Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations
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BACKGROUND: Design of new highly productive livestock breeds, well-adapted to local climatic conditions is one of the aims of modern agriculture and breeding. The genetics underlying economically important traits in cattle are widely studied, whereas our knowledge of the genetic mechanisms of adaptation to local environments is still scarce. To address this issue for cold climates we used an integrated approach for detecting genomic intervals related to body temperature maintenance under acute cold stress. Our approach combined genome-wide association studies (GWAS) and scans for signatures of selection applied to a cattle population (Hereford and Kazakh Whiteheaded beef breeds) bred in Siberia. We utilized the GGP HD150K DNA chip containing 139,376 single nucleotide polymorphism markers. RESULTS: We detected a single candidate region on cattle chromosome (BTA)15 overlapping between the GWAS results and the results of scans for selective sweeps. This region contains two genes, MSANTD4 and GRIA4. Both genes are functional candidates to contribute to the cold-stress resistance phenotype, due to their indirect involvement in the cold shock response (MSANTD4) and body thermoregulation (GRIA4). CONCLUSIONS: Our results point to a novel region on BTA15 which is a candidate region associated with the body temperature maintenance phenotype in Siberian cattle. The results of our research and the follow up studies might be used for the development of cattle breeds better adapted to cold climates of the Russian Federation and other Northern countries with similar climates.
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A GWAS analysis in Siberian cold-tolerant breeds (Hereford and Kazakh Whiteheaded) identified candidate genes MSANTD4 and GRIA4, related to cold shock response and thermoregulation, respectively.
“A GWAS analysis in Siberian cold-tolerant breeds (Hereford and Kazakh Whiteheaded) identified candidate genes MSANTD4 and GRIA4, related to cold shock response and thermoregulation, respectively [91].”
From The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution (2026) · cites this paper as [91]
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Молекулярные маркеры адаптации к холодному климату у крупного рогатого скота
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- Authors
- Igoshin, A. V., Yurchenko, A. A., Belonogova, N. M., Petrovsky, D. V., Aitnazarov, R. B., Soloshenko, V. A., Yudin, N. S., & Larkin, D. M.
- Affiliations
- Institute of Cytology and Genetics (RU)
- Novosibirsk State University (RU)
- University of London (GB)
- Corresponding author
- Larkin, Denis M.
- ORCID
- Venue
- BMC Genetics
- Published
- 2019-03
- Volume
- 20
- Issue
- S1
- Pages
- 26-26
- ISSN
- 1471-2156 (ISSN-L)
- PMC
- PMC6421640
- OpenAlex
- W2921876110
- Cited by
- 42
- References
- 57
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 2
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RVC Research Online (Royal Veterinary College) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Siberian Branch, Russian Academy of Sciences
- Russian Science Foundation (16‐14‐00090)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Effects of Environmental Stressors on Livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- cold stress resistance, body temperature maintenance, Hereford cattle, Kazakh Whiteheaded cattle, candidate genes, GRIA4, chromosome 15, thermoregulation, cold shock response, selection signatures, local adaptation, beef cattle breeding
- MeSH terms
- Animals, Body Temperature, Cattle, Siberia, Genome-Wide Association Study, Cold-Shock Response
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