The hCMEC/D3 cell line as a model of the human blood brain barrier

Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line

Weksler, B. B., Subileau, E.-A., Perrière, N., Charneau, P., Holloway, K. E., Leveque, M., Tricoire-Leignel, H., Nicotra, A., Bourdoulous, S., Turowski, P., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3458fje · Cited by 1,325

Wnt/β-catenin signaling controls development of the blood–brain barrier

Liebner, S., Corada, M., Bangsow, T., Babbage, J., Taddei, A., Czupalla, C. J., Reis, M., Felici, A., Wolburg, H., Fruttiger, M., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200806024 · Cited by 860

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

Lippmann, E. S., Azarin, S. M., Kay, J. E., Nessler, R. A., Wilson, H. K., Al-Ahmad, A., Palecek, S. P., & Shusta, E. V. (2012) · Nature Biotechnology · doi:10.1038/nbt.2247 · Cited by 800

Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study.

Butt, A. M., Jones, H. C., & Abbott, N. J. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018243 · Cited by 775

Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation

Luissint, A.-C., Artus, C., Glacial, F., Ganeshamoorthy, K., & Couraud, P.-O. (2012) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-9-23 · Cited by 654

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood–brain barrier

Dauchy, S., Dutheil, F., Weaver, R. J., Chassoux, F., Daumas‐Duport, C., Couraud, P., Scherrmann, J., de Waziers, I., & Declèves, X. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05720.x · Cited by 361

Development of a three-dimensional, all-human in vitro model of the blood–brain barrier using mono-, co-, and tri-cultivation Transwell models

Hatherell, K. E., Couraud, P., Romero, I. A., Weksler, B. B., & Pilkington, G. J. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.05.012 · Cited by 358

The human brain endothelial cell line hCMEC/D3 as a human blood‐brain barrier model for drug transport studies

Poller, B., Gutmann, H., Krähenbühl, S., Weksler, B. B., Romero, I. A., Couraud, P., Tuffin, G., Drewe, J., & Huwyler, J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05730.x · Cited by 318

Differential effects of hydrocortisone and TNFα on tight junction proteins in an in vitro model of the human blood–brain barrier

Förster, C. Y., Burek, M., Romero, I. A., Weksler, B. B., Couraud, P., & Drenckhahn, D. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.146852 · Cited by 306

Immortalized Human Brain Endothelial Cells and Flow-Based Vascular Modeling: A Marriage of Convenience for Rational Neurovascular Studies

Cucullo, L., Couraud, P., Weksler, B. B., Romero, I. A., Hossain, M. K., Rapp, E., & Janigro, D. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600525 · Cited by 266

Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models

Urich, E., Lazic, S. E., Molnos, J., Wells, I., & Freskgård, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038149 · Cited by 234

Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood–Brain Barrier Model

Ohtsuki, S., Ikeda, C., Uchida, Y., Sakamoto, Y., Miller, F., Glacial, F., Declèves, X., Scherrmann, J., Couraud, P., Kubo, Y., et al. (2012) · Molecular Pharmaceutics · doi:10.1021/mp3004308 · Cited by 231

Meningococcal Type IV Pili Recruit the Polarity Complex to Cross the Brain Endothelium

Coureuil, M., Mikaty, G., Miller, F., Lécuyer, H., Bernard, C., Bourdoulous, S., Duménil, G., Mège, R., Weksler, B., Romero, I., et al. (2009) · Science · doi:10.1126/science.1173196 · Cited by 226

Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells

Dauchy, S., Miller, F., Couraud, P., Weaver, R. J., Weksler, B. B., Romero, I. A., Scherrmann, J., de Waziers, I., & Declèves, X. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.001 · Cited by 207

Cell‐penetrating anti‐GFAP VHH and corresponding fluorescent fusion protein VHH‐GFP spontaneously cross the blood‐brain barrier and specifically recognize astrocytes: application to brain imaging

Li, T., Bourgeois, J., Celli, S., Glacial, F., Sourd, A. L., Mécheri, S., Weksler, B. B., Romero, I. A., Couraud, P., Rougeon, F., et al. (2012) · The FASEB Journal · doi:10.1096/fj.11-201384 · Cited by 202

Identification of an essential endogenous regulator of blood–brain barrier integrity, and its pathological and therapeutic implications

Cristante, E., McArthur, S., Mauro, C., Maggioli, E., Romero, I. A., Wylezinska, M., Couraud, P. O., Lopez-Tremoleda, J., Christian, H., Weksler, B. B., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209362110 · Cited by 197

Solid Lipid Nanoparticles Enhance the Delivery of the HIV Protease Inhibitor, Atazanavir, by a Human Brain Endothelial Cell Line

Chattopadhyay, N., Zastre, J. A., Wong, H. L., Wu, X. Y., & Bendayan, R. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9615-2 · Cited by 194

Meningococcus Hijacks a β2-Adrenoceptor/β-Arrestin Pathway to Cross Brain Microvasculature Endothelium

Coureuil, M., Lécuyer, H., Scott, M. G. H., Boularan, C., Enslen, H., Soyer, M., Mikaty, G., Bourdoulous, S., Nassif, X., & Marullo, S. (2010) · Cell · doi:10.1016/j.cell.2010.11.035 · Cited by 191

Regulation of BCRP (ABCG2) and P-Glycoprotein (ABCB1) by Cytokines in a Model of the Human Blood–Brain Barrier

Poller, B., Drewe, J., Krähenbühl, S., Huwyler, J., & Gutmann, H. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9431-1 · Cited by 184

Uptake and cytotoxicity of citrate-coated gold nanospheres: Comparative studies on human endothelial and epithelial cells

Freese, C., Uboldi, C., Gibson, M. I., Unger, R. E., Weksler, B. B., Romero, I. A., Couraud, P., & Kirkpatrick, C. J. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-23 · Cited by 161

Role of Caspases in Cytokine-Induced Barrier Breakdown in Human Brain Endothelial Cells

Lopez‐Ramirez, M. A., Fischer, R., Torres-Badillo, C. C., Davies, H. A., Logan, K. E., Pfizenmaier, K., Male, D. K., Sharrack, B., & Romero, I. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103460 · Cited by 140

Platelets Potentiate Brain Endothelial Alterations Induced byPlasmodium falciparum

Wassmer, S. C., Combes, V., Candal, F. J., Juhan-Vague, I., & Grau, G. E. (2005) · Infection and Immunity · doi:10.1128/iai.74.1.645-653.2006 · Cited by 137

Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein

Candela, P., Gosselet, F., Saint-Pol, J., Sevin, E., Boucau, M.-C., Boulanger, E., Cecchelli, R., & Fenart, L. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100462 · Cited by 128

Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood–brain barrier function

Sano, Y., Shimizu, F., Abe, M., Maeda, T., Kashiwamura, Y., Ohtsuki, S., Terasaki, T., Obinata, M., Kajiwara, K., Fujii, M., et al. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22232 · Cited by 128

Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans

Vu, K., Weksler, B., Romero, I., Couraud, P.-O., & Gelli, A. (2009) · Eukaryotic Cell · doi:10.1128/ec.00240-09 · Cited by 124

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

van Doorn, R., Pinheiro, M. A. L., Kooij, G., Lakeman, K. A. M., Hof, B. V. H., van der Pol, S. M. A., Geerts, D., van Horssen, J., van der Valk, P., van der Kam, E. L., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-133 · Cited by 124

Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line.

Markoutsa, E., Pampalakis, G., Niarakis, A., Romero, I. A., Weksler, B., Couraud, P.-O., & Antimisiaris, S. G. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.11.015 · Cited by 122

Amyloid-β-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation

Tai, L. M., Holloway, K., Male, D. K., Loughlin, J., & Romero, I. A. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00717.x · Cited by 118

Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions

Jambou, R., Combes, V., Jambou, M.-J., Weksler, B. B., Couraud, P., & Grau, G. E. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001021 · Cited by 116

CCL2 disrupts the adherens junction: implications for neuroinflammation

Roberts, T. K., Eugenin, E. A., Lopez, L., Romero, I. A., Weksler, B. B., Couraud, P.-O., & Berman, J. W. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.80 · Cited by 115

Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain.

El-Bachá, R. D. S., & Minn, A. (1999) · PubMed · Cited by 114

Alteration of Blood–Brain Barrier Integrity by Retroviral Infection

Afonso, P. V., Ozden, S., Cumont, M.-C., Seilhean, D., Cartier, L., Rezaie, P., Mason, S., Lambert, S., Huerre, M., Gessain, A., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000205 · Cited by 112

Expression of Chemokines and Their Receptors by Human Brain Endothelium: Implications for Multiple Sclerosis

Subileau, E. A., Rezaie, P., Davies, H. A., Colyer, F. M., Greenwood, J., Male, D. K., & Romero, I. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318197eca7 · Cited by 111

Caveolin-1 Regulates Human Immunodeficiency Virus-1 Tat-Induced Alterations of Tight Junction Protein Expression via Modulation of the Ras Signaling

Zhong, Y., Smart, E. J., Weksler, B. B., Couraud, P., Hennig, B., & Toborek, M. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0061-08.2008 · Cited by 111

PPARα and PPARγ attenuate HIV‐induced dysrégulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities

Huang, W., Eum, S. Y., Andras, I. E., Hennig, B., & Toborek, M. J. (2009) · The FASEB Journal · doi:10.1096/fj.08-121624 · Cited by 109

P-Glycoprotein and Breast Cancer Resistance Protein Restrict Apical-to-Basolateral Permeability of Human Brain Endothelium to Amyloid-β

Tai, L. M., Loughlin, A. J., Male, D. K., & Romero, I. A. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.42 · Cited by 108

Up‐regulation of P‐glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line

Zastre, J. A., Chan, G. N. Y., Ronaldson, P. T., Ramaswamy, M., Couraud, P. O., Romero, I. A., Weksler, B. B., Bendayan, M., & Bendayan, R. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21898 · Cited by 108

GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC1Portions of this work were presented at the annual meeting of the Federation of the American Societies of Experimental Biology, April 17–21, 1999, Washington, DC [FASEB J. 13(4), 571.4A (1999)].1

Kannan, R., Chakrabarti, R., Tang, D., Kim, K. J., & Kaplowitz, N. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02184-8 · Cited by 99

Human Blood-Brain Barrier Disruption by Retroviral-Infected Lymphocytes: Role of Myosin Light Chain Kinase in Endothelial Tight-Junction Disorganization

Afonso, P. V., Ozden, S., Prévost, M., Schmitt, C., Seilhean, D., Weksler, B. B., Couraud, P., Antoine Gessain, A., Romero, I. A., & Ceccaldi, P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2576 · Cited by 97

ABC and SLC Transporter Expression and Pot Substrate Characterization across the Human CMEC/D3 Blood−Brain Barrier Cell Line

Carl, S. M., Lindley, D. J., Couraud, P. O., Weksler, B. B., Romero, I., Mowery, S. A., & Knipp, G. T. (2010) · Molecular Pharmaceutics · doi:10.1021/mp900178j · Cited by 88

Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid‐β variants in cells composing the cerebral vessel walls

Fossati, S., Cam, J. A., Meyerson, J. L., Mezhericher, E., Romero, I. A., Couraud, P., Weksler, B. B., Ghiso, J. A., & Rostagno, A. A. (2009) · The FASEB Journal · doi:10.1096/fj.09-139584 · Cited by 86

Modulation of blood–brain barrier permeability by neutrophils: in vitro and in vivo studies

Joice, S. L., Mydeen, M. F. M., Couraud, P., Weksler, B. B., Romero, I. A., Fraser, P. A., & Easton, A. S. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.076 · Cited by 85

Lamotrigine is a substrate for OCT1 in brain endothelial cells

Dickens, D., Owen, A., Alfirevic, A., Giannoudis, A., Davies, A., Weksler, B. B., Romero, I. A., Couraud, P., & Pirmohamed, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.12.032 · Cited by 85

The association of statins plus LDL receptor‐targeted liposome‐encapsulated doxorubicin increases in vitro drug delivery across blood–brain barrier cells

Pinzón‐Daza, M., Garzón, R., Couraud, P., Romero, I., Weksler, B., Ghigo, D., Bosia, A., & Riganti, C. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02103.x · Cited by 84

Studies of Plasmodium falciparum cytoadherence using immortalized human brain capillary endothelial cells

Prudhomme, J. G., Sherman, I. W., Land, K. M., Moses, A. V., Stenglein, S., & Nelson, J. A. (1996) · International Journal for Parasitology · doi:10.1016/0020-7519(96)00027-6 · Cited by 80

HIV-1 Tat Triggers Nuclear Localization of ZO-1 via Rho Signaling and cAMP Response Element-Binding Protein Activation

Zhong, Y., Zhang, B., Eum, S. Y., & Toborek, M. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4266-11.2012 · Cited by 79

Tissue-Type Plasminogen Activator Is a Regulator of Monocyte Diapedesis through the Brain Endothelial Barrier

Reijerkerk, A., Kooij, G., van der Pol, S. M. A., Leyen, T. A., Hof, B. V. H., Couraud, P., Vivien, D., Dijkstra, C. D., & de Vries, H. E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3567 · Cited by 75

Evaluation of the immortalized human brain capillary endothelial cell line BB19 as a human cell culture model for the blood–brain barrier

Kusch-Poddar, M., Drewe, J., Fux, I., & Gutmann, H. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.014 · Cited by 74

Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytes

Viegas, P., Chaverot, N., Enslen, H., Perrière, N., Couraud, P., & Cazaubon, S. M. (2006) · Journal of Cell Science · doi:10.1242/jcs.03222 · Cited by 73

Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123

Tai, L. M., Reddy, P. S., Lopez‐Ramirez, M. A., Davies, H. A., Male, D. K., Loughlin, J., & Romero, I. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.039 · Cited by 67

Guanine Nucleotide-Binding Protein Gαi2: A New Partner of Claudin-5 that Regulates Tight Junction Integrity in Human Brain Endothelial Cells

Luissint, A., Fédérici, C., Guillonneau, F., Chrétien, F. C., Camoin, L., Glacial, F., Ganeshamoorthy, K., & Couraud, P. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.202 · Cited by 66

Beta amyloid effects on expression of multidrug efflux transporters in brain endothelial cells.

Kania, K., Wijesuriya, H. C., Hladky, S., & Barrand, M. (2011) · Brain Research · doi:10.1016/j.brainres.2011.08.044 · Cited by 63

Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line

Bahbouhi, B., Berthelot, L., Pettré, S., Michel, L., Wiertlewski, S., Weksler, B. B., Romero, I. A., Miller, F., Couraud, P., Brouard, S., et al. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008666 · Cited by 61

Regulation of Breast Cancer Resistant Protein by Peroxisome Proliferator-Activated Receptor α in Human Brain Microvessel Endothelial Cells

Hoque, M. T., Robillard, K. R., & Bendayan, R. (2012) · Molecular Pharmacology · doi:10.1124/mol.111.076745 · Cited by 59

Intact Lipid Rafts Regulate HIV-1 Tat Protein-Induced Activation of the Rho Signaling and Upregulation of P-Glycoprotein in Brain Endothelial Cells

Zhong, Y., Hennig, B., & Toborek, M. J. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.214 · Cited by 59

Establishment of a new conditionally immortalized cell line from human brain microvascular endothelial cells: A promising tool for human blood–brain barrier studies

Kamiichi, A., Furihata, T., Kishida, S., Ohta, Y., Saito, K., Kawamatsu, S., & Chiba, K. (2012) · Brain Research · doi:10.1016/j.brainres.2012.09.042 · Cited by 57

HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin

Andras, I. E., Eum, S. Y., Huang, W., Zhong, Y., Hennig, B., & Toborek, M. J. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.11.004 · Cited by 56

Matrix Metalloproteinase 2 (MMP-2) Degrades Soluble Vasculotropic Amyloid-β E22Q and L34V Mutants, Delaying Their Toxicity for Human Brain Microvascular Endothelial Cells

Hernández‐Guillamón, M., Mawhirt, S. L., Fossati, S., Blais, S. P., Parés, M., Peñalba, A., Boada, M., Couraud, P., Neubert, T. A., Montaner, J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.135228 · Cited by 49

Metabolic Acidosis Induced by Plasmodium Falciparum Intraerythrocytic Stages Alters Blood—Brain Barrier Integrity

Zougbédé, S., Miller, F., Ravassard, P., Rebollo, A., Cicéron, L., Couraud, P., Mazier, D., & Sabater, A. M. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.121 · Cited by 47

Two Strikingly Different Signaling Pathways Are Induced by Meningococcal Type IV Pili on Endothelial and Epithelial Cells

Lécuyer, H., Nassif, X., & Coureuil, M. (2011) · Infection and Immunity · doi:10.1128/iai.05837-11 · Cited by 46

Simvastatin Protects against Amyloid β and HIV-1 Tat-Induced Promoter Activities of Inflammatory Genes in Brain Endothelial Cells

Andras, I. E., Rha, G. B., Huang, W., Eum, S. Y., Couraud, P., Romero, I. A., Hennig, B., & Toborek, M. J. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.042028 · Cited by 44

Evaluation of Soluble Junctional Adhesion Molecule-A as a Biomarker of Human Brain Endothelial Barrier Breakdown

Haarmann, A., Deiß, A., Prochaska, J. H., Foerch, C., Weksler, B. B., Romero, I. A., Couraud, P., Stoll, G., Rieckmann, P., & Buttmann, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013568 · Cited by 44

PPARα AND PPARγ EFFECTIVELY PROTECT AGAINST HIV-INDUCED INFLAMMATORY RESPONSES IN BRAIN ENDOTHELIAL CELLS

Huang, W., Rha, G., Han, M.-J., Eum, S., András, I., Zhong, Y., Hennig, B., & Toborek, M. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05626.x · Cited by 41

HIV-1-Induced Alterations of Claudin-5 Expression at the Blood–Brain Barrier Level

Andras, I. E., & Toborek, M. J. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-185-7_26 · Cited by 41

Cytokine signaling in the human brain capillary endothelial cell line hCMEC/D3

Fasler‐Kan, E., Suenderhauf, C., Barteneva, N. S., Poller, B., Gygax, D., & Huwyler, J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.077 · Cited by 40

Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro

Chaitanya, G. V., Cromer, W. E., Wells, S., Jennings, M. H., Couraud, P., Romero, I. A., Weksler, B. B., Erdreich‐Epstein, A., Mathis, J. M., Minagar, A., et al. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-162 · Cited by 40

Diesel exhaust particles increase IL-1β-induced human β-defensin expression via NF-κB-mediated pathway in human lung epithelial cells

Nam, H. Y., Ahn, E., Kim, H. J., Lim, Y., Lee, C. B., Lee, K. Y., & Vallyathan, V. (2006) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-3-9 · Cited by 29

Neutrophils block permeability increases induced by oxygen glucose deprivation in a culture model of the human blood–brain barrier

Cowan, K. M., & Easton, A. S. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.066 · Cited by 27

The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood–brain barrier: Evidence for involvement of breast cancer resistance protein

Watson, C., Dogruel, M., Mihoreanu, L., Begley, D. J., Weksler, B. B., Couraud, P. O., Romero, I. A., & Thomas, S. A. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.053 · Cited by 25

Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells

Huang, W., Rha, G. B., Chen, L., Seelbach, M. J., Zhang, B., Andras, I. E., Bruemmer, D., Hennig, B., & Toborek, M. J. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01126.2009 · Cited by 23

The Involvement of a Na+- and Cl–-Dependent Transporter in the Brain Uptake of Amantadine and Rimantadine

Kooijmans, S. A. A., Senyschyn, D., Mezhiselvam, M. M., Morizzi, J., Charman, S. A., Weksler, B. B., Romero, I. A., Couraud, P., & Nicolazzo, J. A. (2012) · Molecular Pharmaceutics · doi:10.1021/mp2004127 · Cited by 23

NKIM-6, a new immortalized human brain capillary endothelial cell line with conserved endothelial characteristics

Ketabi‐Kiyanvash, N., Herold‐Mende, C. C., Kashfi, F., Caldeira, S., Tommasino, M., Haefeli, W. E., & Weiß, J. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0348-4 · Cited by 22

Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment

Hurst, L. A., Bunning, R. A. D., Couraud, P., Romero, I. A., Weksler, B. B., Sharrack, B., & Woodroofe, M. N. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.02.008 · Cited by 22

Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells

Andras, I. E., Eum, S. Y., & Toborek, M. J. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.03.128 · Cited by 20

Molecular Cytogenetic Characterization of the Human Cerebral Microvessel Endothelial Cell Line hCMEC/D3

Mkrtchyan, H., Scheler, S., Klein, I., Fahr, A., Couraud, P., Romero, I. A., Weksler, B. B., & Liehr, T. (2009) · Cytogenetic and Genome Research · doi:10.1159/000253080 · Cited by 14

Expression and Induction of p-Glycoprotein-1 on Cultured Human Brain Endothelium

Male, D. K. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.101 · Cited by 13

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