The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Nitric oxide and cancer: a review
Open accessAbstract
Nitric oxide (NO), is a ubiquitous, water soluble, free radical gas, which plays key role in various physiological as well as pathological processes. Over past decades, NO has emerged as a molecule of interest in carcinogenesis and tumor growth progression. However, there is considerable controversy and confusion in understanding its role in cancer biology. It is said to have both tumoricidal as well as tumor promoting effects which depend on its timing, location, and concentration. NO has been suggested to modulate different cancer-related events including angiogenesis, apoptosis, cell cycle, invasion, and metastasis. On the other hand, it is also emerging as a potential anti-oncogenic agent. Strategies for manipulating in vivo production and exogenous delivery of this molecule for therapeutic gain are being investigated. However, further validation and experimental/clinical trials are required for development of novel strategies based on NO for cancer treatment and prevention. This review discusses the range of actions of NO in cancer by performing an online MEDLINE search using relevant search terms and a review of the literature. Various mechanisms by which NO acts in different cancers such as breast, cervical, gastric,colorectal, and head and neck cancers are addressed. It also offers an insight into the dichotomous nature of NO and discusses its novel therapeutic applications for cancer prevention and treatment.
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Cites
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Reactive oxygen species and cancer paradox: To promote or to suppress?
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Lieu, E. L., Nguyen, T., Rhyne, S., & Kim, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0375-3 · Cited by 818
Signaling pathways in cancer metabolism: mechanisms and therapeutic targets
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New molecular and biochemical insights of doxorubicin-induced hepatotoxicity
Prasanna, P. L., Renu, K., & Valsala Gopalakrishnan, A. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117599 · Cited by 267
Metadata
- Authors
- Korde Choudhari, S., Chaudhary, M., Bagde, S., Gadbail, A. R., & Joshi, V.
- Venue
- World Journal of Surgical Oncology
- Published
- 2013-05-30
- Volume
- 11
- Issue
- 1
- Pages
- 118-118
- ISSN
- 1477-7819 (ISSN-L)
- OpenAlex
- W2163105084
- Cited by
- 634
- References
- 10
- FWCI
- 17.34
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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