Photochemoprevention of skin cancer by botanical agents
Abstract
Photochemoprevention has become an important armamentarium in the fight against ultraviolet radiation (UVR)‐induced damage to the skin. Among many UVR‐induced damages, skin cancer is of the greatest concern as its rates have been steadily increasing in recent years and the same trend is expected to continue in the future. Ultraviolet radiation increases oxidative stress in skin cells by causing excessive generation of reactive oxygen species (ROS), leading to cancer initiation and promotion. Antioxidants have the capability to quench these ROS and much recent work shows that some of these can inhibit many UVR‐induced signal transduction pathways. Thus, identifying nontoxic strong antioxidants – capable of preventing UVR‐induced skin cancer – has become an important area of research. The use of botanical antioxidants in skin care products is growing in popularity. A wide range of such agents has been shown to prevent skin cancer in animal model systems. New agents are constantly being investigated; however, only a few have been tested for their efficacy in humans. Animal model and cell culture studies have clarified that antioxidants act by several mechanisms at various stages of skin carcinogenesis. This review focuses on skin cancer photochemopreventive effects of selected botanical antioxidants.
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Several anti-oxidants from plants are involved in reduced incidence of photocarcinogenesis and photoaging, and extracts can be considered for skin photoprotective effects.
“Several anti-oxidants extracted from plants are involved in reduced incidence of photocarcinogenesis and photoaging, and, for these reasons, the relative extracts can be considered for their skin photoprotective effects [63].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [63]
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- Authors
- F'guyer, S., Afaq, F., & Mukhtar, H.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- Photodermatology, Photoimmunology & Photomedicine
- Publisher
- Wiley
- Published
- 2003-04
- Volume
- 19
- Issue
- 2
- Pages
- 56-72
- ISSN
- 0905-4383 (ISSN-L)
- 1600-0781
- OpenAlex
- W1980224452
- Cited by
- 205
- References
- 4
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 10 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 10 · 2017: 8 · 2016: 10 · 2015: 14 · 2014: 13 · 2013: 10 · 2012: 14
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photodermatology Photoimmunology & Photomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- skin cancer, ultraviolet radiation, reactive oxygen species, oxidative stress, skin carcinogenesis, signaling pathways, skin care products, animal models
- MeSH terms
- Antioxidants, Humans, Phytotherapy, Plants, Medicinal, Skin Neoplasms, Sunscreening Agents, Ultraviolet Rays
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