The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population
Open accessAbstract
BACKGROUND: Metagenomic studies confirm that obesity is associated with a composition of gut microbiota. There are some controversies, however, about the composition of gut microbial communities in obese individuals in different populations. To examine the association between body mass index and microbiota composition in Ukrainian population, fecal concentrations of Bacteroidetes, Firmicutes, Actinobacteria and Firmicutes/Bacteroidetes (F/B) ratio were analyzed in 61 adult individuals. RESULTS: The relative abundance of Actinobacteria was small (5-7%) and comparable in different BMI categories. The content of Firmicutes was gradually increased while the content of Bacteroidetes was decreased with increasing body mass index (BMI). The F/B ratio also raised with increasing BMI. In an unadjusted logistic regression model, F/B ratio was significantly associated with BMI (OR = 1.23, 95% CI 1,09-1,38). This association continued to be significant after adjusting for confounders such as age, sex, tobacco smoking and physical activity (OR = 1.33, 95% CI 1,11-1,60). CONCLUSIONS: The obtained data indicate that obese persons in Ukraine adult population have a significantly higher level of Firmicutes and lower level of Bacteroidetes compared to normal-weight and lean adults.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Animal and human data have reported that the Firmicutes/Bacteroidetes ratio is higher (i.e., increased Firmicutes and/or decreased Bacteroidetes) in obese people compared to lean people [79–82].”
From The athletic gut microbiota (2020) · cites this paper as [82]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Million, M., Angelakis, E., Maraninchi, M., Henry, M., Giorgi, R., Valero, R., Vialettes, B., & Raoult, D. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.20 · Cited by 362
RetractedAn obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048
Microbiota and SCFA in lean and overweight healthy subjects
Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457
Diet–microbiota interactions as moderators of human metabolism
Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257
Human gut microbiota in obesity and after gastric bypass
Zhang, H., DiBaise, J. K., Zuccolo, A., Kudrna, D., Braidotti, M., Yu, Y., Parameswaran, P., Crowell, M. D., Wing, R., Rittmann, B. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812600106 · Cited by 1,880
Hill, J. O., Wyatt, H. R., & Peters, J. C. (2012) · Circulation · doi:10.1161/circulationaha.111.087213 · Cited by 1,317
Human colonic microbiota associated with diet, obesity and weight loss
Duncan, S. H., Lobley, G. E., Holtrop, G., Ince, J., Johnstone, A. M., Louis, P., & Flint, H. J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.155 · Cited by 1,222
Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects
Radilla-Vázquez, R. B., Parra‐Rojas, I., Martínez-Hernández, N. E., Márquez‐Sandoval, F., Illades‐Aguiar, B., & Castro-Alarcón, N. (2016) · Obesity Facts · doi:10.1159/000442479 · Cited by 1,200
The core gut microbiome, energy balance and obesity
Turnbaugh, P. J., & Gordon, J. I. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.174136 · Cited by 993
Guinane, C. M., & Cotter, P. D. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13482996 · Cited by 880
Effects of gut microbes on nutrient absorption and energy regulation
Krajmalnik‐Brown, R., Ilhan, Z., Kang, D., & DiBaise, J. K. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533611436116 · Cited by 852
Assessment of Physical Activity and Energy Expenditure: An Overview of Objective Measures
Hills, A. P., Mokhtar, N., & Byrne, N. M. (2014) · Frontiers in Nutrition · doi:10.3389/fnut.2014.00005 · Cited by 649
Kasai, C., Sugimoto, K., Moritani, I., Tanaka, J., Oya, Y., Inoue, H., Tameda, M., Shiraki, K., Ito, M., Takei, Y., et al. (2015) · BMC Gastroenterology · doi:10.1186/s12876-015-0330-2 · Cited by 581
The Microbiota of the Gut in Preschool Children With Normal and Excessive Body Weight
Karlsson, C., Önnerfält, J., Xu, J., Molin, G., Ahrné, S., & Thorngren‐Jerneck, K. (2012) · Obesity · doi:10.1038/oby.2012.110 · Cited by 556
Gérard, P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2061-5 · Cited by 538
Gut microbiota and metabolic syndrome
Festi, D., Schiumerini, R., Eusebi, L. H., Marasco, G., Taddia, M., & Colecchia, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i43.16079 · Cited by 534
Improvement of phylum- and class-specific primers for real-time PCR quantification of bacterial taxa
Gregoris, T. B. D., Aldred, N., Clare, A. S., & Burgess, J. G. (2011) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2011.06.010 · Cited by 431
Ismail, N. A., Ragab, S. H., ElBaky, A. A., Shoeib, A. R. S., Alhosary, Y., & Fekry, D. (2011) · Archives of Medical Science · doi:10.5114/aoms.2011.23418 · Cited by 277
Role of the Gut Microbiome in Obesity and Diabetes Mellitus
Barlow, G. M., Yu, A. T., & Mathur, R. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615609896 · Cited by 269
Sweeney, T. E., & Morton, J. M. (2013) · JAMA Surgery · doi:10.1001/jamasurg.2013.5 · Cited by 252
Correlation between body mass index and faecal microbiota from children
Ignácio, A., Fernandes, M. R., Rodrigues, V. A. A., Groppo, F. C., Cardoso, A. L., Ávila-Campos, M. J., & Nakano, V. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.10.031 · Cited by 203
Obesity Alters the Microbial Community Profile in Korean Adolescents
Hu, H., Park, S.-G., Jang, H. B., Choi, M.-G., Park, K., Kang, J., Park, S. I., Lee, H.-J., & Cho, S.-H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134333 · Cited by 172
Mathur, R., & Barlow, G. M. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1051029 · Cited by 162
Rial, S. A., Karelis, A. D., Bergeron, K., & Mounier, C. (2016) · Nutrients · doi:10.3390/nu8050281 · Cited by 133
A Widely Applicable Protocol for DNA Isolation from Fecal Samples
Zhang, B., Li, M., Ma, L., & Wei, F. (2006) · Biochemical Genetics · doi:10.1007/s10528-006-9050-1 · Cited by 122
The Obesity Epidemic — Understanding the Disease and the Treatment
Apovian, C. M. (2016) · New England Journal of Medicine · doi:10.1056/nejme1514957 · Cited by 93
Sabbagh, L. C., Revéiz, L., Aponte, D. M., & de Aguiar, S. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-100 · Cited by 66
Higher blood glucose level associated with body mass index and gut microbiota in elderly people
Sepp, E., Kolk, H., Lõivukene, K., & Mikelsaar, M. (2014) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v25.22857 · Cited by 65
The obese gut microbiome across the epidemiologic transition
Dugas, L. R., Fuller, M. H., Gilbert, J. A., & Layden, B. T. (2016) · Emerging Themes in Epidemiology · doi:10.1186/s12982-015-0044-5 · Cited by 50
Has provoking microbiota aggression driven the obesity epidemic?
Chassaing, B., & Gewirtz, A. T. (2016) · BioEssays · doi:10.1002/bies.201500116 · Cited by 35
Gut Microbiota and Energy Expenditure in Health and Obesity
Bakker, G. J., Zhao, J., Herrema, H., & Nieuwdorp, M. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000363 · Cited by 26
Cited by
Sorted by citations
The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?
Magne, F., Gotteland, M., Gauthier, L., Zazueta, A., Pesoa, S., Navarrete, P., & Balamurugan, R. (2020) · Nutrients · doi:10.3390/nu12051474 · Cited by 2,335
Stojanov, S., Berlec, A., & Štrukelj, B. (2020) · Microorganisms · doi:10.3390/microorganisms8111715 · Cited by 1,952
The Human Gut Microbiome – A Potential Controller of Wellness and Disease
Kho, Z. Y., & Lal, S. K. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01835 · Cited by 1,180
Health and disease markers correlate with gut microbiome composition across thousands of people
Manor, O., Dai, C. L., Kornilov, S. A., Smith, B., Price, N. D., Lovejoy, J. C., Gibbons, S. M., & Magis, A. T. (2020) · Nature Communications · doi:10.1038/s41467-020-18871-1 · Cited by 850
Liu, B., Liu, X., Liang, Z., & Wang, J. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i25.3837 · Cited by 658
Metadata
- Authors
- Koliada, A., Syzenko, G., Moseiko, V., Budovska, L., Puchkov, K., Perederiy, V., Gavalko, Y., Dorofeyev, A., Romanenko, M., Tkach, S., Sineok, L., Lushchak, O., & Vaiserman, A.
- Affiliations
- D. F. Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine (UA)
- Bogomolets National Medical University (UA)
- Vasyl Stefanyk Carpathian National University (UA)
- Corresponding author
- Vaiserman, Alexander
- Venue
- BMC Microbiology
- Published
- 2017-05-22
- Volume
- 17
- Issue
- 1
- Pages
- 120-120
- ISSN
- 1471-2180 (ISSN-L)
- PMC
- PMC5440985
- OpenAlex
- W2620098478
- Cited by
- 1,000
- References
- 36
- Citations by year
- 2026: 49 · 2025: 97 · 2024: 112 · 2023: 124 · 2022: 143 · 2021: 150 · 2020: 176 · 2019: 95 · 2018: 51 · 2017: 3
- FWCI
- 36.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Academy of Medical Sciences of Ukraine (0113U002119)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- body mass index, obesity, gut microbiota, Firmicutes/Bacteroidetes ratio, Firmicutes, Bacteroidetes, actinobacteria, fecal microbiota composition
- MeSH terms
- Firmicutes, Bacillota, Gastrointestinal Microbiome, Tobacco Smoking, Adult, Bacteria, DNA, Bacterial, Feces, Female, Humans, Life Style, Male, Middle Aged, Obesity, Ukraine, Exercise, Body Mass Index, Actinobacteria, Bacteroidetes, Gastrointestinal Tract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
