Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits
Open accessAbstract
BACKGROUND: Antipsychotic-induced weight gain constitutes a major unresolved clinical problem which may ultimately be associated with reducing life expectancy by 25 years. Overweight is associated with brain deterioration, cognitive decline and poor quality of life, factors which are already compromised in normal weight patients with schizophrenia.Here we outline the current strategies against antipsychotic-induced weight gain, and we describe peripheral and cerebral effects of the gut hormone glucagon-like peptide-1 (GLP-1). Moreover, we account for similarities in brain changes between schizophrenia and overweight patients. DISCUSSION: Current interventions against antipsychotic-induced weight gain do not facilitate a substantial and lasting weight loss. GLP-1 analogs used in the treatment of type 2 diabetes are associated with significant and sustained weight loss in overweight patients. Potential effects of treating schizophrenia patients with antipsychotic-induced weight gain with GLP-1 analogs are discussed. CONCLUSIONS: We propose that adjunctive treatment with GLP-1 analogs may constitute a new avenue to treat and prevent metabolic and cerebral deficiencies in schizophrenia patients with antipsychotic-induced weight gain. Clinical research to support this idea is highly warranted.
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- Authors
- Ebdrup, B. H., Knop, F. K., Ishøy, P. L., Rostrup, E., Fagerlund, B., Lublin, H., & Glenthøj, B.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Ebdrup, Bjørn H
- Venue
- BMC Medicine
- Published
- 2012-08-15
- Volume
- 10
- Issue
- 1
- Pages
- 92-92
- ISSN
- 1741-7015 (ISSN-L)
- PMC
- PMC3573939
- OpenAlex
- W2021914080
- Semantic Scholar
- d97b47b226d41b4142d239cacea9f600c6818b3f
- Cited by
- 34
- References
- 74
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 2 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 5 · 2013: 1
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Lundbeckfonden
- Region Hovedstaden
- Faculty of Health and Medical Sciences, University of Western Australia
- H. Lundbeck A/S
- Det Sundhedsvidenskabelige Fakultet, Københavns Universitet
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- glucagon-like peptide-1 analogues, antipsychotic-induced weight gain, schizophrenia, obesity, gastrointestinal hormones, weight loss, cognitive decline, metabolic effects, adjunctive therapy
- MeSH terms
- Humans, Obesity, Schizophrenia, Antipsychotic Agents, Weight Gain, Glucagon-Like Peptide 1
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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