Impact of daily supplementation of Spirulina platensis on the immune system of naïve HIV-1 patients in Cameroon: a 12-months single blind, randomized, multicenter trial
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BACKGROUND: Micronutrient deficiencies occur early in Human Immunodeficiency Virus (HIV) infections they have reverse effects on the nutritional status. The diet supplementation with a natural nutraceutical rich in proteins and micronutrient like Spirulina platensis, may be effective and efficient in delaying HIV disease progression by frequently reported improvement in immune response. METHODS: A prospective single-blind, randomized, multicenter study conducted on 320 HIV-1 ARV-naïve participants for 12 months. Participants received either S. platensis supplementation and standard care or standard care and local balanced diet without S. platenis. Selected hematological and biochemical as well as CD4 count cells, viral load copies were assessed at three separate times. RESULTS: Among the 169 ART-naïve participants enrolled in the study, the female was mostly represented (67.1%). The significant increase of CD4 count cells (596.32-614.92 cells count) and significant decrease of viral load levels (74.7 × 10(3)-30.87 × 10(3) copies/mL) of the patients who received a supplementation of S. platensis was found after 6 months of treatment. Haemoglobin level was also significantly higher in the same group while the fasting blood glucose concentration decreased after 12 months compared to control. CONCLUSION: A daily supplementation with S. platensis to diet combined with a reasonable balanced diet has significantly increased the CD4 cells and reduced the viral load after 6 months. Further studies are recommended among a large specific group of people infected by the HIV in order to investigate the mechanisms involved on the effect of S. platensis on immune system.
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Arthrospira platensis exhibits broad-spectrum antiviral activity because of its high content of polysaccharides, inhibiting the replication of enveloped viruses such as herpes simplex virus, influenza virus, measles virus, mumps virus, and HIV-1.
“In addition to its antimicrobial activity, Arthrospira platensis exhibits broad-spectrum antiviral activity because of its high content of polysaccharides, inhibiting the replication of enveloped viruses such as herpes simplex virus, influenza virus, measles virus, mumps virus, and HIV-1 [70,71].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [71]
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Experimental — accuracy not yet measuredOther authors noted a reduction in viral load after six months of Arthrospira platensis intake in combination with a balanced diet.
“Other authors noted a reduction in viral load after six months of Arthrospira platensis intake in combination with a balanced diet [71].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [71]
The increase in CD4+ count was always accompanied by a decrease in the viral load.
“In particular, the increase in CD4+ count was always accompanied by a decrease in the viral load [101–103].”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly <i>Spirulina</i> (2017) · cites this paper as [102]
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Cyanobacterial products with applications in health and industry
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- Authors
- Ngo-Matip, M.-E., Pieme, C. A., Azabji-Kenfack, M., Moukette, B. M., Korosky, E., Stefanini, P., Ngogang, J. Y., & Mbofung, C. M.
- Affiliations
- University of Ngaoundéré (CM)
- Université de Yaoundé I (CM)
- Corresponding author
- Pieme, Constant Anatole
- Venue
- Nutrition Journal
- Published
- 2015-07-21
- Volume
- 14
- Issue
- 1
- Pages
- 70-70
- ISSN
- 1475-2891 (ISSN-L)
- PMC
- PMC4508814
- OpenAlex
- W1605274712
- Cited by
- 71
- References
- 25
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 12 · 2023: 9 · 2022: 6 · 2021: 13 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 2
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nutrition Journal (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- Spirulina platensis, HIV-1, antiretroviral-naive patients, micronutrient supplementation, CD4 count, viral load, immune response, hemoglobin, fasting blood glucose, nutraceuticals
- MeSH terms
- Adult, Cameroon, Diet, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Nutritional Status, Prospective Studies, CD4-Positive T-Lymphocytes, HIV Infections, Body Mass Index, Single-Blind Method, CD4 Lymphocyte Count, Micronutrients, Viral Load, Dietary Supplements, Spirulina
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