The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Hypoxia adipose stem cell-derived exosomes promote high-quality healing of diabetic wound involves activation of PI3K/Akt pathways
Open accessAbstract
Refractory diabetic wounds can cause persistent inflammation and delayed healing due to hypoxia. Currently, no optimal solution is available. Exosomes of adipose stem cells (ADSCs-exo) may promote skin wound healing, however, molecular mechanisms remains mysterious. We found significantly enhanced survival and proliferation of adipose stem cells after hypoxia induction compared to normoxia. Here, we aimed to investigate if hypoxic adipose stem cells exosomes (HypADSCs-exo) participate in hypoxia adaptability and accelerate diabetic wound healing. Based on high-throughput sequencing, 215 microRNAs (miRNAs) were upregulated and 369 miRNAs downregulated in HypADSCs-exo compared to ADSCs-exo. Up-regulated miR-21-3p, miR-126-5p, miR-31-5p whereas down-regulated gene miR-99b and miR-146-a correlated with wound healing. According to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), miRNAs might regulate cell metabolism, differentiation and Transforming growth factor-β (TGF-β) function. Consistently, HpyADSCs-exo could promote diabetic wounds healing and inhibit inflammation through PI3K/AKT signaling pathway. Collectively, HpyADSCs-exo can promote diabetic wound healing as an alternative strategy to improve wound healing.
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Cites
1 retracted
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RetractedBiogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
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Regulation of Wound Healing by Growth Factors and Cytokines
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The global burden of diabetic foot disease
Boulton, A. J., Vileikyte, L., Ragnarson-Tennvall, G., & Apelqvist, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67698-2 · Cited by 2,566
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Cited by
Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements
Kolimi, P., Narala, S., Nyavanandi, D., Youssef, A. A. A., & Dudhipala, N. (2022) · Cells · doi:10.3390/cells11152439 · Cited by 585
Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing
Zhou, C., Zhang, B., Yang, Y., Jiang, Q., Li, T., Gong, J., Tang, H., & Zhang, Q. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03345-0 · Cited by 341
Zhu, D., Wei, W., Zhang, J., Zhao, B., Li, Q., & Jin, P. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24656 · Cited by 48
Metadata
- Authors
- Wang, J., Wu, H., Peng, Y., Zhao, Y., Qin, Y., Zhang, Y., & Xiao, Z.
- Venue
- Journal of Nanobiotechnology
- Published
- 2021-07-07
- Volume
- 19
- Issue
- 1
- Pages
- 202-202
- ISSN
- 1477-3155 (ISSN-L)
- OpenAlex
- W3164297248
- Cited by
- 293
- References
- 51
- FWCI
- 18.73
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, J., Wu, H., Peng, Y., Zhao, Y., Qin, Y., Zhang, Y., & Xiao, Z. (2021). Hypoxia adipose stem cell-derived exosomes promote high-quality healing of diabetic wound involves activation of PI3K/Akt pathways. Journal of Nanobiotechnology. https://doi.org/10.1186/s12951-021-00942-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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