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Docosahexaenoic Acid and Cognition throughout the Lifespan

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Weiser, Michael, Butt, Christopher, Mohajeri, M.·2016·Nutrients
DOI 10.3390/nu8020099PMC PMC4772061
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Abstract

Docosahexaenoic acid (DHA) is the predominant omega-3 (n-3) polyunsaturated fatty acid (PUFA) found in the brain and can affect neurological function by modulating signal transduction pathways, neurotransmission, neurogenesis, myelination, membrane receptor function, synaptic plasticity, neuroinflammation, membrane integrity and membrane organization. DHA is rapidly accumulated in the brain during gestation and early infancy, and the availability of DHA via transfer from maternal stores impacts the degree of DHA incorporation into neural tissues. The consumption of DHA leads to many positive physiological and behavioral effects, including those on cognition. Advanced cognitive function is uniquely human, and the optimal development and aging of cognitive abilities has profound impacts on quality of life, productivity, and advancement of society in general. However, the modern diet typically lacks appreciable amounts of DHA. Therefore, in modern populations, maintaining optimal levels of DHA in the brain throughout the lifespan likely requires obtaining preformed DHA via dietary or supplemental sources. In this review, we examine the role of DHA in optimal cognition during development, adulthood, and aging with a focus on human evidence and putative mechanisms of action.

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  • DHA can influence cellular and physiological processes including membrane fluidity, neurotransmitter release, myelination, neuroinflammation, and neuronal differentiation and growth.

    “DHA can influence cellular and physiological processes, including membrane fluidity, the release of neurotransmitters, myelination, neuroinflammation, and neuronal differentiation and growth [183].”

    From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [183]

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Cited by

Sorted by citations

Authors
Weiser, M., Butt, C., & Mohajeri, M.
Affiliations
  • DSM Nutritional Products, R&amp;D Human Nutrition and Health, Boulder, CO, USA
  • DSM Nutritional Products, R&amp;D Human Nutrition and Health, Basel, Switzerland
Corresponding author
Weiser, Michael
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2016-02-17
Volume
8
Issue
2
Pages
99
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu8020099
PMC
PMC4772061
OpenAlex
W2275882422
Cited by
400
References
28
Citations by year
2026: 40 · 2025: 36 · 2024: 42 · 2023: 34 · 2022: 42 · 2021: 48 · 2020: 52 · 2019: 39 · 2018: 29 · 2017: 31 · 2016: 7
FWCI
4.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
DSM Nutritional Products
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
docosahexaenoic acid, omega-3 polyunsaturated fatty acids, cognition, brain development, cognitive aging, neuroinflammation, synaptic plasticity, membrane organization, lifespan
MeSH terms
Aging, Brain, Cognition, Docosahexaenoic Acids, Humans

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