Distinct functions of BRCA1 and BRCA2 in double-strand break repair
Open accessAbstract
Individuals carrying BRCA mutations are predisposed to breast cancer. The BRCA1 and BRCA2 proteins are required for homologous recombination and DNA break repair, leading to the suggestion that they act in concert. However, direct evidence of a stable BRCA1/BRCA2 complex has not been demonstrated. Rather, the two proteins have been found as constituents of discrete, but perhaps nonexclusive complexes that are critical for repair. We discuss the interaction of BRCA1 with the BACH1 and BARD1 proteins, and suggest that the pleiotropic nature of mutations in BRCA1 may be associated with defects in protein--protein interactions. In contrast, the role of BRCA2 in DNA repair may be more defined by its direct interaction with the RAD51 recombinase.
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BRCA1 and BRCA2 share functions in homologous recombination repair of DNA double-strand breaks.
“The key to targeted therapy, however, is that BRCA1 and BRCA2 have common functions in DNA double-strand break repair in the subpathway of homologous recombination [2,3].”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [2]
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- Authors
- Liu, Y., & West, S. C.
- Corresponding author
- West, Stephen C
- Venue
- Breast Cancer Research
- Published
- 2001-02
- Volume
- 4
- Issue
- 1
- Pages
- 9-13
- ISSN
- 1465-5411 (ISSN-L)
- 1465-542X
- PMC
- PMC138716
- OpenAlex
- W2113920241
- Cited by
- 87
- References
- 36
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Breast Cancer Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- BRCA1, BRCA2, DNA double-strand break repair, homologous recombination, BACH1, BARD1, RAD51, protein-protein interaction, breast cancer predisposition, pleiotropic mutations
- MeSH terms
- Breast Neoplasms, DNA Repair, Female, Humans, Genes, BRCA1, Genes, BRCA2
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