Cited by 34Schizophrenia research and treatmentPharmacology and Obesity TreatmentRegulation of Appetite and Obesity

Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits

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Ebdrup, Bjørn H, Knop, Filip K, Ishøy, Pelle L, Rostrup, Egill, Fagerlund, Birgitte, Lublin, Henrik, Glenthøj, Birte·2012·BMC Medicine

Abstract

BACKGROUND: Antipsychotic-induced weight gain constitutes a major unresolved clinical problem which may ultimately be associated with reducing life expectancy by 25 years. Overweight is associated with brain deterioration, cognitive decline and poor quality of life, factors which are already compromised in normal weight patients with schizophrenia.Here we outline the current strategies against antipsychotic-induced weight gain, and we describe peripheral and cerebral effects of the gut hormone glucagon-like peptide-1 (GLP-1). Moreover, we account for similarities in brain changes between schizophrenia and overweight patients. DISCUSSION: Current interventions against antipsychotic-induced weight gain do not facilitate a substantial and lasting weight loss. GLP-1 analogs used in the treatment of type 2 diabetes are associated with significant and sustained weight loss in overweight patients. Potential effects of treating schizophrenia patients with antipsychotic-induced weight gain with GLP-1 analogs are discussed. CONCLUSIONS: We propose that adjunctive treatment with GLP-1 analogs may constitute a new avenue to treat and prevent metabolic and cerebral deficiencies in schizophrenia patients with antipsychotic-induced weight gain. Clinical research to support this idea is highly warranted.

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Authors
Ebdrup, B. H., Knop, F. K., Ishøy, P. L., Rostrup, E., Fagerlund, B., Lublin, H., & Glenthøj, B.
Affiliations
University of Copenhagen (DK)
Corresponding author
Ebdrup, Bjørn H
Venue
BMC Medicine
Published
2012-08-15
Volume
10
Issue
1
Pages
92-92
ISSN
1741-7015 (ISSN-L)
OpenAlex
W2021914080
Cited by
34
References
74
Citations by year
2026: 4 · 2025: 1 · 2024: 2 · 2023: 2 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 5 · 2013: 1
FWCI
1.51
Type
journal article
Language
en
Open access
Locations
  • BMC Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
  • Lundbeckfonden
  • Region Hovedstaden
  • Faculty of Health and Medical Sciences, University of Western Australia
  • H. Lundbeck A/S
  • Det Sundhedsvidenskabelige Fakultet, Københavns Universitet
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
glucagon-like peptide-1 analogues, antipsychotic-induced weight gain, schizophrenia, obesity, gastrointestinal hormones, weight loss, cognitive decline, metabolic effects, adjunctive therapy
MeSH terms
Humans, Obesity, Schizophrenia, Antipsychotic Agents, Weight Gain, Glucagon-Like Peptide 1

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