Probiotic fermentation augments the skin anti-photoaging properties of Agastache rugosa through up-regulating antioxidant components in UV-B-irradiated HaCaT keratinocytes
Open accessAbstract
BACKGROUND: Agastache rugosa (Fisch. & C.A.Mey.) Kuntze (Korean mint) is used to treat diverse types of human disorders in traditional medicine. In recent years, its non-fermented leaf extract (ARE) has been shown to possess protective properties against ultraviolet-B (UV-B) radiation-induced photooxidative stress. The present work aimed to examine whether probiotic bacterial fermentation would potentiate the skin anti-photoaging activity of ARE or not, by comparing the protective properties of ARE and corresponding fermented extract (ARE-F) against UV-B radiation-induced photooxidative stress in HaCaT keratinocytes. METHODS: ARE-F was produced from ARE by the fermentation with Lactobacillus rhamnosus HK-9, a type of Gram-positive probiotic bacterial strain. Anti-photoaging activities were evaluated by analyzing reactive oxygen species (ROS), promatrix metalloproteinases (proMMPs), total glutathione (GSH) and total superoxide dismutase (SOD) in UV-B-irradiated HaCaT keratinocytes. Antiradical activity was determined using 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assay. RESULTS: ARE-F contained higher attenuating activity on the UV-B-induced ROS generation than ARE. Similarly, ARE-F was able to diminish the UV-B-induced proMMP-9 and -2 more effectively than ARE. ARE-F displayed higher tendencies to augment the UV-B-reduced total GSH content and SOD activity than ARE. However, there were no significant difference between ARE and ARE-F in ABTS radical scavenging activities. CONCLUSIONS: The findings suggest that the UV-B radiation-protective activity of ARE is enhanced by probiotic bacterial fermentation, which might improve the therapeutic and cosmetic values of A. rugosa leaves.
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Dietary probiotics and their products can alleviate skin aging.
“Some studies have reported that dietary probiotics and their products can also alleviate skin aging.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [132]
Some probiotic extracts have the potential to improve aging skin.
“For example, probiotic fermentation can enhance the skin anti-photo-aging activity of Agastache rugosa leaves, and some probiotic extracts also have the potential to improve aging skin. [131,132].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [132]
Probiotic fermentation can enhance the skin anti-photo-aging activity of Agastache rugosa leaves.
“For example, probiotic fermentation can enhance the skin anti-photo-aging activity of Agastache rugosa leaves, and some probiotic extracts also have the potential to improve aging skin. [131,132].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [132]
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Diet and Skin Aging—From the Perspective of Food Nutrition
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- Authors
- Shin, D., Lee, Y., Huang, Y.-H., Lim, H.-W., Jang, K., Kim, D.-D., & Lim, C.-J.
- Affiliations
- Seoul National University (KR)
- Kangwon National University (KR)
- Corresponding author
- Kim, Dae-Duk
- Lim, Chang-Jin
- Venue
- BMC Complementary and Alternative Medicine
- Published
- 2018-06-26
- Volume
- 18
- Issue
- 1
- Pages
- 196-196
- ISSN
- 1472-6882 (ISSN-L)
- PMC
- PMC6019510
- OpenAlex
- W2809946641
- Cited by
- 57
- References
- 50
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 12 · 2022: 11 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 1
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Complementary and Alternative Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- Agastache rugosa, probiotic fermentation, UV-B radiation, photooxidative stress, reactive oxygen species, matrix metalloproteinases, glutathione, superoxide dismutase, antioxidant activity, HaCaT keratinocytes, fermented plant extract
- MeSH terms
- Antioxidants, Fermentation, Glutathione, Humans, Models, Biological, Plant Extracts, Superoxide Dismutase, Ultraviolet Rays, Skin Aging, Up-Regulation, Reactive Oxygen Species, Plant Leaves, Probiotics, Matrix Metalloproteinase 9, Agastache, Cell Line, Tumor, Lacticaseibacillus rhamnosus
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