A meta-analysis of chemokines in major depression
Open accessAbstract
Chemokines are increasingly recognised as playing a role in depression. Here we meta-analyse the data on concentrations of all chemokines in patients diagnosed with a major depression versus healthy controls. We included studies which utilised Diagnostic and Statistical Manual (DSM)-IV diagnostic criteria for major depression, participants free from major medical conditions, studies with healthy controls, and unstimulated measurements of chemokines. We only included chemokines which had ≥3 studies performed. Two chemokines and 15 studies in total met criteria for this meta-analysis; 8 for Monocyte Chemotactic Protein (MCP)-1/CCL2 (n=747), and 7 for Interleukin (IL)-8/CXCL8 (n=560). There were significantly higher concentrations of CCL2/MCP-1 in depressed subjects compared with control subjects - overall mean difference of 36.43pg/mL (95% CI: 2.43 to 70.42). There was significant heterogeneity across these studies (I2=98.5%). The estimates of mean difference between the control and depression groups did not remain significant when the trim-and-fill procedure was used to correct for publication bias. There was no significant difference in concentrations of IL-8/CXCL8 in depressed subjects compared with control subjects. Significant heterogeneity was found across these studies (I2=96.7%). The estimates of mean difference between the control and depression groups remained non-significant when the trim-and-fill procedure was used to correct for publication bias. This meta-analysis reports significantly heterogeneity in this field among studies. There are higher concentrations of the chemokine MCP-1/CCL2 in depressed subjects compared with control subjects, and no differences for IL-8/CXCL8. More high quality research and consistent methodologies are needed in this important area of enquiry.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Meta-analytic evidence suggests that IL-6, TNF-α, IL-10, soluble IL-2 receptor, CCL-2, IL-12, IL-13, IL-18, IL-1 receptor antagonist, soluble TNF receptor 2, and C-reactive protein levels are elevated in individuals with major depressive disorder compared to healthy controls.
“Meta-analytic evidence suggests that IL-6, TNF-α, IL-10, the soluble IL-2 receptor, CCL-2, IL-12, IL-13, IL-18, the IL-1 receptor antagonist, the soluble TNF receptor 2, and C-reactive protein levels are elevated in individuals with MDD compared to healthy controls [33,6,34].”
Depressed patients have higher cytokine levels than healthy controls, with consistent literature findings for IL-1β, IL-6, IL-10, CCL2, TNF-α, and TGF-β.
“Depressed patients are characterized by higher levels of cytokines when compared to healthy controls with consistent results in literature when considering IL-1β, IL-6, IL-10, CCL2, TNF-α, and transforming growth factor-β (TGF-β) (Enache et al., 2019, Eyre et al., 2016, Howren et al., 2009, Kohler et al., 2017, Poletti et al., 2020b).”
From Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up (2021) · cites this paper as Eyre et al., 2016
IL-8 was reported to have no significant changes in MDD by a study of 560 subjects, but it was found to be increased in MDD in a later study of 3788 subjects.
“IL-8 was reported to have no significant changes in MDD by a study of 560 subjects37, but it was found to be increased in MDD in a later study of 3788 subjects38.”
From Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses (2019) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648 · see citing works
Murray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
Murphy, P. M., Baggiolini, M., Charo, I. F., Hébert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., & Power, C. A. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01439-x · Cited by 1,817 · see citing works
Modelling schizophrenia using human induced pluripotent stem cells
Brennand, K. J., Simone, A., Jou, J., Gelboin-Burkhart, C., Tran, N., Sangar, S., Li, Y., Mu, Y., Chen, G., Yu, D., et al. (2011) · Nature · doi:10.1038/nature09915 · Cited by 1,375 · see citing works
Haapakoski, R., Mathieu, J., Ebmeier, K. P., Alenius, H., & Kivimäki, M. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.06.001 · Cited by 1,129 · see citing works
Innate immunity in the central nervous system
Ransohoff, R. M., & Brown, M. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58644 · Cited by 1,034 · see citing works
Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000 · see citing works
The vascular depression hypothesis: mechanisms linking vascular disease with depression
Taylor, W. D., Aizenstein, H. J., & Alexopoulos, G. S. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.20 · Cited by 923 · see citing works
Hannestad, J., DellaGioia, N., & Bloch, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.132 · Cited by 914 · see citing works
Evidence for a cytokine model of cognitive function
McAfoose, J., & Baune, B. T. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.005 · Cited by 760 · see citing works
Self-citationTesting the Newcastle Ottawa Scale showed low reliability between individual reviewers
Hartling, L., Milne, A., Hamm, M. P., Vandermeer, B., Ansari, M., Tsertsvadze, A., & Dryden, D. M. (2013) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2013.03.003 · Cited by 436 · see citing works
O’Brien, S. M., Scully, P., Fitzgerald, P., Scott, L. V., & Dinan, T. G. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.05.013 · Cited by 355 · see citing works
Domenici, E., Willé, D. R., Tozzi, F., Prokopenko, I., Miller, S. L., McKeown, A., Brittain, C. F., Rujescu, D., Giegling, I., Turck, C. W., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009166 · Cited by 347 · see citing works
Chemokines: a new class of neuromodulator?
Rostène, W. H., Kitabgi, P., & Parsadaniantz, S. M. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2255 · Cited by 321 · see citing works
Neuroplastic changes in depression: A role for the immune system
Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319 · see citing works
Self-citationPro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
Sutcigil, L., Oktenli, C., Musabak, U., Bozkurt, A., Cansever, A., Uzun, O., Sanisoglu, S. Y., Yesilova, Z., Ozmenler, N., Ozsahin, A., et al. (2007) · Clinical and Developmental Immunology · doi:10.1155/2007/76396 · Cited by 315 · see citing works
Wong, M.-L., Dong, C., Maestre-Mesa, J., & Licinio, J. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.59 · Cited by 295 · see citing works
Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder
Eller, T., Vasar, V., Shlik, J., & Maron, E. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.015 · Cited by 290 · see citing works
A detailed examination of cytokine abnormalities in Major Depressive Disorder
Simon, N. M., McNamara, K., Chow, C. W., Maser, R. S., Papakostas, G. I., Pollack, M. H., Nierenberg, A. A., Fava, M., & Wong, K. K. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.06.004 · Cited by 286 · see citing works
Inflammatory Markers and Sleep Disturbance in Major Depression
Motivala, S. J., Sarfatti, A., Olmos, L., & Irwin, M. R. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000149259.72488.09 · Cited by 286 · see citing works
Stuart, M. J., & Baune, B. T. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.001 · Cited by 258 · see citing works
Self-citationDepression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity
Stuart, M. J., & Baune, B. T. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.10.001 · Cited by 257 · see citing works
Self-citationCurrent status of chemokines in the adult CNS
Goazigo, A. R.-L., Steenwinckel, J. V., Rostène, W. H., & Parsadaniantz, S. M. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.02.001 · Cited by 237 · see citing works
Song, C., Lin, A., Bonaccorso, S., Heide, C., Verkerk, R., Kenis, G., Bosmans, E., Scharpe, S., Whelan, A., Cosyns, P., et al. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00025-1 · Cited by 232 · see citing works
Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain
Tran, P. B., Banisadr, G., Ren, D., Chenn, A., & Miller, R. J. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21229 · Cited by 229 · see citing works
Rethorst, C. D., Toups, M. S. P., GREER, T. L., Nakonezny, P. A., Carmody, T. J., Grannemann, B. D., Huebinger, R. M., Barber, R. C., & Trivedi, M. H. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.125 · Cited by 211 · see citing works
Cazareth, J., Guyon, A., Heurteaux, C., Chabry, J., & Petit-Paitel, A. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-132 · Cited by 206 · see citing works
Suarez, E. C., Krishnan, R. R., & Lewis, J. G. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000035719.79068.2b · Cited by 199 · see citing works
CCL2/MCP-1 modulation of microglial activation and proliferation
Hinojosa, A. E., García‐Bueno, B., Leza, J. C., & Madrigal, J. L. M. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-77 · Cited by 195 · see citing works
Suarez, E. C., Lewis, J. G., Krishnan, R. R., & Young, K. H. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.01.002 · Cited by 185 · see citing works
Baune, B., Smith, E., Reppermund, S., Air, T., Samaras, K., Lux, O., Brodaty, H., Sachdev, P. S., & Trollor, J. N. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.02.006 · Cited by 184 · see citing works
Self-citationSystematic Review of the Neurobiological Relevance of Chemokines to Psychiatric Disorders
Stuart, M. J., Singhal, G., & Baune, B. T. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00357 · Cited by 163 · see citing works
Self-citationChemokines and neuromodulation
Parsadaniantz, S. M., & Rostène, W. H. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.04.022 · Cited by 162 · see citing works
Giovannelli, A., Limatola, C., Ragozzino, D., Mileo, A. M., Ruggieri, A., Ciotti, M. T., Mercanti, D., Santoni, A., & Eusebi, F. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00192-1 · Cited by 150 · see citing works
Banisadr, G., Gosselin, R., Méchighel, P., Rostène, W. H., Kitabgi, P., & Parsadaniantz, S. M. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20729 · Cited by 135 · see citing works
Rostène, W. H., Dansereau, M., Godefroy, D., Steenwinckel, J. V., Goazigo, A. R.-L., Parsadaniantz, S. M., Apartis, E., Hunot, S., Beaudet, N., & Sarret, P. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07371.x · Cited by 133 · see citing works
Pro-inflammatory biomakers in depression: Treatment with venlafaxine
Piletz, J. E., Halaris, A. E., Iqbal, O., Hoppensteadt, D., Fareed, J., Zhu, H., Sinacore, J. M., & DeVane, C. L. (2009) · The World Journal of Biological Psychiatry · doi:10.3109/15622970802573246 · Cited by 130 · see citing works
de Carvalho, L. A., Bergink, V., Sumaski, L., Wijkhuijs, J. M., Hoogendijk, W. J. G., Birkenhäger, T. K., & Drexhage, H. A. (2014) · Translational Psychiatry · doi:10.1038/tp.2013.118 · Cited by 127 · see citing works
A critical review of the efficacy of non-steroidal anti-inflammatory drugs in depression
Eyre, H. A., Air, T., Proctor, S. J., Rositano, S., & Baune, B. T. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.10.003 · Cited by 121 · see citing works
Self-citationLecithin for dementia and cognitive impairment
Higgins, J. P. T., & Flicker, L. A. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001015 · Cited by 117 · see citing works
Subileau, E. A., Rezaie, P., Davies, H. A., Colyer, F. M., Greenwood, J., Male, D. K., & Romero, I. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318197eca7 · Cited by 111 · see citing works
Cuthbert, B. N. (2014) · Psychophysiology · doi:10.1111/psyp.12342 · Cited by 104 · see citing works
Serum chemokine levels in major depressive disorder
Lehto, S. M., Niskanen, L., Herzig, K.-H., Tolmunen, T., Huotari, A., Viinamäki, H., Koivumaa-Honkanen, H., Honkalampi, K., Ruotsalainen, H., & Hintikka, J. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.007 · Cited by 100 · see citing works
Chemokines and chemokine receptors: New actors in neuroendocrine regulations
Rostène, W. H., Guyon, A., Kular, L., Godefroy, D., Barbieri, F., Bajetto, A., Banisadr, G., Callewaere, C., Conductier, G., & Rovère, C. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.07.001 · Cited by 98 · see citing works
Lu, S., Peng, H., Wang, L., Seewoobudul, V., Zhang, Y., Gao, W., Wu, W., Liao, M., Wang, M., Tang, H., et al. (2013) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2013.03.026 · Cited by 97 · see citing works
Peripheral Chemokine Levels in Women with Recurrent Major Depression with Suicidal Ideation
Grassi-Oliveira, R., Brieztke, E., Teixeira, A., Pezzi, J. C., Zanini, M., Lopes, R. P., & Bauer, M. E. (2012) · Revista Brasileira de Psiquiatria · doi:10.1590/s1516-44462012000100013 · Cited by 91 · see citing works
Chemokines direct neural progenitor cell migration following striatal cell loss
Gordon, R. J., McGregor, A. L., & Connor, B. J. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.03.001 · Cited by 90 · see citing works
Temporal Regulation of Cytokines by the Circadian Clock
Nakao, A. (2014) · Journal of Immunology Research · doi:10.1155/2014/614529 · Cited by 79 · see citing works
Pro-inflammatory cytokine associated with somatic and pain symptoms in depression
Bai, Y., Chiou, W.-F., Su, T., Li, C., & Chen, M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.019 · Cited by 79 · see citing works
Marsland, A. L., Sathanoori, R., Muldoon, M. F., & Manuck, S. B. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.07.006 · Cited by 55 · see citing works
Jónsdóttir, I. H., Hägg, D. A., Glise, K., & Ekman, R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007659 · Cited by 54 · see citing works
Hocaoğlu, Ç., Kural, B. V., Aliyazıcıoğlu, R., Değer, O., & CENGİZ, S. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9323-9 · Cited by 51 · see citing works
Holtzheimer, P. E., Meeks, T. W., Kelley, M. E., Mufti, M., Young, R., McWhorter, K., Vito, N., Chismar, R., Quinn, S., Dey, S., et al. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1951 · Cited by 50 · see citing works
Exercise-induced release of cytokines in patients with major depressive disorder
Hallberg, L., Janelidze, S., Engström, G., Wisén, A. G. M., Westrin, Å., & Brundin, L. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.02.133 · Cited by 49 · see citing works
Weiss, N., Deboux, C., Chaverot, N., Miller, F., Evercooren, A. B., Couraud, P., & Cazaubon, S. M. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.03.009 · Cited by 48 · see citing works
Involvement of fractalkine and macrophage inflammatory protein‐1 alpha in moderate‐severe depression
Merendino, R. A., Di Pasquale, G., De Luca, F., Di Pasquale, L., Ferlazzo, E., Martino, G., Palumbo, M. C., Morabito, F., & Gangemi, S. (2004) · Mediators of Inflammation · doi:10.1080/09511920410001713484 · Cited by 47 · see citing works
Jaehne, E. J., & Baune, B. T. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.006 · Cited by 45 · see citing works
Self-citationMagalhaes, P. V. S., Jansen, K., Stertz, L., Ferrari, P., Pinheiro, R. T., da Silva, R. A., & Kapczinski, F. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.10.007 · Cited by 33 · see citing works
Licinio, J. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.3 · Cited by 31 · see citing works
Harrison, E. L., Jaehne, E. J., Jawahar, M. C., Corrigan, F., & Baune, B. T. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.036 · Cited by 29 · see citing works
Self-citationKelland, E. E., Gilmore, W., Weiner, L. P., & Lund, B. T. (2011) · Glia · doi:10.1002/glia.21230 · Cited by 27 · see citing works
Simultaneous measurement of 23 plasma cytokines in late-life depression
Lee, K. S., Chung, J. H., Lee, K. H., Shin, M., Oh, B. H., Lee, S. H., & Hong, C. H. (2009) · Neurological Sciences · doi:10.1007/s10072-009-0091-1 · Cited by 25 · see citing works
Podlipný, J., Hess, Z., Vrzalová, J., Rosolová, H., Beran, J., & Petrlová, B. (2010) · Physiological Research · doi:10.33549/physiolres.931695 · Cited by 19 · see citing works
Fluoxetine treatment for major depression decreases the plasma levels of cytokines
Shen, Y., Lu, P., Wei, L., Cai, L., Hu, X., & Chen, W. (2010) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb10.1097 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Baune BT Smith E Reppermund S Air T Samaras K Lux O Brodaty H Sachdev P Trollor JN 2012b Inflammatory biomarkers predict depressive, but not anxiety symptoms during aging: the prospective Sydney Memory and Aging Study Psychoneuroendocrinology 22406002
Cited by
Sorted by citations
Mazza, M. G., Palladini, M., De Lorenzo, R., Magnaghi, C., Poletti, S., Furlan, R., Ciceri, F., Rovere-Querini, P., & Benedetti, F. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.02.021 · Cited by 513 · see citing works
“Depressed patients are characterized by higher levels of cytokines when compared to healthy controls with consistent results in literature when considering IL-1β, IL6, IL-10, CCL2, TNF-α, and transforming growth factor-β (TGF-β) (Enache et al., 2019; Eyre et al., 2016; Howren et al., 2009; Kohler et al., 2017; Poletti…”
Köhler, C. A., Freitas, T. H., Stubbs, B., Maes, M., Solmi, M., Veronese, N., de Andrade, N. Q., Morris, G., Fernandes, B. S., Brunoni, A. R., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0632-1 · Cited by 449 · see citing works
Yuan, N., Chen, Y., Xia, Y., Dai, J., & Liu, C. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0570-y · Cited by 428 · see citing works
Biomarkers for depression: recent insights, current challenges and future prospects
Strawbridge, R., Young, A. H., & Cleare, A. J. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s114542 · Cited by 415 · see citing works
Leighton, S. P., Nerurkar, L., Krishnadas, R., Johnman, C., Graham, G. J., & Cavanagh, J. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.205 · Cited by 291 · see citing works
Peripheral Markers of Depression
Nobis, A., Zalewski, D., & Waszkiewicz, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123793 · Cited by 197 · see citing works
Biomarkers of post-covid depression
Lorkiewicz, P., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184142 · Cited by 102 · see citing works
Chemokine alterations in bipolar disorder: A systematic review and meta-analysis
Misiak, B., Bartoli, F., Carrà, G., Małecka, M., Samochowiec, J., Jarosz, K., Banik, A., & Stańczykiewicz, B. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.04.013 · Cited by 102 · see citing works
Costi, S., Morris, L. S., Collins, A., Fernandez, N. F., Patel, M., Xie, H., Kim-Schulze, S., Stern, E. R., Collins, K. A., Cathomas, F., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01668-1 · Cited by 87 · see citing works
An, T., He, Z.-C., Zhang, X.-Q., Li, J., Chen, A.-L., Tan, F., Chen, H.-D., Lv, B.-H., Lian, J., Gao, S.-H., et al. (2019) · Chinese Medicine · doi:10.1186/s13020-019-0225-1 · Cited by 63 · see citing works
Targeting the CCL2-CCR2 Axis in Depressive Disorders
Curzytek, K., & Leśkiewicz, M. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00280-w · Cited by 47 · see citing works
Chemokine profile in women with moderate to severe anxiety and depression during pregnancy
Camacho-Arroyo, I., Flores-Ramos, M., Mancilla-Herrera, I., Cruz, F. M. C., Hernández-Ruiz, J., Diaz, G. P., Labonne, B. F., del Pilar Meza-Rodríguez, M., & Gelman, P. L. (2021) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-021-04225-2 · Cited by 41 · see citing works
Serum levels of chemokines in adolescents with major depression treated with fluoxetine.
Peña, F. R. D. L., Cruz-Fuentes, C., Palacios, L., Girón-Pérez, M. I., Medina-Rivero, E., Ponce-Regalado, M. D., Alvarez-Herrera, S., Pérez-Sánchez, G., Becerril-Villanueva, E., Maldonado-García, J. L., et al. (2020) · World Journal of Psychiatry · doi:10.5498/wjp.v10.i8.175 · Cited by 24 · see citing works
Neuroimmune Advance in Depressive Disorder
Zhao, G., & Liu, X. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-32-9271-0_4 · Cited by 20 · see citing works
- Authors
- Eyre, H. A., Air, T., Pradhan, A., Johnston, J., Lavretsky, H., Stuart, M. J., & Baune, B. T.
- Affiliations
- University of California, Los Angeles (US)
- The University of Adelaide (AU)
- The University of Queensland (AU)
- Corresponding author
- Baune, Bernhard T.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 68
- Pages
- 1-8
- ISSN
- 0278-5846 (ISSN-L)
- PMC
- PMC5536843
- OpenAlex
- W2280064070
- Cited by
- 188
- References
- 69
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 21 · 2023: 22 · 2022: 17 · 2021: 27 · 2020: 22 · 2019: 22 · 2018: 17 · 2017: 13 · 2016: 5
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ResearchOnline - JCU (James Cook University) (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (K24MH086481)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- chemokines, major depressive disorder, MCP-1, interleukin-8, publication bias, heterogeneity of study results
- MeSH terms
- Depressive Disorder, Major, Major Depressive Disorder, Humans, Chemokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
