The hCMEC/D3 cell line as a model of the human blood brain barrier

Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line

Weksler, B. B., Subileau, E.-A., Perrière, N., Charneau, P., Holloway, K. E., Leveque, M., Tricoire-Leignel, H., Nicotra, A., Bourdoulous, S., Turowski, P., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3458fje · Cited by 1,325

Wnt/β-catenin signaling controls development of the blood–brain barrier

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Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

Lippmann, E. S., Azarin, S. M., Kay, J. E., Nessler, R. A., Wilson, H. K., Al-Ahmad, A., Palecek, S. P., & Shusta, E. V. (2012) · Nature Biotechnology · doi:10.1038/nbt.2247 · Cited by 800

Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study.

Butt, A. M., Jones, H. C., & Abbott, N. J. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018243 · Cited by 775

Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation

Luissint, A.-C., Artus, C., Glacial, F., Ganeshamoorthy, K., & Couraud, P.-O. (2012) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-9-23 · Cited by 654

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood–brain barrier

Dauchy, S., Dutheil, F., Weaver, R. J., Chassoux, F., Daumas‐Duport, C., Couraud, P., Scherrmann, J., de Waziers, I., & Declèves, X. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05720.x · Cited by 361

Development of a three-dimensional, all-human in vitro model of the blood–brain barrier using mono-, co-, and tri-cultivation Transwell models

Hatherell, K. E., Couraud, P., Romero, I. A., Weksler, B. B., & Pilkington, G. J. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.05.012 · Cited by 358

The human brain endothelial cell line hCMEC/D3 as a human blood‐brain barrier model for drug transport studies

Poller, B., Gutmann, H., Krähenbühl, S., Weksler, B. B., Romero, I. A., Couraud, P., Tuffin, G., Drewe, J., & Huwyler, J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05730.x · Cited by 318

Differential effects of hydrocortisone and TNFα on tight junction proteins in an in vitro model of the human blood–brain barrier

Förster, C. Y., Burek, M., Romero, I. A., Weksler, B. B., Couraud, P., & Drenckhahn, D. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.146852 · Cited by 306

Immortalized Human Brain Endothelial Cells and Flow-Based Vascular Modeling: A Marriage of Convenience for Rational Neurovascular Studies

Cucullo, L., Couraud, P., Weksler, B. B., Romero, I. A., Hossain, M. K., Rapp, E., & Janigro, D. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600525 · Cited by 266

Targeting monocytic Occludin impairs transendothelial migration and HIV neuroinvasion

Brychka, D., Ayala‐Nunez, V., Dupas, A., Bare, Y., Partiot, E., Mittelheisser, V., Lučanský, V., Goetz, J. G., Osmani, N., & Gaudin, R. (2024) · EMBO Reports · doi:10.1038/s44319-024-00190-x · Cited by 3

Involvement of Proton-Coupled Organic Cation Antiporter in Human Blood–Brain Barrier Transport of Mesoridazine and Metoclopramide

Debori, Y., Igari, T., Nakakariya, M., Hirabayashi, H., Aoyama, K., Amano, N., Kurosawa, T., Kubo, Y., & Deguchi, Y. (2024) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b24-00329 · Cited by 2

Simple and stable transendothelial electrical resistance measurement in organs-on-chips

van der Helm, M. W., Odijk, M., Frimat, J. M. S., Eijkel, J. C. T., van den Berg, A., & Segerink, L. I. (2015) · University of Twente Research Information · Cited by 2

Anti-Malarial Strategies Among Vulnerable Populations: exploring bed net underutilization among internally displaced persons and novel adjunctive therapies for cerebral malaria

Brooks, H. M. (2017) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3jd4q33z · Cited by 2

Inhibition of Interleukin 1β Signaling by Anakinra Ameliorates Proinflammatory Cytokine Responses in Zika Virus–Infected Human Blood-Brain Barrier Endothelial Cells

Hueston, L., Grau, G. E., & Mahalingam, S. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz276 · Cited by 2

Targeting the blood-brain barrier with solid and vesicular nanoparticles decorated with ligands of solute carriers

Mészáros, M. (2019) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.10157 · Cited by 2

A novel epigenetic marker, TET2, is identified in the intractable epileptic brain and regulates ABCB1 in the blood-brain barrierPreprint

Kong, F.-C., Lang, L.-Q., JieHu, Zhang, X., Zhong, M., & Ma, C.-L. (2021) · Research Square · doi:10.21203/rs.3.rs-676547/v1 · Cited by 2

Targeting NRP1 with EG00229 induces neurovascular permeabilityPreprint

Dragoni, S., Brash, J. T., Fantin, A., Burridge, C., Denti, L., Turowski, P., & Ruhrberg, C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.07.564946 · Cited by 4

Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to GDNF secretionPreprint

Yang, L., Lin, Z., Mu, R., Wu, W., Zhi, H., Liu, X., Yang, H., & Liu, L. (2024) · eLife · doi:10.7554/elife.96161.2 · Cited by 2

The Gelatinase Inhibitor ACT-03 Reduces Gliosis in the Rapid Kindling Rat Model of Epilepsy, and Attenuates Inflammation and Loss of Barrier Integrity In Vitro

Broekaart, D. W. M., Zimmer, T. S., Cohen, S. T., Tessers, R., Anink, J. J., de Vries, H. E., Gorter, J. A., Prades, R., Aronica, E., & van Vliet, E. A. (2022) · Biomedicines · doi:10.3390/biomedicines10092117 · Cited by 1

Microvascular Environment Influences Brain Microvascular Heterogeneity: Relative Roles of Astrocytes and Oligodendrocytes for the EPCR Expression in the Brain Endothelium

Thakar, M., Noumbissi, M. E., & Stins, M. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24086908 · Cited by 1

Comprehensive Physicochemical Characterization and in Vitro Human Cell Culture Studies of an Innovative Biocompatible and Biodegradable Silk-Derived Protein Hydrolysate, SDP-4

Sofi, H. S., Lora, A. J., Aggarwal, S., Infanger, D. W., Lawrence, B. D., & Mansour, H. M. (2025) · ACS Omega · doi:10.1021/acsomega.4c08514 · Cited by 1

Ex Vivo Plasma Application on Human Brain Microvascular Endothelial-like Cells for Blood–Brain Barrier Modeling

Nelz, S.-C., Lück, E., Schölzel, A., Sauer, M., Heskamp, J., & Doß, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073334 · Cited by 1

Construction and Functional Evaluation of 2D and 3D Human Blood–Brain Barrier Models

Kurosawa, T., Kubo, Y., & Deguchi, Y. (2025) · Current human cell research and applications · doi:10.1007/978-981-97-9495-9_14 · Cited by 1

Memantine loaded micro/nanoscale magnetic motors for the treatment of Alzheimer's Disease

Tezel, G., Öztürk, E., Ulutürk, S., Öztürk, S. C., Reçber, T., Timur, S. S., Nemutlu, E., Kuralay, F., Esendağlı, G., Gürsoy, R. N., et al. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107043 · Cited by 1

DLF-BBP: A novel deep learning framework for blood-brain barrier penetrating peptides design

Huang, L., Li, Z., Li, H., Li, H., Bing, T., Li, Y., & Yu, C. (2025) · Biochemical Engineering Journal · doi:10.1016/j.bej.2025.110014 · Cited by 1

Let-7f-5p/AIMP1/ZO-1 axis mediates blood–brain barrier dysfunction in neuromyelitis optica spectrum disorders

Yuan, C., Guo, R., Yin, B., Zhang, L., Liu, J., & Li, B. (2025) · Clinical & Experimental Immunology · doi:10.1093/cei/uxaf070 · Cited by 1

The ion transport, GPCR, and RTK toolkit expression in the human cerebrovascular endothelial cell line, hCMEC/D3: an Omics perspective

Scarpellino, G., Brunetti, V., Scolari, F., Visentin, L., Biella, G. R., Ruffinatti, F. A., & Moccia, F. D. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1733266 · Cited by 1

vascr: An R-based toolkit for rapid and robust analysis of cellular impedance sensing data

Hucklesby, J. J. W., Unsworth, C. P., Graham, E. S., & Angel, C. E. (2026) · European Biophysics Journal · doi:10.1007/s00249-026-01852-5 · Cited by 1

Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery

Shalabalija, D., Mihailova, L., Geškovski, N., Zimmer, A., Geiss, O., Gioria, S., Scaccabarozzi, D., & Dodov, M. G. (2026) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.17.9 · Cited by 1

CRISPR interference in a Streptococcus agalactiae multi-locus sequence type 17 strain

Cutts, W. D., Flanagan, A. W., Gorman, B., Sweten, A., Estrada, B. J. V., Subash, V., Klemp, B. T., Seely, K. N., Sandobal, A., Stilen, K., et al. (2026) · Journal of Bacteriology · doi:10.1128/jb.00376-25 · Cited by 1

Adipose tissue‐derived small extracellular vesicles and blood–brain barrier function in adults with overweight and obesity

Mishra, S., Su, Y., Singh, S., Kumar, A., Hsu, F., Deep, G., & Brinkley, T. E. (2026) · Experimental Physiology · doi:10.1113/ep092878 · Cited by 1

Targeting α7nAChR-driven brain endothelial pyroptosis mitigates HIV-1 gp120-induced blood–brain barrier breakdown

Zou, J., Gao, X., Chen, J., Zhou, B., Meng, X., Chen, J., Huang, P., & Cao, H. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106478 · Cited by 1

The Ins and Outs of Manganese: ZIP14 Facilitates Manganese Efflux from the Mouse Brain

Zou, J., Thorn, T. L., Wang, Z., Wang, Y., & Aydemir, T. B. (2026) · Journal of Nutrition · doi:10.1016/j.tjnut.2026.101521 · Cited by 1

Adapting high-resolution respirometry for adherent brain endothelial cells reveals stable and reproducible mitochondrial respiration

Jain, C., Grewal, A., Kuzmychova, H., Mukherjee, R., Chawla, U., Banerji, V., Martell, E., & Sharif, T. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153727 · Cited by 1

Accelerated reprogramming of hiPSCs into functional brain endothelial-like cells using multiplexed CRISPR activation

Hwang, R. W., Khalil, Y. A., Baumann, E., Huang, J., Charlebois, C., Rukhlova, M., Renner, T. M., Liu, Z., Jezierski, A., Kærn, M., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-46961-5 · Cited by 1

In vitro evidence that plasma of women with eclampsia disrupts the blood-brain barrier

Acurio, J., Troncoso, F., Escudero-Guevara, E., Sandoval, H., Ibáñez, B., Vatish, M., Torres‐Vergara, P., Bergman, L., & Escudero, C. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1778955 · Cited by 1

Integrated transcriptomic and proteomic analysis reveals inflammatory activation and blood-brain barrier disruption during meningitis-associated extraintestinal pathogenic Escherichia coli infection

Li, Z., Chen, M., Du, Y., Jia, K., Lu, Y., Yu, X., Cao, X., Peng, L., & Fang, R. (2026) · Virulence · doi:10.1080/21505594.2026.2670939 · Cited by 1

A multi-level characterization of TfR, Mfsd2a and LRP1 in a stem cell derived in vitro model of the blood–brain barrier

König, L., Khin, M., Puris, E., Petralla, S., Gericke, B., & Fricker, G. (2026) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2026.115111 · Cited by 1

Reversible & Microbubble Concentration-Dependent Permeabilization of an In Vitro Human Endothelial Barrier to Small Molecules Using Ultrasound: Implications for Neurodegenerative Diseases Therapy

Ea, K., Pinaud, M., Fouan, D., Presset, A., Tartu, J.-Y., Sasaki, N., Taulier, N., Urbach, W., Contino-Pepin, C., Desgranges, S., et al. (2026) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6c00168 · Cited by 1

Biomedical Materials and Fabrication Methods for Construction of In Vitro Neurovascular Unit Models

Xu, Y., Yu, W., Li, Y., & Zhang, L. (2026) · Materials · doi:10.3390/ma19173590 · Cited by 1

Pre‐Plated Cell Lines for ADMETox Applications in the Pharmaceutical Industry

Torres, F. M., Sáfár, Z., Vázquez-Sánchez, M. A., Kurunczi, A., Kis, E., Magnan, R., Jani, M., Nicolás, O., & Krajcsi, P. (2015) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx2308s65 · Cited by 1

In Vitro CNS Models

Kara, A., Öztürk, N., & Vural, İ. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803796-6.00008-3 · Cited by 1

Novel, Emerging Chip Models of the Blood-Brain Barrier and Future Directions

Holloway, P. M. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2289-6_11 · Cited by 1

Methods for the Screening of New Chemical Entities for Deciphering Neuroinflammatory and Associated Pathways in Seizures: An In Vitro Perspective

Vyas, P., Tulsawani, R., & Vohora, D. (2021) · Neuromethods · doi:10.1007/978-1-0716-1254-5_3 · Cited by 1

In Vitro Models of CNS Barriers

Abbott, N. J., Yusof, S. R., Reichel, A., Dolman, D. E. M., & Preston, J. E. (2022) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-030-88773-5_8 · Cited by 1

Comparative analysis of neuroinvasion by Japanese encephalitis virulent and vaccine strains in an in cellulo model of human blood-brain barrierPreprint

Khou, C., Díaz-Salinas, M. A., Costa, A. D., Prehaud, C. J. N., Jeannin, P., Afonso, P. V., Vignuzzi, M., Lafon, M., & Pardigon, N. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/642033 · Cited by 1

Design of Experiment Based Optimization of an in Vitro Direct Contact Triculture Blood Brain Barrier Model for Permeability ScreeningPreprint

Lubin, K. E., & Knipp, G. T. (2021) · Research Square · doi:10.21203/rs.3.rs-592200/v1 · Cited by 1

Understanding Vascular Endothelial Cell Behavior Using a Mechanical Strain Gradient Generated by an Electromagnetic Stretching DevicePreprint

Yang, M. L., Zuo, C., Liu, J., Man, K., Zuo, Z., & Yang, Y. S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.20.513030 · Cited by 1

Amyloid-beta peptides 40 and 42 employ distinct molecular pathways for cell entry and intracellular transit at the BBB endotheliumPreprint

Wang, Z., Sharda, N., Omtri, R. S., Li, L., & Kandimalla, K. K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.17.516996 · Cited by 1

Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brainPreprint

Chakraborty, M., Shi, S. M., Porter, I. E., Richard, D. J., Marinov, G. K., Murthy, M. N., Moore, A. A., Blum, J. L. E., Natarajan, A., Jahng, J. W. S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.03.680371 · Cited by 2

Blood-brain barrier disrupting stimuli induce production of extracellular vesicles with distinct protein cargoes and functionalityPreprint

Xiang, A., Adeel, Z., Shih, A., & Diamond, B. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.15.699203 · Cited by 1

Traumatic Injury in vitro Elicits JNK-mediated Human Astrocyte Retraction, but Spares Cerebrovascular Endothelial Cells

Augustine, C. (2013) · Scholarship@Western (Western University)

Investigation of the Function and Regulation of ABC Transporters

Akkaya, B. G. (2014)

Effects of absorption enhancer surfactants on culture models of intestinal and vascular barriers

Kiss, L. (2014) · doi:10.14232/phd.2355

An Insect-Based Ex Vivo Blood Brain

Al‐Qadi, S., & Schiøtt, M. (2014)

Transmigration of breast cancer and melanoma cells through the blood-brain barrier: similarities and differences

Molnár, J. (2016)

Mechanisms of Bacterial Interaction with Cells of the Blood–Cerebrospinal Fluid Barrier

Schubert‐Unkmeir, A., & Doran, K. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801078-5.00004-2

Development of Mouse Cell-Based In Vitro Blood-Brain Barrier Models

Burek, M., Salvador, E., & Förster, C. Y. (2017) · Neuromethods · doi:10.1007/978-1-4939-7024-7_9

The influence of astrocytes and their culturing environment on blood-brain barrier modeling in a microfluidic chip

Hällevall, M. (2017) · Lund University Publications Student Papers (Lund University)

Development of Quercetin Brain Delivery Systems for the Treatment of Alzheimer´s disease

Pinheiro, R. G. R. (2017) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/wz2t-9a45

The role of brain endothelial surface charge and glycocalyx in the function and integrity of the blood-brain barrier

Santa-Maria, A. R. (2021) · doi:10.14232/phd.10751

Transmigration of breast cancer and melanoma cells through the blood-brain barrier

Molnár, J. (2016) · doi:10.14232/phd.2967

Recreating the gut on-chip : Sensors and fabrication technologies for aerobic intestinal host - anaerobic microbiota research

Bossink, E. G. B. M. (2022) · doi:10.3990/1.9789036553995

Calcium-Mediated Modulation of Blood-Brain Barrier Permeability by Laser Stimulation of Endothelial-Targeted NanoparticlesPreprint

Li, X., Cai, Q., Wilson, B. A., Fan, H., Giannotta, M., Bachoo, R. M., & Qin, Z. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.02.494541

Wine-Processed Chuanxiong Rhizoma Combined with Aumolertinib for the Treatment of Brain Metastasis in Non-Small Cell Lung CancerPreprint

Wenwen, N., Rong, X.-Y., Xu, L., Zhao, Q., Liu, X.-R., Pang, J.-L., Zhang, Y., Huang, F.-H., Li, S., & Li, X. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4092387

Assessment of zonula occluden-1 expression by Wnt/β-catenin pathway activators in hCMEC/D3 cells

Calabrese, G., & Caprifico, A. E. (2022) · Academia Letters · doi:10.20935/al5472

Configurable Models of the Neurovascular Unit

Mishra, Y., Sáez, J., & Owens, R. M. (2022) · Springer eBooks · doi:10.1007/978-3-031-11409-0_1

Interaction of amisulpride with GLUT1 at the blood-brain barrier. Relevance to Alzheimer’s diseasePreprint

Boyanova, S. T., Lloyd-Morris, E., Corpe, C. P., Rahman, K. M., Farag, D. B., Page, L. K., Wang, H., Fleckney, A. L., Gatt, A. P., Troakes, C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.15.540749

Construction of human iPS cells-derived blood-brain barrier model and evaluation of transporter function

Kurosawa, T., Sako, D., Kubo, Y., & Deguchi, Y. (2023) · Drug Delivery System · doi:10.2745/dds.38.117

Hidroxi-propil-béta-ciklodextrin celluláris internalizációjának és lizoszómákra gyakorolt hatásának vizsgálata

Rusznyák, Á., Réti-Nagy, K. S., Váradi, J., Bácskay, I., Vecsernyés, M., & Fenyvesi, F. (2023) · Egészségügyi Innovációs Szemle · doi:10.56626/egis.v2i2.12924

Efecto de la vitamina C en células endoteliales microvasculares de cerebro humano en modelo de isquemia-reperfusión in vitro.

Rocco, C. R., & Pérez, E. I. (2023) · doi:10.29393/tmudec-65as1ev65

Engineering a Microfluidic Blood-Brain Barrier on a Silicon Chip

Liu, J. (2023) · University of North Texas Digital Library (University of North Texas) · doi:10.12794/metadc2178818

Tissue-based in vitro and ex vivo models for blood–brain barrier permeability studies

Moura, R. P., Pacheco, C., Faria, P. D. P., & Sarmento, B. F. C. C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15510-9.00022-0

Synthesis and Validation of TRIFAPYs as a Family of Transfection Agents for Therapeutic Oligonucleotides

Isanta, B., Delgado, A., Ciudad, C. J., Busquets, M. A., Griera, R., Llor, N., & Noé, V. (2024) · Biomolecules · doi:10.3390/biom14040390

Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to GDNF secretionPreprint

Yang, L., Lin, Z., Mu, R., Wu, W., Zhi, H., Liu, X., Yang, H., & Liu, L. (2024) · eLife · doi:10.7554/elife.96161.1

The neuroprotective effect of hUC-MSCs-derived secretome against alpha-synuclein aggregates on the blood-brain barrierPreprint

Marzookian, K., Aliakbari, F., Hourfar, H., Sabouni, F., Otzen, D. E., & Morshedi, D. (2024) · Research Square · doi:10.21203/rs.3.rs-4552919/v1

Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain targetingPreprint

Shalabalija, D., Mihailova, L., Geškovski, N., Zimmer, A., Geiss, O., Gioria, S., Scaccabarozzi, D., & Dodov, M. G. (2024) · Research Square · doi:10.21203/rs.3.rs-4828653/v1

hsa-miR-9-5p highly expressed in syncytiotrophoblast-derived extracellular vesicles from early-onset preeclampsia impairs cerebral microvascular endothelial cell pro-angiogenic capacityPreprint

Logenthiran, P., Awoyemi, T., Jones, G. D., Rahbar, M., Akbar, N., Cerdeira, A. S., Escudero, C., & Vatish, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.21.619546

Directed Drug Convection Using Magnetic Nanoparticles as Therapeutic Carriers Meeting the Challenge of Specific Brain Pharmacotherapeutics, Non-ligand-Based Central Nervous System Targeting, Including Magnetic Focusing

Shevy, D. S., Kateb, B., Moore, D. F., Yathindranath, V., Hegmann, T., Miller, D. W., Pelletier, M., & Schiffman, R. (2024) · Springer eBooks · doi:10.1007/978-3-030-80662-0_11

Recent Advances in Blood Brain Barrier on Chip ModelsPreprint

Vetter, J., Palagi, I., Waisman, A., & Blaeser, A. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.5047806

Modeling the Blood-brain Barrier Using Rat Brain Cell Cultures

Leonov, G. E., Vakhrushev, I. V., Novikova, V. D., Saryglar, R. Y., Baskaev, K. K., Lupatov, A. Y., Kholodenko, I. V., & Yarygin, K. N. (2024) · Biomedical Chemistry Research and Methods · doi:10.18097/bmcrm00238

SSAO-mediated decrease of endothelial BDNF release affects neuronal GluA1 and PSD95 expression: a peripheral mechanism inducing NVU and CNS disturbancesPreprint

Fábregas, C., Esteban-López, M., Fadó, R., Casals, N., Unzeta, M., Rodrı́guez-Álvarez, J., Miñano-Molina, A. J., & Solé, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.04.641410

Plasma, not extracellular vesicles, disrupts the blood-brain barrier in eclampsiaPreprint

Acurio, J., Troncoso, F., Escudero-Guevara, E., Sandoval, H., Vatish, M., Torres‐Vergara, P., Bergman, L., & Escudero, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.03.641338

A 3D In Vitro Blood-Brain Barrier Model to Study Pathogen and Drug Effects on the BBB

Proust, A. M., & Wilkinson, R. J. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4674-8_5

Meta-analysis of RNA-seq Data Identifies Involvement of Interferon-Induced Genes to Facilitate Blood–Brain Barrier Traversal of Neuroinvasive Pathogens

Kulkarni, A. D., Alagundagi, D. B., Bhide, M. R., & Patil, P. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02400-0 · Cited by 1

Antimicrobial Activity

Ross, I. A. (2025) · Springer eBooks · doi:10.1007/978-3-032-04239-2_5

Endothelial-pericyte interactions activate insulin signaling and its implications for blood-brain barrier dysfunction in Alzheimer’s diseasePreprint

Wang, Z., Veerareddy, V., Eberts, P. M., Azarin, S. M., & Kandimalla, K. K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.24.690270

Contrasting cannabinoid receptor 2 (CB2R)-mediated responses in two different models of Blood Brain Barrier in the context of HIVPreprint

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Additional file 8 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity

Liu, H., Lei, S., Jia, L., Xia, X., Sun, Y., Jiang, H., Zhu, R., Li, S., Qu, G., Gu, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091531

Additional file 3 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity

Liu, H., Lei, S., Jia, L., Xia, X., Sun, Y., Jiang, H., Zhu, R., Li, S., Qu, G., Gu, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091516

Additional file 2 of Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses

Choublier, N., Taghi, M., Menet, M., Gall, M. L., Bruce, J., Chafey, P., Guillonneau, F., Moreau, A., Denizot, C., Parmentier, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20001119

Additional file 1 of The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells

Svane, N., Pedersen, A. B. V., Rodenberg, A., Ozgür, B., Saaby, L., Bundgaard, C., Kristensen, M., Tfelt‐Hansen, P. C., & Brodin, B. (2024) · Figshare · doi:10.6084/m9.figshare.26716528

Additional file 2 of Inflammation-induced TRPV4 channels exacerbate blood–brain barrier dysfunction in multiple sclerosis

Hansen, C. E., Kamermans, A., Mol, K., Berve, K., Rodriguez-Mogeda, C., Fung, W. K., Hof, B. V. H., Fontijn, R. D., van der Pol, S. M. A., Michalick, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25466630

Additional file 2 of A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria

Gopinadhan, A., Hughes, J. M., Conroy, A. L., John, C. C., Canfield, S. G., & Datta, D. (2024) · Figshare · doi:10.6084/m9.figshare.26714833

Additional file 5 of The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells

Svane, N., Pedersen, A. B. V., Rodenberg, A., Ozgür, B., Saaby, L., Bundgaard, C., Kristensen, M., Tfelt‐Hansen, P. C., & Brodin, B. (2024) · Figshare · doi:10.6084/m9.figshare.26716540

Additional file 1 of Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line

Ozgür, B., Puris, E., Brachner, A., Appelt‐Menzel, A., Oerter, S., Balzer, V., Holst, M. R., Christiansen, R. F., Hyldig, K., Buckley, S. T., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24872982

Additional file 7 of A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria

Gopinadhan, A., Hughes, J. M., Conroy, A. L., John, C. C., Canfield, S. G., & Datta, D. (2024) · Figshare · doi:10.6084/m9.figshare.26714851

Additional file 5 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity

Liu, H., Lei, S., Jia, L., Xia, X., Sun, Y., Jiang, H., Zhu, R., Li, S., Qu, G., Gu, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091522

Additional file 1 of A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria

Gopinadhan, A., Hughes, J. M., Conroy, A. L., John, C. C., Canfield, S. G., & Datta, D. (2024) · Figshare · doi:10.6084/m9.figshare.26714830

Additional file 2 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity

Liu, H., Lei, S., Jia, L., Xia, X., Sun, Y., Jiang, H., Zhu, R., Li, S., Qu, G., Gu, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091513

Additional file 6 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity

Liu, H., Lei, S., Jia, L., Xia, X., Sun, Y., Jiang, H., Zhu, R., Li, S., Qu, G., Gu, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091525

Additional file 6 of The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells

Svane, N., Pedersen, A. B. V., Rodenberg, A., Ozgür, B., Saaby, L., Bundgaard, C., Kristensen, M., Tfelt‐Hansen, P. C., & Brodin, B. (2024) · Figshare · doi:10.6084/m9.figshare.26716543

Additional file 1 of Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood − brain barrier function

Hosseinkhani, B., Duran, G., Hoeks, C., Hermans, D., Schepers, M., Baeten, P., Poelmans, J., Coenen, B. A., Bekar, K., Pintelon, I., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24873045

Additional file 6 of A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria

Gopinadhan, A., Hughes, J. M., Conroy, A. L., John, C. C., Canfield, S. G., & Datta, D. (2024) · Figshare · doi:10.6084/m9.figshare.26714848

Additional file 3 of The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells

Svane, N., Pedersen, A. B. V., Rodenberg, A., Ozgür, B., Saaby, L., Bundgaard, C., Kristensen, M., Tfelt‐Hansen, P. C., & Brodin, B. (2024) · Figshare · doi:10.6084/m9.figshare.26716534

Additional file 4 of Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

van der Wijk, A., Georgakopoulou, T., Majolée, J., van Bezu, J. S. M., van der Stoel, M. M., Hof, B. J. V. H., de Vries, H. E., Huveneers, S., Hordijk, P. L., Bakker, E. N. T. P., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13250789

Additional file 1 of Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity

Liu, H., Lei, S., Jia, L., Xia, X., Sun, Y., Jiang, H., Zhu, R., Li, S., Qu, G., Gu, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091510

Additional file 7 of The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells

Svane, N., Pedersen, A. B. V., Rodenberg, A., Ozgür, B., Saaby, L., Bundgaard, C., Kristensen, M., Tfelt‐Hansen, P. C., & Brodin, B. (2024) · Figshare · doi:10.6084/m9.figshare.26716546

Additional file 2 of Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

van der Wijk, A., Georgakopoulou, T., Majolée, J., van Bezu, J. S. M., van der Stoel, M. M., Hof, B. J. V. H., de Vries, H. E., Huveneers, S., Hordijk, P. L., Bakker, E. N. T. P., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13250783

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