Effectiveness of mindful self-compassion therapy on psychopathology symptoms, psychological distress and life expectancy in infertile women treated with in vitro fertilization: a two-arm double-blind parallel randomized controlled trial
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OBJECTIVES: Infertility is a prominent problem affecting millions of couples worldwide. Recently, there has been a hightened emphasis on elucidating the subtle linkages between infertility treatment leveraging assisted reproductive technology and the complex realm of psychological challenges, as well as efforts in implementation of psychological interventions.The Mindful Self-Compassion (MSC) program seeks to improve self-compassion, compassion for others, mindfulness, and life satisfaction while reducing depression, anxiety, and stress. In the current study, an MSC intervention was performed on infertile women (IW) undergoing in vitro fertilization (IVF) to assess the effectiveness of this intervention in reducing psychological distress and psychopathological symptoms and enhancing life expectancy. METHODS: Fifty-seven IW undergoing IVF were randomly allocated to two groups: MSC (n = 29) or treatment as usual (TAU; n = 28). Participants in MSC met once a week for two hours for eight weeks and attended a half-day meditation retreat. The Synder's Hope questionnaire and the Revised 90-Symptom Checklist (SCL-90-R) were used as the primary outcome measures. Data were obtained before the intervention, immediately after the intervention, and two months post-intervention. Repeated measures of ANCOVA and paired t-tests in all assessment points were used to compare the MSC and the TAU groups in outcomes. RESULTS: In the MSC group, hopelessness, anger-hostility, anxiety, interpersonal sensitivity difficulties, and depression were significantly reduced compared with the TAU group, and those improvements persisted at the two-month follow-up. Reliable change index revealed that the MSC group's gains were both clinically significant and durable. CONCLUSIONS: MSC can facilitate higher life satisfaction and mental well-being for IW undergoing IVF by reducing psychological distress, psychopathological symptoms, and hopelessness. These encouraging findings call for more research into the effectiveness of mindfulness-based therapies in addressing psychological problems among IW undergoing IVF.
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MBSR incorporates mindfulness meditation and yoga, helping individuals manage daily stress and emotional pain, building resilience and enhancing coping skills for infertility challenges.
“Mindfulness-based stress reduction incorporates mindfulness meditation and yoga that helps individuals to manage daily stress and emotional pain, and builds resilence [44]. By fostering greater awareness and acceptance of one’s emotional state, MBSR can enhance coping skills for individuals facing infertility challenges [45].”
From Psychosocial interventions for improving marital intimacy, sexual satisfaction, and quality of life of women and couples with infertility problems in low and middle-income countries: Systematic review protocol (2025) · cites this paper as [45]
The ‘Self-compassion and the mindful self-compassion program’ section (page unavailable) says conventional mindfulness therapies improve self-awareness and acceptance, and reports improved coping with infertility after mindfulness-based interventions. The source studies mindful self-compassion (MSC), however, and does not establish that mindfulness-based stress reduction (MBSR) specifically enhances coping with infertility. The meditation-and-yoga description is attached to a different citation in the citing sentence. (LLM, conf=0.84)
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Koparal, B., Gürlek, B., Hocaoğlu, Ç., & Polat, S. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14761 · Cited by 3 · see citing works
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Chakraborty, S., & Roy, P. K. (2021) · Clinical Case Studies · doi:10.1177/15346501211038275 · Cited by 2 · see citing works
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Research works printed but not linked: 2
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- Authors
- Sahraian, K., Abdollahpour Ranjbar, H., Namavar Jahromi, B., Cheung, H. N., Ciarrochi, J., & Habibi Asgarabad, M.
- Affiliations
- Shiraz University of Medical Sciences (IR)
- University of Hong Kong (HK)
- Australian Catholic University (AU)
- ORCID
- Venue
- BMC Psychiatry
- Published
- 2024-03-01
- Volume
- 24
- Issue
- 1
- Pages
- 174-174
- ISSN
- 1471-244X (ISSN-L)
- PMC
- PMC10908010
- OpenAlex
- W4392357700
- Cited by
- 27
- References
- 100
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 3
- FWCI
- 13.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- Funders
- NTNU Norwegian University of Science and Technology
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- mindful self-compassion, infertility, in vitro fertilization, psychological distress, psychopathology, hopelessness, depression, anxiety, mindfulness-based interventions, life satisfaction, women's mental health
- MeSH terms
- Psychological Distress, Self-Compassion, Anxiety Disorders, Female, Fertilization in Vitro, Humans, Infertility, Female, Mindfulness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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