Implication of hepatokines in metabolic disorders and cardiovascular diseases

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works

Adipokines in inflammation and metabolic disease

Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works

Abdominal obesity and metabolic syndrome

Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354 · see citing works

National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants

Finucane, M. M., Stevens, G. A., Cowan, M. J., Danaei, G., Lin, J. K., Paciorek, C. J., Singh, G. M., Gutierrez, H. R., Lu, Y., Bahalim, A. N., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62037-5 · Cited by 4,050 · see citing works

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909 · see citing works

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works

Macrophages, inflammation, and insulin resistance

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Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245 · see citing works

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125 · see citing works

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

Anstee, Q. M., Targher, G., & Day, C. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.41 · Cited by 1,747 · see citing works

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · see citing works

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151 · see citing works

Identification and characterization of metabolically benign obesity in humans

Stefan, N. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.15.1609 · Cited by 1,049 · see citing works

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

Fabbrini, E., Magkos, F., Mohammed, B. S., Pietka, T., Abumrad, N. A., Patterson, B. W., Okunade, A., & Klein, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904944106 · Cited by 972 · see citing works

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908 · see citing works

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885 · see citing works

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

Fisher, F. M., Chui, P. C., Antonellis, P. J., Bina, H. A., Kharitonenkov, A., Flier, J. S., & Maratos-Flier, E. (2010) · Diabetes · doi:10.2337/db10-0193 · Cited by 830 · see citing works

FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

Potthoff, M. J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B. N., Mangelsdorf, D. J., Kliewer, S. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904187106 · Cited by 704 · see citing works

The Epidemic of Obesity

Stein, C. J., & Colditz, G. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0288 · Cited by 635 · see citing works

Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

Dushay, J., Chui, P. C., Gopalakrishnan, G. S., Varela–Rey, M., Crawley, M., Fisher, F. M., Badman, M. K., Martinez–Chantar, M. L., & Maratos–Flier, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.054 · Cited by 607 · see citing works

A liver-derived secretory protein, selenoprotein P, causes insulin resistance

Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.015 · Cited by 583 · see citing works

Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene

Kersten, S., Mandard, S., Tan, N. S., Escher, P., METZGER, D., Chambon, P., Gonzalez, F. J., Desvergne, B., & Wahli, W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004029200 · Cited by 560 · see citing works

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537 · see citing works

Selenoprotein P—Expression, functions, and roles in mammals

Burk, R. F., & Hill, K. E. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.026 · Cited by 516 · see citing works

The role of hepatokines in metabolism

Stefan, N., & Häring, H.-U. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.258 · Cited by 500 · see citing works

Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways

Wente, W., Efanov, A. M., Brenner, M. B., Kharitonenkov, A., Koster, A. M., Sandusky, G. E., Sewing, S., Treinies, I., Zitzer, H., & Gromada, J. (2006) · Diabetes · doi:10.2337/db05-1435 · Cited by 497 · see citing works

α2-Heremans-Schmid Glycoprotein/ Fetuin-A Is Associated With Insulin Resistance and Fat Accumulation in the Liver in Humans

Stefan, N., Hennige, A. M., Staiger, H., Machann, J., Schick, F., Kröber, S. M., Machicao, F. E., Fritsche, A., & Häring, H. (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1938 · Cited by 475 · see citing works

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

Potthoff, M. J., Kliewer, S. A., & Mangelsdorf, D. J. (2012) · Genes & Development · doi:10.1101/gad.184788.111 · Cited by 442 · see citing works

The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity

Mandard, S., Zandbergen, F., van Straten, E., Wahli, W., Kuipers, F., Müller, M., & Kersten, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506519200 · Cited by 433 · see citing works

Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance

Chavez, A. O., Molina-Carrion, M., Abdul-Ghani, M. A., Folli, F., DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-0684 · Cited by 390 · see citing works

Plasma fetuin-A levels and the risk of type 2 diabetes

Stefan, N., Fritsche, A., Weikert, C., Boeing, H., Joost, H.-G., Häring, H.-U., & Schulze, M. B. (2008) · Diabetes · doi:10.2337/db08-0538 · Cited by 379 · see citing works

Fibroblast growth factor 21 protects against cardiac hypertrophy in mice

Planavila, A., Redondo‐Angulo, I., Hondares, E., Vinciguerra, M., Munts, C., Iglesias, R., Gabrielli, L., Sitges, M., Giralt, M., van Bilsen, M., et al. (2013) · Nature Communications · doi:10.1038/ncomms3019 · Cited by 371 · see citing works

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

Badman, M. K., Koester, A., Flier, J. S., Kharitonenkov, A., & Maratos-Flier, E. (2009) · Endocrinology · doi:10.1210/en.2009-0532 · Cited by 362 · see citing works

Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene

Mathews, S. T., Singh, G. P., Ranalletta, M., Cintrón, V. J., Qiang, X., Goustin, A. S., Jen, K. C., Charron, M. J., Jahnen‐Dechent, W., & Grunberger, G. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2450 · Cited by 343 · see citing works

Association Between Human Fetuin-A and the Metabolic Syndrome

Ix, J. H., Shlipak, M. G., Brandenburg, V. M., Ali, S., Ketteler, M., & Whooley, M. A. (2006) · Circulation · doi:10.1161/circulationaha.105.588723 · Cited by 316 · see citing works

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

Xu, A., Lam, M. C., Chan, K. W., Wang, Y., Zhang, J., Hoo, R. L. C., Xu, J. Y., Chen, B., Chow, W.-S., Tso, A. W. K., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408452102 · Cited by 315 · see citing works

Plasma Fetuin-A Levels and the Risk of Myocardial Infarction and Ischemic Stroke

Weikert, C., Stefan, N., Schulze, M. B., Pischon, T., Berger, K., Joost, H., Häring, H., Boeing, H., & Fritsche, A. (2008) · Circulation · doi:10.1161/circulationaha.108.814418 · Cited by 310 · see citing works

Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical perspectives

Woo, Y. C., Xu, A., Wang, Y., & Lam, K. S. L. (2012) · Clinical Endocrinology · doi:10.1111/cen.12095 · Cited by 302 · see citing works

Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene

Kantartzis, K., Peter, A., Machicao, F. E., Machann, J., Wagner, S., Königsrainer, I., Königsrainer, A., Schick, F., Fritsche, A., Häring, H., et al. (2009) · Diabetes · doi:10.2337/db09-0279 · Cited by 299 · see citing works

Fetuin-A Induces Cytokine Expression and Suppresses Adiponectin Production

Hennige, A. M., Staiger, H., Wicke, C., Machicao, F., Fritsche, A., Häring, H.-U., & Stefan, N. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001765 · Cited by 282 · see citing works

Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages

Lichtenstein, L., Mattijssen, F., de Wit, N. J. W., Georgiadi, A., Hooiveld, G. J. E. J., van der Meer, R., He, Y., Qi, L., Koster, A. M., Tamsma, J. T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.002 · Cited by 269 · see citing works

Fetuin-A and Incident Diabetes Mellitus in Older Persons

Ix, J. H. (2008) · JAMA · doi:10.1001/jama.300.2.182 · Cited by 267 · see citing works

Angiopoietin-like 4: a decade of research

Zhu, P., Goh, Y. Y., Chin, H. F. A., Kersten, S., & Tan, N. S. (2011) · Bioscience Reports · doi:10.1042/bsr20110102 · Cited by 261 · see citing works

High Circulating Retinol-Binding Protein 4 Is Associated With Elevated Liver Fat but Not With Total, Subcutaneous, Visceral, or Intramyocellular Fat in Humans

Stefan, N., Hennige, A. M., Staiger, H., Machann, J., Schick, F., Schleicher, E. D., Fritsche, A., & Häring, H. (2007) · Diabetes Care · doi:10.2337/dc06-2342 · Cited by 212 · see citing works

Regulation of lipoprotein lipase by Angptl4

Dijk, W., & Kersten, S. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.12.005 · Cited by 199 · see citing works

Inventing new medicines: The FGF21 story

Kharitonenkov, A., & Adams, A. C. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2013.12.003 · Cited by 198 · see citing works

Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease

Yilmaz, Y. N., Eren, F., Yönal, O., Kurt, R., Aktaş, B., Çelikel, Ç., Özdogan, O. C., İmeryüz, N., Kalaycı, C., & Avşar, E. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02338.x · Cited by 196 · see citing works

Serum Fibroblast Growth Factor-21 Levels Are Associated With Carotid Atherosclerosis Independent of Established Cardiovascular Risk Factors

Chow, W. S., Xu, A., Woo, Y. C., Tso, A. W. K., Cheung, S., Fong, C. H.-Y., Tse, H., Chau, M. T., Cheung, B. M. Y., & Lam, K. S. L. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301599 · Cited by 193 · see citing works

Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis

Yang, S. J., Hwang, S. Y., Choi, H. Y., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., & Choi, K. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0620 · Cited by 191 · see citing works

Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes

Iizuka, K., Takeda, J., & Horikawa, Y. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.053 · Cited by 187 · see citing works

Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans

Staiger, H., Haas, C., Machann, J., Werner, R., Weisser, M., Schick, F., Machicao, F., Stefan, N., Fritsche, A., & Häring, H.-U. (2009) · Diabetes · doi:10.2337/db07-1438 · Cited by 183 · see citing works

α2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor

Mathews, S. T. (2000) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00237-9 · Cited by 179 · see citing works

The Metabolically Benign and Malignant Fatty Liver

Stefan, N., & Häring, H. (2011) · Diabetes · doi:10.2337/db11-0231 · Cited by 172 · see citing works

NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance

Dasgupta, S., Bhattacharya, S., Biswas, A., Majumdar, S. S., Mukhopadhyay, S., Ray, S., & Bhattacharya, S. (2010) · Biochemical Journal · doi:10.1042/bj20100330 · Cited by 168 · see citing works

Fetuin-A: A novel link between obesity and related complications

Trepanowski, J. F., Mey, J., & Varady, K. A. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.203 · Cited by 161 · see citing works

Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans

Stefan, N., & Häring, H.-U. (2013) · Nature Medicine · doi:10.1038/nm.3116 · Cited by 160 · see citing works

LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance

Lan, F., Misu, H., Chikamoto, K., Takayama, H., Kikuchi, A., Mohri, K., Takata, N., Hayashi, H., Matsuzawa-Nagata, N., Takeshita, Y., et al. (2014) · Diabetes · doi:10.2337/db13-0728 · Cited by 158 · see citing works

Protection Against Myocardial Infarction and No-Reflow Through Preservation of Vascular Integrity by Angiopoietin-Like 4

Galaup, A., Perdiguero, E. G., Souktani, R., Durand, M., Cazes, A., Monnot, C., Teillon, J., Jan, S. L., Bouleti, C., Briois, G., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.049072 · Cited by 152 · see citing works

Effects of a three‐month combined exercise programme on fibroblast growth factor 21 and fetuin‐A levels and arterial stiffness in obese women

Yang, S. J., Hong, H. C., Choi, H. Y., Yoo, H. J., Cho, G. J., Hwang, T. G., Baik, S. H., Choi, D. S., Kim, S. M., & Choi, K. M. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04078.x · Cited by 148 · see citing works

FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases

Kim, K. H., & Lee, M.-S. (2014) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2014.38.4.245 · Cited by 146 · see citing works

The search for exercise factors in humans

Catoire, M., & Kersten, S. (2015) · The FASEB Journal · doi:10.1096/fj.14-263699 · Cited by 137 · see citing works

Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease

Shen, Y., Ma, X., Zhou, J., Pan, X., Hao, Y., Zhou, M., Lu, Z., Gao, M., Bao, Y., & Jia, W. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-124 · Cited by 135 · see citing works

Emerging Liver–Kidney Interactions in Nonalcoholic Fatty Liver Disease

Musso, G., Cassader, M., Cohney, S. J., Pinach, S., Saba, F., & Gambino, R. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.08.005 · Cited by 132 · see citing works

Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease: An update

Athyros, V. G., Τζιόμαλος, Κ., Katsiki, N., Doumas, M. N., Karagiannis, A. I., & Mikhailidis, D. P. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i22.6820 · Cited by 131 · see citing works

LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor

Lu, X., Chen, J., Yu, C., Shi, Y., He, Y.-Q., Zhang, R.-C., Huang, Z.-A., Lv, J., Zhang, S., & Xu, L. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121466 · Cited by 130 · see citing works

JNK regulation of hepatic manifestations of the metabolic syndrome

Czaja, M. J. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.010 · Cited by 124 · see citing works

Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes

Gray, N. E., Lam, L. N., Yang, K., Zhou, A. Y., Koliwad, S., & Wang, J.-C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.294124 · Cited by 116 · see citing works

Inhibition of 11β-HSD1 with RO5093151 for non-alcoholic fatty liver disease: a multicentre, randomised, double-blind, placebo-controlled trial

Stefan, N., Ramsauer, M., Jordan, P., Nowotny, B., Kantartzis, K., Machann, J., Hwang, J., Nowotny, P., KAHL, S., Harreiter, J., et al. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70170-0 · Cited by 114 · see citing works

Hepatokines: unlocking the multi-organ network in metabolic diseases

Iroz, A., Couty, J.-P., & Postic, C. (2015) · Diabetologia · doi:10.1007/s00125-015-3634-4 · Cited by 111 · see citing works

Increased selenoprotein P levels in subjects with visceral obesity and nonalcoholic Fatty liver disease

Choi, H. Y., Hwang, S. Y., Lee, C. H., Hong, H. C., Yang, S. J., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., et al. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.1.63 · Cited by 111 · see citing works

The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes

Zhang, Y., Lei, T., Huang, J., Wang, S. B., Zhou, L., Yang, Z., & Chen, X. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.003 · Cited by 110 · see citing works

Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes

Misu, H., Ishikura, K., Kurita, S., Takeshita, Y., Ota, T., Saito, Y., Takahashi, K., Kaneko, S., & Takamura, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034952 · Cited by 105 · see citing works

Connecting Myokines and Metabolism

Ahima, R., & Park, H. (2015) · Endocrinology and Metabolism · doi:10.3803/enm.2015.30.3.235 · Cited by 103 · see citing works

Overexpression of Angiopoietin-Like Protein 4 Protects Against Atherosclerosis Development

Georgiadi, A., Wang, Y., Stienstra, R., Tjeerdema, N., Janssen, A. W. F., Stalenhoef, A. F. H., van der Vliet, J. A., Roos, A., Tamsma, J. T., Smit, J. W. A., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301698 · Cited by 102 · see citing works

Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver

Yamagoe, S., Mizuno, S., & Suzuki, K. T. (1998) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(97)00181-4 · Cited by 98 · see citing works

Association of AHSG Gene Polymorphisms With Fetuin-A Plasma Levels and Cardiovascular Diseases in the EPIC-Potsdam Study

Fisher, E., Stefan, N., Saar, K., Drogan, D., Schulze, M. B., Fritsche, A., Joost, H., Häring, H., Hübner, N., Boeing, H., et al. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.109.870410 · Cited by 97 · see citing works

Plasma fetuin‐ A is associated with endothelial dysfunction and subclinical atherosclerosis in subjects with nonalcoholic fatty liver disease

Doğru, T., Genç, H., Tapan, S., Aslan, F., Erçin, C. N., Örs, F., Kara, M., Sertoğlu, E., Karslıoğlu, Y., Bağcı, S., et al. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04460.x · Cited by 90 · see citing works

Fetuin-A and the cardiovascular system

Mori, K., Emoto, M., & Inaba, M. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-394317-0.00010-8 · Cited by 86 · see citing works

Increase in Hepatic NKT Cells in Leukocyte Cell-Derived Chemotaxin 2-Deficient Mice Contributes to Severe Concanavalin A-Induced Hepatitis

Saito, T., Okumura, A., Watanabe, H., Asano, M., Ishida‐Okawara, A., Sakagami, J., Sudo, K., Hatano-Yokoe, Y., Bezbradica, J. S., Joyce, S., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.579 · Cited by 86 · see citing works

Salsalate and adiponectin ameliorate hepatic steatosis by inhibition of the hepatokine fetuin-A

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Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis

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The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications

Marycz, K., Kornicka‐Garbowska, K., Galuppo, L. D., & Bourebaba, L. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10304-w · Cited by 1 · see citing works

The effect of a 6-month walking program on biochemical parameters in sedentary adults with type 2 diabetes mellitus.

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High serum EDA concentration is associated with metabolic syndrome and its determinants

Deng, X., Li, Y., Gu, T., Wu, X., Sun, Z., Li, H., Yang, L., & Yuan, G. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02408-9 · Cited by 1 · see citing works

Therapeutic potential of sodium selenite in patients with non-alcoholic fatty liver disease and hypertension disease

Tverezovska, I., & Zhelezniakova, N. (2023) · Modern Gastroenterology · doi:10.30978/mg-2023-3-20 · Cited by 1 · see citing works

Hepatic peroxisome and its implications on cardiac function, inflammation and aging

Huang, K. (2020) · doi:10.31274/etd-20210114-64

Increased Circulating Levels of EDA in Newly Diagnosed Type 2 Diabetic PatientsPreprint

Deng, X., Li, Y., Wu, X., Zhao, L., Li, H., Chen, K., Zhang, P., Zhao, Z., Qiu, Y., Yang, L., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-189239/v1

Research Progress of Relationship between Fetuin B and Atherosclerosis

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Additional file 1 of Effects of modified-Paleo and moderate-carbohydrate diets on body composition, serum levels of hepatokines and adipocytokines, and flow cytometric analysis of endothelial microparticles in adults with metabolic syndrome: a study protocol for a randomized clinical trial

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Dynamic Alterations of BMP9 in NAFLD: A Novel Hepatokine Marker of Metabolic Dysfunction and Disease Severity

Cui, F., Chen, F., Dong, F., & Dong, J. (2026) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s552791

Diversité des macrophages dans un modèle murin de stéatohépatite non alcoolique

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Hepassocin drives EGFR-dependent endothelial atherogenic activation via NOX1/ROS amplification and p38 signaling

Pyo, M. K., Park, H. S., Ko, J. H., Lim, D. S., Gwon, H. J., EL-Aty, A. M. A., Yağan, R., Song, J.-H., Shin, Y. K., Jeong, J. H., et al. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.110820

Prevalence of Hypertension, Diabetes, Obesity, and High Cholesterol Among Older People Living With HIV: A Systematic Review and Meta‐Analysis

Rafiee, M., Mehmandoost, S., Harandi, F., Sharifi, M. N., Bazrafshani, M. S., Bazrafshan, A., Borhaninejad, V., & Sharifi, H. P. (2026) · AIDS Research and Treatment · doi:10.1155/arat/6655322

Metabolic Dysfunction–Associated Steatotic Liver Disease as a Systemic Driver of Heart Failure With Preserved Ejection Fraction: Mechanistic Insights and Emerging Therapeutic Perspectives

Wu, J., Zheng, W., Qi, Q., He, C., Zhai, C., & Fan, H. (2026) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm51234

Metainflammation, Mitochondrial Dysfunction, and Organokine Crosstalk: A Central Axis Linking Metabolic Syndrome to Cardiovascular Diseases

Sodré, A. F. P., Rodrigues, L. G., Sloan, K. P., Sloan, L. A., Tanaka, M., Curi, R., Takeda, L. N., Goulart, R. D. Á., de Souza, A. L. D. M., Detregiachi, C. R. P., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156554

Beneficial Hepatokines in MASLD/MASH: Therapeutic Potentials and Drug Delivery Challenges

Amatya, R., Min, K. A., & Shin, M. C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167118

Der Stellenwert der Leber in der Blutdruckregulation

Kasper, P., & Steffen, H. (2026) · Nephrologie aktuell · doi:10.1055/a-2856-7042

Leukocyte cell-derived chemotaxin 2 (LECT2) regulates neuritic extension and branching

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The endocrine role of hepatokines: implications for human health and disease

Iglesias, P. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1663353 · Cited by 22 · see citing works

Interaction between hepatokines and metabolic diseases.

Liang, J., Liu, C., Zhang, W., & Chen, S. (2022) · PubMed · doi:10.16288/j.yczz.22-218 · Cited by 3 · see citing works

Hepatokines and non-alcoholic fatty liver disease

Lebensztejn, D. M., Flisiak-Jackiewicz, M., Białokoz-Kalinowska, I., Bobrus-Chociej, A., & Kowalska, I. (2016) · Acta Biochimica Polonica · doi:10.18388/abp.2016_1252 · Cited by 90 · see citing works

Editorial: The liver as an endocrine organ: Hepatokines and ketone bodies, novel hormones to be acknowledged

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