Cited by 258Gut microbiota and healthOral microbiology and periodontitis researchProbiotics and Fermented Foods

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Aging progression of human gut microbiota

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Xu, Congmin, Zhu, Huaiqiu, Qiu, Peng·2019·BMC Microbiology

DOI 10.1186/s12866-019-1616-2PMC PMC6819604

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Abstract

Background: Human gut microbiota are important for human health and have been regarded as a “forgotten organ”, whose variation is closely linked with various factors, such as host genetics, diet, pathological conditions and external environment. The diversity of human gut microbiota has been correlated with aging, which was characterized by different abundance of bacteria in various age groups. In the literature, most of the previous studies of age-related gut microbiota changes focused on individual species in the gut community with supervised methods. Here, we aimed to examine the underlying aging progression of the human gut microbial community from an unsupervised perspective. Results: We obtained raw 16S rRNA sequencing data of subjects ranging from newborns to centenarians from a previous study, and summarized the data into a relative abundance matrix of genera in all the samples. Without using the age information of samples, we applied an unsupervised algorithm to recapitulate the underlying aging progression of microbial community from hosts in different age groups and identify genera associated to this progression. Literature review of these identified genera indicated that for individuals with advanced ages, some beneficial genera are lost while some genera related with inflammation and cancer increase. Conclusions: The multivariate unsupervised analysis here revealed the existence of a continuous aging progression of human gut microbiota along with the host aging process. The identified genera associated to this aging process are meaningful for designing probiotics to maintain the gut microbiota to resemble a young age, which hopefully will lead to positive impact on human health, especially for individuals in advanced age groups.

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Fig. 1 Sample overview using PCA. Using the relative abundance of 247 genera across all the 367 samples as input, we linearly transformed and visualized the data in a three-dimensional space. Each sample is represented by one dot, colored according to age. Samples from children younger than three (the dark blue dots) scattered most distantly, while older age groups were mixed together in the PCA spaceCC BY · PubMed Central

Fig. 2 SPD recovered aging progression with taxonomical composition of human gut microbiota. a Progression similarity matrix for all genera, with each element counting the number of progression orderings the two corresponding genera shared. b We manually picked the highlighted area from (a). These selected genera were consistent with a common set of putative progression orderings. c An overall minimal spanning tree of the 14 age groups based on the selected genera. Each node represents one age groupCC BY · PubMed Central

Fig. 3 Genera that first increased and then decreased during aging, especially sharply decreased in the 13th or 14th age groups, or bothCC BY · PubMed Central

Fig. 4 Genera that exhibited general increasing patterns during agingCC BY · PubMed Central

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The SILVA ribosomal RNA gene database project: improved data processing and web-based tools
Quast, C., Pruesse, E., Yilmaz, P., Gerken, J., Schweer, T., Yarza, P., Peplies, J., & Glöckner, F. O. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1219 · Cited by 33,055
Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 19,549
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662
Human Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164
Gut metagenome in European women with normal, impaired and diabetic glucose control
Karlsson, F. H., Tremaroli, V., Nookaew, I., Bergström, G., Behre, C. J., Fagerberg, B., Nielsen, J., & Bäckhed, F. (2013) · Nature · doi:10.1038/nature12198 · Cited by 3,115
The gut flora as a forgotten organ
O'Hara, A. M., & Shanahan, F. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400731 · Cited by 2,791

Show all 67 references

Research works printed but not linked: 2

Padmanabhan R, Dubourg G, Lagier J-C, Couderc C, Michelle C, Raoult D, Fournier P-E. Genome sequence and description of corynebacterium ihumii sp. nov. Stand Genomic Sci. 2014; 9(3):1128. https://doi.org/10.4056/sigs.5149006. · DOI
Anderson MJ. Permutation tests for univariate or multivariate analysis of variance and regression. Can J Fish Aquat Sci. 2001; 58(3):626–39. https://doi.org/10.1139/cjfas-58-3-626. · DOI

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Authors: Xu, C., Zhu, H., & Qiu, P.
Affiliations: Georgia Institute of Technology (US)
Peking University (CN)
Corresponding author: Qiu, Peng
ORCID: Xu, Congmin
Zhu, Huaiqiu
Qiu, Peng
Venue: BMC Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2019-10-28
Volume: 19
Issue: 1
Pages: 236-236
ISSN: 1471-2180 (ISSN-L)
DOI: 10.1186/s12866-019-1616-2
PMC: PMC6819604
OpenAlex: W2982520321
Cited by: 258
References: 67
Citations by year: 2026: 21 · 2025: 26 · 2024: 52 · 2023: 39 · 2022: 50 · 2021: 43 · 2020: 27
FWCI: 9.92
Type: journal article
Language: en
Update notices: correction (2021-04-28)
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: BMC Microbiology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Science Foundation (1552784)
Georgia Institute of Technology
China Scholarship Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, aging, age-related microbial changes, 16S rRNA gene sequencing, unsupervised clustering, microbial genera, probiotics, centenarians, inflammation, tumor-associated bacteria
MeSH terms: Gastrointestinal Microbiome, Unsupervised Machine Learning, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Bacteria, Child, Child, Preschool, DNA, Bacterial, DNA, Ribosomal, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Phylogeny, RNA, Ribosomal, 16S, Sequence Analysis, DNA, Young Adult

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