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The hCMEC/D3 cell line as a model of the human blood brain barrier
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Since the first attempts in the 1970s to isolate cerebral microvessel endothelial cells (CECs) in order to model the blood–brain barrier (BBB) in vitro , the need for a human BBB model that closely mimics the in vivo phenotype and is reproducible and easy to grow, has been widely recognized by cerebrovascular researchers in both academia and industry. While primary human CECs would ideally be the model of choice, the paucity of available fresh human cerebral tissue makes wide-scale studies impractical. The brain microvascular endothelial cell line hCMEC/D3 represents one such model of the human BBB that can be easily grown and is amenable to cellular and molecular studies on pathological and drug transport mechanisms with relevance to the central nervous system (CNS). Indeed, since the development of this cell line in 2005 over 100 studies on different aspects of cerebral endothelial biology and pharmacology have been published. Here we review the suitability of this cell line as a human BBB model for pathogenic and drug transport studies and we critically consider its advantages and limitations.
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“Immortalized human microvascular brain endothelial (hCMEC/D3) cells were chosen as the cell line as they (i) are able to form contact-inhibited monolayers when grown on collagen type 1, a key component of the BBB basement membrane, and (ii) express tight and adherens junctions, which help regulate the structural integrity and permeability of the BBB.35,36”
From Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood–Brain Barrier Transfection and Crossing (2024) · cites this paper as [35]
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Self-citationSynthesis and in Vitro Studies of a Series of Carborane-Containing Boron Dipyrromethenes (BODIPYs)
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RetractedZhou, A. L., Swaminathan, S. K., Curran, G. L., Poduslo, J. F., Lowe, V. J., Li, L., & Kandimalla, K. K. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.254201 · Cited by 63
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Metadata
- Authors
- Weksler, B., Romero, I. A., & Couraud, P.-O.
- Affiliations
- Inserm (FR)
- The Open University (GB)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Couraud, Pierre-Olivier
- Venue
- Fluids and Barriers of the CNS
- Published
- 2013-03-26
- Volume
- 10
- Issue
- 1
- Pages
- 16-16
- ISSN
- 2045-8118 (ISSN-L)
- PMC
- PMC3623852
- OpenAlex
- W2115924220
- Cited by
- 753
- References
- 77
- Citations by year
- 2026: 45 · 2025: 70 · 2024: 76 · 2023: 75 · 2022: 68 · 2021: 83 · 2020: 58 · 2019: 63 · 2018: 36 · 2017: 53 · 2016: 42 · 2015: 36 · 2014: 36 · 2013: 10
- FWCI
- 23.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Fluids and Barriers of the CNS (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open Research Online - ORO (The Open University) (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- blood-brain barrier, in vitro BBB model, drug transport across the blood-brain barrier, brain drug delivery, endothelial cell biology
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