BACH1 is a DNA repair protein supporting BRCA1 damage response

Peng, M; Litman, R; Jin, Z; Fong, G; Cantor, S B

doi:10.1038/sj.onc.1209257

Cited by 88DNA Repair MechanismsBRCA gene mutations in cancerPARP inhibition in cancer therapy

BACH1 is a DNA repair protein supporting BRCA1 damage response

Peng, M, Litman, R, Jin, Z, Fong, G, Cantor, S B·2006·Oncogene

DOI 10.1038/sj.onc.1209257

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Abstract

The link between defects in BRCA1 and breast cancer development may be best understood by deciphering the role of associated proteins. BRCA1 associated C-terminal helicase (BACH1) interacts directly with the BRCA1 C-terminal BRCT repeats, which are important for BRCA1 DNA repair and are mutated in the majority of BRCA1 familial cancers. Thus, BACH1 is a likely candidate for mediating BRCA1 DNA repair and tumor suppression functions. Although previous evidence using overexpression of a dominant negative BACH1 has suggested that BACH1 is involved in BRCA1-DNA repair function, our results using BACH1 deficient cells provide direct evidence for involvement of BACH1 in DNA repair as well as for localizing BRCA1. Following DNA damage BACH1 is modified by phosphorylation, displays a BRCA1-like nuclear foci pattern and colocalizes with gamma-H2AX. Given that the BACH1/BRCA1 complex is unaltered by DNA damage and the intensity of BRCA1 foci is diminished in BACH1 deficient cells, BACH1 may serve to not only facilitate DNA repair, but also maintain BRCA1 in DNA damage foci.

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Reduced FANCJ levels correlated with delayed resolution of double-strand breaks, measured by persistent γ-H2AX foci after ionizing radiation.
“Reduced levels of FANCJ correlated with delayed resolution of double-strand breaks as measured by persistent γ-H2AX foci formation following ionizing radiation [74].”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [74]
Unlike BRCA1- or BRCA2-deficient cells, FANCJ-deficient cells are only mildly sensitive to double-strand break-inducing agents such as ionizing radiation.
“Consistent with this idea, unlike BRCA1- or BRCA2-deficient cells, FANCJ-deficient cells are only mildly sensitive to agents that induce double-strand breaks, such as ionizing radiation [74].”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [74]

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BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function
Cantor, S. B., Bell, D. W., Ganesan, S., Kass, E. M., Drapkin, R., Grossman, S., Wahrer, D. C. R., Sgroi, D. C., Lane, W. S., Haber, D. A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00304-x · Cited by 674 · see citing works
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BCLAF1, a functional partner of BACH1, participates in DNA damage response
Jiang, K., Ding, Y., Dong, C., Shan, F., Guo, K., Zhang, J., & Zhang, F. (2022) · DNA repair · doi:10.1016/j.dnarep.2022.103371 · Cited by 7 · see citing works
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations
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Unwind with BACH
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Authors: Peng, M., Litman, R., Jin, Z., Fong, G., & Cantor, S. B.
Affiliations: University of Massachusetts Chan Medical School (US)
Corresponding author: Cantor, S B
ORCID: Peng, M
Jin, Z
Cantor, S B
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2006-02-06
Volume: 25
Issue: 15
Pages: 2245-2253
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1209257
OpenAlex: W2009503121
Cited by: 88
References: 42
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 9
FWCI: 4.21
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
eScholarship@UMassChan (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: BACH1, BRCA1, DNA repair, DNA damage response, BRCA1 phosphorylation, γH2AX foci, tumor suppression, breast cancer, helicase
MeSH terms: Breast Neoplasms, Cell Survival, DNA Damage, DNA Repair, Female, Genes, Dominant, Histones, Humans, Ovarian Neoplasms, Phosphorylation, Retroviridae, Tumor Cells, Cultured, Lentivirus, BRCA1 Protein, Immunoprecipitation, Basic-Leucine Zipper Transcription Factors, Fanconi Anemia Complementation Group Proteins

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BACH1 is a DNA repair protein supporting BRCA1 damage response

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