Cited by 127Hyperglycemia and glycemic control in critically ill and hospitalized patientsDiabetes Management and ResearchClinical Nutrition and Gastroenterology

International recommendations for glucose control in adult non diabetic critically ill patients

Open access
Ichai, Carole, Preiser, Jean-Charles, for the Société Française d'Anesthésie-Réanimation (SFAR), Société de Réanimation de langue Française (SRLF) and the Experts group·2010·Critical Care

Abstract

Introduction: The purpose of this research is to provide recommendations for the management of glycemic control in critically ill patients. Methods: Twenty-one experts issued recommendations related to one of the five pre-defined categories (glucose target, hypoglycemia, carbohydrate intake, monitoring of glycemia, algorithms and protocols), that were scored on a scale to obtain a strong or weak agreement. The GRADE (Grade of Recommendation, Assessment, Development and Evaluation) system was used, with a strong recommendation indicating a clear advantage for an intervention and a weak recommendation indicating that the balance between desirable and undesirable effects of an intervention is not clearly defined. Results: A glucose target of less than 10 mmol/L is strongly suggested, using intravenous insulin following a standard protocol, when spontaneous food intake is not possible. Definition of the severe hypoglycemia threshold of 2.2 mmol/L is recommended, regardless of the clinical signs. A general, unique amount of glucose (enteral/parenteral) to administer for any patient cannot be suggested. Glucose measurements should be performed on arterial rather than venous or capillary samples, using central lab or blood gas analysers rather than point-of-care glucose readers. Conclusions: Thirty recommendations were obtained with a strong (21) and a weak (9) agreement. Among them, only 15 were graded with a high level of quality of evidence, underlying the necessity to continue clinical studies in order to improve the risk-to-benefit ratio of glucose control.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/cc9258

Cites

106 of 106 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • An earlier meta-analysis showed that early enteral nutrition was associated with reduced mortality.

    “An earlier meta-analysis (349) showed that early EN was associated with reduced mortality.”

    From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [349]

    The Discussion’s glucose-target section reports meta-analyses of glucose control and mortality, not early enteral nutrition. The carbohydrate-intake sections discuss enteral feeding but do not report a meta-analysis linking its early initiation to reduced mortality (searched: early enteral nutrition, enteral nutrition). (LLM, conf=0.75)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

2 of the 108 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Wellen KE Hotamisliglil GS Inflammation, stress and diabetes J Clin Invest 2005 115 1111 1119 15864338 PMC1087185

Cited by

Sorted by citations

Authors
Ichai, C., Preiser, J.-C., (SFAR), F. T. S. F. D.-R., & Société de Réanimation de langue Française (SRLF) and the Experts group
Affiliations
  • Erasmus Hospital (BE)
  • Société Française d'Anesthésie et de Réanimation (FR)
  • Société de Réanimation de Langue Française (FR)
Corresponding author
Preiser, Jean-Charles
Venue
Critical Care
Published
2010-09-14
Volume
14
Issue
5
Pages
R166-R166
ISSN
1364-8535 (ISSN-L)
OpenAlex
W2099537395
Cited by
127
References
108
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 10 · 2018: 11 · 2017: 11 · 2016: 11 · 2015: 13 · 2014: 19 · 2013: 11 · 2012: 7
FWCI
6.54
Type
journal article
Language
en
Open access
Locations
  • Critical Care (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lirias (KU Leuven) (submittedVersion, other-oa)
  • HAL (submittedVersion, other-oa)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
Funders
  • Centre Hospitalier Universitaire Vaudois
  • Société de Réanimation de Langue Française
  • Société Française de Nutrition Entérale et Parentérale
  • European Society of Intensive Care Medicine
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
glycemic control, critically ill patients, non-diabetic patients, glycemic targets, hypoglycemia, intravenous insulin, carbohydrate intake, glucose monitoring, arterial blood sampling, expert consensus recommendations, intensive care
MeSH terms
Adult, Age Factors, Blood Glucose, Critical Care, Glucose, Health Planning Guidelines, Humans, Insulin, Critical Illness, Glycemic Index, Internationality

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review