Fermentation of Blackberry with L. plantarum JBMI F5 Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling
Open accessAbstract
Chronic and extensive exposure of ultraviolet (UV)-irradiation causes human skin sunburn, inflammation, or photoaging, which is associated with downregulated collagen synthesis. This study investigated the effects of fermented blackberry (Rubus fruticosus B., FBB) by Lactobacillus plantarum JBMI F5 (LP) on UVB-induced photoaging in human foreskin fibroblast (Hs68) as well as in SKH-1 hairless mice. FBB pretreatment inhibited UVB-mediated type-1 procollagen degradation, matrix metalloproteinase (MMP)-1 and MMP-2 protein expression, and suppressed nuclear factor-κB (NF-κB) activation as well as mitogen-activated protein kinase (MAPK) phosphorylation in Hs68. In addition, FBB administration diminished the wrinkle formation in dorsal skin and epidermal thickening in UVB-irradiated hairless mice. Moreover, UVB-induced Type-1 procollagen reduction and antioxidant enzyme inactivation were reversed by FBB administration. These results suggest that FBB may have antiphotoaging effects on UVB-induced wrinkle formation by maintaining the extracellular matrix density in the dermis, which occurs via regulation of reactive oxygen species and related MAPK and NF-κB signaling. Therefore, FBB can be a potential candidate for protecting skin aging against UV irradiation.
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Activation of the MAPK pathway in penile tissue can lead to tissue injury, inflammation, and changes in the ECM.
“Activation of the MAPK pathway in penile tissue can lead to tissue injury, inflammation, and changes in the ECM.”
From Research advances in Peyronie's disease: a comprehensive review on genomics, pathways, phenotypic manifestation, and therapeutic targets. (2024) · cites this paper as [72]
The Results (§3.8) link MAPK signaling to inflammation and MMP expression, while the Discussion (§4) describes UVB-associated MAPK activation and collagen degradation. But the experiments concern cultured human foreskin fibroblasts and hairless mouse skin, not injury or ECM changes in penile tissue as a whole. (LLM, conf=0.86)
Experimental — accuracy not yet measuredFermented blackberry diminished wrinkle formation and epidermal thickening in mouse dorsal skin, maintained ECM density, and reversed type-1 procollagen reduction and antioxidant enzyme inactivation.
“Fermented blackberry diminished wrinkle formation and epidermal thickening in mouse dorsal skin, maintained ECM density, and reversed type-1 procollagen reduction and antioxidant enzyme inactivation [121].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [121]
Oral supplementation with a fermentation of blackberry with L. plantarum JBMI F5 protects skin from UVB-induced photoaging through regulation of MAPK/NF-kappaB signaling.
“Oral supplementation with a fermentation of blackberry with L. plantarum JBMI F5 protects the skin from UVB-induced photoaging through regulation of MAPK/NF-κB signaling.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [121]
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Boosting the Photoaged Skin: The Potential Role of Dietary Components
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- Authors
- Kim, H.-R., Jeong, D.-H., Kim, S., Lee, S.-W., Sin, H.-S., Yu, K.-Y., Jeong, S.-I., & Kim, S.-Y.
- Affiliations
- Jeonju AgroBio-Materials Institute, Wonjangdong-gil 111-27, Deokjin-gu, Jeonju-si, Jeollabuk-do 54810, Korea
- Chebigen Co. Ltd., Jeonju 54853, Korea
- Corresponding author
- Kim, Seon-Young
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-10-11
- Volume
- 11
- Issue
- 10
- Pages
- 2429
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6835613
- OpenAlex
- W2979867229
- Cited by
- 48
- References
- 31
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 12 · 2023: 8 · 2022: 13 · 2021: 7 · 2020: 2
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Korea Institute for Advancement of Technology
- Ministry of SMEs and Startups
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- blackberry, Lactobacillus plantarum, UVB-induced photoaging, skin aging, MMP-1, MMP-2, NF-κB signaling, MAPK signaling, reactive oxygen species, antioxidant enzymes, wrinkle formation, extracellular matrix, human foreskin fibroblasts, SKH-1 mice
- MeSH terms
- Animals, Cell Line, Cell Survival, Female, Fermentation, Fibroblasts, Fruit, Male, Mice, Hairless, Plant Extracts, Ultraviolet Rays, Skin Aging, Lactiplantibacillus plantarum, Mice, Foreskin, Rubus
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