Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke
Open accessAbstract
Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in inflammatory bowel disease (IBD) and ischemic stroke. A more thorough understanding of the GBMAx could advance our knowledge about the pathophysiology of IBD and ischemic stroke and help to identify novel therapeutic targets via modulation of the GBMAx.
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Bacterial metabolites, also known as post-antibiotics or postbiotics, were treated with the bacterial product butyrate, an SCFA, in a study with SOD1G93A mice.
“Bacterial metabolites, also known as post-antibiotics (121) or postbiotics, were treated with the bacterial product butyrate, an SCFA, in a study with SOD1G93A mice (50).”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [50]
Butyrate treatment improves intestinal integrity and microbial homeostasis, acting along the brain-gut axis, and was found to have beneficial effects in SOD1G93A mice in terms of extending the lifespan and delaying the progression of ALS.
“Butyrate treatment improves intestinal integrity and microbial homeostasis, acting along the brain–gut axis, and was found to have beneficial effects in SOD1G93A mice in terms of extending the lifespan and delaying the progression of ALS.”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [50]
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The Link between Brain Infarction and the Gut Microbiome —— Brain-Gut Axis
Li, Y., Lin, H., & Yu, T. (2022) · MEDS Clinical Medicine · doi:10.23977/medsc.2022.030508
Lai, H., & Shen, T. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-14023-5_14
- Authors
- Zhao, L., Xiong, Q., Stary, C. M., Mahgoub, O. K., Ye, Y., Gu, L., Xiong, X., & Zhu, S.
- Affiliations
- Renmin Hospital of Wuhan University (CN)
- Stanford Medicine (US)
- First Affiliated Hospital Zhejiang University (CN)
- Corresponding author
- Xiong, Xiaoxing
- Zhu, Shengmei
- Venue
- Journal of Neuroinflammation
- Published
- 2018-12
- Volume
- 15
- Issue
- 1
- Pages
- 339-339
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC6290529
- OpenAlex
- W2904712122
- Cited by
- 113
- References
- 97
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 13 · 2023: 23 · 2022: 23 · 2021: 17 · 2020: 14 · 2019: 7
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81571147, 81870939)
- American Heart Association (14FTF19970029)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut-brain-microbiota axis, inflammatory bowel disease, ischemic stroke, gut microbiota, neuroinflammation, two-way communication, therapeutic target
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain Ischemia, Humans, Inflammatory Bowel Diseases
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