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The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Bone regenerative medicine: classic options, novel strategies, and future directions

Open access
Oryan, Ahmad, Alidadi, Soodeh, Moshiri, Ali, Maffulli, Nicola·2014·Journal of Orthopaedic Surgery and Research

Abstract

This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.

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Crossref · 10.1186/1749-799x-9-18

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Metadata

Authors
Oryan, A., Alidadi, S., Moshiri, A., & Maffulli, N.
Venue
Journal of Orthopaedic Surgery and Research
Published
2014-03-17
Volume
9
Issue
1
Pages
18-18
ISSN
1749-799X (ISSN-L)
OpenAlex
W2111195311
Cited by
1,234
References
7
FWCI
39.89
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Bone regenerative medicine: classic options, novel strategies, and future directions. https://app.cochat.ai/papers/10.1186/1749-799x-9-18
The paper
Oryan, A., Alidadi, S., Moshiri, A., & Maffulli, N. (2014). Bone regenerative medicine: classic options, novel strategies, and future directions. Journal of Orthopaedic Surgery and Research. https://doi.org/10.1186/1749-799x-9-18

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.