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Mangiferin: a natural miracle bioactive compound against lifestyle related disorders
Open accessAbstract
The current review article is an attempt to explain the therapeutic potential of mangiferin, a bioactive compound of the mango, against lifestyle-related disorders. Mangiferin (2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) can be isolated from higher plants as well as the mango fruit and their byproducts (i.e. peel, seed, and kernel). It possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. Mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, in order to provide a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. This review summarizes the literature pertaining to mangiferin and its associated health claims.
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![Fig. 2 Inhibition of NFκB via the (A) classical and (B) alternative pathways by mangiferin (adapted from [11, 45, 55, 123, 124])](/paper-figures/bed95bf082554460936c37ebbb61fb3a/mangiferin-a-natural-miracle-bioactive-compound-against-lifestyle-related-figure-2.jpg)
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“It has been widely reported that MGF offers a wide plethora of promising beneficial properties such as antioxidant, antiviral, anti-inflammatory, immunomodulatory, and cytoprotective effects [20,21].”
From Effects of Mangiferin on LPS-Induced Inflammation and SARS-CoV-2 Viral Adsorption in Human Lung Cells (2022) · cites this paper as [20]
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Metadata
- Authors
- Imran, M., Arshad, M. S., Butt, M. S., Kwon, J.-H., Arshad, M. U., & Sultan, M. T.
- Affiliations
- Imperial College of Business Studies (PK)
- Government College University, Faisalabad (PK)
- University of Agriculture Faisalabad (PK)
- Kyungpook National University (KR)
- Bahauddin Zakariya University (PK)
- Corresponding author
- Arshad, Muhammad Sajid
- Arshad, Muhammad Umair
- ORCID
- Venue
- Lipids in Health and Disease
- Published
- 2017-05-02
- Volume
- 16
- Issue
- 1
- Pages
- 84-84
- ISSN
- 1476-511X (ISSN-L)
- PMC
- PMC5414237
- OpenAlex
- W2610241935
- Cited by
- 366
- References
- 125
- Citations by year
- 2026: 38 · 2025: 46 · 2024: 57 · 2023: 59 · 2022: 39 · 2021: 42 · 2020: 41 · 2019: 31 · 2018: 11 · 2017: 1
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Lipids in Health and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- mangiferin, mango, lifestyle-related diseases, antioxidant activity, antidiabetic activity, anticancer activity, neuroprotection, breast cancer, lung cancer, colon cancer, MMP-9, matrix metalloproteinase-7, β-catenin signaling, TNF-α, inducible nitric oxide synthase, apoptosis, immunomodulation, antimicrobial activity, hypocholesterolemic activity, xanthones
- MeSH terms
- Anti-Inflammatory Agents, Antineoplastic Agents, Phytogenic, Antioxidants, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Hyperlipidemias, Hypoglycemic Agents, Neoplasms, Neuralgia, Oxidative Stress, Nootropic Agents, Mangifera, Xanthones, Cognitive Dysfunction
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