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Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function

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Martins, Amanda R, Nachbar, Renato T, Gorjao, Renata, Vinolo, Marco A, Festuccia, William T, Lambertucci, Rafael H, Cury-Boaventura, Maria F, Silveira, Leonardo R, Curi, Rui, Hirabara, Sandro M·2012·Lipids in Health and Disease
DOI 10.1186/1476-511x-11-30
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Abstract

Insulin resistance condition is associated to the development of several syndromes, such as obesity, type 2 diabetes mellitus and metabolic syndrome. Although the factors linking insulin resistance to these syndromes are not precisely defined yet, evidence suggests that the elevated plasma free fatty acid (FFA) level plays an important role in the development of skeletal muscle insulin resistance. Accordantly, in vivo and in vitro exposure of skeletal muscle and myocytes to physiological concentrations of saturated fatty acids is associated with insulin resistance condition. Several mechanisms have been postulated to account for fatty acids-induced muscle insulin resistance, including Randle cycle, oxidative stress, inflammation and mitochondrial dysfunction. Here we reviewed experimental evidence supporting the involvement of each of these propositions in the development of skeletal muscle insulin resistance induced by saturated fatty acids and propose an integrative model placing mitochondrial dysfunction as an important and common factor to the other mechanisms.

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  1. Sakamoto K, Holman GD: Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic. Am J Physiol Endocrinol Metab. 2008, 295: 29-37. · DOI · Paper page
  2. Hirabara SM, Silveira LR, Abdulkader F, Carvalho CR, Procopio J, Curi R: Time-dependent effects of fatty acids on skeletal muscle metabolism. Cell Physiol. 2007, 210: 7-15. · DOI
  3. Silveira LR, Fiamoncini J, Hirabara SM, Procópio J, Cambiaghi TD, Pinheiro CH, Lopes LR, Curi R: Updating the effects of fatty acids on skeletal muscle. J Cell Physiol. 2008, 217: 1-12. · DOI
  4. Ragheb R, Shanab GM, Medhat AM, Seoudi DM, Adeli K, Fantus IG: Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways. Biochem Biophys Res Commun. 2009, 389: 211-216. · DOI
  5. Hirabara SM, Curi R, Maechler P: Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells. J Cell Physiol. 2010, 222: 187-194. · DOI · Paper page
  6. Roden M: How free fatty acids inhibit glucose utilization in human skeletal muscle. News Physiol Sci. 2004, 19: 92-96.
  7. Yuzefovych L, Wilson G, Rachek L: Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Am J Physiol Endocrinol Metab. 2010, 299: 1096-1105. · DOI · Paper page
  8. Hirabara SM, Carvalho CRO, Mendonça JR, Piltcher Haber E, Fernandes LC, Curi R: Palmitate acutely raises glycogen synthesis in rat soleus muscle by a mechanism that requires its metabolization (Randle cycle). FEBS Lett. 2003, 541: 109-114. · DOI
  9. Hirabara SM, Silveira LR, Alberici LC, Leandro CV, Lambertucci RH, Polimeno GC, Cury Boaventura MF, Procopio J, Vercesi AE, Curi R: Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle. Biochim Biophys Acta. 2006, 1757: 57-66. · DOI
  10. Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963, 1: 785-789. · DOI · Paper page
  11. Randle PJ: Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev. 1998, 14: 263-283. · DOI
  12. Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF, Shulman GI: Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest. 1999, 103: 253-259. · DOI · Paper page
  13. Jenkins AB, Storlien LH, Chisholm DJ, Kraegen EW: Effects of nonesterified fatty acid availability on tissue-specific glucose utilization in rats in vivo. J Clin Invest. 1988, 82: 293-299. · DOI
  14. Johnson AB, Argyraki M, Thow JC, Cooper BG, Fulcher G, Taylor R: Effect of increased free fatty acid supply on glucose metabolism and skeletal muscle glycogen synthase activity in normal man. Clin Sci. 1992, 82: 219-226. · DOI
  15. Rothman DL, Shulman RG, Shulman GI: 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. J Clin Invest. 1992, 89: 1069-1075. · DOI
  16. Savage DB, Petersen KF, Shulman GI: Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev. 2007, 87: 507-520. · DOI · Paper page
  17. Dey D, Mukherjee M, Basu D, Datta M, Roy SS, Bandyopadhyay A, Bhattacharya S: Inhibition of insulin receptor gene expression and insulin signaling by fatty acid: interplay of PKC isoforms therein. Cell Physiol Biochem. 2005, 16: 217-228. · DOI
  18. Storz P, Döppler H, Wernig A, Pfizenmaier K, Müller G: Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake. Eur J Biochem. 1999, 266: 17-25. · DOI
  19. Cazzolli R, Carpenter L, Biden TJ, Schmitz-Peiffer C: A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate. Diabetes. 2001, 50: 2210-2218. · DOI
  20. Hajduch E, Balendran A, Batty IH, Litherland GJ, Blair AS, Downes CP, Hundal HS: Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. Diabetologia. 2001, 44: 173-183. · DOI
  21. Schmitz-Peiffer C: Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply. Cell Signal. 2000, 12: 583-594. · DOI · Paper page
  22. Soltys CL, Buchholz L, Gandhi M, Clanachan AS, Walsh K, Dyck JR: Phosphorylation of cardiac protein kinase B is regulated by palmitate. Am J Physiol Heart Circ Physiol. 2002, 283: 1056-1064. · DOI
  23. Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y: A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J Biol Chem. 1997, 272: 29911-29918. · DOI · Paper page
  24. Zhande R, Mitchell JJ, Wu J, Sun XJ: Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1. Mol Cell Biol. 2002, 22: 1016-1026. · DOI
  25. Tirosh A, Potashnik R, Bashan N, Rudich A: Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation. J Biol Chem. 1999, 274: 10595-10602. · DOI · Paper page
  26. Evans JL, Maddux BA, Goldfine ID: The molecular basis for oxidative stress-induced insulin resistance. Antioxid Redox Signal. 2005, 7: 1040-1052. · DOI · Paper page
  27. Khamzina L, Veilleux A, Bergeron S, Marette A: Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology. 2005, 146: 1473-1481. · DOI · Paper page
  28. Rivas DA, Yaspelkis BB, Hawley JA, Lessard SJ: Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside. J Endocrinol. 2009, 202: 441-451. · DOI
  29. Consitt LA, Bell JA, Houmard JA: Intramuscular lipid metabolism, insulin action, and obesity. IUBMB Life. 2009, 61: 47-55. · DOI · Paper page
  30. Samuel VT: Fructose induced lipogenesis: from sugar to fat to insulin resistance. Trends Endocrinol Metab. 2011, 22: 60-65. · DOI · Paper page
  31. Cooney GJ, Thompson AL, Furler SM, Ye J, Kraegen EW: Muscle long-chain acyl CoA esters and insulin resistance. Ann N Y Acad Sci. 2002, 967: 196-207. · DOI
  32. Itani SI, Ruderman NB, Schmieder F, Boden G: Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes. 2002, 51: 2005-2011. · DOI · Paper page
  33. Summers SA: Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res. 2006, 45: 42-72. · DOI · Paper page
  34. Choi JS, Koh IU, Jung MH, Song J: Effects of three different conjugated linoleic acid preparations on insulin signalling, fat oxidation and mitochondrial function in rats fed a high-fat diet. Br J Nutr. 2007, 98: 264-275. · DOI
  35. Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, Friedman JE, Eckel RH: Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues. Diabetes. 2009, 58: 116-124. · DOI · Paper page
  36. Liu L, Yu S, Khan RS, Ables GP, Bharadwaj KG, Hu Y, Huggins LA, Eriksson JW, Buckett LK, Turnbull AV, Ginsberg HN, Blaner WS, Huang LS, Goldberg IJ: DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle. J Lipid Res. 2011, 52: 732-744. · DOI
  37. Samuel VT, Petersen KF, Shulman GI: Lipid-induced insulin resistance: unravelling the mechanism. Lancet. 2010, 375: 2267-2277. · DOI · Paper page
  38. Chavez JA, Holland WL, Bär J, Sandhoff K, Summers SA: Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. J Biol Chem. 2005, 280: 20148-20153. · DOI
  39. Hu W, Bielawski J, Samad F, Merrill AH, Cowart LA: Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity. J Lipid Res. 2009, 50: 1852-1862. · DOI
  40. Holland WL, Summers SA: Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. Endocr Rev. 2008, 29: 381-402. · DOI
  41. Han MS, Lim YM, Quan W, Kim JR, Chung KW, Kang M, Kim S, Park SY, Han JS, Park SY, Cheon HG, Dal Rhee S, Park TS, Lee MS: Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance. J Lipid Res. 2011, 52: 1234-1246. · DOI
  42. Håversen L, Danielsson KN, Fogelstrand L, Wiklund O: Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. Atherosclerosis. 2009, 202: 382-393. · DOI
  43. Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ, Ting JP: Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol. 2011, 12: 408-415. · DOI · Paper page
  44. Hotamisligil GS, Shargill NS, Spiegelman BM: Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993, 259: 87-91. · DOI · Paper page
  45. Hotamisligil GS: Inflammation and endoplasmic reticulum stress in obesity and diabetes. Int J Obes (Lond). 2008, 32: 52-54. · DOI · Paper page
  46. Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Araújo EP, Vassallo J, Curi R, Velloso LA, Saad MJ: Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes. 2007, 56: 1986-1998. · DOI · Paper page
  47. Kaneto H, Nakatani Y, Kawamori D, Miyatsuka T, Matsuoka TA, Matsuhisa M, Yamasaki Y: Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance. Int J Biochem Cell Biol. 2006, 38: 782-793. · DOI
  48. Solinas G, Naugler W, Galimi F, Lee MS, Karin M: Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci USA. 2006, 103: 16454-16459. · DOI · Paper page
  49. Coletta DK, Mandarino LJ: Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria. Am J Physiol Endocrinol Metab. 2011, 301: 749-755. · DOI · Paper page
  50. Bunn RC, Cockrell GE, Ou Y, Thrailkill KM, Lumpkin CK, Fowlkes JL: Palmitate and insulin synergistically induce IL-6 expression in human monocytes. Cardiovasc Diabetol. 2010, 9: 73- · DOI
  51. Ji C, Chen X, Gao C, Jiao L, Wang J, Xu G, Fu H, Guo X, Zhao Y: IL-6 induces lipolysis and mitochondrial dysfunction, but does not affect insulin-mediated glucose transport in 3T3-L1 adipocytes. J Bioenerg Biomembr. 2011, 43: 367-375. · DOI
  52. Yasuhara R, Miyamoto Y, Akaike T, Akuta T, Nakamura M, Takami M, Morimura N, Yasu K, Kamijo R: Interleukin-1beta induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner. Biochem J. 2005, 389: 315-323. · DOI
  53. Schmid GM, Converset V, Walter N, Sennitt MV, Leung KY, Byers H, Ward M, Hochstrasser DF, Cawthorne MA, Sanchez JC: Effect of high-fat diet on the expression of proteins in muscle, adipose tissues, and liver of C57BL/6 mice. Proteomics. 2004, 4: 2270-2282. · DOI
  54. Xu J, Han J, Epstein PN, Liu YQ: Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets. Biochem Biophys Res Commun. 2006, 344: 827-833. · DOI
  55. López IP, Milagro FI, Martí A, Moreno-Aliaga MJ, Martínez JA, De Miguel C: Gene expression changes in rat white adipose tissue after a high-fat diet determined by differential display. Biochem Biophys Res Commun. 2004, 318: 234-239. · DOI
  56. Evans RM, Barish GD, Wang YX: PPARs and the complex journey to obesity. Nat Med. 2004, 10: 355-361. · DOI · Paper page
  57. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM: A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998, 92: 829-839. · DOI · Paper page
  58. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM: Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 1999, 98: 115-124. · DOI · Paper page
  59. Heilbronn LK, Gan SK, Turner N, Campbell LV, Chisholm DJ: Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects. J Clin Endocrinol Metab. 2007, 92: 1467-1473. · DOI · Paper page
  60. Bonnard C, Durand A, Peyrol S, Chanseaume E, Chauvin MA, Morio B, Vidal H, Rieusset J: Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest. 2008, 118: 789-800.
  61. Kumashiro N, Tamura Y, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mochizuki H, Kawamori R, Watada H: Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance. Diabetes. 2008, 57: 2083-2091. · DOI
  62. Rains JL, Jain SK: Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med. 2011, 50: 567-575. · DOI · Paper page
  63. Gomez-Mendikute A, Cajaraville MP: Comparative effects of cadmium, copper, paraquat and benzo[a]pyrene on the actin cytoskeleton and production of reactive oxygen species (ROS) in mussel haemocytes. Toxicol Vitr. 2003, 17: 539-546. · DOI
  64. Haynes CM, Titus EA, Cooper AA: Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death. Molecular cell. 2004, 15: 767-776. · DOI · Paper page
  65. He YY, Hader DP: UV-B-induced formation of reactive oxygen species and oxidative damage of the cyanobacterium Anabaena sp.: protective effects of ascorbic acid and N-acetyl-L-cysteine. J Photochem Photobiol B Biol. 2002, 66: 115-124. · DOI · Paper page
  66. Gutterman DD, Miura H, Liu Y: Redox modulation of vascular tone: focus of potassium channel mechanisms of dilation. Arterioscler Thromb Vasc Biol. 2005, 25: 671-678. · DOI
  67. Taddei ML, Parri M, Mello T, Catalano A, Levine AD, Raugei G, Ramponi G, Chiarugi P: Integrin-mediated cell adhesion and spreading engage different sources of reactive oxygen species. Antioxid redox Signaling. 2007, 9: 469-481. · DOI
  68. Lee HC, Wei YH: Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging. Exp Biol Med. 2007, 232: 592-606.
  69. Duval C, Cámara Y, Hondares E, Sibille B, Villarroya F: Overexpression of mitochondrial uncoupling protein-3 does not decrease production of the reactive oxygen species, elevated by palmitate in skeletal muscle cells. FEBS Lett. 2007, 581: 955-961. · DOI
  70. Lambertucci RH, Hirabara SM, Silveira L, dos R, Levada-Pires AC, Curi R, Pithon-Curi TC: Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells. J Cell Physiol. 2008, 216: 796-804. · DOI
  71. Pilon G, Charbonneau A, White PJ, Dallaire P, Perreault M, Kapur S, Marette A: Endotoxin mediated-iNOS induction causes insulin resistance via ONOO- induced tyrosine nitration of IRS-1 in skeletal muscle. PLoS One. 2010, 5: 15912- · DOI
  72. Perreault M, Marette A: Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med. 2001, 7: 1138-1143. · DOI
  73. Dallaire P, Bellmann K, Laplante M, Gélinas S, Centeno-Baez C, Penfornis P, Peyot ML, Latour MG, Lamontagne J, Trujillo ME, Scherer PE, Prentki M, Deshaies Y, Marette A: Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism. Diabetes. 2008, 57: 1999-2011. · DOI
  74. Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, Sano H, Utsumi H, Nawata H: High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes. 2000, 49: 1939-1945. · DOI · Paper page
  75. Desco MC, Asensi M, Marquez R, Martinez-Valls J, Vento M, Pallardo FV, Sastre J, Vina J: Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol. Diabetes. 2002, 51: 1118-1124. · DOI
  76. Erdei N, Toth A, Pasztor ET, Papp Z, Edes I, Koller A, Bagi Z: High-fat diet-induced reduction in nitric oxide-dependent arteriolar dilation in rats: role of xanthine oxidase-derived superoxide anion. Am J Physiol Heart Circulatory Physiol. 2006, 291: H2107-H2115. · DOI
  77. Ogihara T, Asano T, Katagiri H, Sakoda H, Anai M, Shojima N, Ono H, Fujishiro M, Kushiyama A, Fukushima Y, Kikuchi M, Noguchi N, Aburatani H, Gotoh Y, Komuro I, Fujita T: Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase. Diabetologia. 2004, 47: 794-805. · DOI
  78. Blouet C, Mariotti F, Mikogami T, Tome D, Huneau JF: Meal cysteine improves postprandial glucose control in rats fed a high-sucrose meal. J Nutr Biochem. 2007, 18: 519-524. · DOI
  79. Maddux BA, Goldfine ID: Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. Diabetes. 2000, 49: 13-19. · DOI
  80. Haber CA, Lam TK, Yu Z, Gupta N, Goh T, Bogdanovic E, Giacca A, Fantus IG: N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress. Am J Physiol Endocrinol Metab. 2003, 285: 744-753. · DOI
  81. Zhai L, Ballinger SW, Messina JL: Role of reactive oxygen species in injury-induced insulin resistance. Mol Endocrinol. 2011, 25: 492-502. · DOI
  82. Maddux BA, See W, Lawrence JC, Goldfine AL, Goldfine ID, Evans JL: Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid. Diabetes. 2001, 50: 404-410. · DOI · Paper page
  83. Indo HP, Davidson M, Yen HC, Suenaga S, Tomita K, Nishii T, Higuchi M, Koga Y, Ozawa T, Majima HJ: Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion. 2007, 7: 106-118. · DOI
  84. Rousset S, Alves-Guerra MC, Mozo J, Miroux B, Cassard-Doulcier AM, Bouillaud F, Ricquier D: The biology of mitochondrial uncoupling proteins. Diabetes. 2004, 53: 130-135. · DOI · Paper page
  85. Fisler JS, Warden CH: Uncoupling proteins, dietary fat and the metabolic syndrome. Nutr Metab (Lond). 2006, 3: 38- · DOI
  86. Weigle DS, Selfridge LE, Schwartz MW, Seeley RJ, Cummings DE, Havel PJ, Kuijper JL, BeltrandelRio H: Elevated free fatty acids induce uncoupling protein 3 expression in muscle: a potential explanation for the effect of fasting. Diabetes. 1998, 47: 298-302. · DOI · Paper page
  87. Millet L, Vidal H, Andreelli F, Larrouy D, Riou JP, Ricquier D, Laville M, Langin D: Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans. J Clin Invest. 1997, 100: 2665-2670. · DOI · Paper page
  88. Schrauwen P, Hinderling V, Hesselink MK, Schaart G, Kornips E, Saris WH, Westerterp-Plantenga M, Langhans W: Etomoxir-induced increase in UCP3 supports a role of uncoupling protein 3 as a mitochondrial fatty acid anion exporter. FASEB J. 2002, 16: 1688-1690. · DOI
  89. Samec S, Seydoux J, Dulloo AG: Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate?. FASEB J. 1998, 12: 715-724. · DOI · Paper page
  90. Hoeks J, Hesselink MK, Sluiter W, Schaart G, Willems J, Morrisson A, Clapham JC, Saris WH, Schrauwen P: The effect of high-fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice. FEBS Lett. 2006, 580: 1371-1375. · DOI
  91. Schrauwen P, Troost FJ, Xia J, Ravussin E, Saris WH: Skeletal muscle UCP2 and UCP3 expression in trained and untrained male subjects. Int J Obes Relat Metab Disord. 1999, 23: 966-972. · DOI
  92. Mingrone G, Rosa G, Greco AV, Manco M, Vega N, Hesselink MK, Castagneto M, Schrauwen P, Vidal H: Decreased uncoupling protein expression and intramyocytic triglyceride depletion in formerly obese subjects. Obes Res. 2003, 11: 632-640. · DOI
  93. Hoeks J, van Baak MA, Hesselink MK, Hul GB, Vidal H, Saris WH, Schrauwen P: Effect of beta1- and beta2-adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans. Am J Physiol Endocrinol Metab. 2003, 285: E775-E782. · DOI
  94. Samec S, Seydoux J, Dulloo AG: Interorgan signaling between adipose tissue metabolism and skeletal muscle uncoupling protein homologs: is there a role for circulating free fatty acids?. Diabetes. 1998, 47: 1693-1698. · DOI
  95. Echtay KS, Esteves TC, Pakay JL, Jekabsons MB, Lambert AJ, Portero-Otín M, Pamplona R, Vidal-Puig AJ, Wang S, Roebuck SJ, Brand MD: A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J. 2003, 22: 4103-4110. · DOI · Paper page
  96. Nabben M, Hoeks J, Briedé JJ, Glatz JF, Moonen-Kornips E, Hesselink MK, Schrauwen P: The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice. FEBS Lett. 2008, 582: 4147-4152. · DOI
  97. Holloway GP, Thrush AB, Heigenhauser GJ, Tandon NN, Dyck DJ, Bonen A, Spriet LL: Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women. Am J Physiol Endocrinol Metab. 2007, 292: 1782-1789. · DOI · Paper page
  98. Lim S, Park KS, Kim MS, Cho BY, Lee HK: Relationship between various surrogate indices of insulin resistance and mitochondrial DNA content in the peripheral blood of 18 healthy volunteers. Mitochondrion. 2001, 1: 71-77. · DOI
  99. Guo LJ, Oshida Y, Fuku N, Takeyasu T, Fujita Y, Kurata M, Sato Y, Ito M, Tanaka M: Mitochondrial genome polymorphisms associated with type-2 diabetes or obesity. Mitochondrion. 2005, 5: 15-33. · DOI
  100. Juo SHH, Lu MY, Bai RK, Liao YC, Trieu RB, Yu ML, Wong LJC: A common mitochondrial polymorphism 10398A > G is associated metabolic syndrome in a Chinese population. Mitochondrion. 2010, 10: 294-299. · DOI
  101. Wallace DC, Fan W: Energetics, epigenetics, mitochondrial genetics. Mitochondrion. 2010, 10: 12-31. · DOI · Paper page
  102. Chanseaume E, Malpuech-Brugère C, Patrac V, Bielicki G, Rousset P, Couturier K, Salles J, Renou JP, Boirie Y, Morio B: Diets high in sugar, fat, and energy induce muscle typespecific adaptations in mitochondrial functions in rats. J Nutr. 2006, 136: 2194-2200. · DOI
  103. Szendroedi J, Schmid AI, Meyerspeer M, Cervin C, Kacerovsky M, Smekal G, Graser-Lang S, Groop L, Roden M: Impaired mitochondrial function and insulin resistance of skeletal muscle in mitochondrial diabetes. Diabetes Care. 2009, 32: 677-679. · DOI
  104. Coll T, Jové M, Rodríguez-Calvo R, Eyre E, Palomer X, Sánchez RM, Merlos M, Laguna JC, Vázquez-Carrera M: Palmitate-mediated downregulation of peroxisome proliferator-activated receptorgamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation. Diabetes. 2006, 55: 2779-2787. · DOI
  105. Pimenta AS, Gaidhu MP, Habib S, So M, Fediuc S, Mirpourian M, Musheev M, Curi R, Ceddia RB: Prolonged exposure to palmitate impairs fatty acid oxidation despite activation of AMP-activated protein kinase in skeletal muscle cells. J Cell Physiol. 2008, 217: 478-485. · DOI
  106. Jove M, Laguna JC, Vázquez-Carrera M: Agonist-induced activation releases peroxisome proliferator-activated receptor beta/delta from its inhibition by palmitate-induced nuclear factor-kappaB in skeletal muscle cells. Biochim Biophys Acta. 2005, 1734: 52-61. · DOI
  107. Bloch-Damti A, Potashnik R, Gual P, Le Marchand-Brustel Y, Tanti JF, Rudich A, Bashan N: Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress. Diabetologia. 2006, 49: 2463-2473. · DOI
  108. Watt MJ, Steinberg GR, Chen ZP, Kemp BE, Febbraio MA: Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes. J Physiol. 2006, 574: 139-147. · DOI
  109. Krebs M, Roden M: Molecular mechanisms of lipid-induced insulin resistance in muscle, liver and vasculature. Diabetes Obes Metab. 2005, 7: 621-632. · DOI
  110. Talukdar I, Szeszel-Fedorowicz W, Salati LM: Arachidonic acid inhibits the insulin induction of glucose-6-phosphate dehydrogenase via p38 MAP kinase. J Biol Chem. 2005, 280: 40660-40667. · DOI

Cited by

See all 290

Metadata

Authors
Martins, A. R., Nachbar, R. T., Gorjao, R., Vinolo, M. A., Festuccia, W. T., Lambertucci, R. H., Cury-Boaventura, M. F., Silveira, L. R., Curi, R., & Hirabara, S. M.
Venue
Lipids in Health and Disease
Publisher
Springer Science and Business Media LLC
Published
2012-02-23
Volume
11
Issue
1
Pages
30-30
ISSN
1476-511X (ISSN-L)
DOI
10.1186/1476-511x-11-30
OpenAlex
W2165705576
Cited by
290
References
36
FWCI
20.00
Type
journal article
Language
en
Open access
gold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

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How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function. https://app.cochat.ai/papers/10.1186/1476-511x-11-30
The paper
Martins, A. R., Nachbar, R. T., Gorjao, R., Vinolo, M. A., Festuccia, W. T., Lambertucci, R. H., Cury-Boaventura, M. F., Silveira, L. R., Curi, R., & Hirabara, S. M. (2012). Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function. Lipids in Health and Disease. https://doi.org/10.1186/1476-511x-11-30

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.