Cited by 113Gut microbiota and healthInflammatory Bowel DiseaseGastrointestinal motility and disorders

Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke

Open access
Zhao, Liang, Xiong, Qiutang, Stary, Creed M., Mahgoub, Omer Kamal, Ye, Yingze, Gu, Lijuan, Xiong, Xiaoxing, Zhu, Shengmei·2018·Journal of Neuroinflammation

Abstract

Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in inflammatory bowel disease (IBD) and ischemic stroke. A more thorough understanding of the GBMAx could advance our knowledge about the pathophysiology of IBD and ischemic stroke and help to identify novel therapeutic targets via modulation of the GBMAx.

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  • Bacterial metabolites, also known as post-antibiotics or postbiotics, were treated with the bacterial product butyrate, an SCFA, in a study with SOD1G93A mice.

    “Bacterial metabolites, also known as post-antibiotics (121) or postbiotics, were treated with the bacterial product butyrate, an SCFA, in a study with SOD1G93A mice (50).”
  • Butyrate treatment improves intestinal integrity and microbial homeostasis, acting along the brain-gut axis, and was found to have beneficial effects in SOD1G93A mice in terms of extending the lifespan and delaying the progression of ALS.

    “Butyrate treatment improves intestinal integrity and microbial homeostasis, acting along the brain–gut axis, and was found to have beneficial effects in SOD1G93A mice in terms of extending the lifespan and delaying the progression of ALS.”

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Authors
Zhao, L., Xiong, Q., Stary, C. M., Mahgoub, O. K., Ye, Y., Gu, L., Xiong, X., & Zhu, S.
Affiliations
  • Renmin Hospital of Wuhan University (CN)
  • Stanford Medicine (US)
  • First Affiliated Hospital Zhejiang University (CN)
Corresponding author
  • Xiong, Xiaoxing
  • Zhu, Shengmei
Venue
Journal of Neuroinflammation
Published
2018-12
Volume
15
Issue
1
Pages
339-339
ISSN
1742-2094 (ISSN-L)
OpenAlex
W2904712122
Cited by
113
References
97
Citations by year
2026: 5 · 2025: 11 · 2024: 13 · 2023: 23 · 2022: 23 · 2021: 17 · 2020: 14 · 2019: 7
FWCI
0.93
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroinflammation (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81571147, 81870939)
  • American Heart Association (14FTF19970029)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut-brain-microbiota axis, inflammatory bowel disease, ischemic stroke, gut microbiota, neuroinflammation, two-way communication, therapeutic target
MeSH terms
Gastrointestinal Microbiome, Animals, Brain Ischemia, Humans, Inflammatory Bowel Diseases

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