Neuroprotective effects of Liriope platyphylla extract against hydrogen peroxide-induced cytotoxicity in human neuroblastoma SH-SY5Y cells
Open accessAbstract
BACKGROUND: Oxidative stress is involved in neuronal cell death and mitochondrial dysfunction in neurodegenerative diseases. Liriope platyphylla (LP) has been suggested to have anti-inflammation, anti-bacterial, and anti-cancer effects. However, whether LP exerts neuroprotective effects on neuronal cells is unknown. METHODS: The present study was performed to investigate the neuroprotective effects of LP extract (LPE) against hydrogen peroxide (H2O2)-induced injury in human neuroblastoma cells SH-SY5Y. To test neuroprotective effects of LPE, we performed cell viability assay, flow cytometry analysis and western blot analysis. In addition, mitochondrial membrane potential (MMP) and oxidative stress were performed to evaluate the anti-apoptotic and anti-oxidant effects. RESULTS: LPE pretreatment conferred significant protection against the H2O2-induced decrease of SH-SY5Y cell viability. H2O2-induced increases of intracellular oxidative stress and mitochondrial dysfunction were attenuated by LPE pretreatment. Therefore, LPE pretreatment prevented SH-SY5Y cell injury. Treatment with H2O2 significantly induced poly(ADP ribose) polymerase (PARP) and caspase-3 cleavage, which was blocked by LPE. We found that p38 activation was involved in the neuroprotective effects of LPE. CONCLUSIONS: Current findings suggest that LPE exerts neuroprotective effects against H2O2-induced apoptotic cell death by modulating p38 activation in SH-SY5Y cells. Therefore, LPE has potential anti-apoptotic effects that may be neuroprotective in neurodegenerative diseases and aging-related dementia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In vitro models with neurons isolated from the CNS and/or immortalized cell lines demonstrated that H2O2 causes cell death through apoptosis.
“Various in vitro models carried out with neurons isolated from the CNS and/or with immortalized cell lines, demonstrated that H2O2 causes cell death through apoptosis [118,131,132,133,134,135].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [135]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Pathological roles of MAPK signaling pathways in human diseases
Kim, E. K., & Choi, E.-J. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.12.009 · Cited by 2,472 · see citing works
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383 · see citing works
International Journal of Molecular Medicine
(2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm · Cited by 2,247 · see citing works
The Role of Oxidative Stress in Parkinson's Disease
Dias, V., Junn, E., & Mouradian, M. M. (2013) · Journal of Parkinson’s Disease · doi:10.3233/jpd-130230 · Cited by 1,845 · see citing works
Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease
Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357 · see citing works
Self-citationMitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?
Son, Y., Cheong, Y.-K., Kim, N.-H., Chung, H.-T., Kang, D. G., & Pae, H.-O. (2011) · Journal of Signal Transduction · doi:10.1155/2011/792639 · Cited by 1,219 · see citing works
Reactive Oxygen Species-Induced Activation of the MAP Kinase Signaling Pathways
McCubrey, J. A., LaHair, M. M., & Franklin, R. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1775 · Cited by 804 · see citing works
The mitochondrial energy transduction system and the aging process
Navarro, A., & Boveris, A. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00213.2006 · Cited by 646 · see citing works
Hydrogen peroxide: a Jekyll and Hyde signalling molecule
Gough, D. R., & Cotter, T. G. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.96 · Cited by 563 · see citing works
Oxidative Stress and Neurodegenerative Disorders
Li, J., Wuliji, O., Li, W., Jiang, Z.-G., & Ghanbari, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141224438 · Cited by 511 · see citing works
Mitochondrial oxidative stress in aging and healthspan
Dai, D., Chiao, Y. A., Marcinek, D. J., Szeto, H. H., & Rabinovitch, P. S. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-6 · Cited by 481 · see citing works
Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases
Hsieh, H., & Yang, C. (2013) · BioMed Research International · doi:10.1155/2013/484613 · Cited by 370 · see citing works
Urrutia, P. J., Mena, N. P., & NÃoñez, M. T. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00038 · Cited by 244 · see citing works
Ruffels, J., Griffin, M., & Dickenson, J. M. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.10.032 · Cited by 201 · see citing works
Regulation of neuron mitochondrial biogenesis and relevance to brain health
Onyango, I. G., Lu, J., Rodova, M., Lezi, E., Crafter, A. B., & Swerdlow, R. H. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.07.014 · Cited by 188 · see citing works
Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice
Budzyńska, B., Boguszewska‐Czubara, A., Kruk-Słomka, M., Skalicka‐Woźniak, K., Michalak, A., Musik, I., & Biała, G. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3728-6 · Cited by 184 · see citing works
Pollari, E., Goldsteins, G., Bart, G., Koıstınaho, J., & Giniatullin, R. A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00131 · Cited by 151 · see citing works
The oxidative stress hypothesis in Alzheimer's disease.
Pădurariu, M., Ciobica, A. S., Lefter, R. M., Șerban, I. L., Ștefănescu, C., & Chiriță, R. (2013) · PubMed · Cited by 151 · see citing works
Mitochondrial import and degradation of amyloid-β peptide
Pinho, C. M., Teixeira, P. F., & Glaser, E. G. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2014.02.007 · Cited by 145 · see citing works
Hypersensitivity to oxaliplatin: clinical features and risk factors
Parel, M., Ranchon, F., Nosbaum, A., You, B., Vantard, N., Schwiertz, V., Gourc, C., Gauthier, N., Guédat, M.-G., He, S., et al. (2014) · BMC Pharmacology and Toxicology · doi:10.1186/2050-6511-15-1 · Cited by 105 · see citing works
Sáez-Atiénzar, S., Bonet‐Ponce, L., Blesa, J. R., Romero, F. J., Murphy, M. P., Jordán, J., & Galindo, M. F. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.320 · Cited by 101 · see citing works
Ophiopogonin D prevents H2O2-induced injury in primary human umbilical vein endothelial cells
Qian, J., Fengrong, J., Wang, B., Yu, Y., Zhang, X., Yin, Z., & Liu, C. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.01.031 · Cited by 98 · see citing works
Age-Dependent Exacerbation of White Matter Stroke Outcomes
Rosenzweig, S., & Carmichael, S. T. (2013) · Stroke · doi:10.1161/strokeaha.113.001796 · Cited by 95 · see citing works
Reactive Oxygen Species Activate Mitogen-Activated Protein Kinases in Pancreatic Acinar Cells
Dâbrowski, A., Boguslowicz, C., Dąbrowska, M., Tribillo, I., & Gabryelewicz, A. (2000) · Pancreas · doi:10.1097/00006676-200011000-00008 · Cited by 89 · see citing works
Zhang, Y., Meng, C., Zhang, X.-M., Yuan, C., Wen, M.-D., Chen, Z., Dong, D., Gao, Y., Liu, C., & Zhang, Z. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.219261 · Cited by 85 · see citing works
Park, W. H. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.1215 · Cited by 85 · see citing works
Signore, M., Pelacchi, F., Martino, S. D., Runci, D., Biffoni, M., Giannetti, S., Morgante, L., de Majo, M., Petricoin, E., Stancato, L. F., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.188 · Cited by 82 · see citing works
Hur, J., Lee, P., Moon, E., Kang, I., Kim, S., Oh, M. S., & Kim, S. Y. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.08.016 · Cited by 74 · see citing works
Shokoohinia, Y., Hosseinzadeh, L., Moieni-Arya, M., Mostafaie, A., & Mohammadi‐Motlagh, H. (2014) · BioMed Research International · doi:10.1155/2014/156848 · Cited by 72 · see citing works
Lee, Y., Lee, J.-C., Seo, Y.-B., & Kook, Y. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.04.030 · Cited by 68 · see citing works
Ismail, N., Ismail, M., Imam, M. U., Azmi, N. H., Fathy, S. F., Foo, J. B., & Bakar, M. F. A. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-467 · Cited by 55 · see citing works
Xie, Y., Zhang, Y., Zhang, L., Zeng, S., Guo, Z.-B., & Zheng, B. (2013) · Molecules · doi:10.3390/molecules180910285 · Cited by 53 · see citing works
Neuroprotection by Kukoamine A against oxidative stress may involve N-methyl-d-aspartate receptors
Hu, X., Gao, L., Niu, Y., Tian, X., Wang, J., Meng, W., Zhang, Q., Cui, C., Han, L., & Zhao, Q. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.11.006 · Cited by 45 · see citing works
Ma, S., Liu, X., Xun, Q., & Zhang, X. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00378 · Cited by 42 · see citing works
Anti-viral effect of a compound isolated from Liriope platyphylla against hepatitis B virus in vitro
Huang, T., Tsai, Y., Chiang, S.-Y., Wang, G.-J., Kuo, Y.-C., Chang, Y.-C., Wu, Y., & Wu, Y.-C. (2014) · Virus Research · doi:10.1016/j.virusres.2014.07.015 · Cited by 42 · see citing works
Lin, X., Huang, Z., Chen, X., Rong, Y., Zhang, S., Jiao, Y., Huang, Q., & Huang, R. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.09.037 · Cited by 42 · see citing works
Murakami, S., Miyazaki, I., Sogawa, N., Miyoshi, K., & Asanuma, M. (2014) · Neurotoxicity Research · doi:10.1007/s12640-014-9480-1 · Cited by 40 · see citing works
Wu, L., Li, P., Zhao, Q., Piao, J., Jiao, Y., Kadowaki, M., & Kondo, T. (2014) · APOPTOSIS · doi:10.1007/s10495-014-1032-x · Cited by 39 · see citing works
Tian, X., Guo, L.-P., Hu, X., Huang, J., Fan, Y., Ren, T., & Zhao, Q. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0129-7 · Cited by 39 · see citing works
Gallelli, L., Daniela, F., Scaramuzzino, M., Pelaia, G., D’Agostino, B., Mesuraca, M., Terracciano, R., Spaziano, G., Maselli, R., Navarra, M., et al. (2014) · BMC Pharmacology and Toxicology · doi:10.1186/2050-6511-15-67 · Cited by 37 · see citing works
Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects
Garcimartín, A., Merino, J. J., González, M. P., Sánchez-Reus, M. I., Sánchez-Muniz, F. J., Bastida, S., & Benedı́, J. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-384 · Cited by 34 · see citing works
Sakuma, S., Abe, M., Kohda, T., & Fujimoto, Y. (2014) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.14-34 · Cited by 33 · see citing works
Hwang (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2010.581 · Cited by 32 · see citing works
Cheng, Y., Zhang, L., Sun, W., Tang, J., Lv, Z., Xu, Z., & Yu, H. (2014) · Biotechnology Letters · doi:10.1007/s10529-014-1521-6 · Cited by 26 · see citing works
Park, S. H., Lee, H. J., Ryu, J., Son, K. H., Kwon, S. Y., Lee, S. K., Kim, Y. S., Hong, J. H., Seok, J. H., & Lee, H. J. (2013) · Phytomedicine · doi:10.1016/j.phymed.2013.08.013 · Cited by 26 · see citing works
Self-citationHan, Y., Jung, H. W., Lee, D. H., Kwon, S. Y., Son, K. H., & Park, Y. (2013) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2013.825253 · Cited by 22 · see citing works
Park, W. H. (2014) · Oncology Reports · doi:10.3892/or.2014.3084 · Cited by 21 · see citing works
Effects of methylophiopogonanone B on melanosome transfer and dendrite retraction
Ito, Y., Kanamaru, A., & Tada, A. (2006) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2005.12.015 · Cited by 21 · see citing works
Chen, B., Yue, R., Yang, Y., Zeng, H., Chang, W.-L., Gao, N., Yuan, X., Zhang, W., & Shan, L. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1498-5 · Cited by 20 · see citing works
Zhou, X., Su, C.-F., Zhang, Z., Wang, C.-Y., Luo, J.-Q., Zhou, X., Cai, L., Li, Y., Zhang, W., & Luo, H. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13055fp · Cited by 18 · see citing works
Spicatoside A enhances memory consolidation through the brain-derived neurotrophic factor in mice
Kwon, G., Lee, H. E., Lee, D. H., Woo, H., Park, S. J., Gao, Q., Ahn, Y. J., Son, K. H., & Ryu, J. H. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.04.034 · Cited by 17 · see citing works
Self-citationLee, H. R., Kim, J. E., Goo, J. S., Choi, S. Y., Hwang, I. S., Lee, Y. J., Son, H. J., Lee, H. S., Lee, J. S., & Hwang, D. Y. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.1081 · Cited by 14 · see citing works
Self-citationCHOI, S. I., Goo, J. S., Kim, J. E., Nam, S. H., Hwang, I. S., Lee, H. R., Lee, Y. J., Son, H. J., Lee, H. S., Lee, J. S., et al. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.1024 · Cited by 10 · see citing works
Self-citationHou, C.-W., Chang, S.-Y., & Jeng, K.-C. G. (2014) · Archives of Pharmacal Research · doi:10.1007/s12272-014-0426-1 · Cited by 9 · see citing works
Choi, S., Goo, J.-S., Kim, J., Hwang, I.-S., Lee, H.-R., Lee, Y.-J., Son, H., Lee, H., Lee, J.-S., & Hwang, D. (2012) · Laboratory Animal Research · doi:10.5625/lar.2012.28.3.155 · Cited by 9 · see citing works
Self-citationChoi, S., Go, J., Kim, J., Lee, Y.-J., Kwak, M.-H., Jung, Y., & Hwang, D. (2013) · Laboratory Animal Research · doi:10.5625/lar.2013.29.4.212 · Cited by 8 · see citing works
A novel agent, methylophiopogonanone B, promotes Rho activation and tubulin depolymerization
Ito, Y., Kanamaru, A., & Tada, A. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-9336-y · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer’s Disease
Shal, B., Ding, W., Ali, H., Kim, Y. S., & Khan, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00548 · Cited by 234 · see citing works
González-Sarrías, A., Núñez-Sánchez, M. A., Tomás-Barberán, F. A., & Espín, J. C. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04538 · Cited by 174 · see citing works
Gong, Y., Zhang, J., Gao, F., Zhou, J., Xiang, Z.-N., Zhou, C., Wan, L.-S., & Chen, J. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.05.076 · Cited by 145 · see citing works
Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
Kim, K. B., Lee, S., & Kim, J.-H. (2020) · Nutrition Research and Practice · doi:10.4162/nrp.2020.14.1.3 · Cited by 54 · see citing works
Park, H. R., Lee, H.-E., Lee, J., Yim, N., Gu, M.-J., & Yeul, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0652-x · Cited by 43 · see citing works
Self-citationKim, Y., Oh, T. W., Park, E., Yim, N., Park, K. J., Cho, W., & Ma, J. (2018) · Nutrients · doi:10.3390/nu10030282 · Cited by 44 · see citing works
Self-citationFernández‐Moriano, C., Divakar, P. K., Crespo, A., & Gómez-Serranillos, M. P. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.12.020 · Cited by 42 · see citing works
Park, H. R., Lee, H.-E., Park, H., Cho, W., & Yeul, J. (2016) · Scientific Reports · doi:10.1038/srep22405 · Cited by 39 · see citing works
Self-citationSong, J., Li, N., Xia, Y., Gao, Z., Zou, S.-F., Yan, Y., Li, S., Wang, Y., Meng, Y.-K., Yang, J., et al. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0784-x · Cited by 39 · see citing works
Tie, F., Fu, Y.-Y., Hu, N., & Wang, H. (2022) · Antioxidants · doi:10.3390/antiox11061101 · Cited by 36 · see citing works
Lei, F., Weckerle, C. S., & Heinrich, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.769929 · Cited by 35 · see citing works
Thangnipon, W., Puangmalai, N., Soi‐ampornkul, R., Suwanna, N., Tuchinda, P., & Nobsathian, S. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.215262 · Cited by 35 · see citing works
Wang, C., Yang, C., Cheng, B., Chen, J., & Bai, B. (2018) · International Journal of Immunopathology and Pharmacology · doi:10.1177/2058738418785739 · Cited by 34 · see citing works
Kim, K. B., Lee, S., Kang, I., & Kim, J.-H. (2018) · Nutrients · doi:10.3390/nu10101368 · Cited by 33 · see citing works
Rodrigues, M. J., Ślusarczyk, S., Pecio, Ł., Matkowski, A., Salmas, R. E., Durdağı, S., Pereira, C. G., Varela, J. C. S., Barreira, L. A., & Custódio, L. M. B. (2017) · Industrial Crops and Products · doi:10.1016/j.indcrop.2017.10.046 · Cited by 32 · see citing works
Issac, P. K., Velayutham, M., Guru, A., Sudhakaran, G., Pachaiappan, R., & Arockiaraj, J. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07261-z · Cited by 31 · see citing works
Mohammed, J. S., Nordin, N., Rosli, R., Shaari, K., Bako, H. Y., Saad, N., Noor, N. M., & Razis, A. F. A. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.09.008 · Cited by 30 · see citing works
Chwastek, J., Jantas, D., & Lasoń, W. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.03.015 · Cited by 30 · see citing works
Li, F., Song, X., Xu, J., Shi, Y., Hu, R., Ren, Z., Qi, Q., Lü, H., Cheng, X., & Hu, J. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1889186 · Cited by 26 · see citing works
Kim, C. J., Ryu, H. Y., Lee, S., Han-Joo, L., Chun, Y. S., Kim, J., Yu, C.-Y., Ghimire, B. K., & Lee, J. G. (2021) · Molecules · doi:10.3390/molecules26103001 · Cited by 25 · see citing works
Truong, V., Bae, Y.-J., Rarison, R. H. G., Bang, J.-H., Park, S.-Y., & Jeong, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914958 · Cited by 24 · see citing works
Effects of the roots of Liriope Platyphylla Wang Et tang on gastrointestinal motility function
Kim, H. J., Park, S. Y., Kim, D. G., Park, S., Lee, H., Hwang, D. Y., Jung, M. H., Ha, K., & Kim, B. J. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.03.012 · Cited by 24 · see citing works
Self-citationCitrulline prevents age-related LTP decline in old rats
Ginguay, A., Regazzetti, A., Laprévôte, O., Moinard, C., Bandt, J. P. D., Cynober, L., Billard, J., Allinquant, B., & Dutar, P. (2019) · Scientific Reports · doi:10.1038/s41598-019-56598-2 · Cited by 23 · see citing works
An, L., Zhang, W., Ma, G., Wang, K., Ji, Y., Ren, H., & Wang, Y. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1742 · Cited by 22 · see citing works
Zhou, L., Ao, L., Yan, Y., Li, W.-T., Ye, A., Li, C.-Y., Shen, W., Liang, B., Xiong-Zhu, & Li, Y. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.08.053 · Cited by 20 · see citing works
Enhancement of neuroprotective activity of Sagunja-tang by fermentation with lactobacillus strains
Yim, N., Gu, M. J., Park, H. R., Hwang, Y., & Yeul, J. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2361-z · Cited by 19 · see citing works
Self-citation[Retracted] Protective Effect of Triphala against Oxidative Stress‐Induced Neurotoxicity
Ning, W., Li, S., Tsering, J., Ma, Y., Li, H., Ma, Y., Ogbuehi, A. C., Pan, H., Li, H., Hu, S., et al. (2021) · BioMed Research International · doi:10.1155/2021/6674988 · Cited by 18 · see citing works
RetractedKim, J. H., Quilantang, N. G., Kim, H. Y., Lee, S., & Cho, E. J. (2018) · Chemical Papers · doi:10.1007/s11696-018-0664-7 · Cited by 16 · see citing works
Murlanova, K., Cohen, N., Pinkus, A., Vinnikova, L., Pletnikov, M. V., Kirby, M., Gorelick, J., Drori, E., & Pinhasov, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-04840-9 · Cited by 18 · see citing works
Atoki, A. V., Aja, P. M., Ondari, E. N., & Shinkafi, T. S. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2243050 · Cited by 19 · see citing works
Huang, C., Liao, Y., Chen, C.-L., & Tsai, G. (2024) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-024-04409-1 · Cited by 13 · see citing works
Sim, M., Jang, J.-H., Lee, H., Jung, H.-K., & Cho, H.-W. (2017) · Food Science and Biotechnology · doi:10.1007/s10068-017-0130-2 · Cited by 12 · see citing works
Self-citationThe genus Liriope : Phytochemistry and pharmacology
Shang, Z., Wang, F., Zhang, J., Wang, Z., Lu, J., Wang, H., & Li, N. (2017) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(18)30014-1 · Cited by 12 · see citing works
Kim, K. B., Lee, S., Heo, J. H., & Kim, J.-H. (2017) · Journal of Nutrition and Health · doi:10.4163/jnh.2017.50.5.415 · Cited by 12 · see citing works
Acer okamotoanum protects SH-SY5Y neuronal cells against hydrogen peroxide-induced oxidative stress
Kim, J. H., Lee, S., & Cho, E. J. (2018) · Food Science and Biotechnology · doi:10.1007/s10068-018-0381-6 · Cited by 12 · see citing works
Song, S. J., Hyun, S., Lee, T. G., Park, B., Jo, K., Lee, I. S., & Kim, C. (2019) · Journal of Ophthalmology · doi:10.1155/2019/1429548 · Cited by 12 · see citing works
Tao, L.-X., Ji, S.-S., Szalóki, D., Kovacs, T. G., Mándi, A., Antus, S., Ding, X., Kurtán, T., & Zhang, H.-Y. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0391-9 · Cited by 12 · see citing works
Apigenin Ameliorates Oxidative Stress-induced Neuronal Apoptosis in SH-SY5Y Cells
Kim, Y. J., Cho, E. J., Lee, A. Y., & Seo, W. T. (2021) · Microbiology and Biotechnology Letters · doi:10.48022/mbl.2009.09006 · Cited by 11 · see citing works
Correia, A. S., Cardoso, A., & Vale, N. (2022) · International Journal of Translational Medicine · doi:10.3390/ijtm2030036 · Cited by 11 · see citing works
Mourya, A., Pingle, P., Katta, C. B., Veerabomma, H., Jyothi, V. G. S. S., Novak, J., Pathak, P., Grishina, M., Verma, A., Kumar, R., et al. (2022) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2022.130283 · Cited by 11 · see citing works
Serotonin Type 3 Receptor Is Potentially Involved in Cellular Stress Induced by Hydrogen Peroxide
Correia, A. S., da Silva, I. C. B., Oliveira, J. C., Reguengo, H., & Vale, N. (2022) · Life · doi:10.3390/life12101645 · Cited by 11 · see citing works
Marmitt, D. J., Alves, C., Silva, J., Pintéus, S., Schneider, T., Santos, R. C. V., de Freitas, E. M., Pedrosa, R., Laufer, S., & Goettert, M. I. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00652-y · Cited by 11 · see citing works
Nourbakhsh, F., Read, M. I., Barreto, G. E., & Sahebkar, A. (2020) · IUBMB Life · doi:10.1002/iub.2369 · Cited by 10 · see citing works
Casaril, A. M., Segatto, N. V., Simões, L. D., Paschoal, J. D., Domingues, M., Vieira, B. M., Sousa, F. S. S., Lenardao, E. J., Seixas, F. K., Collares, T. V., et al. (2021) · Neurochemical Research · doi:10.1007/s11064-020-03190-0 · Cited by 9 · see citing works
An, C.-N., Pu, X., Wang, Q., & Zhang, H. (2019) · Brain and Behavior · doi:10.1002/brb3.1304 · Cited by 9 · see citing works
Sun, X., Ren, Z., Pan, Y., & Zhang, C. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.121 · Cited by 9 · see citing works
α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage
Zhu, Y. X., Bi, F., Li, Y., Yin, H., Deng, N., Pan, H., Li, D., & Xiao, B. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4045 · Cited by 9 · see citing works
Hasriadi, H., Wong-on, M., Lapphanichayakool, P., & Limpeanchob, N. (2017) · International Journal of Pharmacy and Pharmaceutical Sciences · doi:10.22159/ijpps.2017v9i11.21827 · Cited by 8 · see citing works
Shah, A. J., Mir, P. A., Adnan, M., Patel, M. B., Maqbool, M., Mir, R. H., & Masoodi, M. H. (2023) · ACS Omega · doi:10.1021/acsomega.3c05662 · Cited by 9 · see citing works
Mahajan, K. D., Sharma, S., Gautam, R. K., Goyal, R., Mishra, D. K., & Singla, R. K. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241296557 · Cited by 6 · see citing works
Divyashri, G., Suprajaa, V., Nairy, C. U., Sastry, A., Sanjana, R., Sharada, B., & Murthy, T. P. K. (2024) · Discover Food · doi:10.1007/s44187-024-00120-9 · Cited by 6 · see citing works
Hassan, I. M., Ibrahim, W. N. W., Yusuf, F. B. M., Ahmad, S. A., & Ahmad, S. (2020) · Biochemistry Research International · doi:10.1155/2020/2640873 · Cited by 5 · see citing works
Acer okamotoanum Inhibit the Hydrogen Peroxide-Induced Oxidative Stress in C6 Glial Cells
Choi, S. Y., Kim, J. H., Quilantang, N. G., Lee, S., & Cho, E. J. (2018) · Natural Product Sciences · doi:10.20307/nps.2018.24.3.148 · Cited by 4 · see citing works
Hijam, A. C., Koijam, A. S., & Haobam, R. (2024) · International Journal of experimental research and review · doi:10.52756/ijerr.2024.v39spl.016 · Cited by 4 · see citing works
Pohl, F., Goua, M., Yates, K., Bermano, G., Russell, W. R., Maciel, P., & Lin, P. K. T. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13592 · Cited by 4 · see citing works
A potential treatment option for advanced non-small cell lung cancer: Three cases
Lee, S., Park, S., Lee, H. Y., Jeon, H., Lee, S., Choi, S., & Eo, W. K. (2022) · EXPLORE · doi:10.1016/j.explore.2022.04.001 · Cited by 3 · see citing works
Self-citationEstresse oxidativo em células SH-SY5Y diante da exposição ao peróxido de hidrogênio
Zabeu, A. M. C., Rossato, R. C., Soares, C. P., & da Silva, N. S. (2022) · Research Society and Development · doi:10.33448/rsd-v11i3.26474 · Cited by 3 · see citing works
Kim, K., Nam, Y. R., Bae, E. Y., & Ly, S. Y. (2023) · Korean Journal of Human Ecology · doi:10.5934/kjhe.2023.32.6.857 · Cited by 3 · see citing works
Yoon, D., Ryu, I. S., Shin, W. C., Ka, M., Kim, H., Jang, E. Y., Kim, O., Lee, Y., Seo, J., & Lee, D. (2020) · Brain Sciences · doi:10.3390/brainsci10090654 · Cited by 3 · see citing works
Effect of media and gelling agents on shoot organogenesis of Liriope platyphylla
Kim, Y., Park, W. T., Sathasivam, R., Kim, H.-H., Kim, J. K., & Park, S. U. (2023) · The Journal of Phytology · doi:10.25081/jp.2023.v15.8319 · Cited by 2 · see citing works
Phytochemical and pharmacological overview on Liriopes radix
Ramalingam, M., & Kim, S. (2016) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v15i11.29 · Cited by 1 · see citing works
Gier, M. L. (2018) · University of the Western Cape Electronic Theses and Dissertations Repository (University of the Western Cape) · Cited by 1 · see citing works
Park, K. H., Kang, S. Y., Jung, H. W., & Park, Y.-K. (2020) · The Korea Journal of Herbology · doi:10.6116/kjh.2020.35.4.9
Rajeswari, R., Azhaguchamy, M., Christyraj, J. R. S. S., & Kanagaraj, L. (2024) · 3 Biotech · doi:10.1007/s13205-024-04185-2
Huang, C.-H., Liao, Y.-T., Chen, C.-L., & Tsai, G.-J. (2024) · Figshare · doi:10.6084/m9.figshare.25556482
Protective Effect of Liriope platyphylla Extract in a Thioacetamide Induced Hepatotoxicity Model
Park, S.-I., Seo, H. W., Oh, J.-H., Baek, S. H., & Hwang, S.-Y. (2025) · 동의생리병리학회지 · doi:10.15188/kjopp.2025.02.39.1.15
- Authors
- Park, H. R., Lee, H., Park, H., Jeon, J. W., Cho, W.-K., & Ma, J. Y.
- Affiliations
- Korea Institute of Oriental Medicine (KR)
- Venue
- BMC Complementary and Alternative Medicine
- Published
- 2015-06-09
- Volume
- 15
- Issue
- 1
- Pages
- 171-171
- ISSN
- 1472-6882 (ISSN-L)
- PMC
- PMC4459069
- OpenAlex
- W1533508825
- Cited by
- 68
- References
- 57
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 10 · 2016: 7
- FWCI
- 17.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Complementary and Alternative Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Korea Institute of Oriental Medicine (K15280)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Liriope platyphylla, neuroprotection, hydrogen peroxide, oxidative stress, apoptosis, mitochondrial dysfunction, mitochondrial membrane potential, p38 MAPK, caspase-3, PARP cleavage, SH-SY5Y cells, neurodegenerative diseases, plant extracts
- MeSH terms
- Antioxidants, Cell Survival, Dementia, Humans, Hydrogen Peroxide, Phytotherapy, Mitochondria, Neuroblastoma, Neurons, Plant Extracts, Poly(ADP-ribose) Polymerases, Cell Death, Apoptosis, Oxidative Stress, Neuroprotective Agents, Neurodegenerative Diseases, Liliaceae, Cell Line, Tumor, Membrane Potential, Mitochondrial, Caspase 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review