Baduanjin exerts anti-diabetic and anti-depression effects by regulating the expression of mRNA, lncRNA, and circRNA
Open accessAbstract
BACKGROUND: Baduanjin, a traditional Chinese exercise therapy, has been widely used in China to treat type 2 diabetes (T2DM) with depression (DD). However, the underlying mechanism of Baduanjin in anti-DD is unclear. This study was focused on investigating the effects of Baduanjin on symptoms of depression and blood glucose in patients with DD and the underlying mechanism. METHODS: We performed a 12-week Baduanjin intervention on patients with DD and longitudinally compared the differential expressions of lncRNAs, circRNAs, and mRNAs between pre- (BDD) and post- (ADD) Baduanjin intervention in the same group. Subsequently, Gene Ontology (GO) and pathway analysis was performed to investigate the function of differentially expressed mRNAs. Finally, Reverse Transcription-Polymerase Chain Reaction (RT-PCR) was used to verify the sequencing result and the mRNA-lncRNA regulatory network was constructed. RESULTS: The blood glucose level, depression index scores, and PHQ9 scores of the patients with DD were significantly decreased (P < 0.05) after Baduanjin intervention. Compared to BDD, 207 lncRNAs, 266 circRNAs, and 610 differentially expressed mRNAs were identified in ADD. Kyoto Encyclopedia of Genes and Genomes (KEGG) and GO showed that the significantly dysregulated mRNAs were mainly involved in immune function and inflammatory response pathways, and various signaling pathways including IL-17 and TNF. In addition, we selected five differentially expressed lncRNAs to construct an lncRNA-mRNA regulatory network, and found a total of 1045 mRNAs associated with them. CONCLUSIONS: Our research is the first systematic profiling of mRNA, lncRNA, and circRNA in patients of ADD and BDD, and provides valuable insights in the potential mechanism of Baduanjin in anti-DD. Further, it was confirmed that Baduanjin is a safe and effective intervention for patients with DD because it can effectively ameliorate the symptoms of depression and blood glucose levels in patients with DD by regulating the dysregulated expression of lncRNA, mRNA, and circRNA.
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Baduanjin may ameliorate the symptoms of depression and alter blood glucose levels in depression patients via changes in circRNA expression.
“This study provided valuable insights into potential mechanisms by which Baduanjin may ameliorate the symptoms of depression and alter blood glucose levels in depression patients [94].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [94]
An et al. identified 266 differentially expressed circRNAs (170 down-regulated and 96 up-regulated) during a 12-week Baduanjin intervention.
“An et al. investigated molecular changes that occurred during a 12-week Baduanjin intervention and identified 266 differentially expressed circRNAs (170 down-regulated and 96 up-regulated).”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [94]
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- Authors
- An, T., He, Z.-C., Zhang, X.-Q., Li, J., Chen, A.-L., Tan, F., Chen, H.-D., Lv, B.-H., Lian, J., Gao, S.-H., & Jiang, G.-J.
- Affiliations
- Beijing University of Chinese Medicine (CN)
- Corresponding author
- Gao, Si-Hua
- ORCID
- Venue
- Chinese Medicine
- Published
- 2019-02-01
- Volume
- 14
- Issue
- 1
- Pages
- 3-3
- ISSN
- 1749-8546 (ISSN-L)
- PMC
- PMC6359771
- OpenAlex
- W2923052285
- Cited by
- 63
- References
- 40
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 11 · 2021: 14 · 2020: 10 · 2019: 5
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Chinese Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81774171)
- Tangshan Science and Technology Innovation Team Training Program (18130219A)
- Beijing Municipal Commission of Education (1000062520025)
- Collaborative innovation project of Chaoyang District in Beijing (CYXC1719)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- Baduanjin, type 2 diabetes, depression, blood glucose, long non-coding RNA, circular RNA, mRNA expression profiling, lncRNA-mRNA regulatory network, inflammation, IL-17, TNF signaling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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