Cited by 175Fatty Acid Research and HealthEdible Oils Quality and AnalysisAquaculture Nutrition and Growth

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Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil

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Ramprasath, Vanu R, Eyal, Inbal, Zchut, Sigalit, Jones, Peter JH·2013·Lipids in Health and Disease

DOI 10.1186/1476-511x-12-178PMC PMC4235028

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Abstract

BACKGROUND: Due to structural differences, bioavailability of krill oil, a phospholipid based oil, could be higher than fish oil, a triglyceride-based oil, conferring properties that render it more effective than fish oil in increasing omega-3 index and thereby, reducing cardiovascular disease (CVD) risk. OBJECTIVE: The objective was to assess the effects of krill oil compared with fish oil or a placebo control on plasma and red blood cell (RBC) fatty acid profile in healthy volunteers. PARTICIPANTS AND METHODS: Twenty four healthy volunteers were recruited for a double blinded, randomized, placebo-controlled, crossover trial. The study consisted of three treatment phases including krill or fish oil each providing 600 mg of n-3 polyunsaturated fatty acids (PUFA) or placebo control, corn oil in capsule form. Each treatment lasted 4 wk and was separated by 8 wk washout phases. RESULTS: Krill oil consumption increased plasma (p = 0.0043) and RBC (p = 0.0011) n-3 PUFA concentrations, including EPA and DHA, and reduced n-6:n-3 PUFA ratios (plasma: p = 0.0043, RBC: p = 0.0143) compared with fish oil consumption. Sum of EPA and DHA concentrations in RBC, the omega-3 index, was increased following krill oil supplementation compared with fish oil (p = 0.0143) and control (p < 0.0001). Serum triglycerides and HDL cholesterol concentrations did not change with any of the treatments. However, total and LDL cholesterol concentrations were increased following krill (TC: p = 0.0067, LDL: p = 0.0143) and fish oil supplementation (TC: p = 0.0028, LDL: p = 0.0143) compared with control. CONCLUSIONS: Consumption of krill oil was well tolerated with no adverse events. Results indicate that krill oil could be more effective than fish oil in increasing n-3 PUFA, reducing n-6:n-3 PUFA ratio, and improving the omega-3 index. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01323036.

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Figure 1 Schematic representation of the experimental protocol. B - 12 h fasted blood collection; AN - Anthropometric measurements; IE - Inclusion and Exclusion criteria; PE - Physician examination; AE - Adverse events; CD - Capsule dispensation (KO or FO or corn oil capsules); CR - Left over capsules return; Q - Questionnaires (Fish and sea food consumption, concomitant medications); GI - Gastro intestinal questionnaires.CC BY · PubMed Central

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Authors: Ramprasath, V. R., Eyal, I., Zchut, S., & Jones, P. J.
Affiliations: University of Manitoba (CA)
Tower Semiconductor (Israel) (IL)
Corresponding author: Jones, Peter JH
ORCID: Jones, Peter JH
Venue: Lipids in Health and Disease
Publisher: Springer Science and Business Media LLC
Published: 2013-12
Volume: 12
Issue: 1
Pages: 178-178
ISSN: 1476-511X (ISSN-L)
DOI: 10.1186/1476-511x-12-178
PMC: PMC4235028
OpenAlex: W2140531245
Cited by: 175
References: 53
Citations by year: 2026: 8 · 2025: 4 · 2024: 20 · 2023: 14 · 2022: 13 · 2021: 8 · 2020: 12 · 2019: 22 · 2018: 14 · 2017: 12 · 2016: 21 · 2015: 15 · 2014: 12
FWCI: 14.85
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Lipids in Health and Disease (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Mspace (University of Manitoba) (submittedVersion)
Funders: University of Haifa
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Keywords: krill oil, fish oil, omega-3 index, omega-3 fatty acids, EPA, docosahexaenoic acid, n-6/n-3 ratio, plasma fatty acid profile, cholesterol, serum triglycerides, cardiovascular risk, dietary supplementation
MeSH terms: Adult, Animals, Corn Oil, Dietary Fats, Unsaturated, Docosahexaenoic Acids, Double-Blind Method, Female, Fish Oils, Humans, Cholesterol, HDL, Male, Triglycerides, Eicosapentaenoic Acid, Cross-Over Studies, Euphausiacea, Healthy Volunteers

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Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil

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