Epithelial-mesenchymal transition orchestrates tumor microenvironment: Current perceptions and challenges
Open accessAbstract
The epithelial-mesenchymal transition (EMT) is a critical process in cancer progression, facilitating tumor cells to develop invasive traits and augmenting their migratory capabilities. EMT is primed by tumor microenvironment (TME)-derived signals, whereupon cancer cells undergoing EMT in turn remodel the TME, thereby modulating tumor progression and therapeutic response. This review discusses the mechanisms by which EMT coordinates TME dynamics, including secretion of soluble factors, direct cell contact, release of exosomes and enzymes, as well as metabolic reprogramming. Recent evidence also indicates that cells undergoing EMT may differentiate into cancer-associated fibroblasts, thereby establishing themselves as functional constituents of the TME. Elucidating the relationship between EMT and the TME offers novel perspectives for therapeutic strategies to enhance cancer treatment efficacy. Although EMT-directed therapies present significant therapeutic potential, the current lack of effective targeting approaches-attributable to EMT complexity and its microenvironmental context dependency-underscores the necessity for mechanistic investigations and translational clinical validation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Epithelial-to-mesenchymal transition (EMT) plays a critical role in driving phenotypic diversity in solid tumors by suppressing epithelial markers such as E-cadherin and upregulating mesenchymal markers like vimentin and N-cadherin.
“In addition to these models, EMT plays a critical role in driving phenotypic diversity in solid tumors. Through EMT, epithelial cancer cells undergo a dynamic reprogramming process that suppresses epithelial markers, such as E-cadherin, while upregulating mesenchymal markers, like vimentin and N-cadherin [130,131].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [130]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes
Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770 · see citing works
The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196 · see citing works
Epithelial-Mesenchymal Transitions in Development and Disease
Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931 · see citing works
<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., et al. (2004) · Science · doi:10.1126/science.1099314 · Cited by 9,368 · see citing works
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M. W., Reinhard, F., Zhang, C. C., Shipitsin, M. V., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,679 · see citing works
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works
Understanding the tumor immune microenvironment (TIME) for effective therapy
Binnewies, M., Roberts, E. W., Kersten, K., Chan, V., Fearon, D. F., Merad, M., Coussens, L. M., Gabrilovich, D. I., Ostrand-Rosenberg, S., Hedrick, C. C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0014-x · Cited by 6,145 · see citing works
Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492 · see citing works
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
de Visser, K. E., & Joyce, J. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.016 · Cited by 4,059 · see citing works
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
Dongre, A., & Weinberg, R. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0080-4 · Cited by 3,876 · see citing works
Cano, A., Pérez‐Moreno, M., Rodrigo, I., Locascio, A., Blanco, M. J., Barrio, M. G. D., Portillo, F., & Nieto, M. A. (2000) · Nature Cell Biology · doi:10.1038/35000025 · Cited by 3,672 · see citing works
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., et al. (2000) · Nature Cell Biology · doi:10.1038/35036374 · Cited by 2,797 · see citing works
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
Singh, A., & Settleman, J. (2010) · Oncogene · doi:10.1038/onc.2010.215 · Cited by 2,545 · see citing works
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
Shibue, T., & Weinberg, R. A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.44 · Cited by 2,539 · see citing works
The ErbB signaling network: receptor heterodimerization in development and cancer
Olayioye, M. A., Neve, R. M., Lane, H. A., & Hynes, N. E. (2000) · The EMBO Journal · doi:10.1093/emboj/19.13.3159 · Cited by 2,438 · see citing works
Concepts of extracellular matrix remodelling in tumour progression and metastasis
Winkler, J., Abisoye-Ogunniyan, A., Metcalf, K. J., & Werb, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-18794-x · Cited by 2,296 · see citing works
Guidelines and definitions for research on epithelial-mesenchymal transition
Yang, J., Antin, P., Berx, G., Blanpain, C., Brabletz, T., Bronner, M., Campbell, K., Cano, A., Casanova, J., Christofori, G., et al. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0237-9 · Cited by 2,226 · see citing works
EMT and Dissemination Precede Pancreatic Tumor Formation
Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.025 · Cited by 2,136 · see citing works
Yu, Q., & Stamenkovic, I. (2000) · PubMed · Cited by 1,952 · see citing works
Yu, Q., & Stamenkovic, I. (2000) · Genes & Development · doi:10.1101/gad.14.2.163 · Cited by 1,754 · see citing works
Phenotype molding of stromal cells in the lung tumor microenvironment
Lambrechts, D., Wauters, E., Boeckx, B., Aibar, S., Nittner, D., Burton, O., Bassez, A., Decaluwé, H., Pircher, A., Van den Eynde, K., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0096-5 · Cited by 1,648 · see citing works
Pathways of Antigen Processing
Blum, J. S., Wearsch, P. A., & Cresswell, P. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095910 · Cited by 1,561 · see citing works
Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice
Albrengues, J., Shields, M. A., Ng, D., Park, C. G., Ambrico, A., Poindexter, M. E., Upadhyay, P., Uyeminami, D. L., Pommier, A., Küttner, V., et al. (2018) · Science · doi:10.1126/science.aao4227 · Cited by 1,476 · see citing works
Extracellular Vesicles: Unique Intercellular Delivery Vehicles
Maas, S. L. N., Breakefield, X. O., & Weaver, A. M. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.11.003 · Cited by 1,419 · see citing works
Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., Le, Q.-T., & Giaccia, A. J. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.11.012 · Cited by 1,231 · see citing works
Su, S., Chen, J., Yao, H., Liu, J., Yu, S., Lao, L., Wang, M., Luo, M., Xing, Y., Chen, F., et al. (2018) · Cell · doi:10.1016/j.cell.2018.01.009 · Cited by 1,230 · see citing works
Salmon, H., Idoyaga, J., Rahman, A. H., Leboeuf, M., Remark, R., Jordan, S., Casanova-Acebes, M., Khudoynazarova, M. N., Agudo, J., Tung, N., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.03.012 · Cited by 1,187 · see citing works
Role of extracellular matrix assembly in interstitial transport in solid tumors.
Netti, P. A., Berk, D. A., Swartz, M. A., Grodzinsky, A. J., & Jain, R. K. (2000) · PubMed · Cited by 1,165 · see citing works
Targeting TGF-β signal transduction for fibrosis and cancer therapy
Peng, D., Fu, M., Wang, M., Wei, Y., & Wei, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01569-x · Cited by 1,106 · see citing works
Role of Extracellular Matrix in Development and Cancer Progression
Walker, C., Mojares, E., & Hernández, A. E. D. R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103028 · Cited by 1,103 · see citing works
Lactate: A Metabolic Key Player in Cancer
Hirschhaeuser, F., Sattler, U. G. A., & Mueller‐Klieser, W. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1457 · Cited by 1,093 · see citing works
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Huang, Y., Hong, W., & Wei, X. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01347-8 · Cited by 1,065 · see citing works
Jabłońska-Trypuć, A., Matejczyk, M., & Rosochacki, S. (2016) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2016.1161620 · Cited by 1,042 · see citing works
Taube, J. H., Herschkowitz, J. I., Komurov, K., Zhou, A. Y., Gupta, S. K., Yang, J., Hartwell, K. A., Önder, T. T., Gupta, P. B., Evans, K. W., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004900107 · Cited by 1,041 · see citing works
Krebs, A. M., Mitschke, J., Losada, M. L., Schmalhofer, O., Boerries, M., Busch, H. S., Böttcher, M., Mougiakakos, D., Reichardt, W., Bronsert, P., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3513 · Cited by 979 · see citing works
Ocaña, O. H., Córcoles, R. C., Fabra, À., Moreno‐Bueno, G., Acloque, H., Vega, S., Barrallo‐Gimeno, A., Cano, A., & Nieto, M. A. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.012 · Cited by 973 · see citing works
Chen, L., Gibbons, D. L., Goswami, S., Cortez, M. A., Ahn, Y., Byers, L. A., Zhang, X., Yi, X., Dwyer, D. W., Lin, W., et al. (2014) · Nature Communications · doi:10.1038/ncomms6241 · Cited by 972 · see citing works
Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells
Nieto, M. A. (2013) · Science · doi:10.1126/science.1234850 · Cited by 962 · see citing works
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell
Kagan, H. M., & Li, W. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10413 · Cited by 954 · see citing works
Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells
Kudo‐Saito, C., Shirako, H., Takeuchi, T., & Kawakami, Y. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.023 · Cited by 872 · see citing works
We need to talk about the Warburg effect
DeBerardinis, R. J., & Chandel, N. S. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0172-2 · Cited by 864 · see citing works
TGF-β Activation and Function in Immunity
Travis, M. A., & Sheppard, D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120257 · Cited by 856 · see citing works
Targeting immunosuppressive adenosine in cancer
Vijayan, D., Young, A., Teng, M. W. L., & Smyth, M. J. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.86 · Cited by 852 · see citing works
Bartoschek, M., Oskolkov, N., Bocci, M., Lövrot, J., Larsson, C., Sommarin, M., Madsen, C. D., Lindgren, D., Pekar, G., Karlsson, G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07582-3 · Cited by 826 · see citing works
Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer
Dong, C., Yuan, T., Wu, Y., Wang, Y., Fan, T. W. ‐., Miriyala, S., Lin, Y., Yao, J., Shi, J., Kang, T., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.01.022 · Cited by 806 · see citing works
A guide to antigen processing and presentation
Pishesha, N., Harmand, T. J., & Ploegh, H. L. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-022-00707-2 · Cited by 805 · see citing works
Teijeira, Á., Garasa, S., Gato, M., Alfaro, C., Miguéliz, I., Cirella, A., de Andrea, C., Ochoa, M. C., Otano, I., Etxeberría, I., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.03.001 · Cited by 799 · see citing works
Interleukins in cancer: from biology to therapy
Briukhovetska, D., Dörr, J., Endres, S., Libby, P., Dinarello, C. A., & Kobold, S. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00363-z · Cited by 791 · see citing works
Su, S., Liu, Q., Chen, J., Chen, J., Chen, F., He, C., Huang, D., Wu, W., Lin, L., Huang, W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.021 · Cited by 775 · see citing works
Dynamic EMT: a multi‐tool for tumor progression
Brabletz, S., Schuhwerk, H., Brabletz, T., & Stemmler, M. P. (2021) · The EMBO Journal · doi:10.15252/embj.2021108647 · Cited by 770 · see citing works
Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1
Noë, V., Fingleton, B., Jacobs, K., Crawford, H. C., Vermeulen, S. J. T., Steelant, W. F. A., Bruyneel, E. A., Matrisian, L. M., & Mareel, M. M. K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.1.111 · Cited by 697 · see citing works
Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and InfectionPreprint
Sanjabi, S., Oh, S. A., & Li, M. O. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022236 · Cited by 626 · see citing works
Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment
Fu, C., & Jiang, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03059 · Cited by 602 · see citing works
The rationale for targeting the LOX family in cancer
Barker, H. E., Cox, T. R., & Erler, J. T. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3319 · Cited by 592 · see citing works
Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer
Topper, M. J., Vaz, M., Chiappinelli, K. B., DeStefano Shields, C. E., Niknafs, N., Yen, R.-W. C., Wenzel, A., Hicks, J., Ballew, M., Stone, M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.022 · Cited by 537 · see citing works
Mak, M. P., Tong, P., Diao, L., Cardnell, R. J., Gibbons, D. L., William, W. N., Skoulidis, F., Parra, E. R., Rodriguez‐Canales, J., Wistuba, I. I., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0876 · Cited by 526 · see citing works
Yamaguchi, H., Hsu, J.-M., Yang, W., & Hung, M. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00601-9 · Cited by 507 · see citing works
The UCSC Genome Browser database: 2016 update
Speir, M. L., Zweig, A. S., Rosenbloom, K. R., Raney, B. J., Paten, B., Nejad, P., Lee, B. T., Learned, K., Karolchik, D., Hinrichs, A. S., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1275 · Cited by 451 · see citing works
Material stiffness influences the polarization state, function and migration mode of macrophages
Sridharan, R., Cavanagh, B., Cameron, A. R., Kelly, D. J., & O'Brien, F. J. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.02.048 · Cited by 450 · see citing works
Collagen density regulates the activity of tumor-infiltrating T cells
Kuczek, D. E., Larsen, A. M. H., Thorseth, M., Carretta, M., Kalviša, A., Siersbæk, M. S., Simões, A. M. C., Roslind, A., Engelholm, L. H., Noeßner, E., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0556-6 · Cited by 441 · see citing works
Peng, D. H., Rodriguez, B. L., Diao, L., Chen, L., Wang, J., Byers, L. A., Wei, Y., Chapman, H. A., Yamauchi, M., Behrens, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18298-8 · Cited by 441 · see citing works
Cella, M., Döhring, C., Samaridis, J., Dessing, M., Brockhaus, M., Lanzavecchia, A., & Colonna, M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.10.1743 · Cited by 430 · see citing works
Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
Viganó, S., Alatzoglou, D., Irving, M. B., Ménétrier‐Caux, C., Caux, C., Romero, P. J., & Coukos, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00925 · Cited by 422 · see citing works
New insights into the role of <scp>EMT</scp> in tumor immune escape
Terry, S., Savagner, P., Ortiz‐Cuaran, S., Mahjoubi, L., Saintigny, P., Thiery, J., & Chouaib, S. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12093 · Cited by 414 · see citing works
Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion
Sun, X., Wu, B., Chiang, H.-C., Deng, H., Zhang, X., Xiong, W., Liu, J., Rozeboom, A. M., Harris, B. T., Blommaert, E., et al. (2021) · Nature · doi:10.1038/s41586-021-04057-2 · Cited by 407 · see citing works
CD39/CD73/A2AR pathway and cancer immunotherapy
Xia, C., Yin, S., To, K. K. W., & Fu, L. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01733-x · Cited by 406 · see citing works
Mechanisms of RNA loading into exosomes
Janas, T., Janas, M. M., Sapoń, K., & Janas, T. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.04.036 · Cited by 397 · see citing works
Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas
Dongre, A., Rashidian, M., Reinhardt, F., Bagnato, A., Keckesova, Z., Ploegh, H. L., & Weinberg, R. A. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3292 · Cited by 395 · see citing works
Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer
Saatci, Ö., Kaymak, A., Raza, U., Ersan, P. G., Akbulut, Ö., Banister, C. E., Sikirzhytski, V., Tokat, Ü. M., Aykut, G., Ansari, S. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16199-4 · Cited by 373 · see citing works
Hidalgo-Carcedo, C., Hooper, S., Chaudhry, S. I., Williamson, P., Harrington, K. J., Leitinger, B., & Sahai, E. A. (2010) · Nature Cell Biology · doi:10.1038/ncb2133 · Cited by 363 · see citing works
Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c‐Jun activation
Mendler, A. N., Hu, B., Prinz, P. U., Kreutz, M. P., Gottfried, E., & Noeßner, E. (2011) · International Journal of Cancer · doi:10.1002/ijc.26410 · Cited by 320 · see citing works
Tharp, K. M., Kersten, K., Maller, O., Timblin, G. A., Stashko, C., Canale, F. P., Menjivar, R. E., Hayward, M.-K., Berestjuk, I., ten Hoeve, J., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00775-4 · Cited by 304 · see citing works
Taki, M., Abiko, K., Baba, T., Hamanishi, J., Yamaguchi, K. D., Murakami, R., Yamanoi, K., Horikawa, N., Hosoe, Y., Nakamura, E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03966-7 · Cited by 296 · see citing works
Hwang, W., Yang, M., Tsai, M., Lan, H., Su, S., Chang, S., Teng, H., Yang, S., Lan, Y., Chiou, S., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.008 · Cited by 295 · see citing works
B7-H3/CD276: An Emerging Cancer Immunotherapy
Zhou, W.-T., & Jin, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.701006 · Cited by 295 · see citing works
Miller, B. W., Morton, J. P., Pinese, M., Saturno, G., Jamieson, N. B., McGhee, E. J., Timpson, P., Leach, J. D. G., McGarry, L., Shanks, E. J., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404827 · Cited by 289 · see citing works
Alsuliman, A., Çolak, D., Al‐Harazi, O., Fitwi, H., Tulbah, A. M., Al‐Tweigeri, T., Al-Alwan, M. M., & Ghebeh, H. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0421-2 · Cited by 288 · see citing works
Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells
Miyoshi, A., Kitajima, Y., Sumi, K., Sato, K., Hagiwara, A., Koga, Y., & Miyazaki, K. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601685 · Cited by 283 · see citing works
Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers
Krześlak, A., Wójcik‐Krowiranda, K., Forma, E., Jóźwiak, P., Romanowicz, H., Bieńkiewicz, A., & Bryś, M. (2012) · Pathology & Oncology Research · doi:10.1007/s12253-012-9500-5 · Cited by 280 · see citing works
Luo, N., Nixon, M. J., Gonzalez-Ericsson, P. I., Sanchez, V., Opalenik, S. R., Li, H., Zahnow, C. A., Nickels, M. L., Liu, F., Tantawy, M. N., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02630-w · Cited by 275 · see citing works
Epithelial-to-Mesenchymal Transition: Epigenetic Reprogramming Driving Cellular Plasticity
Skrypek, N., Goossens, S., Smedt, E. D., Vandamme, N., & Berx, G. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.08.004 · Cited by 270 · see citing works
Vimentin regulates activation of the NLRP3 inflammasome
dos Santos, G., Rogel, M. R., Baker, M. A., Troken, J. R., Urich, D., Morales‐Nebreda, L., Sennello, J. A., Kutuzov, M. A., Sitikov, A. S., Davis, J. M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7574 · Cited by 269 · see citing works
Regulation of epithelial–mesenchymal and mesenchymal–epithelial transitions by microRNAs
Lamouille, S., Subramanyam, D., Blelloch, R. H., & Derynck, R. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.01.008 · Cited by 257 · see citing works
New frontiers in immune checkpoint B7-H3 (CD276) research and drug development
Getu, A. A., Tigabu, A., Zhou, M., Lu, J., Fodstad, Ø., & Tan, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01751-9 · Cited by 255 · see citing works
Noman, M. Z., Janji, B., Abdou, A., Hasmim, M., Terry, S., Tan, T. Z., Mami-Chouaib, F., Thiery, J. P., & Chouaib, S. (2017) · OncoImmunology · doi:10.1080/2162402x.2016.1263412 · Cited by 253 · see citing works
Immune Modulatory Properties of Collagen in Cancer
Rømer, A. M. A., Thorseth, M., & Madsen, D. H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.791453 · Cited by 231 · see citing works
Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer
Bhome, R., Vecchio, F. D., Lee, G.-H., Bullock, M. D., Primrose, J. M., Sayan, E., & Mirnezami, A. H. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.02.002 · Cited by 224 · see citing works
Huang, X., Zhang, P., Wei, C., Peng, R., Lu, J., Gao, C., Cai, J.-B., Yang, X., Fan, J., Ke, A., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01213-6 · Cited by 223 · see citing works
Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition
Shaul, Y. D., Freinkman, E., Comb, W. C., Cantor, J. R., Tam, W. L., Thiru, P., Kim, D., Kanarek, N., Pacold, M. E., Chen, W. W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.032 · Cited by 217 · see citing works
Zhao, L., Liu, Y., Zhang, J., Liu, Y., & Qi, Q. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1886-5 · Cited by 217 · see citing works
Miyoshi, A., Kitajima, Y., Kido, S., Shimonishi, T., Matsuyama, S., Kitahara, K., & Miyazaki, K. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602266 · Cited by 216 · see citing works
Yang, C., Dou, R., Chen, W., Liu, K., Shi, D., Zhang, C., Liu, Q., Wang, S., & Xiong, B. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.02.006 · Cited by 215 · see citing works
Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy
Zhao, B., Li, H., Xia, Y., Wang, Y., Wang, Y., Shi, Y., Xing, H., Qu, T., Wang, Y., & Ma, W. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01364-7 · Cited by 213 · see citing works
Peng, D. H., Ungewiss, C., Tong, P., Byers, L. A., Wang, J., Canales, J. R., Villalobos, P. A., Uraoka, N., Mino, B., Behrens, C., et al. (2016) · Oncogene · doi:10.1038/onc.2016.358 · Cited by 211 · see citing works
Matrix Metalloproteinases and Cancer - Roles in Threat and Therapy
Yadav, L., Puri, N., Rastogi, V., Satpute, P., Ahmad, R., & Kaur, G. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.3.1085 · Cited by 209 · see citing works
Tripathi, S. C., Peters, H. L., Taguchi, A., Katayama, H., Wang, H., Momin, A. A., Jolly, M. K., Çeliktaş, M., Rodriguez‐Canales, J., Liu, H., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521812113 · Cited by 203 · see citing works
KLRG1—more than a marker for T cell senescence
Henson, S. M., & Akbar, A. N. (2009) · AGE · doi:10.1007/s11357-009-9100-9 · Cited by 191 · see citing works
Hsu, D. S., Wang, H.-J., Tai, S., Chou, C.-H., Hsieh, C.-H., Chiu, P.-H., Chen, N., & Yang, M. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.002 · Cited by 191 · see citing works
Twist1 Induces CCL2 and Recruits Macrophages to Promote Angiogenesis
Low-Marchelli, J. M., Ardi, V. C., Vizcarra, E. A., van Rooijen, N., Quigley, J. P., & Yang, J. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-0653 · Cited by 191 · see citing works
Jiang, H., Wei, H., Wang, H., Wang, Z., Li, J., Ou, Y., Xiao, X., Wang, W., Chang, A., Sun, W., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04632-z · Cited by 190 · see citing works
Self-citationHsieh, C.-H., Tai, S., & Yang, M. (2018) · Neoplasia · doi:10.1016/j.neo.2018.06.004 · Cited by 186 · see citing works
Epithelial-Mesenchymal Transition (EMT) as a Therapeutic Target
Jonckheere, S., Adams, J., Groote, D. D., Campbell, K., Berx, G., & Goossens, S. (2021) · Cells Tissues Organs · doi:10.1159/000512218 · Cited by 173 · see citing works
The prognostic value of GLUT1 in cancers: a systematic review and meta-analysis
Yu, M., Yongzhi, H., Chen, S., Luo, X., Lin, Y., Zhou, Y., Jin, H., Hou, B., Deng, Y., Tu, L., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17445 · Cited by 167 · see citing works
Erratum: Targeting immunosuppressive adenosine in cancer
Vijayan, D., Young, A., Teng, M. W. L., & Smyth, M. J. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.110 · Cited by 167 · see citing works
Kim, S., Koh, J., Kim, M., Kwon, D., Go, H., Kim, Y. A., Jeon, Y. K., & Chung, D. H. (2016) · Human Pathology · doi:10.1016/j.humpath.2016.07.007 · Cited by 166 · see citing works
Zhou, Y., Lin, F., Wan, T. Y., Chen, A., Wang, H., Jiang, B., Zhao, W., Liao, S., Wang, S., Li, G., et al. (2021) · Theranostics · doi:10.7150/thno.56490 · Cited by 163 · see citing works
Xia, H., Wang, W., Crespo, J., Kryczek, I., Li, W., Wei, S., Bian, Z., Maj, T., He, M., Liu, J. R., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aan4631 · Cited by 155 · see citing works
Self-citationMasin, M., Vázquez, J., Rossi, S., Groeneveld, S., Samson, N., Schwalie, P. C., Deplancke, B., Frawley, L. E., Gouttenoire, J., Moradpour, D., et al. (2014) · Cancer & Metabolism · doi:10.1186/2049-3002-2-11 · Cited by 154 · see citing works
Ock, C.-Y., Kim, S., Keam, B., Kim, M., Kim, T. M., Kim, J.-H., Jeon, Y. K., Lee, J., Kwon, S. K., Hah, J. H., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7431 · Cited by 146 · see citing works
PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation
Qiu, X. Y., Hu, D. X., Chen, W., Chen, R. Q., Shi, Q., Li, C. Y., Li, Y. J., Xiong, X., Liu, D., Pan, F., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.03.002 · Cited by 144 · see citing works
Chen, X.-J., Deng, Y.-R., Wang, Z., Wei, W.-F., Zhou, C.-F., Zhang, Y., Yan, R.-M., Liang, L.-J., Zhong, M., Li, L., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1748-1 · Cited by 139 · see citing works
Self-citationJinushi, M., Nakazaki, Y., Carrasco, D. R., Draganov, D., Souders, N. C., Johnson, M., Mihm, M. C., & Dranoff, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2147 · Cited by 125 · see citing works
HDAC6 Inhibition Synergizes with Anti-PD-L1 Therapy in ARID1A-Inactivated Ovarian Cancer
Fukumoto, T., Fatkhutdinov, N., Zundell, J. A., Tcyganov, E. N., Nacarelli, T., Karakashev, S. V., Wu, S., Liu, Q., Gabrilovich, D. I., & Zhang, R. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1302 · Cited by 124 · see citing works
Tsutsumi, S., Saeki, H., Nakashima, Y., Ito, S., Oki, E., Morita, M., Oda, Y., Okano, S., & Maehara, Y. (2017) · Cancer Science · doi:10.1111/cas.13237 · Cited by 119 · see citing works
Matrix stiffness regulates macrophage polarisation via the <scp>Piezo1‐YAP</scp> signalling axis
Mei, F., Guo, Y., Wang, Y., Zhou, Y., Heng, B. C., Xie, M., Huang, X., Zhang, S., Ding, S., Liu, F., et al. (2024) · Cell Proliferation · doi:10.1111/cpr.13640 · Cited by 118 · cited 1× · see citing works
“In contrast, softer conditions encourage Mφ to take on an anti-inflammatory and highly phagocytic phenotype [132, 133].”
PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma
Wang, Y., Wang, H., Zhao, Q., Xia, Y., Hu, X., & Guo, J. (2015) · Medical Oncology · doi:10.1007/s12032-015-0655-2 · Cited by 114 · see citing works
PD-L1 Expression Promotes Epithelial to Mesenchymal Transition in Human Esophageal Cancer
Chen, L., Xiong, Y., Li, J., Zheng, X. W., Zhou, Q., Turner, A., Wu, C., Lu, B., & Jiang, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000480000 · Cited by 110 · see citing works
Immune Promotion of Epithelial-mesenchymal Transition and Generation of Breast Cancer Stem Cells
Reiman, J. M., Knutson, K. L., & Radisky, D. C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4041 · Cited by 107 · see citing works
CD73 Promotes Resistance to HER2/ErbB2 Antibody Therapy
Turcotte, M., Allard, D., Mittal, D., Barèche, Y., Buisseret, L., José, V., Pommey, S., Delisle, V., Loi, S., Joensuu, H., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0707 · Cited by 106 · see citing works
Sun, C., Lan, P., Han, Q., Huang, M., Zhang, Z., Xu, G., Song, J., Wang, J., Wei, H., Zhang, J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03584-3 · Cited by 102 · see citing works
Franciszkiewicz, K., Floc’h, A. L., Jalil, A., Vigant, F., Robert, T., Vergnon, I., Mackiewicz, A. A., Benihoud, K., Validire, P., Chouaı̈b, S., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3571 · Cited by 96 · see citing works
ZEB1 transcription factor promotes immune escape in melanoma
Plaschka, M., Benboubker, V., Grimont, M., Berthet, J., Tonon, L., Lopez, J., Bouar, M. L., Balme, B., Tondeur, G., de la Fouchardière, A., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003484 · Cited by 96 · see citing works
Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases
Rachman-Tzemah, C., Zaffryar‐Eilot, S., Grossman, M., Ribero, D., Timaner, M., Mäki, J. M., Myllyharju, J., Bertolini, F., Hershkovitz, D., Sagi, I., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.005 · Cited by 96 · see citing works
Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy
B, J. R. V. B., Huijbers, E. J. M., van Loon, K., Blanas, A., Akbari, P., Roos, A., Wong, T. J., Denisov, S. S., Hackeng, T. M., Jiménez, C. R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30063-7 · Cited by 96 · see citing works
Cao, Y., Zhang, L., Kamimura, Y., Ritprajak, P., Hashiguchi, M., Hirose, S., & Azuma, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2217 · Cited by 94 · see citing works
Cheng, H.-Y., Hsieh, C.-H., Lin, P., Chen, Y.-T., Hsu, D. S., Tai, S., Chu, P., & Yang, M. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004832 · Cited by 93 · see citing works
Qian, Y., Yao, W., Yang, T., Yang, Y., Liu, Y., Shen, Q., Zhang, J., Qi, W., & Wang, J. (2017) · Hepatology · doi:10.1002/hep.29296 · Cited by 93 · see citing works
Hu, Y., Liu, J., Jiang, B., Chen, J., Fu, Z., Bai, F., Jiang, J., & Tang, Z. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3136-0 · Cited by 91 · see citing works
Interaction of KLRG1 with E‐cadherin: New functional and structural insights
Rosshart, S. P., Hofmann, M., Schweier, O., Pfaff, A.-K., Yoshimoto, K., Takeuchi, T., Molnár, E., Schamel, W. W. A., & Pircher, H. (2008) · European Journal of Immunology · doi:10.1002/eji.200838690 · Cited by 89 · see citing works
Zeng, W., Xiong, L., Wu, W., Li, S., Liu, J., Yang, L., Lao, L., Huang, P., Zhang, M., Chen, H., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02540-2 · Cited by 88 · see citing works
Characterization of mouse CD4 T cell subsets defined by expression of KLRG1
Beyersdorf, N., Ding, X., Tietze, J. K., & Hanke, T. (2007) · European Journal of Immunology · doi:10.1002/eji.200737126 · Cited by 81 · see citing works
Niu, N., Yao, J., Bast, R. C., Sood, A. K., & Liu, J. (2021) · Oncogenesis · doi:10.1038/s41389-021-00349-4 · Cited by 81 · see citing works
Alonso‐Nocelo, M., Ruíz-Cañas, L., Sancho, P., Görgülü, K., Alcalá, S., Pedrero, C., Vallespinós, M., López-Gil, J. C., Ochando, M., García-García, E., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-325564 · Cited by 80 · see citing works
Noman, M. Z., Moer, K. V., Marani, V., Gemmill, R. M., Tranchevent, L.-C., Azuaje, F. J., Muller, A., Chouaı̈b, S., Thiery, J. P., Berchem, G., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1345415 · Cited by 79 · see citing works
Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment
García-Mendoza, M. G., Inman, D. R., Ponik, S. M., Jeffery, J. J., Sheerar, D. S., Doorn, R. R. V., & Keely, P. J. (2016) · Breast Cancer Research · doi:10.1186/s13058-016-0703-7 · Cited by 79 · see citing works
Hypoxia promotes the invasion and metastasis of laryngeal cancer cells via EMT
Zuo, J., Wen, J., Lei, M., Wen, M., Li, S., Lv, X., Luo, Z., & Wen, G. (2016) · Medical Oncology · doi:10.1007/s12032-015-0716-6 · Cited by 77 · see citing works
Schwartzkopff, S., Gründemann, C., Schweier, O., Rosshart, S. P., Karjalainen, K., Becker, K., & Pircher, H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1022 · Cited by 76 · see citing works
Calvé, B. L., Griveau, A., Vindrieux, D., Maréchal, R., Wiel, C., Svrcek, M., Gout, J., Martin, L. A., Payen, L. F., Cros, J. F., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8527 · Cited by 75 · see citing works
Park, H., Kim, K. M., Lee, H. C., Choi, H. N., Kim, D. J., Kim, B., & Moon, W. (2007) · Oncology Reports · doi:10.3892/or.18.6.1435 · Cited by 74 · see citing works
Blaser, C., Kaufmann, M., & Pircher, H. (1998) · PubMed · Cited by 73 · see citing works
Blaser, C., Kaufmann, M., & Pircher, H. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.6451 · Cited by 71 · see citing works
Takai, K., Drain, A. P., Lawson, D. A., Littlepage, L. E., Karpuj, M. V., Kessenbrock, K., Le, A. M., Inoue, K., Weaver, V. M., & Werb, Z. (2018) · Genes & Development · doi:10.1101/gad.301366.117 · Cited by 69 · see citing works
The Fibronectin–ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells
Paavola, K. J., Roda, J. M., Lin, V. Y., Chen, P., O'Hollaren, K. P., Ventura, R., Crawley, S., Li, B., Chen, H.-I. H., Malmersjö, S., et al. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0240 · Cited by 68 · see citing works
Peng, X., Li, L., Chen, J., Ren, Y., Liu, J., Yu, Z., Cao, H., & Chen, J. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01863 · Cited by 68 · see citing works
Zhang, Q., Zhang, Y., Chen, Y., Qian, J., Zhang, X., & Yu, K. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2548 · Cited by 65 · see citing works
Liu, J., Chiang, H.-C., Xiong, W., Laurent, V., Griffiths, S. C., Dülfer, J., Deng, H., Sun, X., Yin, Y. W., Li, W., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-006720 · Cited by 65 · see citing works
Koh, M., Woo, Y., Valiathan, R. R., Jung, H. Y., Park, S. Y., Kim, Y. N., Kim, H.-R. C., Fridman, R. A., & Moon, A. (2014) · International Journal of Cancer · doi:10.1002/ijc.29154 · Cited by 63 · see citing works
Long, L., Hu, Y., Long, T., Lu, X., Tuo, Y., Li, Y., Wang, M., & Ke, Z. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003973 · Cited by 63 · see citing works
ZEB1 Upregulates VEGF Expression and Stimulates Angiogenesis in Breast Cancer
Liu, L., Tong, Q., Liu, S., Cui, J., Zhang, Q., Sun, W., & Yang, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148774 · Cited by 62 · see citing works
Self-citationArrindell, J., & Desnues, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1224352 · Cited by 62 · see citing works
Kim, S., Cho, W., Kim, I., Lee, S., Oh, G. T., & Park, Y. M. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01923-w · Cited by 59 · see citing works
Extracellular vimentin modulates human dendritic cell activation
Yu, M. B., Guerra, J., Firek, A. F., & Langridge, W. H. R. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.09.017 · Cited by 59 · see citing works
DDR1 enhances invasion and metastasis of gastric cancer via epithelial-mesenchymal transition
Xie, R., Wang, X., Qi, G., Wu, Z., Wei, R., Li, P., & Zhang, D. (2016) · Tumor Biology · doi:10.1007/s13277-016-5070-6 · Cited by 54 · see citing works
Self-citationEzzoukhry, Z., Henriet, E., Piquet, L., Boyé, K., Bioulac‐Sage, P., Balabaud, C. P., Couchy, G., Zucman‐Rossi, J., Moreau, V., & Saltel, F. (2016) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2016.09.003 · Cited by 54 · see citing works
Xia, Y., Wang, W., Shen, W., Xu, K., Hu, Y., Han, G., & Liu, Y.-B. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109652 · Cited by 53 · see citing works
Self-citationmiR-128 Regulates Tumor Cell CD47 Expression and Promotes Anti-tumor Immunity in Pancreatic Cancer
Xi, Q., Chen, Y., Yang, G.-Z., Zhang, J., Zhang, L., Guo, X.-D., Zhao, J., Xue, Z., Yan, L., & Zhang, R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00890 · Cited by 50 · see citing works
Bhome, R., Emaduddin, M., James, V. H., House, L. M., Thirdborough, S. M., Mellone, M., Tulkens, J., Primrose, J. N., Thomas, G. J., Wever, O. D., et al. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12226 · Cited by 50 · see citing works
Liang, Y., Liu, Y., Zhang, Q., Zhang, H., & Du, J. (2020) · Translational research · doi:10.1016/j.trsl.2020.12.003 · Cited by 47 · see citing works
Epigenetic regulation of hybrid epithelial-mesenchymal cell states in cancer
Sample, R. A., Nogueira, M. F., Mitra, R. D., & Puram, S. V. (2023) · Oncogene · doi:10.1038/s41388-023-02749-9 · Cited by 47 · see citing works
Targeting vimentin: a multifaceted approach to combatting cancer metastasis and drug resistance
Tabatabaee, A., Nafari, B., Farhang, A., Hariri, A., Khosravi, A., Zarrabi, A., & Mirian, M. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10154-7 · Cited by 47 · see citing works
Slug Is Associated With Tumor Metastasis and Angiogenesis in Ovarian Cancer
Gu, A., Jie, Y., Yao, Q., Zhang, Y., & Mingyan, E. (2016) · Reproductive Sciences · doi:10.1177/1933719116654989 · Cited by 46 · see citing works
Ueno, T., Tsuchikawa, T., Hatanaka, K. C., Hatanaka, Y., Mitsuhashi, T., Nakanishi, Y., Noji, T., Nakamura, T., Okamura, K., Matsuno, Y., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25050 · Cited by 46 · see citing works
Rouanne, M., Adam, J., Radulescu, C., Letourneur, D., Bredel, D., Mouraud, S., Goubet, A.-G., Leduc, M., Chen, N., Tan, T. Z., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci145666 · Cited by 43 · see citing works
The Yin and Yang of Targeting KLRG1+ Tregs and Effector Cells
Borys, S. M., Bag, A. K., Brossay, L., & Adeegbe, D. O. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.894508 · Cited by 42 · see citing works
T cell adhesion and cytolysis of pancreatic cancer cells: a role for E-cadherin in immunotherapy?
French, J., Cresswell, J., Wong, W. K., Seymour, K., Charnley, R., & Kirby, J. A. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600597 · Cited by 42 · see citing works
Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer
Ippolito, L., Duatti, A., Iozzo, M., Comito, G., Pardella, E., Lorito, N., Bacci, M., Pranzini, E., Santi, A., Sandrini, G., et al. (2024) · EMBO Reports · doi:10.1038/s44319-024-00180-z · Cited by 41 · see citing works
Song, J., Chen, X., Bai, J., Liu, Q., Li, H., Xie, J., Jing, H., & Zheng, J. (2016) · Tumor Biology · doi:10.1007/s13277-016-5021-2 · Cited by 40 · see citing works
Wu, T., Tang, C., Tao, R.-C., Yong, X., Jiang, Q.-Z., & Feng, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.693881 · Cited by 38 · see citing works
Conserved immuno‐collagenic subtypes predict response to immune checkpoint blockade
Mei, J., Cai, Y., Xu, R., Li, Q., Chu, J., Luo, Z., Sun, Y., Shi, Y., Xu, J., Li, D., et al. (2024) · 癌症:英文版 · doi:10.1002/cac2.12538 · Cited by 37 · see citing works
Fei, Z., Deng, Z., Zhou, L., Li, K., Xia, X., & Xie, R. (2019) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504018x15446984186056 · Cited by 36 · see citing works
Ajam-Hosseini, M., Heydari, R., Rasouli, M., Akhoondi, F., Hanjani, N. A., Bekeschus, S., & Doroudian, M. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116098 · Cited by 34 · see citing works
Shrestha, R., Bridle, K. R., Crawford, D. H., & Jayachandran, A. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.54239 · Cited by 28 · see citing works
Gu, Y., Zhang, Z., Camps, M. G. M., OSSENDORP, F. A., Wijdeven, R. H. M., & ten Dijke, P. (2023) · Science Advances · doi:10.1126/sciadv.adf9915 · Cited by 23 · see citing works
Xu, J., Yang, X., Pan, J., Fan, H., Mei, J., & Hua, D. (2022) · Journal of Oncology · doi:10.1155/2022/3224373 · Cited by 22 · see citing works
LILRB4 Checkpoint for Immunotherapy: Structure, Mechanism and Disease Targets
Xiang, Z., Yin, X., Wei, L., Peng, M., Zhu, Q. K., Lu, X., Guo, J., Zhang, J., Li, X., & Zou, Y. (2024) · Biomolecules · doi:10.3390/biom14020187 · Cited by 21 · see citing works
Collino, F., Revelli, A., Massobrio, M., Katsaros, D., Schmitt-Ney, M., Camussi, G., & Bussolati, B. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.06.010 · Cited by 20 · see citing works
Kanemura, T., Miyata, H., Makino, T., Tanaka, K., Sugimura, K., Hamada‐Uematsu, M., Mizote, Y., Uchida, H., Miyazaki, Y., Takahashi, T., et al. (2018) · Cancer Science · doi:10.1111/cas.13785 · Cited by 18 · see citing works
Itagaki, F., Nakatsuka, K., Sakai, H., Endo, S., Su, M., & Takai, T. (2023) · International Immunology · doi:10.1093/intimm/dxad012 · Cited by 17 · see citing works
Hasmim, M., Xiao, M., Moer, K. V., Kumar, A., Oniga, A., Mittelbronn, M. G. A., Duhem, C., Chammout, A., Berchem, G., Thiery, J. P., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.982821 · Cited by 15 · see citing works
Immunoproteasome acted as immunotherapy ‘coffee companion’ in advanced carcinoma therapy
Shi, S., Ou, X., Liu, C., Wen, H., & Jiang, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1464267 · Cited by 6 · see citing works
Metabolic Rewiring Is Required for Epithelial–Mesenchymal Transition
(2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2014-190 · Cited by 1 · see citing works
Short peptides sensitize target cells to CTL specific for the MHC class Ib molecule, H2-M3
Dabhi, V. M., & Fischer Lindahl, K. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199811)28:11
Flagged first, then by citations
Research works printed but not linked: 2
- [2]Nieto MA, Huang RY, Jackson RA, Thiery JP. EMT: 2016. Cell. 2016;166(1):21–45. 27368099
- [70]Butcher S, Arney KL, Cook GP. MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells. Eur J Immunol. 1998;28(11):3755–62. 9842918
Cited by
Sorted by citations
Shah, S., & D’Souza, G. G. M. (2025) · Cells · doi:10.3390/cells14100732 · Cited by 66 · see citing works
“Through EMT, epithelial cancer cells undergo a dynamic reprogramming process that suppresses epithelial markers, such as E-cadherin, while upregulating mesenchymal markers, like vimentin and N-cadherin [130,131].”
Bakrim, S., Fessikh, M. E., Elhrech, H., Omari, N. E., Amanullah, M. R., Ming, L. C., Moshawih, S., & Bouyahya, A. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06583-3 · Cited by 52 · see citing works
Cancer Metastasis: Therapeutic Challenges and Opportunities
Garemilla, S. S. S., Kadambala, M. C., Gampa, S. C., Chinthala, S., & Garimella, S. V. (2025) · Medical Oncology · doi:10.1007/s12032-025-03072-x · Cited by 13 · see citing works
Chohan, S., & Zaheer, S. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156183 · Cited by 9 · see citing works
Zhang, A., Zhang, Y., Xu, J., Zhu, R., Liang, T., & Guo, L. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104946 · Cited by 8 · see citing works
Gratie, M. I., Manna, O. M., Accomando, S., Tomasello, G., Cappello, F., & Fucarino, A. (2025) · Cells · doi:10.3390/cells14211652 · Cited by 8 · see citing works
EMT: from embryogenesis, through cancer progression, to the development of carcinosarcoma
Guarino, M. (2025) · Differentiation · doi:10.1016/j.diff.2025.100903 · Cited by 7 · see citing works
Qu, Y. A., Huang, J. C. N., Wang, Z. V., Ferguson, A. L., Nguyen, J. M. H. N., Zhang, M. N., Osborne, K., Boumelhem, B. B., McCaughan, G. W., Liu, K., et al. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl44837 · Cited by 7 · see citing works
Jiang, H., & Xu, B. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105189 · Cited by 6 · see citing works
Bertoldi, A., Cusumano, G., Calzoni, E., Alabed, H. B. R., Pellegrino, R. M., Buratta, S., Urbanelli, L., & Emiliani, C. (2025) · Cells · doi:10.3390/cells14161233 · Cited by 5 · see citing works
Nappi, A., Crocetto, F., Conforti, P., Sagliocchi, S., Cicatiello, A. G., Restolfer, F., Acampora, L., Mastro, S. D., Sirica, R., Spirito, L., et al. (2026) · The Journal of Liquid Biopsy · doi:10.1016/j.jlb.2025.100454 · Cited by 5 · see citing works
Radwan, Z., Kassir, R., Feghali, F. A., Zaiter, R., Daher, M. A., Roufayel, R., Fajloun, Z., Mawlawi, H., El-Sabban, M. E., & Dassouki, Z. (2025) · Biomolecules · doi:10.3390/biom15101361 · Cited by 4 · see citing works
Hallmarks of epithelial-mesenchymal plasticity in cancer
Clauzon, L., Verona, F., Shams, K., Brancato, O. R., Bella, S. D., di Miceli, N., Stassi, G., & Franco, S. D. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02690-x · Cited by 4 · see citing works
Chen, Y., Zeng, B., Xiang, M., Han, X. T., Zhang, X., Chen, H. H., Zhao, Q., Liu, D., Li, X., Li, J., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117086 · Cited by 4 · see citing works
Cai, H., Shen, D., Hu, X., Yin, H., & Yan, Z. (2025) · Toxins · doi:10.3390/toxins17080388 · Cited by 4 · see citing works
Yang, Q., Feng, N., Shen, F., Bai, L., Li, R., Li, S., & Zhang, W. (2025) · PeerJ · doi:10.7717/peerj.19785 · Cited by 3 · see citing works
Cytoskeletal dynamics in breast cancer: mechanistic insights and therapeutic opportunities
Malla, R. R., Tumbali, A., Chode, P., Manda, K., Samudrala, A. S., Nuthalapati, Y., Mangam, C., Bhamidipati, P., Srilatha, M., & Nagaraju, G. P. (2025) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2025.09.006 · Cited by 3 · see citing works
Guo, L., Zhang, B., Cui, X., Wang, X., Xiao, J., Miao, S., Song, K., & Sun, J. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70520 · Cited by 3 · see citing works
Self-citationCellular signaling and radioresistance in prostate cancer
Sosa, G. A., Crosswhite, B., & Kirschner, A. N. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112367 · Cited by 3 · see citing works
Jin, L., Wang, Y., Mao, S., Yao, Y., Yang, X., & Qian, J. (2026) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2026.100185 · Cited by 3 · see citing works
Nanthaprakash, T. V., Gourlay, C. W., Oehme, I., Garrett, M. D., Cínatl, J., Wass, M. N., & Michaelis, M. (2025) · FEBS Open Bio · doi:10.1002/2211-5463.70076 · Cited by 2 · see citing works
Li, Q., Liu, Y., Zhang, L., Zheng, Y., Feng, X., & Wang, Y. (2025) · Human Cell · doi:10.1007/s13577-025-01299-4 · Cited by 2 · see citing works
Chen, J.-W., Ouyang, J.-J., Wang, Z., Ma, D.-M., Zhang, Z., Teng, Q., Yu, G., & Li, X. (2025) · World Journal of Clinical Oncology · doi:10.5306/wjco.v16.i12.112626 · Cited by 2 · see citing works
Al‐Khreisat, M. J., Abdulsahib, W. K., Jasim, I. K., Malathi, H., Nayak, P. P., Anand, D. A., Mukherjee, G., Sinha, A., & Kholboyev, N. (2026) · Discover Oncology · doi:10.1007/s12672-026-04731-9 · Cited by 2 · see citing works
Natural Modulators of Aquaporins in Cancer Therapy: Functional Mechanisms and Clinical Potential
Małkowska, P., & Tarnowski, M. (2026) · Molecules · doi:10.3390/molecules31071072 · Cited by 2 · see citing works
Zuccalà, V., Fiorentino, V., Martorana, T. M., Ricciardi, G., Tralongo, P., Ciappina, G., Abbonante, V., Ammendola, M., Berretta, M., Fadda, G., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27114971 · Cited by 2 · see citing works
Mechanobiology of solid tumor vasculature: implications for tumor progression
Kondapaneni, R. V., Libring, S., Dsa, S., & Reinhart‐King, C. A. (2026) · Cancer and Metastasis Reviews · doi:10.1007/s10555-026-10345-y · Cited by 2 · see citing works
Watanabe, A., Jin, L., Ishihara, K., Iwabuchi, S., Ohno, K., Hashimoto, S., Asakage, T., Takahashi, K., Podyma‐Inoue, K. A., & Watabe, T. (2025) · Oncology Letters · doi:10.3892/ol.2025.15219 · Cited by 2 · see citing works
Ding, J., Shen, H., Ji, J., Li, J., Shi, Z., Wang, X., Li, B., Hou, Y., Min, W., Sun, C., et al. (2025) · Advanced Science · doi:10.1002/advs.202506718 · Cited by 1 · see citing works
Self-citationKalantari-Dehaghi, M., Rahimi-Tamandegani, H., & Emadi‐Baygi, M. (2025) · Cancer Informatics · doi:10.1177/11769351251352892 · Cited by 1 · see citing works
Thakur, K. K., Harsha, C., Sailo, B. L., Chinnathambi, A., Alharbi, S. A., Hegde, M., Monisha, J., Ma, Z., & Kunnumakkara, A. B. (2025) · Clinical & Translational Oncology · doi:10.1007/s12094-025-04081-y · Cited by 1 · see citing works
Alghzzawy, Z. M., Awwad, M. H., Elmaghraby, T. K., Hagag, S. A. E.-H., Kayed, A. E., & Ibrahim, D. S. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202500453 · Cited by 1 · see citing works
Wu, Z., Liu, H., & Wu, D. (2025) · Medical Oncology · doi:10.1007/s12032-025-03158-6 · Cited by 1 · see citing works
Negahi, A., Negahban, H., Sayad, S., Khosravi-Mashizi, M., Alijanpour, A., Rahmani, A., Shahbazi, A., Jayervand, F., Dastgheib, S. A., Yeganegi, M., et al. (2026) · Indian Journal of Surgical Oncology · doi:10.1007/s13193-025-02517-z · Cited by 1 · see citing works
El-Khazragy, N. N., Alsolami, A. A., Aref, A. M., Hassan, M. N. M., & Othman, M. S. (2026) · BMC Cancer · doi:10.1186/s12885-026-15574-6 · Cited by 1 · see citing works
Zhang, M., Zhang, Y., Shen, F., Yan, M., Cheng, P., Teng, J., Zou, M., Yao, W., Wang, Z., & Li, W. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1761280 · Cited by 1 · see citing works
Bertoldi, A., Calzoni, E., Cusumano, G., Alabed, H. B. R., Pellegrino, R. M., Emiliani, C., & Urbanelli, L. (2026) · Nanomaterials · doi:10.3390/nano16070394 · Cited by 1 · see citing works
Marczuk, K. M., Mamala, M. B., Szuster, E., & Murawski, M. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15082891 · Cited by 1 · see citing works
Perioperative local anesthetics as modulators of tumor progression and metastasis
Zheng, X., & Wei, H. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1793731 · Cited by 1 · see citing works
The application of federated learning in breast cancer diagnosis and treatment: a survey
Wu, H., & Ghorbian, M. (2026) · Artificial Intelligence Review · doi:10.1007/s10462-026-11574-x · Cited by 1 · see citing works
Wang, Z., Zhang, F., Bingshuai, 周. Z., Cui, Y., Sun, L., Won, M., Xu, L., Sun, J., Wang, L., Kim, J. S., et al. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124299 · Cited by 1 · see citing works
Peptides as integrative modulators for clinical prognosis and targeted therapy in pancreatic cancer
Yadav, B., Kollur, S. P., Ali, A., Arora, P., Gupta, A., Saranraj, P., Upadhye, V. J., & Singh, P. (2026) · Discover Oncology · doi:10.1007/s12672-026-05130-w · Cited by 1 · see citing works
Ogundele, A. V., Nongthombam, G. S., Nwagu, A. D., Silva, H. H., & Fabiyi, O. A. (2026) · Molecules · doi:10.3390/molecules31132398 · Cited by 1 · see citing works
SHADE: A Multilevel Bayesian Approach to Modeling Directional Spatial Associations in TissuesPreprint
Eliason, J., Peruzzi, M., & Rao, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.24.661393
Advances in application of single-cell sequencing in colorectal cancer
Gong, T., & Liu, Y.-K. (2025) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v33.i10.771
Liu, N.-T., Yang, S. D., Chang, Y., Yu, J.-H., Chen, S.-F., Lin, Y.-S., & Lin, Y.-C. (2025) · Journal of Dental Sciences · doi:10.1016/j.jds.2025.10.010
Li, X., Fu, X., Dai, X., Sun, H., Wang, M., Deng, Y., Zhang, H., & Lin, Y. (2025) · Research Square · doi:10.21203/rs.3.rs-8127673/v1
Targeting epithelial-to-mesenchymal transition of cancer cells by sulfated glycans from marine algae
Malyarenko, O. S., Kravchenko, A. O., Druzhinina, V. R., Gundamaraju, R., Ermakova, S. P., & Ambati, R. R. (2026) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2026.100172
Богуш, Т. А., Grishanina, A. N., Богуш, Е. А., Scherbakov, A. M., Ogurechnikova, E. A., Равчеева, А. Б., Kapura-Brekhovskikh, E. M., & Melnikov, M. Y. (2025) · Lomonosov chemistry journal · doi:10.55959/msu0579-9384-2-2026-67-1-35-42
Büyükkılıç, Ş., Alotaibi, H., Georgakilas, A. G., & Pavlopoulou, A. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl48085
Novruzov, M., Mammadova, M., Raval, K. Y., Khan, W. U., & Shiraliyeva, U. (2026) · JMIRx Bio · doi:10.2196/91528
Богуш, Т. А., Grishanina, A. N., Bogush, E. A., Scherbakov, A. M., Ogurechnikova, E. A., Равчеева, А. Б., Kapura-Brekhovskikh, E. M., & Melnikov, M. Y. (2026) · Moscow University Chemistry Bulletin · doi:10.3103/s0027131425700476
Zheng, F., Lan, Z., Chen, H., & Ma, M. (2026) · Biomedicines · doi:10.3390/biomedicines14040868
Dissecting molecular heterogeneity in primary gastric cancer by IGFBP7-related analysis
Liu, Y.-J., Ye, Q., Zhang, W., Li, J.-P., Ji, L.-P., Liu, S.-L., & Zou, X. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08110-4
Lv, J., Yang, P., Zheng, W., Huang, D., Feng, Y., Huang, B., Mu, R., Dai, S., Li, P., Yang, P., et al. (2026) · BMC Medical Imaging · doi:10.1186/s12880-026-02342-y
Hemozoin-induced immunomodulation and prostate carcinogenesis: mechanisms and implications
Akinyosoye, A. D., Rotimi, S. O., Olasehinde, O. E., Oduselu, G. O., Oranusi, S. U., & Akinnola, O. O. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1786079
Jiang, P., Fan, Z., Wang, Y., Li, J., Kang, X., Feng, L. L., & Chen, P. (2026) · Advanced Functional Materials · doi:10.1002/adfm.75631
Résistance à l’immunothérapie dans le CBNPC : état des connaissances actuelles
Ancel, J., Dewolf, M., Nawrocki‐Raby, B., Durlach, A., Dalstein, V., Cortot, A. B., Dormoy, V., Gilles, C., Polette, M., & Deslée, G. (2026) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2026.04.002
Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma
Wang, F., Ge, B., Li, M., Xia, X., Zhang, F., & Xu, P. (2026) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.70222
Pathogenetic features of sarcomatoid carcinoma
Freynd, G. G., & Chub, I. S. (2026) · Perm Medical Journal · doi:10.17816/pmj4325-14
Rahman, M. A., Bellah, S. F., & Rahman, M. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.22.727338
Yang, J., Qiu, Z., Song, W., Liu, X., Ouyang, T., Shu, J., Wang, J., & Yang, Y. (2026) · Molecules · doi:10.3390/molecules31111901
Kohwi, Y., Vayn, Y., Grange, M., Ho, B., Heditsian, D. M., & Kohwi-shigematsu, T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.29.728584
Acevedo‐Acevedo, S., Ackerman, H. D., Rubio, V. Y., Hackel, N. R., Carr, C. L., Miranda, K., Baldwin, J. R., Reiser, M. A., Lockhart, J. H., Lui, A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.14.731898
Fu, Y., Wang, Y., Cai, Z., Huang, S., & Chen, J. (2026) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-026-01226-3
Sima, J., Ren, X., Chen, Y., Fan, J., Li, X., Li, K., Yang, Q., & Xie, Y. (2026) · Microbial Pathogenesis · doi:10.1016/j.micpath.2026.108746
Self-citationChen, D., Zhou, M., Xu, H., Li, R., Quanhong, X., & Sun, Y. (2026) · Research Square · doi:10.21203/rs.3.rs-9474770/v1
Role of epithelial-mesenchymal transition (EMT) in malignancies: current status and future prospects
Meftahpour, V., Dakal, T. C., Maciaczyk, J., Sharma, A., & Schmidt‐Wolf, I. G. H. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02881-4
Toxicity and Safety Assessment of Heterocyclic Anticancer Agents
Kesharwani, G., Mishra, A., Mishra, P., & Dewangan, S. (2026) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898817084126010012
Yang, C., Wen, Z., Huang, X., Yang, Y., Zhang, J., Li, Y., Wang, Y., & Zhong, Y. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12620-1
Chaperone-mediated autophagy as a regulator of hallmarks of cancer
Tiwari, M., Sharma, L. K., Chakravarti, B., Singh, V. K., Singh, S., & Shrivastava, A. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1927298
Hope is linked with more favorable tumor molecular signatures in serous ovarian cancer
Lutgendorf, S. K., Corn, B. W., Thaker, P. H., Goodheart, M. J., Penedo, F. J., Sood, A. K., & Cole, S. W. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.107001
Gopinadh, M., Sreehari, A. P., Sunish, K. S., Ashif, M., Sivan, U., & Daniel, S. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05836-2
Kabakov, A. E., Николаевна, М. О., Khokhlova, A. V., & Kaprin, A. D. (2026) · Cells · doi:10.3390/cells15201916
Khan, M. M. U., Khan, M. A., Azam, M., Afzal, M., & Alsahli, T. G. (2026) · Cells · doi:10.3390/cells15191812
Mishra, D., Agrawal, S., Malik, D., Pathak, E., & Mishra, R. (2026) · Clinical & Translational Oncology · doi:10.1007/s12094-026-04569-1
Yu, Z., Zhou, Z., Yin, N., & Ge, H. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1969337
Das, R., Yadav, S., Das, S., & Prajapati, S. (2026) · Pathology - Research and Practice · doi:10.1016/j.prp.2026.156710
Bakhle, K. M., Stephanou, A., Sahoo, S., Ntekas, I., Priebe, K., Rahman, M., Puri, R., Butler, S. D., Schweitzer, P. A., Chandraganti, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.17.759751
- Authors
- Xie, Y., Wang, X., Wang, W., Pu, N., & Liu, L.
- Affiliations
- Fudan University (CN)
- Corresponding author
- Liu, Liang
- Venue
- Journal of Translational Medicine
- Published
- 2025-04-02
- Volume
- 23
- Issue
- 1
- Pages
- 386-386
- ISSN
- 1479-5876 (ISSN-L)
- PMC
- PMC11963649
- OpenAlex
- W4409124165
- Cited by
- 80
- References
- 182
- Citations by year
- 2026: 51 · 2025: 29
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Translational Medicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82473459, 82303443, 82273382, 82272929, 82103409, 82103417)
- Program of Shanghai Academic Research Leader (23XD1400600)
- Science and Technology Commission of Shanghai Municipality (24SF1900300)
- Shanghai Municipal Health Commission (20244Y0023, 201940019)
- Beijing Xisike Clinical Oncology Research Foundation (Y-2022METAZQN-0003, Y-Gilead2024-PT-0002, Y-HR2022MS-0251, Y-HR2022QN-0085)
- Yunnan Provincial Science and Technology Department (202305AF150148)
- Shanghai Health and Medical Development Foundation
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- epithelial-mesenchymal transition, tumor microenvironment, tumor progression, tumor invasion, cell migration, exosomes, metabolic reprogramming, cancer-associated fibroblasts, soluble factors, cell-cell contact, therapeutic targeting
- MeSH terms
- Animals, Humans, Neoplasms, Epithelial-Mesenchymal Transition, Tumor Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review