Candidate genes associated with heat stress and breeding strategies to relieve its effects in dairy cattle: a deeper insight into the genetic architecture and immune response to heat stress

Worku, Destaw; Hussen, Jamal; De Matteis, Giovanna; Schusser, Benjamin; Alhussien, Mohanned Naif

doi:10.3389/fvets.2023.1151241

Cited by 43Effects of Environmental Stressors on LivestockGenetic and phenotypic traits in livestockReproductive Physiology in Livestock

Candidate genes associated with heat stress and breeding strategies to relieve its effects in dairy cattle: a deeper insight into the genetic architecture and immune response to heat stress

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Worku, Destaw, Hussen, Jamal, De Matteis, Giovanna, Schusser, Benjamin, Alhussien, Mohanned Naif·2023·Frontiers in Veterinary Science

DOI 10.3389/fvets.2023.1151241PMC PMC10527375

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Abstract

The need for food products of animal origin is increasing worldwide. Satisfying these needs in a way that has minimal impact on the environment requires cutting-edge technologies and techniques to enhance the genetic quality of cattle. Heat stress (HS), in particular, is affecting dairy cattle with increasing frequency and severity. As future climatic challenges become more evident, identifying dairy cows that are more tolerant to HS will be important for breeding dairy herds that are better adapted to future environmental conditions and for supporting the sustainability of dairy farming. While research into the genetics of HS in the context of the effect of global warming on dairy cattle is gaining momentum, the specific genomic regions involved in heat tolerance are still not well documented. Advances in omics information, QTL mapping, transcriptome profiling and genome-wide association studies (GWAS) have identified genomic regions and variants associated with tolerance to HS. Such studies could provide deeper insights into the genetic basis for response to HS and make an important contribution to future breeding for heat tolerance, which will help to offset the adverse effects of HS in dairy cattle. Overall, there is a great interest in identifying candidate genes and the proportion of genetic variation associated with heat tolerance in dairy cattle, and this area of research is currently very active worldwide. This review provides comprehensive information pertaining to some of the notable recent studies on the genetic architecture of HS in dairy cattle, with particular emphasis on the identified candidate genes associated with heat tolerance in dairy cattle. Since effective breeding programs require optimal knowledge of the impaired immunity and associated health complications caused by HS, the underlying mechanisms by which HS modulates the immune response and renders animals susceptible to various health disorders are explained. In addition, future breeding strategies to relieve HS in dairy cattle and improve their welfare while maintaining milk production are discussed.

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The authors provide exon-level annotation of genes that have contributed to livestock domestication and desirable commercial traits.
“As a first step to support a possible future marker assisted selection scheme152–154 for the muskox, we provide exon-level annotation of genes that have contributed to livestock domestication (Supplementary Table S8) and desirable commercial traits such as meat and dairy production, wool quality, prolificity, and heat tolerance155–159 (Supplementary Table S9).”
From Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics (2024) · cites this paper as [158]
The section “Signatures of selection for heat tolerance in dairy cattle” identifies candidate genes associated with heat tolerance, supporting that part of the citing sentence. The cited paper does not provide the muskox exon-level annotation described as “we provide” in the citing sentence, nor does it establish the full range of domestication and commercial traits listed there. No page number is available in our copy. (LLM, conf=0.88)
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The hitch-hiking effect of a favourable gene
Smith, J. M., & Haigh, J. (1974) · Genetical Research · doi:10.1017/s0016672300014634 · Cited by 3,415 · cited 1× · see citing works
“This indicates positions that are close to regions under selection are mostly affected by background selection and genetic hitchhiking (115).”
The hitch-hiking effect of a favourable gene
MAYNARD, J., & Haigh, J. (2007) · Genetics Research · doi:10.1017/s0016672308009579 · Cited by 2,663 · see citing works
Effects of Heat-Stress on Production in Dairy Cattle
West, J. W. (2003) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(03)73803-x · Cited by 2,000 · cited 1× · see citing works
“It was worth mentioning that, increasing THI linearly decreases milk production in lactating dairy cows (6, 37, 38).”
Background
A guide to genome engineering with programmable nucleases
Kim, S., & Kim, J. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3686 · Cited by 1,162 · see citing works
The interface between innate and adaptive immunity
Hoebe, K. H. N., Janssen, E. M., & Beutler, B. (2004) · Nature Immunology · doi:10.1038/ni1004-971 · Cited by 919 · cited 1× · see citing works
“The acquired (adaptive) immune response is composed of T cells and B cells that contribute to cell-mediated immunity and humoral immunity, respectively (59, 60).”
Background
Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection and Immunopathology
Dhabhar, F. S. (2009) · Neuroimmunomodulation · doi:10.1159/000216188 · Cited by 903 · cited 1× · see citing works
“Immune cells have glucocorticoid receptors which allow glucocorticoids to stimulate immune response during acute stress, however, the functions of the immune system get impaired when the exposure to stress is elongated (chronic stress) (58).”
Invited review: Effects of heat stress on dairy cattle welfare
Polsky, L., & von Keyserlingk, M. A. G. (2017) · Journal of Dairy Science · doi:10.3168/jds.2017-12651 · Cited by 874 · see citing works
Changes in genetic selection differentials and generation intervals in US Holstein dairy cattle as a result of genomic selection
García-Ruíz, A., Cole, J. B., VanRaden, P. M., Wiggans, G. R., Lopez, F. J., & Tassell, C. P. V. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519061113 · Cited by 574 · see citing works
The bovine neutrophil: Structure and function in blood and milk
Paape, M. J., Bannerman, D. D., Zhao, X., & Lee, J. (2003) · Veterinary Research · doi:10.1051/vetres:2003024 · Cited by 490 · cited 1× · see citing works
“Neutrophils, the most common type of granulocyte found in SCCs, are recruited by chemo-attractants to infection sites such as interleukin-8 ( IL-8 ), including the mammary gland, where they phagocytose and destroy pathogens (56).”
The role of genomic imprinting in biology and disease: an expanding view
Peters, J. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3766 · Cited by 432 · cited 1× · see citing works
“…imprinted genes DLK1 and DIO3 expressed at postnatal stages are associated with non-fresh thermogenesis in brown adipose tissue, which is essential to prevent hypothermia (152), and other imprinted genes such as Gnas , Gnasxl , Ndn , and Dio3 are involved in brown adipose tissue metabolism (153).”
Harnessing genomic information for livestock improvement
Georges, M., Charlier, C., & Hayes, B. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0082-2 · Cited by 384 · cited 2× · see citing works
“As global demand for food products of animal origin is expected to rise by 70% by 2050, this demand must be met in a manner that has a negligible impact on the environment by improving the genetic quality of livestock using cutting-edge technologies and techniques (1).”
Background
The future of livestock breeding: genomic selection for efficiency, reduced emissions intensity, and adaptation
Hayes, B. J., Lewin, H. A., & Goddard, M. E. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.11.009 · Cited by 383 · see citing works
Constitutive immune mechanisms: mediators of host defence and immune regulation
Paludan, S. R., Pradeu, T., Masters, S. L., & Mogensen, T. H. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0391-5 · Cited by 363 · see citing works
The impact of heat stress on the immune system in dairy cattle: A review
Bagath, M., Krishnan, G., Devaraj, C., Rashamol, V. P., Prathap, P., Lees, A. M., & Sejian, V. (2019) · Research in Veterinary Science · doi:10.1016/j.rvsc.2019.08.011 · Cited by 356 · see citing works
Review: Genetic selection of high-yielding dairy cattle toward sustainable farming systems in a rapidly changing world
Brito, L. F., Bédère, N., Douhard, F., de Oliveira, H. R., Arnal, M., Peñagaricano, F., Schinckel, A. P., Baes, C. F., & Miglior, F. (2021) · animal · doi:10.1016/j.animal.2021.100292 · Cited by 324 · see citing works
Molecular and genetic bases of heat stress responses in crop plants and breeding for increased resilience and productivity
Janni, M., Gullì, M., Maestri, E., Marmiroli, M., Valliyodan, B., Nguyen, H. T., & Marmiroli, N. (2020) · Journal of Experimental Botany · doi:10.1093/jxb/eraa034 · Cited by 320 · see citing works
Opportunities to Improve Resilience in Animal Breeding Programs
Berghof, T. V. L., Poppe, M., & Mulder, H. A. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2018.00692 · Cited by 318 · see citing works
Effect of late-gestation maternal heat stress on growth and immune function of dairy calves
Tao, S., Monteiro, A. P. A., Thompson, I. M., Hayen, M. J., & Dahl, G. E. (2012) · Journal of Dairy Science · doi:10.3168/jds.2012-5697 · Cited by 290 · cited 1× · see citing works
“Especially during the late-gestation and prepartum period, HS of the dairy cow not only impaired their post-partial immune function resulting in higher susceptibility to uterine infections (75) but also carried over negative effects on the passive transfer of colostral IgG to the newborn dairy calves and compromised t…”
Background
The Genome Landscape of Indigenous African Cattle
Kim, J., Hanotte, O., Mwai, O. A., Dessie, T., Bashir, S., Diallo, B., Agaba, M., Kim, K., Kwak, W., Sung, S., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1153-y · Cited by 271 · cited 1× · see citing works
“In addition, the region on BTA22 (95) and BTA26 (96) was reported to have a significant association with heat tolerance in dairy cows.”
Background
The Effect of Season on Somatic Cell Count and the Incidence of Clinical Mastitis
Riekerink, R. G. M. O., Barkema, H. W., & Stryhn, H. (2007) · Journal of Dairy Science · doi:10.3168/jds.2006-567 · Cited by 267 · see citing works
Heat stress directly impairs gut integrity and recruits distinct immune cell populations into the bovine intestine
Koch, F., Thom, U., Albrecht, E., Weikard, R., Nolte, W., Kuhla, B., & Kuehn, C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820130116 · Cited by 257 · cited 1× · see citing works
“An M2-like macrophage phenotype, which was identified by the high expression of the M2 cell marker CD163 , was also found in the intestinal lymphoid tissue of dairy cows under HS (66).”
Genomic selection for tolerance to heat stress in Australian dairy cattle
Nguyen, T. T. T., Bowman, P. J., Haile‐Mariam, M., Pryce, J. E., & Hayes, B. J. (2016) · Journal of Dairy Science · doi:10.3168/jds.2015-9685 · Cited by 240 · cited 19× · see citing works
“Similar findings by Hammami et al. (91) observed higher heritability estimates for PUFA and C18:1 at high THI levels in Belgium Holstein cows.”
Influential
Dendritic cells and other innate determinants of T helper cell polarisation
Walsh, K. P., & Mills, K. H. G. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.07.006 · Cited by 233 · cited 1× · see citing works
“…IL-4 , IL-5, IL-10 and TGF-β ) that play a regulatory role during the immune response ( IL-10 and TGF- TGF-β ) favorite allergic reactions ( IL-4 and IL-5 ), and stimulate B cells for the production of special antibody isotypes ( IL-4 and IL-13 ) to fight extracellular bacteria and helminths (69).”
Impact of heat stress on lactational performance of dairy cows
Tao, S., Rivas, R. M. O., Marins, T. N., Chen, Y.-C., Gao, J. Q., & Bernard, J. K. (2020) · Theriogenology · doi:10.1016/j.theriogenology.2020.02.048 · Cited by 226 · cited 5× · see citing works
“It was worth mentioning that, increasing THI linearly decreases milk production in lactating dairy cows (6, 37, 38).”
Influential
Marker-Assisted Introgression in Backcross Breeding Programs
Visscher, P. M., Haley, C., & Thompson, R. (1996) · Genetics · doi:10.1093/genetics/144.4.1923 · Cited by 225 · see citing works
Exploration of variance, autocorrelation, and skewness of deviations from lactation curves as resilience indicators for breeding
Poppe, M., Veerkamp, R. F., van Pelt, M. L., & Mulder, H. A. (2019) · Journal of Dairy Science · doi:10.3168/jds.2019-17290 · Cited by 219 · see citing works
Heat stress abatement during the dry period influences metabolic gene expression and improves immune status in the transition period of dairy cows
do Amaral, B. C., Connor, E. E., Tao, S., Hayen, M. J., Bubolz, J. W., & Dahl, G. E. (2010) · Journal of Dairy Science · doi:10.3168/jds.2009-3004 · Cited by 196 · cited 3× · see citing works
“On the contrary, IgG response to an innocuous antigen and to booster immunizations was significantly lower in heat-stressed compared to cooled cows during the dry period and after parturition (53).”
Background
Symposium review: The influences of heat stress on bovine mammary gland function
Tao, S., Orellana, R. M., Weng, X.-S., Marins, T. N., Dahl, G. E., & Bernard, J. K. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13727 · Cited by 195 · see citing works
Heat Stress Impacts Immune Status in Cows Across the Life Cycle
Dahl, G. E., Tao, S., & Laporta, J. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.00116 · Cited by 194 · cited 4× · see citing works
“Therefore, the specific candidate genes on BTA3, BTA5, and BTA14 may hold promise for simultaneously improving heat tolerance and milk-related traits in dairy cattle.”
Influential
Genomic Selection Improves Heat Tolerance in Dairy Cattle
Garner, J. B., Douglas, M. L., Williams, S. R. O., Wales, W. J., Marett, L. C., Nguyen, T. T. T., Reich, C. M., & Hayes, B. J. (2016) · Scientific Reports · doi:10.1038/srep34114 · Cited by 190 · cited 7× · see citing works
“Additionally, these strategies might not work well in pasture-based dairy production systems where cows are exposed to solar radiation for a large part of their time while grazing (13).”
Influential
The SLICK hair locus derived from Senepol cattle confers thermotolerance to intensively managed lactating Holstein cows
Dikmen, S., Khan, F. A., Huson, H. J., Sonstegard, T. S., Moss, J. I., Dahl, G. E., & Hansen, P. J. (2014) · Journal of Dairy Science · doi:10.3168/jds.2014-8087 · Cited by 180 · see citing works
Large-Scale Phenotyping of Livestock Welfare in Commercial Production Systems: A New Frontier in Animal Breeding
Brito, L. F., de Oliveira, H. R., McConn, B. R., Schinckel, A. P., Arrazola, A., Marchant, J. N., & Johnson, J. S. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00793 · Cited by 173 · see citing works
Late-gestation heat stress impairs daughter and granddaughter lifetime performance
Laporta, J., Ferreira, F. C., Ouellet, V., Dado-Senn, B., Almeida, A. K., Vries, A. D., & Dahl, G. E. (2020) · Journal of Dairy Science · doi:10.3168/jds.2020-18154 · Cited by 159 · cited 1× · see citing works
“Despite the fact that lactating cows are more susceptible to heat stress, HS exposure during the dry period affects subsequent lactation and has long-lasting effects on the progeny (35, 36).”
Background
Heat Stress in Dairy Cattle Alters Lipid Composition of Milk
Liu, Z., Ezernieks, V., Wang, J., Arachchillage, N. W., Garner, J. B., Wales, W. J., Cocks, B. G., & Rochfort, S. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-01120-9 · Cited by 154 · cited 1× · see citing works
“Heat stress could also alter the triacylglycerol profile of milk, which is characterized by a decrease in triacylglycerol groups with predominantly short-chain FAs to medium-chain FAs and a concomitant increase in groups with predominantly long-chain FAs (48).”
Background
Epigenetics: A way to bridge the gap between biological fields
Nicoglou, A., & Merlin, F. (2017) · Studies in History and Philosophy of Science Part C Studies in History and Philosophy of Biological and Biomedical Sciences · doi:10.1016/j.shpsc.2017.10.002 · Cited by 153 · cited 1× · see citing works
“Epigenetics is defined as the study of heritable molecular changes that regulate gene expression and other genomic functions, leading to phenotypic variations without altering the underlying DNA sequence (136, 137).”
Modeling heat stress under different environmental conditions
Carabaño, M. J., Logar, B., Bormann, J., Minet, J., Vanrobays, M.-L., Díaz, C., Tychon, B., Gengler, N., & Hammami, H. (2016) · Journal of Dairy Science · doi:10.3168/jds.2015-10212 · Cited by 152 · cited 2× · see citing works
“Another way to assess heat tolerance is to monitor changes in milk production traits under warm environmental conditions (88–91).”
Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle
Littlejohn, M. D., Henty, K., Tiplady, K., Johnson, T., Harland, C., Lopdell, T., Sherlock, R. G., Li, W., Lukefahr, S. D., Shanks, B. C., et al. (2014) · Nature Communications · doi:10.1038/ncomms6861 · Cited by 151 · cited 1× · see citing works
“For example, the slick-hair gene is clearly linked to heat tolerance in dairy cows as a result of a single gene effect (51), i.”
Background
Genetic analysis of heat stress effects on yield traits, udder health, and fatty acids of Walloon Holstein cows
Hammami, H., Vandenplas, J., Vanrobays, M.-L., Rekik, B., Bastin, C., & Gengler, N. (2015) · Journal of Dairy Science · doi:10.3168/jds.2014-9148 · Cited by 151 · cited 2× · see citing works
“(91) observed higher heritability estimates for PUFA and C18:1 at high THI levels in Belgium Holstein cows.”
Background
Impact of heat stress on milk and meat production
Summer, A., Lora, I., Formaggioni, P., & Gottardo, F. (2018) · Animal Frontiers · doi:10.1093/af/vfy026 · Cited by 151 · cited 2× · see citing works
“To reduce their heat load, the cow reduces her feed intake and consequently milk production (34).”
BackgroundMethod
Selection signatures in livestock genome: A review of concepts, approaches and applications
Saravanan, K. A., Panigrahi, M., Kumar, H., Bhushan, B., Dutt, T., & Mishra, B. P. (2020) · Livestock Science · doi:10.1016/j.livsci.2020.104257 · Cited by 150 · cited 4× · see citing works
“Selection pressure leaves distinct footprints in the areas of the genome that are exposed to selection called selection signature (25, 26, 114).”
Influential
A user’s guide to the ambiguous word ‘epigenetics’
Greally, J. M. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.135 · Cited by 142 · cited 1× · see citing works
“Epigenetics is defined as the study of heritable molecular changes that regulate gene expression and other genomic functions, leading to phenotypic variations without altering the underlying DNA sequence (136, 137).”
Selecting for heat tolerance
Carabaño, M. J., Ramón, M., Menéndez‐Buxadera, A., Molina, A., & Díaz, C. (2019) · Animal Frontiers · doi:10.1093/af/vfy033 · Cited by 141 · cited 7× · see citing works
“Some countries, including Puerto Rico and the United States, have already started to include the slick variant in breeding programs for Holstein (40, 125), and carriers of the slick variant of Holstein bulls are already being marketed by artificial insemination companies.”
Influential
Heat Stress and Dairy Cow: Impact on Both Milk Yield and Composition
Prathap, P., Archana, P., Aleena, J., Sejian, V., Krishnan, G., Bagath, M., Manimaran, A., Beena, V., Kurien, E. K., Varma, G., et al. (2016) · International Journal of Dairy Science · doi:10.3923/ijds.2017.1.11 · Cited by 137 · see citing works
Genome-Wide Association Mapping for Identification of Quantitative Trait Loci for Rectal Temperature during Heat Stress in Holstein Cattle
Dikmen, S., Cole, J. B., Null, D. J., & Hansen, P. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069202 · Cited by 135 · see citing works
Heritability of rectal temperature and genetic correlations with production and reproduction traits in dairy cattle
Dikmen, S., Cole, J. B., Null, D. J., & Hansen, P. J. (2012) · Journal of Dairy Science · doi:10.3168/jds.2011-4306 · Cited by 128 · cited 4× · see citing works
“The ability of an animal to respond to HS can be assessed by physiological indicators of HS traits, such as RT, RR, and DS, which increase when the animal is exposed to a warm environment (13, 87).”
BackgroundInfluential
Linking epigenetics and biological conservation: Towards a conservation epigenetics perspective
Rey, O., Eizaguirre, C., Angers, B., Baltazar‐Soares, M., Sagonas, Κ., Prunier, J. G., & Blanchet, S. (2019) · Functional Ecology · doi:10.1111/1365-2435.13429 · Cited by 127 · see citing works
Lymphocyte functions in dairy cows in hot environment
Lacetera, N., Bernabucci, U., Scalia, D., Ronchi, B., Kuzminsky, G., & Nardone, A. (2005) · International Journal of Biometeorology · doi:10.1007/s00484-005-0273-3 · Cited by 122 · cited 2× · see citing works
“Several studies have shown that thermal stress suppresses the secretion of Th1 cytokines (cellular immunity) and stimulates the secretion of Th2 cytokines (humoral immunity), which impairs cell-mediated immunity, decreases lymphocyte proliferation, and increases the susceptibility of heat-stressed animals to various i…”
Background
Scans for Signatures of Selection in Russian Cattle Breed Genomes Reveal New Candidate Genes for Environmental Adaptation and Acclimation
Yurchenko, A. A., Daetwyler, H. D., Yudin, N., Schnabel, R. D., Vander Jagt, C. J., Soloshenko, V., Lhasaranov, B., Popov, R., Taylor, J. F., & Larkin, D. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-31304-w · Cited by 117 · cited 1× · see citing works
“…there is an increased interest in genome-wide detection of selection signature, providing insights on the mechanisms of natural and/or artificial selection and uncovering candidate genomic regions under selection related to adaptation and climate resilience in cattle (20, 29–31, 100, 101, 118).”
The past, present and future of genomic scans for selection
Jensen, J. D., Foll, M., & Bernatchez, L. (2015) · Molecular Ecology · doi:10.1111/mec.13493 · Cited by 114 · cited 1× · see citing works
“Selection pressure leaves distinct footprints in the areas of the genome that are exposed to selection called selection signature (25, 26, 114).”
In Utero Heat Stress Alters the Offspring Epigenome
Skibiel, A. L., Peñagaricano, F., Amorín, R., Ahmed, B. M. S., Dahl, G. E., & Laporta, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-32975-1 · Cited by 111 · see citing works
Signatures of positive selection in East African Shorthorn Zebu: A genome-wide single nucleotide polymorphism analysis
Bahbahani, H. M., Clifford, H., Wragg, D., Mbole-Kariuki, M. N., Tassell, C. P. V., Sonstegard, T. S., Woolhouse, M. E. J., & Hanotte, O. (2015) · Scientific Reports · doi:10.1038/srep11729 · Cited by 110 · see citing works
New breeding objectives and selection indices for the Australian dairy industry
Byrne, T. J., Santos, B., Amer, P. R., Collado, D., Pryce, J. E., & Axford, M. (2016) · Journal of Dairy Science · doi:10.3168/jds.2015-10747 · Cited by 103 · cited 1× · see citing works
“To do this, farmers use a two-step approach to first filter bulls based on a balanced performance index, that encompasses a wide range of traits, such as production, health, fertility, type, and feed efficiency (130) and then on heat tolerance (2).”
Impacts of Epigenetic Processes on the Health and Productivity of Livestock
Wang, M., & Ibeagha-Awemu, E. M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.613636 · Cited by 101 · cited 2× · see citing works
“…histone modifications, non-coding RNAs (ncRNA) and chromatin remodeling respond to environmental cues to influence the expression of genes and specific phenotypes, suggest the influence of epigenome variations on environmental adaptation and other economic important traits in livestock (138–140).”
Conservation status and historical relatedness of Italian cattle breeds
Mastrangelo, S., Ciani, E., Ajmone‐Marsan, P., Bagnato, A., Battaglini, L., Bozzi, R., Carta, A., Catillo, G., Cassandro, M., Casu, S., et al. (2018) · Genetics Selection Evolution · doi:10.1186/s12711-018-0406-x · Cited by 98 · cited 1× · see citing works
“…how selection acts on livestock genomes and detection of selection signature provides a better insight into the progress of artificial selection, which may especially benefit the optimization of breeding programs to improve animal resilience and other traits of economic importance (20, 25, 117).”
Genomic Scans for Selection Signatures Revealed Candidate Genes for Adaptation and Production Traits in a Variety of Cattle Breeds
Saravanan, K. A., Panigrahi, M., Kumar, H., Parida, S., Bhushan, B., Gaur, G. K., Dutt, T., Mishra, B. P., & Singh, R. K. (2021) · Genomics · doi:10.1016/j.ygeno.2021.02.009 · Cited by 98 · see citing works
Identification and bioinformatics analysis of microRNAs associated with stress and immune response in serum of heat-stressed and normal Holstein cows
Zheng, Y., Chen, K., Zheng, X., Li, H., & Wang, G. (2014) · Cell Stress and Chaperones · doi:10.1007/s12192-014-0521-8 · Cited by 96 · cited 1× · see citing works
“The UCN3 gene that is engaged in the genetic regulation of stress tolerance and oxidative stress in Holstein Friesian was described by (108).”
Background
Whole-Genome Sequencing of Three Native Cattle Breeds Originating From the Northernmost Cattle Farming Regions
Weldenegodguad, M., Popov, R. G., Pokharel, K., Ammosov, I., Ming, Y., Ivanova, Z., & Kantanen, J. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2018.00728 · Cited by 95 · see citing works
Whole Genome Mapping Reveals Novel Genes and Pathways Involved in Milk Production Under Heat Stress in US Holstein Cows
Sigdel, A., Abdollahi-Arpanahi, R., Aguilar, I., & Peñagaricano, F. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00928 · Cited by 95 · cited 4× · see citing works
“Routine selection of dairy cows for higher milk yield may result in poor response of dairy cows to HS, due to the antagonistic genetic relationship between production level and specific ability to respond to HS (11, 37, 40).”
BackgroundInfluential
Economic feasibility of cooling dry cows across the United States
Ferreira, F. C., Gennari, R. S., Dahl, G. E., & Vries, A. D. (2016) · Journal of Dairy Science · doi:10.3168/jds.2016-11566 · Cited by 94 · cited 1× · see citing works
“Despite the fact that lactating cows are more susceptible to heat stress, HS exposure during the dry period affects subsequent lactation and has long-lasting effects on the progeny (35, 36).”
Background
Prospects for gene introgression or gene editing as a strategy for reduction of the impact of heat stress on production and reproduction in cattle
Hansen, P. J. (2020) · Theriogenology · doi:10.1016/j.theriogenology.2020.05.010 · Cited by 93 · see citing works
Quantifying the effect of thermal environment on production traits in three breeds of dairy cattle in New Zealand
Bryant, J. R., Lopez-Villalobos, N., Pryce, J. E., Holmes, C. W., & Johnson, D. L. (2007) · New Zealand Journal of Agricultural Research · doi:10.1080/00288230709510301 · Cited by 92 · see citing works
Application of genome editing in farm animals: cattle
Eenennaam, A. L. V. (2019) · Transgenic Research · doi:10.1007/s11248-019-00141-6 · Cited by 92 · cited 1× · see citing works
“The CRISPR-Cas9 system made it possible to maintain or even accelerate the rate of genetic gain already achieved through conventional breeding programs by introducing desired alleles, such as those related to heat tolerance or disease resistance, into dairy breeds (133).”
The effect of heat stress on gene expression and synthesis of heat‐shock and milk proteins in bovine mammary epithelial cells
Hu, H., Zhang, Y., Zheng, N., Cheng, J., & Wang, J. (2015) · Animal Science Journal · doi:10.1111/asj.12375 · Cited by 89 · cited 1× · see citing works
“Additionally, HS negatively affects the synthesis of milk proteins by decreasing the transcription of metabolism-related genes and increasing inflammation-related genes (47).”
Background
Signatures of Selection for Environmental Adaptation and Zebu × Taurine Hybrid Fitness in East African Shorthorn Zebu
Bahbahani, H. M., Tijjani, A., Mukasa, C., Wragg, D., Almathen, F. S., Nash, O., Akpa, G. N., Mbole-Kariuki, M. N., Malla, S., Woolhouse, M. E. J., et al. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00068 · Cited by 89 · see citing works
Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance
Taye, M., Lee, W., Caetano-Anollés, K., Dessie, T., Hanotte, O., Mwai, O. A., Kemp, S. J., Cho, S., Oh, S. J., Lee, H., et al. (2017) · Animal Science Journal · doi:10.1111/asj.12851 · Cited by 85 · cited 1× · see citing works
“…there is an increased interest in genome-wide detection of selection signature, providing insights on the mechanisms of natural and/or artificial selection and uncovering candidate genomic regions under selection related to adaptation and climate resilience in cattle (20, 29–31, 100, 101, 118).”
New Loci and Neuronal Pathways for Resilience to Heat Stress in Cattle
Cheruiyot, E. K., Haile-Mariam, M., Cocks, B. G., MacLeod, I. M., Xiang, R., & Pryce, J. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-95816-8 · Cited by 81 · cited 5× · see citing works
“…the researchers have conducted validation of GWAS to prioritize the variants most likely to be causal to thermo-tolerance and to provide several biological insights that can be leveraged to minimize HS while maintaining milk production in dairy cattle using a large dataset (2, 12, 14, 93).”
Influential
Heat stress negatively affects the transcriptome related to overall metabolism and milk protein synthesis in mammary tissue of midlactating dairy cows
Gao, S., Ma, L., Zhou, Z., Zhou, Z., Baumgard, L. H., Jiang, D., Bionaz, M., & Bu, D. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00039.2019 · Cited by 79 · cited 1× · see citing works
“More fundamentally, heat exposure appears to impair the capacity of the mammary gland to synthesize milk proteins by down-regulating the expression of key milk protein genes such as β-casein and butyrophilin (46).”
Background
Genetic Diversity and Signatures of Selection for Thermal Stress in Cattle and Other Two Bos Species Adapted to Divergent Climatic Conditions
Freitas, P. H. F., Wang, Y., Yan, P., de Oliveira, H. R., Schenkel, F. S., Zhang, Y., Xu, Q., & Brito, L. F. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.604823 · Cited by 77 · see citing works
Behavioural, physiological, neuro-endocrine and molecular responses of cattle against heat stress: an updated review
Mishra, S. R. (2021) · Tropical Animal Health and Production · doi:10.1007/s11250-021-02790-4 · Cited by 77 · cited 1× · see citing works
“Exposure to HS causes a variety of changes in the physiology of the body, including activation of the hypothalamic–pituitary–adrenal (HPA) axis and secretion of glucocorticoids (7, 57).”
Short communication: Implementation of a breeding value for heat tolerance in Australian dairy cattle
Nguyen, T. T. T., Bowman, P. J., Haile‐Mariam, M., Nieuwhof, G. J., Hayes, B. J., & Pryce, J. E. (2017) · Journal of Dairy Science · doi:10.3168/jds.2017-12898 · Cited by 76 · cited 2× · see citing works
“These physiological indicators of HS traits shown to be heritable (12, 14, 15, 49, 87), indicate that genetic gain can be made through selection.”
Background
Heterogeneity of Bovine Peripheral Blood Monocytes
Hussen, J., & Schuberth, H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01875 · Cited by 76 · cited 1× · see citing works
“Classically activated M1 monocytes/macrophages are pro-inflammatory cells with a higher potential for antimicrobial functions, while alternatively activated M2 monocytes/macrophages have an anti-inflammatory phenotype with a special role during the resolution of inflammation (63, 64).”
BackgroundSelf-citation
Predicting rectal temperature and respiration rate responses in lactating dairy cows exposed to heat stress
Li, G., Chen, S., Chen, J., Dandan, P., & Gu, X. (2020) · Journal of Dairy Science · doi:10.3168/jds.2019-16411 · Cited by 75 · see citing works
Genome-wide scan for selection signatures reveals novel insights into the adaptive capacity in local North African cattle
Jemaa, S. B., Mastrangelo, S., Lee, S. H., Lee, J. H., & Boussaha, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-76576-3 · Cited by 74 · cited 1× · see citing works
“ASIC3 GWSS HSR African cattle 278 North Africa (103)”
Background
Genome Sequence Analysis Reveals Selection Signatures in Endangered Trypanotolerant West African Muturu Cattle
Tijjani, A., Utsunomiya, Y. T., Ezekwe, A. G., Nashiru, O., & Hanotte, O. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00442 · Cited by 72 · see citing works
Genetics of heat tolerance for milk yield and quality in Holsteins
Santana, M. L., Bignardi, A. B., Pereira, R. J., Stefani, G., & Faro, L. E. (2016) · animal · doi:10.1017/s1751731116001725 · Cited by 71 · cited 3× · see citing works
“Routine selection of dairy cows for higher milk yield may result in poor response of dairy cows to HS, due to the antagonistic genetic relationship between production level and specific ability to respond to HS (11, 37, 40).”
Background
Gene expression of the heat stress response in bovine peripheral white blood cells and milk somatic cells in vivo
Garner, J. B., Chamberlain, A. J., Jagt, C. V., Nguyen, T. T. T., Mason, B., Marett, L. C., Leury, B. J., Wales, W. J., & Hayes, B. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-75438-2 · Cited by 71 · cited 3× · see citing works
“Heat shock proteins ( HSPs ) are highly conserved stress proteins that have been proposed as promising biomarkers of HS, of which HSP70 has been shown to be upregulated in dairy cows’ mammary epithelial cells during HS to increase mammary gland thermotolerance (22).”
Influential
In vitro assessment of the effects of temperature on phagocytosis, reactive oxygen species production and apoptosis in bovine polymorphonuclear cells
Lecchi, C., Rota, N., Vitali, A., Ceciliani, F., & Lacetera, N. (2016) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2016.10.007 · Cited by 70 · cited 1× · see citing works
“Heat stress impairs the potential of bovine neutrophils for phagocytosis and reactive oxygen species (ROS) production under in vitro and in vivo conditions (41, 53, 62).”
Background
Signatures of Selection in Admixed Dairy Cattle in Tanzania
Cheruiyot, E. K., Bett, R. C., Amimo, J. O., Zhang, Y., Mrode, R., & Mujibi, F. D. N. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00607 · Cited by 69 · see citing works
Mitochondrial respiratory chain dysfunction mediated by ROS is a primary point of fluoride-induced damage in Hepa1-6 cells
Wang, H., Zhang, Y., Tan, P., Jia, L.-S., Chen, Y., & Zhou, B.-H. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113359 · Cited by 69 · see citing works
Interaction of MC1R and PMEL alleles on solid coat colors in H ighland cattle
Schmutz, S. M., & Dreger, D. L. (2012) · Animal Genetics · doi:10.1111/j.1365-2052.2012.02361.x · Cited by 68 · cited 1× · see citing works
“In addition, a deletion of a leucine codon in the signal peptide ( p. Leu18del ) of PMEL that segregates in Highland, Galloway, and Tuli cattle has been proposed as a causative mutation for coat color effects (135).”
Derivation and genome-wide association study of a principal component-based measure of heat tolerance in dairy cattle
Macciotta, N. P. P., Biffani, S., Bernabucci, U., Lacetera, N., Vitali, A., Ajmone‐Marsan, P., & Nardone, A. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-12249 · Cited by 68 · cited 1× · see citing works
“In addition, the region on BTA22 (95) and BTA26 (96) was reported to have a significant association with heat tolerance in dairy cows.”
Background
CRISPR-Cas9 system: A genome-editing tool with endless possibilities
Tyagi, S., Kumar, R., Das, A., Won, S. Y., & Shukla, P. (2020) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2020.05.008 · Cited by 67 · see citing works
BREEDING AND GENETICS SYMPOSIUM: Breeding for resilience to heat stress effects in dairy ruminants. A comprehensive review1
Carabaño, M. J., Ramón, M., Díaz, C., Molina, A., Pérez-Guzmán, M. D., & Serradilla, J. M. (2017) · Journal of Animal Science · doi:10.2527/jas.2016.1114 · Cited by 65 · see citing works
Genome-wide selection signatures detection in Shanghai Holstein cattle population identified genes related to adaption, health and reproduction traits
Liu, D., Chen, Z., Zhao, W., Guo, L., Sun, H., Zhu, K., Liu, G.-L., Shen, X., Zhao, X., Wang, Q., et al. (2021) · BMC Genomics · doi:10.1186/s12864-021-08042-x · Cited by 64 · cited 5× · see citing works
“AQP1 GWSS Adaptation HF 1,092 China (100)”
BackgroundInfluential
Expression Analysis of Toll like Receptors and Interleukins in Tharparkar Cattle during Acclimation to Heat Stress Exposure
Bharati, J., Dangi, S. S., Mishra, S. R., Chouhan, V. S., Verma, V., Shankar, O., Bharti, M. K., Paul, A., Mahato, D. K., Rajesh, G., et al. (2017) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2017.02.002 · Cited by 63 · see citing works
Genotype-by-environment (temperature-humidity) interaction of milk production traits in Australian Holstein cattle
Cheruiyot, E. K., Nguyen, T. T. T., Haile‐Mariam, M., Cocks, B. G., Abdelsayed, M., & Pryce, J. E. (2019) · Journal of Dairy Science · doi:10.3168/jds.2019-17609 · Cited by 63 · cited 2× · see citing works
“(77) reported the existence of substantial genetic variation for heat tolerance in dairy cattle, which can provide a better insight into the genetic selection of thermo-tolerant dairy cows.”
Background
Transcriptome Analysis Reveals Potential Regulatory Genes Related to Heat Tolerance in Holstein Dairy Cattle
Liu, S., Yue, T., Ahmad, M. J., Hu, X., Zhang, X., Deng, T., Hu, Y., He, C., Zhou, Y., & Yang, L. (2020) · Genes · doi:10.3390/genes11010068 · Cited by 63 · see citing works
Genome-wide association studies for heat stress response in Bos taurus × Bos indicus crossbred cattle
Otto, P. I., Guimarães, S. E. F., Verardo, L. L., Azevedo, A. L. S., Vandenplas, J., Sevillano, C. A., Marques, D. B. D., Pires, M. D. F. Á., de Freitas, C., Verneque, R. S., et al. (2019) · Journal of Dairy Science · doi:10.3168/jds.2018-15305 · Cited by 62 · cited 7× · see citing works
“These physiological indicators of HS traits shown to be heritable (12, 14, 15, 49, 87), indicate that genetic gain can be made through selection.”
Influential
Heat stress develops with increased total-tract gut permeability, and dietary organic acid and pure botanical supplementation partly restores lactation performance in Holstein dairy cows
Fontoura, A. B. P., Javaid, A., de la Maza-Escolà, V. S., Salandy, N. S., Sl, F., Grilli, E., & McFadden, J. W. (2022) · Journal of Dairy Science · doi:10.3168/jds.2022-21820 · Cited by 61 · cited 2× · see citing works
“It is argued that exposure to HS in a high THI environment appears to inhibit milk fat and protein synthesis in lactating dairy cows, which in turn directly affects the synthesis of energy-corrected milk yields (45).”
Background
Weighted single-step GWAS and RNA sequencing reveals key candidate genes associated with physiological indicators of heat stress in Holstein cattle
Luo, H., Hu, L., Brito, L. F., Dou, J., Sammad, A., Chang, Y., Ma, L., Guo, G., Liu, L., Zhai, L., et al. (2022) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-022-00748-6 · Cited by 60 · cited 11× · see citing works
“These physiological indicators of HS traits shown to be heritable (12, 14, 15, 49, 87), indicate that genetic gain can be made through selection.”
BackgroundInfluential
Single nucleotide polymorphisms associated with thermoregulation in lactating dairy cows exposed to heat stress
Dikmen, S., Wang, X. ‐., Ortega, M. S., Cole, J. B., Null, D. J., & Hansen, P. J. (2015) · Journal of Animal Breeding and Genetics · doi:10.1111/jbg.12176 · Cited by 59 · cited 4× · see citing works
“This prompts the need to identify genomic variants associated with heat tolerance phenotype, thus contributing an additional feature in the headway of genomic selection (GS) of heatresistant dairy animals (16).”
BackgroundInfluential
Effects of thermal stress on tumor antigenicity and recognition by immune effector cells
Milani, V., & Noeßner, E. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0052-3 · Cited by 59 · cited 1× · see citing works
“Although there is scanty information on the effect of thermal stress on antigen processing and presentation in bovines, several studies on humans and mice reported that heat shock impairs the presentation of exogenous antigens by MHC II and suppresses co-stimulatory functions in APCs such as macrophages, dendritic cel…”
Background
Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits
Imumorin, I. G., Kim, E. H., Lee, Y.-M., de Koning, D., van Arendonk, J. A. M., Donato, M. D., Taylor, J. F., & Kim, J.-J. (2011) · Frontiers in Genetics · doi:10.3389/fgene.2011.00044 · Cited by 56 · see citing works
Detrimental effect of selection for milk yield on genetic tolerance to heat stress in purebred Zebu cattle: Genetic parameters and trends
Santana, M. L., Pereira, R. J., Bignardi, A. B., Filho, A. E. V., Menéndez‐Buxadera, A., & Faro, L. E. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-9817 · Cited by 55 · see citing works
Genomic-based genetic parameters for resilience across lactations in North American Holstein cattle based on variability in daily milk yield records
Chen, S., Boerman, J. P., Glória, L. S., Pedrosa, V. B., Doucette, J. S., & Brito, L. F. (2023) · Journal of Dairy Science · doi:10.3168/jds.2022-22754 · Cited by 55 · see citing works
Validation of resilience indicators by estimating genetic correlations among daughter groups and with yield responses to a heat wave and disturbances at herd level
Poppe, M., Mulder, H. A., & Veerkamp, R. F. (2021) · Journal of Dairy Science · doi:10.3168/jds.2020-19817 · Cited by 53 · see citing works
Cellular and epigenetic changes induced by heat stress in bovine preimplantation embryos
de Barros, F. R. O., & de Paula-Lopes, F. F. (2018) · Molecular Reproduction and Development · doi:10.1002/mrd.23040 · Cited by 52 · cited 4× · see citing works
“Notably, susceptibility and dynamic epigenetic changes are shown in response to drastic temperature fluctuations in bovine pre-implantation embryos (144).”
Influential
Genome‐wide scan reveals divergent selection among taurine and zebu cattle populations from different regions
Edea, Z., Dadi, H., Dessie, T., Uzzaman, M. R., Rothschild, M. F., Kim, E. ‐., Sonstegard, T. S., & Kim, K. ‐. (2018) · Animal Genetics · doi:10.1111/age.12724 · Cited by 52 · see citing works
Transcriptome Functional Analysis of Mammary Gland of Cows in Heat Stress and Thermoneutral Condition
Yue, S., Wang, Z., Wang, L., Peng, Q., & Xue, B. (2020) · Animals · doi:10.3390/ani10061015 · Cited by 52 · see citing works
Holstein Friesian dairy cattle edited for diluted coat color as a potential adaptation to climate change
Laible, G., Cole, S., Brophy, B., Wei, J., Leath, S. R., Jivanji, S., Littlejohn, M. D., & Wells, D. N. (2021) · BMC Genomics · doi:10.1186/s12864-021-08175-z · Cited by 52 · cited 1× · see citing works
“…of the naturally occurring mutation p. Leu18del in the pre-melanosomal protein 17 ( PMEL ) gene, known from Galloway and Highland cattle, in Holstein-Friesian cattle, confirmed the causative status of a coat color phenotype mutation to a changed environmental condition in cattle (134).”
Gene Expression from the Imprinted Dio3 Locus Is Associated with Cell Proliferation of Cultured Brown Adipocytes
Hernández, A., García, B., & Obregón, M.-J. (2007) · Endocrinology · doi:10.1210/en.2007-0029 · Cited by 51 · cited 1× · see citing works
“…imprinted genes DLK1 and DIO3 expressed at postnatal stages are associated with non-fresh thermogenesis in brown adipose tissue, which is essential to prevent hypothermia (152), and other imprinted genes such as Gnas , Gnasxl , Ndn , and Dio3 are involved in brown adipose tissue metabolism (153).”
Genomic selection strategies for breeding adaptation and production in dairy cattle under climate change
Strandén, I., Kantanen, J., Russo, I. M., Orozco‐terWengel, P., & Bruford, M. W. (2019) · Heredity · doi:10.1038/s41437-019-0207-1 · Cited by 51 · see citing works
Identification of important genomic footprints using eight different selection signature statistics in domestic cattle breeds
Rajawat, D., Panigrahi, M., Kumar, H., Nayak, S. S., Parida, S., Bhushan, B., Gaur, G. K., Dutt, T., & Mishra, B. P. (2022) · Gene · doi:10.1016/j.gene.2021.146165 · Cited by 51 · cited 1× · see citing works
“Recently, genomic data provided additional possibilities to identify these footprints or genomic areas of selection linked to adaptation and productivity in cattle (27, 28).”
Improving Genomic Selection for Heat Tolerance in Dairy Cattle: Current Opportunities and Future Directions
Cheruiyot, E. K., Haile‐Mariam, M., Cocks, B. G., & Pryce, J. E. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.894067 · Cited by 51 · cited 10× · see citing works
“…systems functions (interaction between neuroactive ligands and receptors, and glutamatergic synapses) and metabolism (citrate or Krebs cycle) are important factors in elucidating the mechanisms of heat tolerance in dairy cattle, warranting extensive follow-up of functional investigations (2).”
Influential
Genomic analyses and biological validation of candidate genes for rectal temperature as an indicator of heat stress in Holstein cattle
Luo, H., Li, X., Hu, L., Xu, W., Chu, Q., Liu, A., Guo, G., Liu, L., Brito, L. F., & Wang, Y. (2021) · Journal of Dairy Science · doi:10.3168/jds.2020-18725 · Cited by 50 · cited 7× · see citing works
“These physiological indicators of HS traits shown to be heritable (12, 14, 15, 49, 87), indicate that genetic gain can be made through selection.”
BackgroundInfluential
Identification of key Genes and Pathways Associated With Thermal Stress in Peripheral Blood Mononuclear Cells of Holstein Dairy Cattle
Fang, H., Kang, L., Abbas, Z., Hu, L., Chen, Y., Tan, X., Wang, Y., & Xu, Q. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.662080 · Cited by 50 · see citing works
Heat stress during the transition period is associated with impaired production, reproduction, and survival in dairy cows
Menta, P. R., Machado, V. S., Piñeiro, J. M., Thatcher, W. W., Santos, J. E. P., & Vieira-Neto, A. (2022) · Journal of Dairy Science · doi:10.3168/jds.2021-21185 · Cited by 49 · see citing works
Application of gene expression studies in livestock production systems: a European perspective
Cassar‐Malek, I., Picard, B. B., Bernard, C., & Hocquette, J.-F. J.-F. (2008) · Australian Journal of Experimental Agriculture · doi:10.1071/ea08018 · Cited by 48 · cited 1× · see citing works
“Histone modification is another important epigenetic mechanism from activation to epigenetic regulation of transcription of HS-related genes (e.g., HSPs ) during embryonic development in response to HS (144–146).”
Heat stress and immune response phenotype affect DNA methylation in blood mononuclear cells from Holstein dairy cows
Livernois, A., Mallard, B. A., Cartwright, S., & Cánovas, Á. (2021) · Scientific Reports · doi:10.1038/s41598-021-89951-5 · Cited by 47 · see citing works
Dynamic changes in blood immune cell composition and function in Holstein and Jersey steers in response to heat stress
Park, D. S., Gu, B., Park, Y. J., Joo, S. S., Lee, S., Kim, S., Kim, E. T., Kim, D. H., Lee, S. S., Lee, S. J., et al. (2021) · Cell Stress and Chaperones · doi:10.1007/s12192-021-01216-2 · Cited by 47 · cited 1× · see citing works
“This is also confirmed by the reduced number of CD21-positive B cells in cows exposed to HS compared to normal cows (70).”
Background
Epigenetics: A New Challenge in the Post-Genomic Era of Livestock
González-Recio, Ó. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2011.00106 · Cited by 45 · cited 2× · see citing works
“…histone modifications, non-coding RNAs (ncRNA) and chromatin remodeling respond to environmental cues to influence the expression of genes and specific phenotypes, suggest the influence of epigenome variations on environmental adaptation and other economic important traits in livestock (138–140).”
Impact of different seasons on the milk somatic and differential cell counts, milk cortisol and neutrophils functionality of three Indian native breeds of cattle
Alhussien, M. N., & Dang, A. K. (2018) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2018.08.020 · Cited by 44 · cited 3× · see citing works
“Of interest, Alhussien and Dang (41) have reported genetic variability in resilience to HS in Indian native breeds of tropical environments.”
BackgroundSelf-citation
Relative extended haplotype homozygosity signals across breeds reveal dairy and beef specific signatures of selection
Bomba, L., Nicolazzi, E. L., Milanesi, M., Negrini, R., Mancini, G., Biscarini, F., Stella, A., Valentini, A., & Ajmone-Marsan, P. (2015) · Genetics Selection Evolution · doi:10.1186/s12711-015-0113-9 · Cited by 42 · see citing works
Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations
Igoshin, A. V., Yurchenko, A. A., Belonogova, N. M., Petrovsky, D. V., Aitnazarov, R. B., Soloshenko, V. A., Yudin, N. S., & Larkin, D. M. (2019) · BMC Genetics · doi:10.1186/s12863-019-0725-0 · Cited by 42 · see citing works
Monocyte biology conserved across species: Functional insights from cattle
Talker, S. C., Barut, G. T., Lischer, H. E. L., Rufener, R., von Münchow, L., Bruggmann, R., & Summerfield, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.889175 · Cited by 42 · see citing works
Potential roles of neutrophils in maintaining the health and productivity of dairy cows during various physiological and physiopathological conditions: a review
Alhussien, M. N., & Dang, A. K. (2019) · Immunologic Research · doi:10.1007/s12026-019-9064-5 · Cited by 41 · cited 1× · see citing works
“Of the cells of the innate immune system, neutrophils are the first line of defense, and they kill and eliminate invading microorganisms by phagocytosis, degranulation, and release of neutrophil extracellular traps (61).”
Self-citation
Genome-Wide SNP Discovery in Indigenous Cattle Breeds of South Africa
Zwane, A. A., Schnabel, R. D., Hoff, J. L., Choudhury, A., Makgahlela, M. L., Maiwashe, A., van Marle-Köster, E., & Taylor, J. F. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00273 · Cited by 41 · see citing works
Random regression models to account for the effect of genotype by environment interaction due to heat stress on the milk yield of Holstein cows under tropical conditions
Santana, M. L., Bignardi, A. B., Pereira, R. J., Menéndez‐Buxadera, A., & Faro, L. E. (2015) · Journal of Applied Genetics · doi:10.1007/s13353-015-0301-x · Cited by 36 · see citing works
Effects of Chronic Heat Stress on Immune Responses of the Foot-and-Mouth Disease DNA Vaccination
Hu, Y., Jin, H., Du, X., Xiao, C., Luo, D., Wang, B., & Ruiping, S. (2007) · DNA and Cell Biology · doi:10.1089/dna.2007.0581 · Cited by 36 · cited 1× · see citing works
“In addition, Hu et al. (71) reported that chronic HS significantly impairs the immune response to foot and mouth disease response to HS exposure (73, 74).”
BREEDING AND GENETICS SYMPOSIUM:Breeding heat tolerant dairy cattle: the case for introgression of the “slick” prolactin receptor variant into Bos taurus dairy breeds1
Davis, S. R., Spelman, R. J., & Littlejohn, M. D. (2017) · Journal of Animal Science · doi:10.2527/jas.2016.0956 · Cited by 35 · see citing works
Trajectory of livestock genomics in South Asia: A comprehensive review
Panigrahi, M., Kumar, H., Saravanan, K. A., Rajawat, D., Nayak, S. S., Ghildiyal, K., Kaisa, K., Parida, S., Bhushan, B., & Dutt, T. (2022) · Gene · doi:10.1016/j.gene.2022.146808 · Cited by 35 · see citing works
In-vitro effect of heat stress on bovine monocytes lifespan and polarization
Catozzi, C., Ávila, G., Zamarian, V., Pravettoni, D., Sala, G., Ceciliani, F., Lacetera, N., & Lecchi, C. (2019) · Immunobiology · doi:10.1016/j.imbio.2019.11.023 · Cited by 34 · cited 1× · see citing works
“(65) exposed bovine monocytes to high temperatures and investigated the expression profile of genes responsible for monocyte/macrophage polarization.”
Background
Genome-wide associations for heat stress response suggest potential candidate genes underlying milk fatty acid composition in dairy cattle
Bohlouli, M., Halli, K., Yin, T., Gengler, N., & König, S. (2022) · Journal of Dairy Science · doi:10.3168/jds.2021-21152 · Cited by 32 · cited 7× · see citing works
“(18) claimed that the highest number of significant SNP markers on BTA14 were significantly associated with HS response of milk fatty acids profiles (e.”
BackgroundInfluential
Evaluation of Seasonal Heat Stress on Transcriptomic Profiles and Global DNA Methylation of Bovine Oocytes
Diaz, F., Gutierrez, E. J., Foster, B. A., Hardin, P. T., Bondioli, K. R., & Jiang, Z. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.699920 · Cited by 31 · see citing works
Climate sensitivity of milk production traits and milk fatty acids in genotyped Holstein dairy cows
Bohlouli, M., Yin, T., Hammami, H., Gengler, N., & König, S. (2021) · Journal of Dairy Science · doi:10.3168/jds.2020-19411 · Cited by 30 · cited 5× · see citing works
“…genome analysis and gene annotation is a novel approach, where HS exacerbates changes in milk fatty acid profiles including stearic acid (C18:0), polyunsaturated fatty acids (PUFA), saturated fatty acids (SFA) and unsaturated fatty acids (UFA) during early lactation in high-yielding cows (18, 44).”
Influential
Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows
Molinari, P. C. C., Davidson, B. D., Laporta, J., Dahl, G. E., Sheldon, I. M., & Bromfield, J. J. (2022) · Journal of Dairy Science · doi:10.3168/jds.2022-22405 · Cited by 29 · cited 1× · see citing works
“Especially during the late-gestation and prepartum period, HS of the dairy cow not only impaired their post-partial immune function resulting in higher susceptibility to uterine infections (75) but also carried over negative effects on the passive transfer of colostral IgG to the newborn dairy calves and compromised t…”
Background
Animal board invited review: Genomic-based improvement of cattle in response to climate change
Strandén, I., Kantanen, J., Lidauer, M., Mehtiö, T., & Negussie, E. (2022) · animal · doi:10.1016/j.animal.2022.100673 · Cited by 26 · see citing works
Genetic Markers Associated with Milk Production and Thermotolerance in Holstein Dairy Cows Managed in a Heat-Stressed Environment
Zamorano‐Algandar, R., Medrano, J. F. F., Thomas, M., Enns, R. M., Speidel, S. E., Sanchez-Castro, M. A., Luna-Nevárez, G., Leyva-Corona, J. C., & Luna‐Nevárez, P. (2023) · Biology · doi:10.3390/biology12050679 · Cited by 26 · cited 1× · see citing works
“In these cases, the heat tolerance trait has been associated with a number of QTL regions and candidate genes (14, 15, 18, 92).”
Background
Heat shock during in vitro maturation induces chromatin modifications in the bovine embryo
Camargo, L. S. A., Aguirre-Lavin, T., Adenot, P. G., de Araújo, T. D., Mendes, V. R. A., Louro, I. D., Beaujean, N., & Souza, E. D. (2019) · Reproduction · doi:10.1530/rep-19-0245 · Cited by 25 · cited 1× · see citing works
“…offspring by altering gene expression, which subsequently affects embryo chromatin and induces the aggregation of histone H3 lysine 9 trimethylation, histone H3K9 hypoacetylation and heterochromatin protein 1 (144, 147), possibly affecting the future performance of offspring into adulthood (143).”
Genome-wide association study reveals genes crucial for coat color production in Vrindavani cattle
Chhotaray, S., Panigrahi, M., Bhushan, B., Gaur, G. K., Dutt, T., Mishra, B. P., & Singh, R. (2021) · Livestock Science · doi:10.1016/j.livsci.2021.104476 · Cited by 24 · see citing works
Insights into adaption and growth evolution: a comparative genomics study on two distinct cattle breeds from Northern and Southern China
Mei, C., Gui, L., Hong, J., Raza, S. H. A., Aorigele, C., Tian, W., Garcia, M., Xin, Y., Yang, W., Zhang, S., et al. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.12.028 · Cited by 23 · see citing works
Impact of hot weather on animal performance and genetic strategies to minimise the effect
Pryce, J. E., Nguyen, T. T. T., Cheruiyot, E. K., Marett, L. C., Garner, J. B., & Haile‐Mariam, M. (2022) · Animal Production Science · doi:10.1071/an21259 · Cited by 23 · cited 3× · see citing works
“In this context, the use of crossbreds or synthetic breeds containing some proportion of Bos-indicus genetics, such as the Girolando breed in Brazil, which is the result of crossing Gir and Holstein animals, is an alternative for managing HS in tropical areas (105).”
Influential
Imprinted loci in domestic livestock species as epigenomic targets for artificial selection of complex traits
Magee, D. A., Spillane, C., Berkowicz, E. W., Sikora, K. M., & MacHugh, D. E. (2014) · Animal Genetics · doi:10.1111/age.12168 · Cited by 22 · see citing works
Heat Stress in Dairy Cattle: Major Effects and Practical Management Measures for Prevention and Control
Noordhuizen, J. P. T. M. (2015) · SOJ Veterinary Sciences · doi:10.15226/2381-2907/1/1/00103 · Cited by 22 · cited 1× · see citing works
“In terms of losses, HS causes production losses of 600–900 kg of milk per cow/lactation (39).”
Determining Heat Stress Effects of Multiple Genetic Traits in Tropical Dairy Cattle Using Single-Step Genomic BLUP
Sungkhapreecha, P., Chankitisakul, V., Duangjinda, M., Buaban, S., & Boonkum, W. (2022) · Veterinary Sciences · doi:10.3390/vetsci9020066 · Cited by 22 · cited 1× · see citing works
“(89) reported heritability estimates varied from moderate to low, with values of 0.”
Background
Genetic effects of heat stress on milk fatty acids in Brazilian Holstein cattle
Dauria, B. D., Sigdel, A., Petrini, J., Bóscollo, P. P., Pilonetto, F., Salvian, M., de Rezende, F. M., Pedrosa, V. B., Bittar, C. M. M., Machado, P. F., et al. (2022) · Journal of Dairy Science · doi:10.3168/jds.2021-20914 · Cited by 22 · cited 1× · see citing works
“For milk fatty acid profiles, heritability estimates were higher for UFA (UFA, MUFA, and PUFA), while lower for SFA traits (SFA, C16:0, and C18:0) under the THI of 10 degrees over its threshold of 68 than an average THI threshold of 68 in Brazilian Holstein cattle (82).”
Background
Characterization of OAR1 and OAR18 QTL associated with muscle depth in British commercial terminal sire sheep
Matika, O., Sechi, S., Pong‐Wong, R., Houston, R. D., Clop, A., Woolliams, J. A., & Bishop, S. C. (2010) · Animal Genetics · doi:10.1111/j.1365-2052.2010.02121.x · Cited by 20 · see citing works
Application of a Bayesian non-linear model hybrid scheme to sequence data for genomic prediction and QTL mapping
Wang, T., Chen, Y. P., MacLeod, I. M., Pryce, J. E., Goddard, M. E., & Hayes, B. J. (2017) · BMC Genomics · doi:10.1186/s12864-017-4030-x · Cited by 20 · see citing works
Heat Stress Increases Mammary Epithelial Cells and Reduces Viable Immune Cells in Milk of Dairy Cows
Lengi, A. J., Stewart, J. W., Makris, M. R., Rhoads, M. L., & Corl, B. A. (2022) · Animals · doi:10.3390/ani12202810 · Cited by 20 · cited 1× · see citing works
“It is important to remember that, Lengi et al. (55) observed significantly lower concentrations of granulocytes in milk from heat-stressed dairy cows.”
Heat stress and milk production in the first parity Holsteins – threshold determination in eastern Croatia
Gantner, V., Mijić, P., Kuterovac, K., Barać, Z., & Potočnik, K. (2015) · Poljoprivreda · doi:10.18047/poljo.21.1.sup.22 · Cited by 19 · cited 1× · see citing works
“For instance, when lactating dairy cows are exposed to high ambient temperature and high relative humidity for prolonged periods, their ability to dissipate heat gained through metabolic process and from the environment is reduced, making them susceptible to HS (32, 33).”
Physiological responses of Holstein calves and heifers carrying the SLICK1 allele to heat stress in California and Florida dairy farms
Carmickle, A. T., Larson, C. C., Sosa, F., Pereira, J. M. V., Ferreira, F. C., Haimon, M. L. J., Jensen, L. M., Hansen, P. J., & Denicol, A. C. (2022) · Journal of Dairy Science · doi:10.3168/jds.2022-22177 · Cited by 19 · see citing works
Response of regulatory T cells to classic heat stroke in mice
Hu, J., Kang, H., Liu, C., Hu, P., Yang, M., & Zhou, F. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6766 · Cited by 17 · cited 1× · see citing works
“In addition, Hu et al. (71) reported that chronic HS significantly impairs the immune response to foot and mouth disease response to HS exposure (73, 74).”
Transcriptome Analyses Reveal Essential Roles of Alternative Splicing Regulation in Heat-Stressed Holstein Cows
Hu, L., Sammad, A., Zhang, C., Brito, L. F., Xu, Q., & Wang, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810664 · Cited by 17 · see citing works
Host transcriptome and microbiome interactions in Holstein cattle under heat stress condition
Czech, B., Wang, Y., Wang, K., Luo, H., Hu, L., & Szyda, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.998093 · Cited by 16 · cited 1× · see citing works
“(106), the RAB39B gene was found to be significantly associated with RT, DS and RS under HS conditions in dairy cattle.”
Background
The Methylome of Vertebrate Sex Chromosomes
Waters, S. A., Capraro, A., McIntyre, K. L., Graves, J. A. M., & Waters, P. D. (2018) · Genes · doi:10.3390/genes9050230 · Cited by 15 · cited 1× · see citing works
“DNA methylation is thus far the most stable and extensively studied epigenetic modification in most mammalian genomes (140), which is best known for its function in genomic imprinting and X chromosome inactivation and is crucial for transcriptional regulation throughout the genome (141).”
Heat stress response in slick vs normal-haired Criollo Limonero heifers in a tropical environment
Landaeta‐Hernández, A. J., Zambrano, S., Verde, O., Pinto-Santini, L., Montero-Urdaneta, M., Hernández-Fonseca, J. P., Fuenmayor-Morales, C., Sonstegard, T. S., Huson, H. J., & Olson, T. A. (2021) · Tropical Animal Health and Production · doi:10.1007/s11250-021-02856-3 · Cited by 15 · see citing works
Mild Hyperthermia Modulates the Relative Frequency of Lymphocyte Cell Subpopulations: an Increase in a Cytolytic NK Cell Subset and a Decrease in a Regulatory T Cell Subset
Terunuma, H., WADA, A., Deng, X., Yasuma, Y., ONISHI, T., Toki, A., & ABE, H. (2007) · Thermal Medicine(Japanese Journal of Hyperthermic Oncology) · doi:10.3191/thermalmedicine.23.41 · Cited by 14 · see citing works
Estimation of Genetic Parameters of Heat Tolerance for Production Traits in Canadian Holsteins Cattle
Campos, I. L., Chud, T. C. S., Júnior, G. A. O., Baes, C. F., Cánovas, Á., & Schenkel, F. S. (2022) · Animals · doi:10.3390/ani12243585 · Cited by 14 · cited 2× · see citing works
“While physiological measures such as changes in core body temperature in animals are often used to partially capture genetic effects for heat tolerance in cattle, these traits are unfavorably correlated with milk production (2, 77, 83, 87).”
Influential
Genome-wide expression analysis reveals different heat shock responses in indigenous (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle
Sajjanar, B., Aalam, M. T., Khan, O., Tanuj, G. N., Sahoo, A. P., Manjunathareddy, G. B., Gandham, R. K., Dhara, S. K., Gupta, P. K., Mishra, B. P., et al. (2023) · Genes and Environment · doi:10.1186/s41021-023-00271-8 · Cited by 14 · see citing works
The Suppression of Th1 Response by Inducing TGF-β1 From Regulatory T Cells in Bovine Mycoplasmosis
Sajiki, Y., Konnai, S., Goto, S., Okagawa, T., Ohira, K., Shimakura, H., Maekawa, N., Gondaira, S., Higuchi, H., Tajima, M., et al. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.609443 · Cited by 13 · cited 1× · see citing works
“Regulatory T cells (Tregs) secrete anti-inflammatory cytokines such as TGF-β and IL-10, which maintain host immune homeostasis by balancing Th1:Th2 activity and are characterized by the expression of the IL-2 receptor CD25 and the transcription factor forkhead box P3 (FOXP3) (72).”
Background
Editorial: Epigenetic Variation Influences on Livestock Production and Disease Traits
Ibeagha-Awemu, E. M., Kiefer, H., McKay, S., & Liu, G. E. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.942747 · Cited by 10 · see citing works
Bovine Science - Challenges and Advances
Abubakar, M. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.94736 · Cited by 8 · see citing works
Analysing the Motions of Spray Droplets on a Cow’s Surface to Relieve Heat Stress
Li, G., Wang, Z., Shi, Z., Ding, T., He, Q., & Hong, S. (2019) · Scientific Reports · doi:10.1038/s41598-018-38354-0 · Cited by 3 · cited 1× · see citing works
“The impact of HS in the dairy industry can be mitigated through a combination of different approaches including physical adjustments of the environment, enhanced nutrition, and management practices (10, 11).”
Background

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Enhancing Genomic Selection in Dairy Cattle Through Artificial Intelligence: Integrating Advanced Phenotyping and Predictive Models to Advance Health, Climate Resilience, and Sustainability
Džermeikaitė, K., Šidlauskaitė, M., Antanaitis, R., & Anskienė, L. (2025) · Dairy · doi:10.3390/dairy6050050 · Cited by 25 · see citing works
“While many associations have been detected, biological validation is essential to confirm causality [50].”
Influential
Heat stress affects dairy cow performance via oxidative stress, hypothalamic–pituitary–adrenal axis, gut microbiota, and multi-dimensional mitigation
Zhang, Q., Yang, L., Li, Y., Gu, P., Si, R., Zhu, L., & Zhang, W. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1686241 · Cited by 21 · see citing works
Unraveling the genetic basis of methane emission in dairy cattle: a comprehensive exploration and breeding approach to lower methane emissions
Worku, D. (2024) · Animal Biotechnology · doi:10.1080/10495398.2024.2362677 · Cited by 16 · see citing works
Self-citation
Hyperthermia-induced changes in leukocyte survival and phagocytosis: a comparative study in bovine and buffalo leukocytes
Scatà, M. C., Alhussien, M. N., Grandoni, F., Reale, A., Zampieri, M., Hussen, J., & MATTEIS, G. D. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1327148 · Cited by 12 · see citing works
Self-citation
Deciphering Heat Stress Mechanisms and Developing Mitigation Strategies in Dairy Cattle: A Multi-Omics Perspective
Xiong, Z., Li, L., Ouyang, K., Qu, M., & Qiu, Q. (2025) · Agriculture · doi:10.3390/agriculture15141477 · Cited by 11 · see citing works
Functional transcriptome analysis revealed upregulation of MAPK-SMAD signalling pathways in chronic heat stress in crossbred cattle
Dutta, G., Alex, R., Singh, A., Gowane, G. R., Vohra, V., De, S., Verma, A., & Ludri, A. (2024) · International Journal of Biometeorology · doi:10.1007/s00484-024-02672-y · Cited by 8 · see citing works
“Finding the important candidate genes causing variation in thermoregulation will undoubtedly aid in enhancing the effectiveness of selective breeding, particularly for traits with low heritability in programs for the breeding of dairy calves (Worku et al. 2023).”
Heat stress and recovery induce transcriptomic changes in lactogenic-like bovine mammary epithelial (MAC-T) cells
Yu, X., Harman, R. M., Danev, N., Li, G., Fang, Y., de Walle, G. R. V., & Duan, J. E. (2025) · Physiological Genomics · doi:10.1152/physiolgenomics.00127.2024 · Cited by 6 · see citing works
Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics
Lok, S., Lau, T. N. H., Trost, B., Tong, A. H. Y., Paton, T., Wintle, R. F., Engstrom, M. D., Gunn, A., & Scherer, S. W. (2024) · Scientific Reports · doi:10.1038/s41598-024-67270-9 · Cited by 4 · see citing works
Genome‐Wide Association Study for Test‐Day Milk Yield, Proteins, and Composition Traits of Crossbred Dairy Cattle in Ethiopia
Bekele, R., Mestawet, T. A., Girma, A., Seid, M., Besufekad, J., & Meseret, S. (2024) · International Journal of Genomics · doi:10.1155/2024/1472779 · Cited by 4 · see citing works
Evidence for temporal effect of exposure to heat stress during various developmental stages on productive and reproductive performance as well as thermotolerance of reproductive performance in the offspring in dairy cows
Zarabadipour, S., Mobedi, E., Allahyari, I., Gharagozlou, F., Vojgani, M., Baghbanani, R. H., Akbarinejad, A., & Akbarinejad, V. (2025) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2025.104326 · Cited by 3 · see citing works
STUDY OF THE NEGATIVE EFFECT OF HEAT STRESS ON DAIRY PRODUCTIVITY OF COWS UNDER DIFFERENT HOUSING METHODS
Mukhanina, E. N., Шакиров, Ш. К., Safina, N. Y., & Gaynutdinova, E. R. (2025) · International Journal of Veterinary Medicine · doi:10.52419/issn2072-2419.2024.4.509 · Cited by 3 · see citing works
Detection of genomic regions affecting thermotolerance traits in growing pigs during acute and chronic heat stress
Gilbert, H., Labrune, Y., Fève, K., Renaudeau, D., Rosé, R., Gıorgı, M., Billon, Y., Gourdine, J.-L., & Riquet, J. (2025) · Genetics Selection Evolution · doi:10.1186/s12711-025-00995-x · Cited by 2 · see citing works
“In contrast to cattle [8] and poultry [9, 10], where multiple studies have searched for genomic regions affecting thermotolerance using genome-wide association studies (GWAS) or for traces of selection, very few studies have examined the genetic determinism underlying those responses in pigs.”
Genetic and non‐genetic factors influencing lambskin traits: A review
Habtegiorgis, K., Xie, J., Tariq, M., Quddus, A., & Mao, D. (2025) · Animal Genetics · doi:10.1111/age.70061 · Cited by 3 · see citing works
Genetic and genomic analyses of the effect of heat stress, measured as temperature-humidity index, on cow fertility in Australian Holstein cattle
Bolormaa, S., MacLeod, I. M., Xiang, R., Goddard, M. E., Pryce, J. E., & Haile‐Mariam, M. (2026) · Journal of Dairy Science · doi:10.3168/jds.2025-27314 · Cited by 2 · see citing works
Fucoidan alleviates spleen damage in heat-stressed broilers by suppressing oxidative stress, ferroptosis and inflammation
Liu, Q.-Q., Chen, Y., Liang, Q.-H., Tian, S.-Z., Yao, Q.-H., Ye, X.-Q., Jun-hong, C., & Liu, W. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107022 · Cited by 2 · see citing works
Omics and precision livestock farming for heat stress resilience: integrating molecular biomarkers with real-time phenotyping for climate-smart livestock systems
Idowu, P. A., & Idowu, A. P. (2026) · Frontiers in Animal Science · doi:10.3389/fanim.2026.1810017 · Cited by 2 · see citing works
Scientific knowledge about gene expression in ruminants under heat stress - A scientometric review
Vasconcelos, M. W., Dada, J. M. V., Pereira, V. A., Zandi-Karimi, A., Ghisi, N. D. C., & de Barros, F. R. O. (2024) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2024.104028 · Cited by 2 · see citing works
The Use of Assisted Reproductive Technologies to Improve Genetic Selection in Cattle
Rabel, R. A. C., Bangert, E. A., Wilson, K., & Wheeler, M. B. (2024) · Springer eBooks · doi:10.1007/978-3-031-73079-5_8 · Cited by 2 · see citing works
Heat Stress and Its Impact on Corpus Luteum (CL) Function and Reproductive Efficiency in Mammals: A Critical Review
Tariq, M., Saeed, S., Victor, K. K. A. S., Fatima, A., & Mao, D. (2025) · Reproductive Sciences · doi:10.1007/s43032-025-01787-w · Cited by 3 · see citing works
“To represent the complexity of thermotolerance in future heat tolerant breeding values, it may be possible to combine genomics, conventional and innovative heat tolerance measures with intermediate metabolic indicators and prioritized genetic variations [119] (Table 4).”
Editorial: Exploring ‘omic' biomarkers in animal production and reproduction
Aponte, P. M., Gutiérrez-Reinoso, M. A., & García‐Herreros, M. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1688780 · Cited by 2 · see citing works
Potential Applications of Genome-Wide Association Studies in Establishing Climate Resilience in Livestock: A Comprehensive Review
Kalaignazhal, G., Silpa, M. V., Mishra, C., Rebez, E. B., Voggu, S. P., Visha, P., Pandiyan, G. D. V., SAHOO, A., Browne, C., Bernabucci, U., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083498 · Cited by 1 · see citing works
Applications of omics-based phenotyping technologies in animal genetic breeding
LI, Y., Yin, Y., & He, Q. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3224-6 · Cited by 1 · see citing works
“Nevertheless, the implementation of sustainable genetic improvement methods can provide a viable solution to address this issue effectively (Worku et al., 2023).”
Candidate genes and genomic regions relevant for adaptation to extreme climates in livestock
Cheruiyot, E. K., Negussie, E., Tarekegn, G. M., & Haile‐Mariam, M. (2025) · CABI Reviews · doi:10.1079/cabireviews.2025.0052 · Cited by 1 · see citing works
Heat stress and recovery induce transcriptomic changes in lactogenic bovine mammary epithelial (MAC-T) cellsPreprint
Yu, X., Harman, R. M., Danev, N., Li, G., Fang, Y., de Walle, G. R. V., & Duan, J. E. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.15.594241 · Cited by 1 · see citing works
Toward Climate-Smart Ruminant Production: Best Practices and Future Directions
Kazemi, M., Elghandour, M. M. M. Y., & Salem, A. Z. M. (2025) · Springer eBooks · doi:10.1007/978-1-4614-6431-0_212-1
Bactrian Camel Whey Protein Powder Alleviates Acute Heat Stress-Induced Kidney Injury and Apoptosis in Rats
Jing, X., Suriguga, S., Hasi, S., & Qi, W. (2025) · Journal of Camel Practice and Research · doi:10.5958/2277-8934.2025.00019.7
Toward Climate-Smart Ruminant Production: Best Practices and Future Directions
Kazemi, M., Elghandour, M. M. M. Y., & Salem, A. Z. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-84483-6_212
Effect of Air Humidity on Cow’s Milk Yield during Grazing
Temirdasheva, K. A., & Gukezhev, V. M. (2025) · Dairy Industry · doi:10.21603/1019-8946-2025-5-58
Comprehensive whole genome sequence analysis unravels QTLs and genes under selection in Indian native riverine buffalo
Surati, U., Niranjan, S. K., Pundir, R. K., Koul, Y., Vohra, V., Gandham, R. K., & Kumar, A. (2026) · Genome · doi:10.1139/gen-2025-0011
A new type of biomarker for heat stress: insights from immunology
Ye, C., Zhang, Z., & Yang, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1742202
32. Essentiality of local indigenous livestock breed systems for organic animal husbandry
Sadana, D., Das, S., & Bhatti, R. (2026) · Animal - science proceedings · doi:10.1016/j.anscip.2026.03.033
Deiodinase gene expression profiles underlie breed-specific thyroid metabolism and heat stress resilience in cattle
Sikiru, A. B., Egena, A. S. S., Sejian, V., & Isa, N. B. M. (2026) · Gene Reports · doi:10.1016/j.genrep.2026.102521
Alterations in Blood Markers, Rumen Fermentation, and Microbiota Due to Heat Stress in Holstein Cows During the Dry Period and Early Lactation
Naing, Y. P., & Kim, S.-H. (2026) · Animals · doi:10.3390/ani16111682
Genome editing in Africa: A review of technological advances, applications, and the path forward
Johnson, A. M., Isiaka, I. D., Merenini, I. F., Iyanuoluwa, O. V., Violet, M. S., & Abubakari, A. W. (2026) · Scientific African · doi:10.1016/j.sciaf.2026.e03445
Consequences of Heat Stress on Physiology, Microbiome Dynamics, and Multi-Omics in Dairy Cows: More than Meets the Eye
Giannoulis, T., Dovolou, E., Mamuris, Z., & Amiridis, G. S. (2026) · Biology · doi:10.3390/biology15120918
“…, HSP90AB1 , GRXCR1 , and FKBP4 —and DNAJ chaperone members through selection signature analyses in trop-ically adapted Bos indicus populations [72] while identifying HSF1 as a causal variant and MGST1 as a candidate associated with rectal temperature and respiration rate in US Holsteins [135,136].”
Contrasting genomic architectures and linkage disequilibrium landscapes with insights into adaptive potential of Sahiwal and Kangayam cattle from whole-genome resequencing
Koloi, S., Mehla, K., Ganguly, I., Singh, S., & Dixit, S. (2026) · The Nucleus · doi:10.1007/s13237-026-00692-0
Thermotolerance-Related SNPs and Heat Stress Effects on Productive Performance and Gene Expression in Holstein Cows
Pineda-Montes, A., Reyna-Granados, J. R., Luna-Ramirez, R. I., Mondaca-Duarte, M. R., Macías‐Cruz, U., Avendaño‐Reyes, L., García-Benitez, C., Leyva-Corona, J.-C., Hernández‐Chávez, J. F., & Luna‐Nevárez, P. (2026) · Dairy · doi:10.3390/dairy7040052
“These findings support the use of molecular markers as a potential tool for selecting animals with enhanced capacity to cope with challenging thermal environments [18].”
Study-Aware Meta-Analysis Reveals a Recurrent Proteostasis Program and Context-Dependent Gene-Level Responses in Bovine Heat-Stress Transcriptomes
Zhao, X., Chang, H., Zhang, Q., Zhao, Z., He, S., Lu, Z., & Xiang, X. (2026) · Genes · doi:10.3390/genes17080946
“Because the trait is polygenic and biologically distributed, molecular candidates require evidence beyond a single tissue, exposure protocol, or processing strategy [4,5].”
Bridging precision agriculture and human medicine through comparative genetics
Liu, X., Li, B., & Fang, L. (2026) · Nature Reviews Genetics · doi:10.1038/s41576-026-01000-x
Impact of Climate Change on Farm Animals: Physiological Mechanisms, Health and Productivity, and Integrated Adaptation Strategies
Kamal, M., Alrauji, Y., Roshdy, M., Khalil, H. A., Ayoub, M. A., & Shehab-El-Deen, M. (2026) · Veterinary Sciences · doi:10.3390/vetsci13090954
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Habimana, V., Ekine-Dzivenu, C. C., Nguluma, A. S., Nziku, Z. C., Morota, G., Chenyambuga, S. W., & Mrode, R. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1127175 · Cited by 26 · see citing works
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0402 Breeding for resilience to heat stress effects: A comparison across dairy ruminant species
Carabaño, M. J., Ramón, M., Díaz, C., Molina-López, A. M., Serradilla, J. M., & Pérez-Guzmán, M. D. (2016) · Journal of Animal Science · doi:10.2527/jam2016-0402 · Cited by 2 · see citing works

Authors: Worku, D., Hussen, J., De Matteis, G., Schusser, B., & Alhussien, M. N.
Affiliations: Injibara University (ET)
King Faisal University (SA)
Technical University of Munich (DE)
Corresponding author: Worku, Destaw
Alhussien, Mohanned Naif
ORCID: Worku, Destaw
Hussen, Jamal
Schusser, Benjamin
Alhussien, Mohanned Naif
Venue: Frontiers in Veterinary Science
Publisher: Frontiers Media SA
Published: 2023-09-13
Volume: 10
Pages: 1151241-1151241
ISSN: 2297-1769 (ISSN-L)
DOI: 10.3389/fvets.2023.1151241
PMC: PMC10527375
OpenAlex: W4386707830
Cited by: 43
References: 154
Citations by year: 2026: 20 · 2025: 15 · 2024: 8
FWCI: 1.29
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Veterinary Science (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Effects of Environmental Stressors on Livestock
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
Keywords: heat stress, dairy cattle, heat tolerance, candidate genes, genetic architecture, immune response, heat tolerance breeding, genome-wide association study, QTL mapping, gene expression profiling, animal welfare, milk production, climate change adaptation

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Candidate genes associated with heat stress and breeding strategies to relieve its effects in dairy cattle: a deeper insight into the genetic architecture and immune response to heat stress

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