 · Cited by 782 · see citing works
ω-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: A Randomized Double-blind Trial
Freund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., Vedin, I., Vessby, B., Wahlund, L.-O., & Palmblad, J. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1402 · Cited by 751 · see citing works
Prefrontal Dopamine D1Receptors and Working Memory in Schizophrenia
Abi-Dargham, A., Mawlawi, O., Lombardo, I., Gil, R., Martinez, D., Huang, Y., Hwang, D.-R., Keilp, J., Kochan, L., Van Heertum, R., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03708.2002 · Cited by 724 · see citing works
A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model
Lim, G. P., Calon, F., Morihara, T., Yang, F., Teter, B., Ubeda, O. J., Salem, N., Frautschy, S. A., & Cole, G. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4225-04.2005 · Cited by 687 · see citing works
Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease
Söderberg, M., Edlund, C., Kristensson, K., & Dallner, G. (1991) · Lipids · doi:10.1007/bf02536067 · Cited by 667 · see citing works
Essential Fatty Acids: Biochemistry, Physiology and Pathology
Das, U. N. (2006) · Biotechnology Journal · doi:10.1002/biot.200600012 · Cited by 650 · see citing works
Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder
Nemets, B., Stahl, Z., & Belmaker, R. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.3.477 · Cited by 627 · see citing works
A Dose-Ranging Study of the Effects of Ethyl-Eicosapentaenoate in Patients With Ongoing Depression Despite Apparently Adequate Treatment With Standard Drugs
Peet, M., & Horrobin, D. F. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.10.913 · Cited by 615 · see citing works
Alpha-linolenic acid and its conversion to longer chain n−3 fatty acids: Benefits for human health and a role in maintaining tissue n−3 fatty acid levels
Barceló‐Coblijn, G., & Murphy, E. J. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.07.002 · Cited by 605 · see citing works
Omega-3 fatty acids in major depressive disorder
Su, K.-P., Huang, S.-Y., Chiu, C.-C., & Shen, W. W. (2003) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(03)00032-4 · Cited by 596 · see citing works
Beneficial effects of docosahexaenoic acid on cognition in age‐related cognitive decline
Yurko‐Mauro, K., McCarthy, D., Rom, D., Nelson, E. B., Ryan, A. S., Blackwell, A. D., Salem, N., Stedman, M., & MIDAS Investigators (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.01.013 · Cited by 584 · see citing works
Role of omega-3 fatty acids in brain development and function: Potential implications for the pathogenesis and prevention of psychopathology
McNamara, R. K., & Carlson, S. E. (2006) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2006.07.010 · Cited by 546 · see citing works
A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression
Lin, P.-Y., Huang, S.-Y., & Su, K.-P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.018 · Cited by 530 · see citing works
Seafood consumption, the DHA content of mothers’ milk and prevalence rates of postpartum depression: a cross-national, ecological analysis
Hibbeln, J. R. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00374-3 · Cited by 508 · see citing works
Dietary fat intakes for pregnant and lactating women
Koletzko, B., Cetin, I., Brenna, J. T., & for the Perinatal Lipid Intake Working Group (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507764747 · Cited by 484 · see citing works
Modulation of inflammation in brain: A matter of fat
Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04371.x · Cited by 460 · see citing works
The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment
Lee, B.-H., & Kim, Y. (2010) · Psychiatry Investigation · doi:10.4306/pi.2010.7.4.231 · Cited by 447 · see citing works
The Oxford-Durham Study: A Randomized, Controlled Trial of Dietary Supplementation With Fatty Acids in Children With Developmental Coordination Disorder
Richardson, A. J., & Montgomery, P. (2005) · PEDIATRICS · doi:10.1542/peds.2004-2164 · Cited by 438 · see citing works
Behavioral Deficits Associated with Dietary Induction of Decreased Brain Docosahexaenoic Acid Concentration
Moriguchi, T., Greiner, R. S., & Salem, N. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752563.x · Cited by 421 · see citing works
Meta-Analysis of the Effects of Eicosapentaenoic Acid (EPA) in Clinical Trials in Depression
Sublette, M. E., Ellis, S. P., Geant, A. L., & Mann, J. J. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06634 · Cited by 421 · see citing works
Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis
Bloch, M. H., & Qawasmi, A. (2011) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2011.06.008 · Cited by 417 · see citing works
The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study
Chiu, C.-C., Su, K., Cheng, T., Liu, H., Chang, C.-J., Dewey, M. E., Stewart, R. J., & Huang, S. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.05.015 · Cited by 407 · see citing works
Extrauterine fatty acid accretion in infant brain: implications for fatty acid requirements
Clandinin, M. T., Chappell, J. E., Leong, S. F., Heim, T. F., Swyer, P. R., & CHANCE, G. W. (1980) · Early Human Development · doi:10.1016/0378-3782(80)90016-x · Cited by 406 · see citing works
The role of polyunsaturated fatty acids in restoring the aging neuronal membrane
Yehuda, S., Rabinovitz, S., LCARASSO, R., & Mostofsky, D. I. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00074-x · Cited by 404 · see citing works
Effect of fish oil on cognitive performance in older subjects
van de Rest, O., Geleijnse, J. M., Kok, F. J., van Staveren, W. A., Dullemeijer, C., Olde-Rikkert, M. G. M., Beekman, A. T. F., & de Groot, C. P. G. M. (2008) · Neurology · doi:10.1212/01.wnl.0000324268.45138.86 · Cited by 380 · see citing works
A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties
Richardson, A. J., & Puri, B. K. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00254-8 · Cited by 379 · see citing works
A Double-Blind, Placebo-Controlled Study of the Omega-3 Fatty Acid Docosahexaenoic Acid in the Treatment of Major Depression
Marangell, L. B., Martinez, J. M., Zboyan, H. A., Kertz, B. L., Kim, H. F. S., & Puryear, L. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.5.996 · Cited by 379 · see citing works
A randomized, double-blind, placebo-controlled trial of docosahexaenoic acid supplementation in children with attention-deficit/hyperactivity disorder
Voigt, R. G., Llorente, A. M., Jensen, C. L., Fraley, J. K., Berretta, M. C., & Heird, W. C. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.116050 · Cited by 365 · see citing works
Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats
Hashimoto, M., Hossain, S., Shimada, T., Sugioka, K., Yamasaki, H., Fujii, Y., Ishibashi, Y., Oka, J., & Shido, O. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00905.x · Cited by 364 · see citing works
Omega-3 Treatment of Childhood Depression: A Controlled, Double-Blind Pilot Study
Nemets, H., Nemets, B., Apter, A. S., Bracha, Z., & Belmaker, R. H. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.6.1098 · Cited by 359 · see citing works
Omega-3 fatty acids suppleMentation in children with autism: A double-blind randomized, placebo-controlled pilot study
Amminger, G. P., Berger, G. E., Schäfer, M. R., Klier, C., Friedrich, M. H., & Feucht, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.007 · Cited by 355 · see citing works
Omega-3 Fatty Acid Treatment of Women With Borderline Personality Disorder: A Double-Blind, Placebo-Controlled Pilot Study
Zanarini, M. C., & Frankenburg, F. R. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.167 · Cited by 351 · see citing works
Omega-3 supplementation lowers inflammation and anxiety in medical students: A randomized controlled trial
Kiecolt-Glaser, J. K., Belury, M. A., Andridge, R., Malarkey, W. B., & Glaser, R. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.07.229 · Cited by 340 · see citing works
EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors
Stevens, L., Zhang, W., Peck, L. W., Kuczek, T., Grevstad, N., Mahon, A. K., Zentall, S. S., Arnold, L. E., & Burgess, J. R. (2003) · Lipids · doi:10.1007/s11745-006-1155-0 · Cited by 337 · see citing works
Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia
Peet, M., Brind, J., Ramchand, C. N., Shah, S., & Vankar, G. K. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00083-9 · Cited by 329 · see citing works
A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms
Peet, M., & Horrobin, D. F. (2002) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00048-6 · Cited by 329 · see citing works
Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving Presenilin 1 Levels
Green, K. N., Martínez‐Coria, H., Khashwji, H., Hall, E. B., Yurko‐Mauro, K., Ellis, L., & LaFerla, F. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0055-07.2007 · Cited by 326 · see citing works
Long-Chain Omega-3 Fatty Acids Improve Brain Function and Structure in Older Adults
Witte, A. V., Kerti, L., Hermannstädter, H. M., Fiebach, J. B., Schreiber, S. J., Schuchardt, J. P., Hahn, A., & Flöel, A. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht163 · Cited by 326 · see citing works
A Placebo-Controlled Trial of Omega-3 Fatty Acid (Ethyl Eicosapentaenoic Acid) Supplementation for Residual Symptoms and Cognitive Impairment in Schizophrenia
Fenton, W. S., Dickerson, F., Boronow, J. J., Hibbeln, J. R., & Knable, M. B. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.2071 · Cited by 322 · see citing works
Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction
Kotani, S., Sakaguchi, E., Warashina, S., Matsukawa, N., Ishikura, Y., Kiso, Y., Sakakibara, M., Yoshimoto, T., Guo, J., & Yamashima, T. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.06.010 · Cited by 321 · see citing works
Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: Randomised double-blind placebo-controlled study
Frangou, S., Lewis, M., & McCrone, P. (2006) · British Journal of Psychiatry · doi:10.1192/bjp.188.1.46 · Cited by 309 · see citing works
Omega-3 Fatty Acids for Major Depressive Disorder During Pregnancy: Results From a Randomized, Double-Blind, Placebo-Controlled Trial
Su, K.-P., Huang, S.-Y., Chiu, T.-H., Huang, K.-C., Huang, C.-L., Chang, H.-C., & Pariante, C. M. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0418 · Cited by 308 · see citing works
Randomized, Placebo-Controlled Study of Ethyl-Eicosapentaenoic Acid as Supplemental Treatment in Schizophrenia
Emsley, R. A., Myburgh, C., Oosthuizen, P. P., & van Rensburg, S. J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.9.1596 · Cited by 306 · see citing works
Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition
Wu, A., Ying, Z., & Gómez‐Pinilla, F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.061 · Cited by 299 · see citing works
Effects ofn-3 fatty acids, EPAv. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial
Sinn, N., Milte, C. M., Street, S. J., Buckley, J. D., Coates, A. M., Petkov, J., & Howe, P. R. C. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511004788 · Cited by 297 · see citing works
Effect of 2-y n−3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial
Dangour, A. D., Allen, E., Elbourne, D., Fasey, N., Fletcher, A. E., Hardy, P., Holder, G. E., Knight, R., Letley, L., Richards, M., et al. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.29121 · Cited by 296 · see citing works
Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women
Johnson, E. J., McDonald, K. Q., Caldarella, S. M., Chung, H.-Y., Troen, A. M., & Snodderly, D. M. (2008) · Nutritional Neuroscience · doi:10.1179/147683008x301450 · Cited by 292 · see citing works
Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder — a placebo-controlled double-blind study
Hirayama, S., Hamazaki, T., & TERASAWA, K. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601830 · Cited by 288 · see citing works
Chronic Administration of Docosahexaenoic Acid Ameliorates the Impairment of Spatial Cognition Learning Ability in Amyloid β–Infused Rats
Hashimoto, M., Tanabe, Y., Fujii, Y., Kikuta, T., Shibata, H., & Shido, O. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.3.549 · Cited by 288 · see citing works
Dietary Fish Oil Affects Monoaminergic Neurotransmission and Behavior in Rats
Chalon, S., Vancassel, S., Belzung, C., Guilloteau, D., Leguisquet, A.-M., Besnard, J., & Durand, G. (1998) · Journal of Nutrition · doi:10.1093/jn/128.12.2512 · Cited by 286 · see citing works
Cognitive and physiological effects of omega-3 polyunsaturated fatty acid supplementation in healthy subjects
Fontani, G., Corradeschi, F., Felici, A., Alfatti, F., Migliorini, S., & Lodi, L. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01570.x · Cited by 284 · see citing works
Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants
Jensen, C. L., Voigt, R. G., Prager, T. C., Zou, Y., Fraley, J. K., Rozelle, J. C., Turcich, M. R., Llorente, A. M., Anderson, R. E., & Heird, W. C. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.1.125 · Cited by 279 · see citing works
The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study.
Hamazaki, T., Sawazaki, S., Itomura, M., Asaoka, E., Nagao, Y., Nishimura, N., Yazawa, K., Kuwamori, T., & Kobayashi, M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118507 · Cited by 275 · see citing works
Essential fatty acids, DHA and human brain
Singh, M. (2005) · The Indian Journal of Pediatrics · doi:10.1007/bf02859265 · Cited by 268 · see citing works
Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood
Robertson, R. C., Seira Oriach, C., Murphy, K., Moloney, G. M., Cryan, J. F., Dinan, T. G., Paul Ross, R., & Stanton, C. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.145 · Cited by 268 · see citing works
Effect of Supplementation with Polyunsaturated Fatty Acids and Micronutrients on Learning and Behavior Problems Associated with Child ADHD
Parletta, N., & Bryan, J. (2007) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/01.dbp.0000267558.88457.a5 · Cited by 262 · see citing works
Selective Deficits in the Omega-3 Fatty Acid Docosahexaenoic Acid in the Postmortem Orbitofrontal Cortex of Patients with Major Depressive Disorder
McNamara, R. K., Hahn, C.-G., Jandacek, R. J., Rider, T., Tso, P., Stanford, K. E., & Richtand, N. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.026 · Cited by 261 · see citing works
DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial
Stonehouse, W., Conlon, C. A., Podd, J., Hill, S. R., Minihane, A. M., Haskell, C., & Kennedy, D. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.053371 · Cited by 252 · see citing works
Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection
Bazan, N. G. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32802b7030 · Cited by 244 · see citing works
No effect ofn-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial
Rogers, P. J., Appleton, K. M., Kessler, D., Peters, T. J., Gunnell, D., Hayward, R. C., Heatherley, S. V., Christian, L. M., McNaughton, S. A., & Ness, A. R. (2008) · British Journal of Nutrition · doi:10.1017/s0007114507801097 · Cited by 243 · see citing works
One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats
DeMar, J. C., Ma, K., Bell, J. M., Igarashi, M., GREENSTEIN, D. K., & Rapoport, S. I. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500362-jlr200 · Cited by 243 · see citing works
A Randomized Trial of Docosahexaenoic Acid Supplementation During the Third Trimester of Pregnancy
Smuts, C. M., Huang, M., Mundy, D., Plasse, T., Major, S., & Carlson, S. E. (2003) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(02)02585-1 · Cited by 243 · see citing works
Gender differences in then-3 fatty acid content of tissues
Childs, C. E., Romeu-Nadal, M., Burdge, G. C., & Calder, P. C. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108005983 · Cited by 238 · see citing works
Genetic Contributions of Inflammation to Depression
Barnes, J., Mondelli, V., & Pariante, C. M. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.169 · Cited by 237 · see citing works
Double-Blind, Randomized, Placebo-Controlled Trials of Ethyl-Eicosapentanoate in the Treatment of Bipolar Depression and Rapid Cycling Bipolar Disorder
Keck, P. E., Mintz, J., McElroy, S. L., Freeman, M. P., Suppes, T., Frye, M. A., Altshuler, L. L., Kupka, R., Nolen, W. A., Leverich, G. S., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.056 · Cited by 234 · see citing works
Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder
Burgess, J. R., Stevens, L., Zhang, W., & Peck, L. W. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.327s · Cited by 223 · see citing works
Stereoacuity at age 3.5 y in children born full-term is associated with prenatal and postnatal dietary factors: a report from a population–based cohort study
Williams, C., Birch, E. E., Emmett, P. M., & Northstone, K. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.316 · Cited by 222 · see citing works
Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial
Lee, L. K., Shahar, S., Chin, A.-V., & Yusoff, N. A. M. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2848-0 · Cited by 219 · see citing works
Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants
Jensen, C. L., Voigt, R. G., Prager, T. C., et al. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.125 · Cited by 217 · see citing works
N-3 Polyunsaturated Fatty Acids (PUFAs) Reverse the Impact of Early-Life Stress on the Gut Microbiota
Pusceddu, M. M., El Aidy, S., Crispie, F., O’Sullivan, O., Cotter, P., Stanton, C., Kelly, P., Cryan, J. F., & Dinan, T. G. (2015) · PLOS ONE · doi:10.1371/journal.pone.0139721 · Cited by 214 · see citing works
Self-citation
Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study
McNamara, R. K., Able, J. A., Jandacek, R. J., Rider, T., Tso, P., Eliassen, J. C., Alfieri, D. C., Weber, W., Jarvis, K., DelBello, M. P., et al. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28549 · Cited by 213 · see citing works
Modulation of Inflammatory Cytokines by Omega-3 Fatty Acids
Kang, J. X., & Weylandt, K. H. (2008) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-8831-5_5 · Cited by 209 · see citing works
Recovery of brain docosahexaenoate leads to recovery of spatial task performance
Moriguchi, T., & Salem, N. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01966.x · Cited by 209 · see citing works
Global Epidemiology of Mental Disorders: What Are We Missing?
Baxter, A. J., Patton, G. C., Scott, K. M., Degenhardt, L. J., & Whiteford, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065514 · Cited by 209 · see citing works
Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression
Silvers, K. M., Woolley, C. C., Hamilton, F. C., Watts, P. M., & Watson, R. A. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.11.004 · Cited by 207 · see citing works
Omega-3 fatty acids in the prevention of interferon-alpha-induced depression: results from a randomized, controlled trial
Su, K.-P., Lai, H.-C., Yang, H.-T., Su, W.-P., Peng, C.-Y., Chang, J. P.-C., Chang, H.-C., & Pariante, C. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.01.008 · Cited by 205 · see citing works
Chronic Administration Of Docosahexaenoic Acid Improves The Performance Of Radial Arm Maze Task In Aged Rats
Gamoh, S., Hashimoto, M., Hossain, S., & Masumura, S. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03437.x · Cited by 205 · see citing works
Why and How Meet n-3 PUFA Dietary Recommendations?
Molendi‐Coste, O., Legry, V., & Leclercq, I. A. (2010) · Gastroenterology Research and Practice · doi:10.1155/2011/364040 · Cited by 204 · see citing works
Effect of a 12-mo micronutrient intervention on learning and memory in well-nourished and marginally nourished school-aged children: 2 parallel, randomized, placebo-controlled studies in Australia and Indonesia
The NEMO Study Group (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.4.1082 · Cited by 202 · see citing works
Fish oil prevents the adrenal activation elicited by mental stress in healthy men
Delarue, J., Matzinger, O., Binnert, C., Schneiter, P., Chioléro, R., & Tappy, L. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70039-3 · Cited by 202 · see citing works
Omega-3/Omega-6 Fatty Acids for Attention Deficit Hyperactivity Disorder: A Randomized Placebo-Controlled Trial in Children and Adolescents
Johnson, M., Östlund, S., Fransson, G., Kadesjö, B., & Gillberg, C. (2009) · Journal of Attention Disorders · doi:10.1177/1087054708316261 · Cited by 198 · see citing works
Fatty acid metabolism in neurodevelopmental disorder: a new perspective on associations between attention-deficit/hyperactivity disorder, dyslexia, dyspraxia and the autistic spectrum
Richardson, A. J., & Ross, M. A. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0184 · Cited by 196 · see citing works
Omega-3 fatty acid supplementation in patients with recurrent self-harm
Hallahan, B. P., Hibbeln, J. R., Davis, J. M., & Garland, M. R. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.022707 · Cited by 191 · see citing works
Omega‐3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms
Freund‐Levi, Y., Basun, H., Cederholm, T., Irving, G. F., Garlind, A., Grut, M., Vedin, I., Palmblad, J. E. W., Wahlund, L., & Eriksdotter, M. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1857 · Cited by 182 · see citing works
Docosahexaenoic Acid for Reading, Cognition and Behavior in Children Aged 7–9 Years: A Randomized, Controlled Trial (The DOLAB Study)
Richardson, A. J., Burton, J., Sewell, R. P., Spreckelsen, T. F., & Montgomery, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043909 · Cited by 169 · see citing works
Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter
Gainetdinov, R. R., Mohn, A. R., Bohn, L., & Caron, M. G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191353298 · Cited by 168 · see citing works
Chronic ω-3 fatty acids supplementation promotes beneficial effects on anxiety, cognitive and depressive-like behaviors in rats subjected to a restraint stress protocol
Ferraz, A. C., Delattre, A. M., Almendra, R. G., Sonagli, M., Borges, C. R., Araujo, P., Andersen, M. L., Tufik, S. B., & Lima, M. M. S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.12.028 · Cited by 165 · see citing works
Phospholipase A2 and Cyclooxygenase 2 Genes Influence the Risk of Interferon-α–Induced Depression by Regulating Polyunsaturated Fatty Acids Levels
Su, K., Huang, S., Peng, C., Lai, H., Huang, C., Chen, Y.-C., Aitchison, K. J., & Pariante, C. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.005 · Cited by 165 · see citing works
Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression.
Logan, A. C. (2003) · PubMed · Cited by 163 · see citing works
Polyunsaturated fatty acids (PUFA) for attention deficit hyperactivity disorder (ADHD) in children and adolescents
Gillies, D. M., Sinn, J. K. H., Lad, S. S., Leach, M., & Ross, M. J. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007986.pub2 · Cited by 160 · see citing works
Facilitatory effect of docosahexaenoic acid on N‐methyl‐D‐aspartate response in pyramidal neurones of rat cerebral cortex.
Nishikawa, M., Kimura, S., & Akaike, N. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020051 · Cited by 155 · see citing works
The Relationship of Docosahexaenoic Acid (DHA) with Learning and Behavior in Healthy Children: A Review
Kuratko, C. N., Barrett, E., Nelson, E., & Salem, N. (2013) · Nutrients · doi:10.3390/nu5072777 · Cited by 153 · see citing works
Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age
Boucher, O., Burden, M. J., Muckle, G., Saint‐Amour, D., Ayotte, P., Dewailly, É., Nelson, C. A., Jacobson, S. W., & Jacobson, J. L. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.000323 · Cited by 152 · see citing works
Ethyl-Eicosapentaenoic Acid in First-Episode Psychosis
Berger, G. E., & Proffitt, T. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n1206 · Cited by 152 · see citing works
Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis
Cattaneo, A., Macchi, F., Plazzotta, G., Veronica, B., Bocchio-Chiavetto, L., Riva, M. A., & Pariante, C. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00040 · Cited by 152 · see citing works
Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor
Ikemoto, A., Ohishi, M., Sato, Y., Hata, N., Misawa, Y., Fujii, Y. R., & Okuyama, H. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32220-3 · Cited by 150 · see citing works
Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion
Larrieu, T., Hilal, L. M., Fourrier, C., Smedt, V. D., Sans, N., Capuron, L., & Layé, S. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.77 · Cited by 146 · see citing works
Fish Oil Supplementation of Control and (n-3) Fatty Acid-Deficient Male Rats Enhances Reference and Working Memory Performance and Increases Brain Regional Docosahexaenoic Acid Levels3
Chung, W.-L., Chen, J.-J., & Su, H. (2008) · Journal of Nutrition · doi:10.1093/jn/138.6.1165 · Cited by 144 · see citing works
Eicosapentaenoic acid confers neuroprotection in the amyloid-β challenged aged hippocampus
Lynch, A. M., Loane, D. J., Minogue, A. M., Clarke, R. M., Kilroy, D., Nally, R. E., Roche, Ó. J., O'Connell, F., & Lynch, M. A. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.04.006 · Cited by 144 · see citing works
Nutritional psychiatry research: an emerging discipline and its intersection with global urbanization, environmental challenges and the evolutionary mismatch
Logan, A., & Jacka, F. (2014) · Journal of Physiological Anthropology · doi:10.1186/1880-6805-33-22 · Cited by 144 · see citing works
Regulatory potential ofn-3 fatty acids in immunological and inflammatory processes
Grimm, H., Mayer, K., Mayser, P. A., & EIGENBRODT, E. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2001457 · Cited by 143 · see citing works
Essential Fatty Acids Preparation (Sr-3) Improves Alzheimer's Patients Quality of Life
Yehuda, S., Rabinovtz, S., Carasso, R. L., & Mostofsky, D. I. (1996) · International Journal of Neuroscience · doi:10.3109/00207459609070833 · Cited by 142 · see citing works
Possible regulatory mechanism of DHA-induced anti-stress reaction in rats
Takeuchi, T., Iwanaga, M., & Harada, E. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04113-6 · Cited by 141 · see citing works
Omega-3 Augmentation of Sertraline in Treatment of Depression in Patients With Coronary Heart Disease
Carney, R. M., Freedland, K. E., Rubin, E. H., Rich, M. W., Steinmeyer, B. C., & Harris, W. S. (2009) · JAMA · doi:10.1001/jama.2009.1487 · Cited by 140 · see citing works
The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat
Kelly, L., Grehan, B., Chiesa, A. D., O’Mara, S. M., Downer, E. J., Sahyoun, G., Massey, K. A., Nicolaou, A., & Lynch, M. A. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.001 · Cited by 140 · see citing works
n-3 Polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice
Vancassel, S., Leman, S., Hanonick, L., Denis, S., Roger, J., Nollet, M., Bodard, S., Kousignian, I., Belzung, C., & Chalon, S. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700328-jlr200 · Cited by 136 · see citing works
Fish oil supplementation in the treatment of major depression: A randomised double-blind placebo-controlled trial
Grenyer, B. F. S., Crowe, T. P., Meyer, B. J., Owen, A. J., Grigonis-Deane, E., Caputi, P., & Howe, P. R. C. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.06.004 · Cited by 132 · see citing works
Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid‐β oligomers
Florent‐Béchard, S., Malaplate, C., Youssef, I., Kriem, B., Koziel, V., Escanyé, M., Fifre, A., Sponne, I., Leininger‐Muller, B., Olivier, J. L., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03541.x · Cited by 131 · see citing works
Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain
Dyall, S. C., Michael, G. J., Whelpton, R., Scott, A. G., & Michael-Titus, A. T. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.01.002 · Cited by 126 · see citing works
Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediation
Levant, B., Radel, J. D., & Carlson, S. E. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.029 · Cited by 124 · see citing works
n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice
Cutuli, D., Bartolo, P. D., Caporali, P., Laricchiuta, D., Foti, F., Ronci, M., Rossi, C., Neri, C., Spalletta, G., Caltagirone, C., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00220 · Cited by 123 · see citing works
Effects of docosahexaenoic acid on the survival and neurite outgrowth of rat cortical neurons in primary cultures
Cao, D., Xue, R., Xu, J., & Liu, Z. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.02.002 · Cited by 117 · see citing works
Oiling the brain: a review of randomized controlled trials of Omega-3 fatty acids in psychopathology across the lifespan
Sinn, N., Milte, C., & Howe, P. R. C. (2010) · Nutrients · doi:10.3390/nu2020128 · Cited by 115 · see citing works
The role of 5-HT1A receptors in fish oil-mediated increased BDNF expression in the rat hippocampus and cortex: A possible antidepressant mechanism
Vines, A., Delattre, A. M., Lima, M. M. S., Rodrigues, L. S., Suchecki, D., Machado, R. B., Tufik, S., Pereira, S. I. R., Zanata, S. M., & Ferraz, A. C. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.06.017 · Cited by 115 · see citing works
A randomised control trial in schoolchildren showed improvement in cognitive function after consuming a bread spread, containing fish flour from a marine source
Dalton, A., Wolmarans, P., Witthuhn, R. C., van Stuijvenberg, M. E., Swanevelder, S. A., & Smuts, C. M. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2008.12.006 · Cited by 114 · see citing works
Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: Relationship with central serotonin turnover
McNamara, R. K., Jandacek, R. J., Rider, T., Tso, P., Cole-Strauss, A., & Lipton, J. W. (2010) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2010.08.004 · Cited by 113 · see citing works
Effect of fish-oil supplementation on mental well-being in older subjects: a randomized, double-blind, placebo-controlled trial
van de Rest, O., Geleijnse, J. M., Kok, F. J., van Staveren, W. A., Hoefnagels, W. H. L., Beekman, A. T. F., & de Groot, C. P. G. M. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.3.706 · Cited by 113 · see citing works
Docosahexaenoic Acid-rich Phospholipid Supplementation: Effect on Behavior, Learning Ability, and Retinal Function in Control and n-3 Polyunsaturated Fatty Acid Deficient Old Mice
Carrié, I., Smirnova, M., Clément, M., de Javel, D., Francès, H., & Bourre, J. M. (2002) · Nutritional Neuroscience · doi:10.1080/10284150290007074 · Cited by 112 · see citing works
Effects of iron and n-3 fatty acid supplementation, alone and in combination, on cognition in school children: a randomized, double-blind, placebo-controlled intervention in South Africa
Baumgartner, J., Smuts, C. M., Malan, L., Kvalsvig, J. D., van Stuijvenberg, M. E., Hurrell, R. F., & Zimmermann, M. B. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.041004 · Cited by 112 · see citing works
Adolescent Behavior and Dopamine Availability Are Uniquely Sensitive to Dietary Omega-3 Fatty Acid Deficiency
Bondi, C. O., Taha, A. Y., Tock, J., Totah, N. K. B., Cheon, Y., Torres, G. E., Rapoport, S. I., & Moghaddam, B. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.007 · Cited by 111 · see citing works
Cognitive effects of polyunsaturated fatty acids in children with attention deficit hyperactivity disorder symptoms: A randomised controlled trial
Sinn, N., Bryan, J., & Wilson, C. J. (2008) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2008.04.004 · Cited by 111 · see citing works
Effects of n‐3 fatty acids on cognitive decline: A randomized, double‐blind, placebo‐controlled trial in stable myocardial infarction patients
Geleijnse, J. M., Giltay, E. J., & Kromhout, D. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.06.002 · Cited by 111 · see citing works
Omega-3 Fatty Acids in Psychiatry
Mischoulon, D., & Freeman, M. P. (2013) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2012.12.002 · Cited by 111 · see citing works
Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial
Lucas, M., Asselin, G., Mérette, C., Poulin, M.-J., & Dodin, S. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26749 · Cited by 111 · see citing works
Long term adequate n-3 polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice
Moranis, A., Delpech, J.-C., Smedt, V. D., Aubert, A., Guesnet, P., Lavialle, M., Joffre, C., & Layé, S. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.11.001 · Cited by 110 · see citing works
Reduced Symptoms of Inattention after Dietary Omega-3 Fatty Acid Supplementation in Boys with and without Attention Deficit/Hyperactivity Disorder
Bos, D. J., Oranje, B., Veerhoek, E. S., Van Diepen, R. M., Weusten, J. M., Demmelmair, H., Koletzko, B., de Sain-van der Velden, M. G., Eilander, A., Hoeksma, M., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.73 · Cited by 110 · see citing works
Nutritional n-3 polyunsaturated fatty acids deficiency alters cannabinoid receptor signaling pathway in the brain and associated anxiety-like behavior in mice
Larrieu, T., Madore, C., Joffre, C., & Layé, S. (2012) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-012-0179-6 · Cited by 108 · see citing works
Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases
Terano, T., Fujishiro, S., Ban, T., Yamamoto, K., Tanaka, T., Noguchi, Y., Tamura, Y., Yazawa, K., & Hirayama, T. (1999) · Lipids · doi:10.1007/bf02562338 · Cited by 105 · see citing works
Phosphatidylserine Containing ω–3 Fatty Acids May Improve Memory Abilities in Non-Demented Elderly with Memory Complaints: A Double-Blind Placebo-Controlled Trial
Vakhapova, V., Cohen, T., Richter, Y., Herzog, Y., & Korczyn, A. D. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000310330 · Cited by 101 · see citing works
Effect of fortification with multiple micronutrients and n–3 fatty acids on growth and cognitive performance in Indian schoolchildren: the CHAMPION (Children’s Health and Mental Performance Influenced by Optimal Nutrition) Study
Muthayya, S., Eilander, A., Transler, C., Thomas, T. S., van der Knaap, H. C. M., Srinivasan, K., van Klinken, B. J. W., Osendarp, S. J. M., & Kurpad, A. V. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26993 · Cited by 101 · see citing works
A double-blind, placebo-controlled study investigating the effects of omega-3 supplementation in children aged 8–10 years from a mainstream school population
Kirby, A., Woodward, A. J., Jackson, S., Wang, Y., & Crawford, M. A. (2010) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2010.01.014 · Cited by 99 · see citing works
Mood by microbe: towards clinical translation
Dinan, T. G., & Cryan, J. F. (2016) · Genome Medicine · doi:10.1186/s13073-016-0292-1 · Cited by 99 · see citing works
Self-citation
Preliminary in vivo evidence of increased N-acetyl-aspartate following eicosapentanoic acid treatment in patients with bipolar disorder
Frangou, S., Lewis, M., Wollard, J., & Simmons, A. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106067787 · Cited by 98 · see citing works
The effects of 90-day supplementation with the Omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population
Stough, C. K. K., Downey, L. A., Silber, B. Y., Lloyd, J., Kure, C., Wesnes, K. A., & Camfield, D. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.019 · Cited by 97 · see citing works
Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder
Paloyelis, Y., Mehta, M. A., Faraone, S. V., Asherson, P., & Kuntsi, J. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.05.006 · Cited by 94 · see citing works
N-3 Fatty Acid Deficiency Induced by a Modified Artificial Rearing Method Leads to Poorer Performance in Spatial Learning Tasks
Lim, S., Hoshiba, J., Moriguchi, T., & Salem, N. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000180547.46725.cc · Cited by 92 · see citing works
Cognitive and mood effects of 8 weeks' supplementation with 400 mg or 1000 mg of the omega-3 essential fatty acid docosahexaenoic acid (DHA) in healthy children aged 10–12 years
Kennedy, D. O., Jackson, P. A., Elliott, J. M., Scholey, A. B., Robertson, B. C., Greer, J. M. H., Tiplady, B., Buchanan, T., & Haskell‐Ramsay, C. F. (2009) · Nutritional Neuroscience · doi:10.1179/147683009x388887 · Cited by 92 · see citing works
Omega-3 fatty acids (fish-oil) and depression-related cognition in healthy volunteers
Antypa, N., van der Does, W. A. J., Smelt, A., & Rogers, R. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108092120 · Cited by 92 · see citing works
Serum Phospholipid Docosahexaenonic Acid Is Associated with Cognitive Functioning during Middle Adulthood
Muldoon, M. F., Ryan, C. M., Sheu, L., Yao, J. K., Conklin, S. M., & Manuck, S. B. (2010) · The Journal of Nutrition · doi:10.3945/jn.109.119578 · Cited by 91 · see citing works
Role of perinatal long-chain omega-3 fatty acids in cortical circuit maturation: Mechanisms and implications for psychopathology
McNamara, R. K. (2015) · World Journal of Psychiatry · doi:10.5498/wjp.v5.i1.15 · Cited by 88 · see citing works
Long‐chain polyunsaturated fatty acids in childhood developmental and psychiatric disorders
Richardson, A. J. (2004) · Lipids · doi:10.1007/s11745-004-1350-z · Cited by 86 · see citing works
Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study
Nilsson, A., Radeborg, K., Salo, I., & Björck, I. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-99 · Cited by 86 · see citing works
Fatty acid deficiency signs predict the severity of reading and related difficulties in dyslexic children
Richardson, A. J., Calvin, C. M., Clisby, C., et al. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0194 · Cited by 84 · see citing works
Spontaneously hypertensive rat (SHR) as an animal model for ADHD: a short overview
Meneses, A., Perez-Garcia, G., Ponce-López, T., Tellez, R., Gallegos‐Cari, A., & Castillo, C. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.024 · Cited by 83 · see citing works
Docosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adults
Jackson, P. A., Reay, J. L., Scholey, A. B., & Kennedy, D. O. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.10.006 · Cited by 81 · see citing works
No effect of 12 weeks' supplementation with 1 g DHA-rich or EPA-rich fish oil on cognitive function or mood in healthy young adults aged 18–35 years
Jackson, P. A., Deary, M. E., Reay, J. L., Scholey, A. B., & Kennedy, D. O. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451100403x · Cited by 81 · see citing works
The effect of dietary vitamin E and fatty acid supplementation of pregnant and lactating ewes on placental and mammary transfer of vitamin E to the lamb
Capper, J. L., Wilkinson, R. G., Kasapidou, E., Pattinson, S. E., Mackenzie, A. M., & Sinclair, L. A. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051376 · Cited by 81 · see citing works
Dietary α-linolenate/linoleate balance influences learning and memory in the senescence-accelerated mouse (SAM)
Umezawa, M., Ohta, A., Tojo, H., Yagi, H., Hosokawa, M., & Takeda, T. (1995) · Brain Research · doi:10.1016/0006-8993(94)01250-l · Cited by 79 · see citing works
n-3 PUFAs have beneficial effects on anxiety and cognition in female rats: Effects of early life stress
Pusceddu, M. M., Kelly, P. M., Ariffin, N., Cryan, J. F., Clarke, G. A., & Dinan, T. G. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.04.015 · Cited by 77 · see citing works
Self-citation
A Double-Blind, Randomized Controlled Clinical Trial Comparing Eicosapentaenoic Acid Versus Docosahexaenoic Acid for Depression
Mischoulon, D., Nierenberg, A. A., Schettler, P. J., Kinkead, B. L., Fehling, K., Martinson, M. A., & Rapaport, M. H. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m08986 · Cited by 73 · see citing works
Omega-3 Treatment of Childhood Depression: A Controlled, Double-Blind Pilot Study
Nemets, H. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.6.1098 · Cited by 72 · see citing works
A nutrient combination that can affect synapse formation
Wurtman, R. (2014) · Nutrients · doi:10.3390/nu6041701 · Cited by 68 · see citing works
Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers.
Michaeli, B., M. Berger, M., Revelly, J.-P., Tappy, L., & Chioléro, R. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2006.06.001 · Cited by 68 · see citing works
Influence of testosterone administration on the biosynthesis of unsaturated fatty acids in male and female rats
Marra, C. A., & de Alaniz, M. J. T. (1989) · Lipids · doi:10.1007/bf02544071 · Cited by 67 · see citing works
The protective effect of dietary eicosapentaenoic acid against impairment of spatial cognition learning ability in rats infused with amyloid β(1–40)
Hashimoto, M., Hossain, S., Tanabe, Y., Kawashima, A., Harada, T., Yano, T., Mizuguchi, K., & Shido, O. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.08.009 · Cited by 64 · see citing works
Omega-3 fatty acids deprivation affects ontogeny of glutamatergic synapses in rats: Relevance for behavior alterations
Moreira, J. D., Knorr, L., Ganzella, M., Thomazi, A. P., de Souza, C. G., de Souza, D. G., Pitta, C. F., Souza, T. M. E., Wofchuk, S. T., Elisabetsky, E., et al. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.02.010 · Cited by 63 · see citing works
Dopamine receptors and learned helplessness in the rat
Kram, M., Kramer, G. L., Ronan, P. J., Steciuk, M. R., & Petty, F. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00222-6 · Cited by 62 · see citing works
Effects of fish oil supplementation on learning and behaviour of children from Australian Indigenous remote community schools: A randomised controlled trial
Parletta, N., Cooper, P., Gent, D., Petkov, J., & O’Dea, K. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.05.001 · Cited by 62 · see citing works
Docosahexaenoic acid facilitates cell maturation and β-adrenergic transmission in astrocytes
Joardar, A., Sen, A. K., & Das, S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500415-jlr200 · Cited by 58 · see citing works
Perinatal Supplementation with Omega-3 Polyunsaturated Fatty Acids Improves Sevoflurane-Induced Neurodegeneration and Memory Impairment in Neonatal Rats
Lei, X., Zhang, W., Liu, T., Xiao, H., Liang, W., Xia, W., & Zhang, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070645 · Cited by 53 · see citing works
Brain Docosahexaenoic Acid Status and Learning in Young Rats Submitted to Dietary Long-Chain Polyunsaturated Fatty Acid Deficiency and Supplementation Limited to Lactation
Calatayud, S. G., Redondo, C., Martín, E., Ruiz-Sanz, J. I., García‐Fuentes, M., & Sanjurjo, P. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000156506.03057.ad · Cited by 52 · see citing works
Phospholipid metabolism and depression: the possible roles of phospholipase A2 and coenzyme A‐independent transacylase
Horrobin, D. F. (2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.182 · Cited by 49 · see citing works
Dopamine receptor alterations in female rats with diet-induced decreased brain docosahexaenoic acid (DHA): interactions with reproductive status
Davis, P. F., Ozias, M. K., Carlson, S. E., Reed, G. A., Winter, M. K., McCarson, K. E., & Levant, B. (2010) · Nutritional Neuroscience · doi:10.1179/147683010x12611460764282 · Cited by 48 · see citing works
Clinical significance of neuropsychological improvement after supplementation with omega-3 in 8–12 years old malnourished Mexican children: A randomized, double-blind, placebo and treatment clinical trial
Reyes, V. P., Pérez-Garcı́a, M., Méndez, Y. L., & Puente, A. E. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.01.013 · Cited by 46 · see citing works
Omega-3 polyunsaturated fatty acids and cognition in a college-aged population.
Karr, J. E., Grindstaff, T. R., & Alexander, J. E. (2012) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0026945 · Cited by 44 · see citing works
DHA enhances the noradrenaline release by SH-SY5Y cells
Géraldine, M., Denis, S., Langelier, B., Denis, I., Lavialle, M., & Vancassel, S. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.09.006 · Cited by 43 · see citing works
An adaptogenic role for omega-3 fatty acids in stress; a randomised placebo controlled double blind intervention study (pilot) [ISRCTN22569553]
Bradbury, J., Myers, S. P., & Oliver, C. (2004) · Nutrition Journal · doi:10.1186/1475-2891-3-20 · Cited by 43 · see citing works
Marine omega-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD
Dervola, K.-S. N., Roberg, B., Wøien, G., Bogen, I. L., Sandvik, T., Sagvolden, T., Drevon, C. A., Johansen, E. B., & Walaas, S. I. (2012) · Behavioral and Brain Functions · doi:10.1186/1744-9081-8-56 · Cited by 42 · see citing works
Polyunsaturated fatty acids, cognition and literacy in children with ADHD with and without learning difficulties
Milte, C. M., Parletta, N., Buckley, J. D., Coates, A. M., Young, R. M., & Howe, P. R. C. (2011) · Journal of Child Health Care · doi:10.1177/1367493511403953 · Cited by 39 · see citing works
Cognitive deficits in adult rats by lead intoxication are related with regional specific inhibition of cNOS
García‐Arenas, G. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00195-5 · Cited by 36 · see citing works
Improved Working Memory but No Effect on Striatal Vesicular Monoamine Transporter Type 2 after Omega-3 Polyunsaturated Fatty Acid Supplementation
Narendran, R., Frankle, W. G., Mason, N. S., Muldoon, M. F., & Moghaddam, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046832 · Cited by 35 · see citing works
Polyunsaturated fatty acids in emerging psychosis: a safer alternative?
Schlögelhofer, M., Amminger, G. P., Schaefer, M. R., Fusar‐Poli, P., Smesny, S., McGorry, P. D., Berger, G. E., & Mossaheb, N. (2014) · Early Intervention in Psychiatry · doi:10.1111/eip.12151 · Cited by 34 · see citing works
Docosahexaenoic acid supplementation of primary rat hippocampal neurons attenuates the neurotoxicity induced by aggregated amyloid beta protein42 and up-regulates cytoskeletal protein expression
Wang, P.-Y., Chen, J.-J., & Su, H. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.01.012 · Cited by 30 · see citing works
Nutritional Omega-3 Deficiency Alters Glucocorticoid Receptor-Signaling Pathway and Neuronal Morphology in Regionally Distinct Brain Structures Associated with Emotional Deficits
Larrieu, T., Hilal, M. L., Smedt, V. D., Sans, N., & Layé, S. (2015) · Neural Plasticity · doi:10.1155/2016/8574830 · Cited by 27 · see citing works
The Omega-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid (DHA) Reverses Corticosterone-Induced Changes in Cortical Neurons
Pusceddu, M. M., Nolan, Y. M., Green, H. F., Robertson, R. C., Stanton, C., Kelly, P. M., Cryan, J. F., & Dinan, T. G. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv130 · Cited by 23 · see citing works
Self-citation
Long-term omega-3 supplementation modulates behavior, hippocampal fatty acid concentration, neuronal progenitor proliferation and central TNF-α expression in 7 month old unchallenged mice
Grundy, T., Toben, C. G., Jaehne, E. J., Corrigan, F., & Baune, B. T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00399 · Cited by 20 · see citing works
Long-term effects of perinatal essential fatty acid deficiency on anxiety-related behavior in mice.
Pálsdóttir, V., Månsson, J., Blomqvist, M., et al. (2012) · Behavioral Neuroscience · doi:10.1037/a0027161 · Cited by 11 · see citing works
Oral health and nutritional biochemical variables in adult patients with AIDS
Slobodianik, N., Perris, P. D., Squassi, A., et al. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108006289 · Cited by 10 · see citing works
Effects of Low Doses of Polyunsaturated Fatty Acids on the Attention Deficit/Hyperactivity Disorder of Children: A Systematic Review
Grassmann, V., Galduróz, J. C. F., & Galduróz, J. C. F. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311020005 · Cited by 5 · see citing works

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ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ
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Authors: Pusceddu, M. M., Kelly, P., Stanton, C., Cryan, J. F., & Dinan, T. G.
Affiliations: Teagasc - The Irish Agriculture and Food Development Authority (IE)
Corresponding author: Dinan, Timothy G.
ORCID: Pusceddu, Matteo M.
Kelly, Philip
Stanton, Catherine
Cryan, John F.
Dinan, Timothy G.
Venue: International Journal of Neuropsychopharmacology
Publisher: Oxford University Press (OUP)
Published: 2016-09-08
Volume: 19
Issue: 12
Pages: pyw078
ISSN: 1461-1457 (ISSN-L)
1469-5111
DOI: 10.1093/ijnp/pyw078
PMC: PMC5203760
OpenAlex: W2512060323
Cited by: 70
References: 191
Citations by year: 2026: 4 · 2025: 8 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 15 · 2018: 9 · 2017: 12
FWCI: 1.61
Type: journal article
Language: en
Open access: gold
doi.org
Locations: The International Journal of Neuropsychopharmacology (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by-nc)
HighWire Press Open Archive (submittedVersion)
T-Stór (Teagasc) (submittedVersion, cc-by-nc-sa)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Keywords: omega-3 polyunsaturated fatty acids, EPA, docosahexaenoic acid, psychopathology, lifespan, dietary habits, attention deficit hyperactivity disorder, depression, bipolar disorder, schizophrenia, Alzheimer's disease, anxiety, neuroinflammation, neurogenesis, cognitive decline, aging, quality of life
MeSH terms: Age Factors, Aging, Animals, Mental Disorders, Brain, Cognition, Feeding Behavior, Humans, Mental Health, Risk Factors, Fatty Acids, Omega-3, Protective Factors

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N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology

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