Cited by 145Air Quality and Health ImpactsHealth, Environment, Cognitive AgingIndoor Air Quality and Microbial Exposure

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Mitochondrial oxidative DNA damage and exposure to particulate air pollution in mother-newborn pairs

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Grevendonk, Lotte, Janssen, Bram G., Vanpoucke, Charlotte, Lefebvre, Wouter, Hoxha, Mirjam, Bollati, Valentina, Nawrot, Tim S.·2016·Environmental Health

DOI 10.1186/s12940-016-0095-2PMC PMC4719654

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Abstract

BACKGROUND: Studies emphasize the importance of particulate matter (PM) in the formation of reactive oxygen species and inflammation. We hypothesized that PM exposure during different time windows in pregnancy influences mitochondrial 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels, which is an established biomarker for oxidative stress, in both maternal and foetal blood. METHODS: We investigated maternal (n = 224) and cord blood (n = 293) from mother-newborn pairs that were enrolled in the ENVIRONAGE birth cohort. We determined mitochondrial 8-OHdG by quantitative polymerase chain reaction (qPCR). Multivariable regression models were used to assess the association between mitochondrial 8-OHdG with PM10 and PM2.5 exposure over various time windows during pregnancy. RESULTS: In multivariable analysis, PM10 exposure during the entire pregnancy was positively associated with levels of mitochondrial 8-OHdG in maternal blood. For an IQR increment in PM10 exposure an increase of 18.3 % (95 % confidence interval (CI): 5.6 to 33.4 %, p = 0.004) in 8-OHdG was observed. PM10 exposure during the last trimester of pregnancy was positively associated with levels of 8-OHdG (28.1, 95 % CI: 8.6 to 51.2 %, p = 0.004, for an IQR increment in PM10). In a similar way, PM2.5 exposure was significantly associated with an increase of mitochondrial 8-OHdG levels in maternal blood during the entire pregnancy (13.9, 95 % CI: 0.4 to 29.4 %, p = 0.04 for an IQR increment in PM2.5 exposure) and third trimester of pregnancy (28.1, 95 % CI: 3.6 to 58.4 %, p = 0.02 for an IQR increment in PM2.5 exposure). In umbilical cord blood, 8-OHdG levels were significantly associated with PM10 exposure during first and second trimester of pregnancy with respectively an increase of 23.0 % (95 % CI: 5.9 to 42.8 %, p = 0.007) and 16.6 % (95 % CI: 1.8 to 33.5 %, p = 0.03) for an IQR increment in PM10 exposure. CONCLUSIONS: We found PM-associated increased mitochondrial oxidative DNA damage during pregnancy in both mothers and their newborns. Accordingly, our study showed that particulate air pollution exposure in early life plays a role in increasing systemic oxidative stress, at the level of the mitochondria, both in mother and foetus.

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Influential
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Constructing an adverse outcome pathway framework for the impact of maternal exposure to PM2.5 on liver development and injury in offspring
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Effect Of Atmospheric Particulate Matter On The Functional State Of Mitochondria
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Background

Authors: Grevendonk, L., Janssen, B. G., Vanpoucke, C., Lefebvre, W., Hoxha, M., Bollati, V., & Nawrot, T. S.
Affiliations: University of Milan (IT)
Hasselt University (BE)
Flemish Institute for Technological Research (BE)
Corresponding author: Nawrot, Tim S.
ORCID: Grevendonk, Lotte
Janssen, Bram G.
Lefebvre, Wouter
Hoxha, Mirjam
Bollati, Valentina
Nawrot, Tim S.
Venue: Environmental Health
Publisher: Springer Science and Business Media LLC
Published: 2016-01-20
Volume: 15
Issue: 1
Pages: 10-10
ISSN: 1476-069X (ISSN-L)
DOI: 10.1186/s12940-016-0095-2
PMC: PMC4719654
OpenAlex: W2286090902
Cited by: 145
References: 43
Citations by year: 2026: 6 · 2025: 17 · 2024: 13 · 2023: 16 · 2022: 16 · 2021: 28 · 2020: 8 · 2019: 13 · 2018: 12 · 2017: 12 · 2016: 4
FWCI: 8.59
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Environmental Health (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Lirias (KU Leuven) (submittedVersion, cc-by)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Document Server@UHasselt (UHasselt) (submittedVersion, cc-by)
Funders: EU Programme “Ideas” (ERC-2011-StG 282413)
EU Program “Ideas” (ERC-2012-StG 310898)
Flemish Scientific Fund (FWO) (N1516112/G.0.873.11.N.10)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Keywords: particulate matter, PM10, PM2.5, prenatal air pollution exposure, 8-hydroxy-2'-deoxyguanosine, oxidative stress, maternal blood, umbilical cord blood, pregnancy trimesters, ENVIRONAGE birth cohort, prenatal exposure, birth cohort studies, biomarkers of exposure, inflammation, reactive oxygen species
MeSH terms: Adult, Air Pollutants, DNA, Mitochondrial, Environmental Exposure, Female, Fetal Blood, Humans, Infant, Newborn, Placenta, Pregnancy, Cohort Studies, Maternal Exposure, Particulate Matter, Young Adult

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Mitochondrial oxidative DNA damage and exposure to particulate air pollution in mother-newborn pairs

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