The role of 5-HT receptors in depression

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120

Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report

Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015

Antidepressant effects of ketamine in depressed patients

Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766

The Neuroendocrinology of Stress: A Never Ending Story

Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,588

A Neurotrophic Model for Stress-Related Mood Disorders

Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375

The serotonin theory of depression: a systematic umbrella review of the evidence

Moncrieff, J., Cooper, R. E., Stockmann, T., Amendola, S., Hengartner, M. P., & Horowitz, M. A. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01661-0 · Cited by 960

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

Remes, O., Mendes, J. F., & Templeton, P. (2021) · Brain Sciences · doi:10.3390/brainsci11121633 · Cited by 482

The emerging role of exosomes in mental disorders

Saeedi, S., Israel, S. A., Nagy, C., & Turecki, G. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0459-9 · Cited by 373

Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala

Zheng, Z.-H., Tu, J., Li, X., Hua, Q., Liu, W.-Z., Liu, Y., Pan, B., Hu, P., & Zhang, W. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.11.007 · Cited by 319

Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms

Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232

Circadian regulation of depression: A role for serotonin

Daut, R. A., & Fonken, L. K. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.04.003 · Cited by 237

Pharmacological Treatment of Anxiety Disorders: The Role of the HPA Axis

Tafet, G. E., & Nemeroff, C. B. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00443 · Cited by 216

Possible role of exercise therapy on depression: Effector neurotransmitters as key players

Pahlavani, H. A. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114791 · Cited by 214

The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression

Pitsillou, E., Bresnehan, S. M., Kagarakis, E. A., Wijoyo, S. J., Liang, J., Hung, A., & Karagiannis, T. C. (2020) · Molecular Biology Reports · doi:10.1007/s11033-019-05129-3 · Cited by 206

Animal Models of Depression: What Can They Teach Us about the Human Disease?

Becker, M., Pinhasov, A., & Ornoy, A. (2021) · Diagnostics · doi:10.3390/diagnostics11010123 · Cited by 194

Short-chain fatty acids-producing probiotics: A novel source of psychobiotics

Cheng, Y., Liu, J., & Ling, Z. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1920884 · Cited by 156

Molecular aspects of depression: A review from neurobiology to treatment

Boas, G. R. V., de Lacerda, R. B., Paes, M. M., Gubert, P., Almeida, W. L. D. C., Rescia, V. C., Galdino, P. M., de Carvalho, A. A. V., & Oesterreich, S. A. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.02.024 · Cited by 140

An Insight into the Roles of Dietary Tryptophan and Its Metabolites in Intestinal Inflammation and Inflammatory Bowel Disease

Li, X., Zhang, Z., Zabed, H. M., Yun, J., Zhang, G., & Qi, X. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000461 · Cited by 129

Serotonergic system, cognition, and BPSD in Alzheimer’s disease

Chakraborty, S., Lennon, J. C., Malkaram, S. A., Zeng, Y., Fisher, D. W., & Dong, H. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.03.050 · Cited by 127

Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels

Sales, A. J., Crestani, C. C., Guimarães, F. S., & Joca, S. R. L. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.06.002 · Cited by 118

The receptor hypothesis and the pathogenesis of depression: Genetic bases and biological correlates

Wang, H., Wang, Z., & Chen, N. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105542 · Cited by 122

Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states

González-Arias, C., Sánchez-Ruiz, A., Esparza, J., Sánchez‐Puelles, C., Arancibia, L., Ramírez‐Franco, J., Gobbo, D., Kirchhoff, F., & Perea, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02269-8 · Cited by 124

The Role of Central Serotonin Neurons and 5-HT Heteroreceptor Complexes in the Pathophysiology of Depression: A Historical Perspective and Future Prospects

Borroto‐Escuela, D. O., Ambrogini, P., Chruścicka, B., Lindskog, M., Crespo‐Ramírez, M., Hernández-Mondragón, J. C., de la Mora, M. P., Schellekens, H., & Fuxé, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041927 · Cited by 114

Fifty years on: Serotonin and depression

Jauhar, S., Cowen, P. J., & Browning, M. D. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231161813 · Cited by 124

Akkermansia muciniphila in neuropsychiatric disorders: friend or foe?

Lei, W., Cheng, Y., Gao, J., Liu, X., Shao, L., Kong, Q., Zheng, N., Ling, Z., & Hu, W. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1224155 · Cited by 104

Dissecting functional phenotypes of microglia and macrophages in the rat brain after transient cerebral ischemia

Rajan, W. D., Wojtaś, B., Gielniewski, B., Gieryng, A., Zawadzka, M., & Kaminska, B. (2018) · Glia · doi:10.1002/glia.23536 · Cited by 97

Latest updates on the serotonergic system in depression and anxiety

Lin, J., Liu, W., Guan, J., Cui, J.-N., Shi, R.-L., Wang, L., Chen, D., & Liu, Y. (2023) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2023.1124112 · Cited by 88

The Relationship between DNA Methylation and Antidepressant Medications: A Systematic Review

Webb, L. M., Phillips, K. E., Ho, M. C., Veldic, M., & Blacker, C. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030826 · Cited by 84

Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons

Li, C., Meng, F., Garza, J. C., Liu, J., Lei, Y., Kirov, S. A., Guo, M., & Lu, X. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0649-0 · Cited by 83

Pathophysiological implications of neuroinflammation mediated HPA axis dysregulation in the prognosis of cancer and depression

Ahmad, M. H., Rizvi, M. M. A., Fatima, M., & Mondal, A. C. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111093 · Cited by 87

Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues

Song, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114647 · Cited by 88

Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation

Amorim, I. S., Kedia, S., Kouloulia, S., Simbriger, K., Gantois, I., Jafarnejad, S. M., Li, Y., Kampaite, A., Pooters, T., Romanò, N., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2673-17.2018 · Cited by 80

The Negative Affect of Protracted Opioid Abstinence: Progress and Perspectives From Rodent Models

Welsch, L., Bailly, J., Darcq, E., & Kieffer, B. L. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.027 · Cited by 84

Serotonin receptors in epilepsy: Novel treatment targets?

Sourbron, J., & Lagae, L. G. (2022) · Epilepsia Open · doi:10.1002/epi4.12580 · Cited by 81

Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale

Dag, U., Nwabudike, I., Kang, D., Gomes, M. A., Kim, J. S., Atanas, A. A., Bueno, E., Estrem, C., Pugliese, S. M., Wang, Z., et al. (2023) · Cell · doi:10.1016/j.cell.2023.04.023 · Cited by 96

Anxiety: An ignored aspect of Parkinson's disease lacking attention.

Khatri, D., Choudhary, M., Sood, A., & Singh, S. B. (2020) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2020.110776 · Cited by 65

Dietary polyphenols and neurogenesis: Molecular interactions and implication for brain ageing and cognition

Sarubbo, F., Moranta, D., & Pani, G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.011 · Cited by 77

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

Shen, C., Tang, Y., Gao, Y., Nie, K., Wang, H., Su, H., Wang, Z., Lu, F., Huang, W., & Dong, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.865376 · Cited by 83

Schizophrenia, Bipolar and Major Depressive Disorders: Overview of Clinical Features, Neurotransmitter Alterations, Pharmacological Interventions, and Impact of Oxidative Stress in the Disease Process

Mandal, P. K., Gaur, S., Roy, R. G., Samkaria, A., Ingole, R., & Goel, A. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00420 · Cited by 78

Antidepressant‐Like Effects and Cognitive Enhancement of Coadministration of Chaihu Shugan San and Fluoxetine: Dependent on the BDNF‐ERK‐CREB Signaling Pathway in the Hippocampus and Frontal Cortex

Yan, L., Xu, X., He, Z., Wang, S., Zhao, L., Qiu, J., Wang, D., Gong, Z., Qiu, X., & Huang, H. (2020) · BioMed Research International · doi:10.1155/2020/2794263 · Cited by 77

CA2 beyond social memory: Evidence for a fundamental role in hippocampal information processing

Lehr, A. B., Kumar, A., Tetzlaff, C., Hafting, T., Fyhn, M., & Stöber, T. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.020 · Cited by 84

A critical review on quercetin bioflavonoid and its derivatives: Scope, synthesis, and biological applications with future prospects

Udaya Rajesh, R., & Sangeetha, D. (2023) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2023.104881 · Cited by 81

Neuroinflammation in HIV-associated depression: evidence and future perspectives

Rakshasa-Loots, A. M., Whalley, H. C., Vera, J. H., & Cox, S. R. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01619-2 · Cited by 77

Stress-Related Dysfunction of Adult Hippocampal Neurogenesis—An Attempt for Understanding Resilience?

Leschik, J., Lutz, B., & Gentile, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147339 · Cited by 77

The role and mechanism of tryptophan – kynurenine metabolic pathway in depression

Gong, X., Chang, R., Zou, J., Tan, S., & Huang, Z. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0047 · Cited by 72

Structure, dynamics and lipid interactions of serotonin receptors: excitements and challenges

Sarkar, P., Mozumder, S., Bej, A., Mukherjee, S., Sengupta, J., & Chattopadhyay, A. (2020) · Biophysical Reviews · doi:10.1007/s12551-020-00772-8 · Cited by 68

Classical Psychedelics as Therapeutics in Psychiatry – Current Clinical Evidence and Potential Therapeutic Mechanisms in Substance Use and Mood Disorders

Mertens, L. J., & Preller, K. H. (2021) · Pharmacopsychiatry · doi:10.1055/a-1341-1907 · Cited by 65

Proximate causes and ultimate effects of common antidepressants, fluoxetine and venlafaxine, on fish behavior

Salahinejad, A., Attaran, A., Meuthen, D., Chivers, D. P., & Niyogi, S. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.150846 · Cited by 65

Risk of Suicidal Behaviors and Antidepressant Exposure Among Children and Adolescents: A Meta-Analysis of Observational Studies

Li, K., Zhou, G., Yan, X., Gu, J., Chen, Q., Xie, S., & Wu, J. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.880496 · Cited by 74

Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology

Park, B., Kebets, V., Larivière, S., Hettwer, M. D., Paquola, C., van Rooij, D., Buitelaar, J. K., Franke, B., Hoogman, M., Schmaal, L., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03963-z · Cited by 65

Antidepressants’ effects on testosterone and estrogens: What do we know?

Pavlidi, P., Kokras, N., & Dalla, C. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173998 · Cited by 62

Depression in multiple sclerosis: Is one approach for its management enough?

Jones, C. D., Motl, R. W., & Sandroff, B. M. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.102904 · Cited by 64

Major Depressive Disorder: Existing Hypotheses about Pathophysiological Mechanisms and New Genetic Findings

Kamran, M., Bibi, F., Rehman, A. U., & Morris, D. W. (2022) · Genes · doi:10.3390/genes13040646 · Cited by 65

Pathogenesis and treatment of depression: Role of diet in prevention and therapy

Mrozek, W., Socha, J., Sidorowicz, K., Skrok, A., Syrytczyk, A., Piątkowska‐Chmiel, I., & Herbet, M. (2023) · Nutrition · doi:10.1016/j.nut.2023.112143 · Cited by 65

Antidepressants Rescue Stress-Induced Disruption of Synaptic Plasticity via Serotonin Transporter–Independent Inhibition of L-Type Calcium Channels

Normann, C., Frase, S., Haug, V., von Wolff, G., Clark, K., Münzer, P., Dorner, A., Scholliers, J., Horn, M., Vo Van, T., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.008 · Cited by 56

The Role of Pharmacogenetics in Personalizing the Antidepressant and Anxiolytic Therapy

Radosavljević, M., Štrac, D. Š., Jančić, J., & Samardžić, J. (2023) · Genes · doi:10.3390/genes14051095 · Cited by 68

Hippocampal area CA2: an emerging modulatory gateway in the hippocampal circuit

Benoy, A., Dasgupta, A., & Sajikumar, S. (2018) · Experimental Brain Research · doi:10.1007/s00221-018-5187-5 · Cited by 60

Consumption of ultra-processed foods is associated with depression, mesocorticolimbic volume, and inflammation

Contreras‐Rodríguez, O., Reales-Moreno, M., Fernández‐Barrés, S., Cimpean, A., Arnoriaga‐Rodríguez, M., Puig, J., Biarnés, C., Motger‐Albertí, A., Cano, M., & Fernández‐Real, J. M. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.05.009 · Cited by 68

Lepidium meyenii Walp (Maca)‐derived extracellular vesicles ameliorate depression by promoting 5‐HT synthesis via the modulation of gut–brain axis

Hong, R., Luo, L., Wang, L., Hu, Z., Yin, Q., Li, M., Gu, B., Wang, B., Zhuang, T., Zhang, X., et al. (2023) · iMeta · doi:10.1002/imt2.116 · Cited by 57

Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer’s disease

Reddy, A. P., Yin, X., Sawant, N. A., & Reddy, P. H. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab054 · Cited by 54

Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota

Chung, J. Y., Jeong, J., & Song, J. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.588044 · Cited by 56

Gene regulatory mechanisms underlying sex differences in brain development and psychiatric disease

Manoli, D. S., & Tollkühn, J. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13564 · Cited by 58

Association between Diffusion Tensor Imaging, inflammation and immunological alterations in unipolar and bipolar depression: A review

Aronica, R., Enrico, P., Squarcina, L., Brambilla, P., & Delvecchio, G. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104922 · Cited by 56

CBD modulates DNA methylation in the prefrontal cortex and hippocampus of mice exposed to forced swim

Sales, A. J., Guimarães, F. S., & Joca, S. R. L. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112627 · Cited by 58

Down and High: Reflections Regarding Depression and Cannabis

Langlois, C. C., Potvin, S., Khullar, A., & Tourjman, V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.625158 · Cited by 51

Fluoxetine-induced recovery of serotonin and norepinephrine projections in a mouse model of post-stroke depression

Zahrai, A., Vahid-Ansari, F., Daigle, M., & Albert, P. R. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01008-9 · Cited by 54

Insulin modulates emotional behavior through a serotonin-dependent mechanism

Martin, H., Bullich, S., Martinat, M., Chataigner, M., Di Miceli, M., Simon, V., Clark, S., Butler, J., Schell, M., Chopra, S., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-022-01812-3 · Cited by 50

Neuroendocrine Stress System in Bipolar Disorder

Juruena, M. F., Cleare, A. J., & Young, A. H. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_184 · Cited by 52

Histamine and histamine receptors: Roles in major depressive disorder

Qian, H., Shu, C., Xiao, L., & Wang, G. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.825591 · Cited by 49

Brain Inflammation Connects Cognitive and Non-Cognitive Symptoms in Alzheimer’s Disease

Sellés, M. C., Oliveira, M. M., & Ferreira, S. T. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179925 · Cited by 51

Dietary inulin alleviated constipation induced depression and anxiety-like behaviors: Involvement of gut microbiota and microbial metabolite short-chain fatty acid

Zou, H. L., Gao, H., Liu, Y., Zhang, Z., Zhao, J. W., Wang, W., Ren, B., & Tan, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129420 · Cited by 50

5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology

Sharma, A., Smith, M. A., Muresanu, D. F., Dey, P. K., & Sharma, H. S. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.06.005 · Cited by 48

Antidepressant-like effects of a novel curcumin derivative J147: Involvement of 5-HT1A receptor

Lian, L., Xu, Y., Zhang, J., Yu, Y., Zhu, N., Guan, X., Huang, H., Chen, R., Chen, J., Shi, G., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.04.003 · Cited by 48

Folic acid ameliorates depression-like behaviour in a rat model of chronic unpredictable mild stress

Zhou, Y., Cong, Y., & Liu, H. (2020) · BMC Neuroscience · doi:10.1186/s12868-020-0551-3 · Cited by 47

Drug repurposing of selective serotonin reuptake inhibitors: Could these drugs help fight COVID-19 and save lives?

Pashaei, Y. (2021) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2021.03.010 · Cited by 48

Monoamine alterations in Alzheimer’s disease and their implications in comorbid neuropsychiatric symptoms

Saggu, S., Bai, A., Aida, M., Rehman, H., Pless, A., Ware, D., Deák, F., Jiao, K., & Wang, Q. (2024) · GeroScience · doi:10.1007/s11357-024-01359-x · Cited by 48

Recent Studies on Anti-Depressant Bioactive Substances in Selected Species from the Genera Hemerocallis and Gladiolus: A Systematic Review

Matraszek, R., Chwil, M., Terlecka, P., & Skoczylas, M. M. (2019) · Pharmaceuticals · doi:10.3390/ph12040172 · Cited by 50

Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder

Nisar, S., Bhat, A. A., Hashem, S., Syed, N., Yadav, S. K., Shahab Uddin, M. S., Fakhro, K. A., Bagga, P., Thompson, P. M., Reddy, R. D., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124503 · Cited by 48

The endocannabinoidome in neuropsychiatry: Opportunities and potential risks

Morris, G., Walder, K. R., Kloiber, S. M., Amminger, G. P., Berk, M., Bortolasci, C. C., Maes, M. H. J., Puri, B. K., & Carvalho, A. F. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105729 · Cited by 48

Gut Microbiome, Diet and Depression: Literature Review of Microbiological, Nutritional and Neuroscientific Aspects

Clerici, L., Bottari, D., & Bottari, B. (2025) · Current Nutrition Reports · doi:10.1007/s13668-025-00619-2 · Cited by 54

Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression

Hen-Shoval, D., Amar, S., Shbiro, L., Smoum, R., Haj, C. G., Mechoulam, R., Zalsman, G., Weller, A., & Shoval, G. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.05.027 · Cited by 44

Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD)

Govindula, A., Ranadive, N., Nampoothiri, M., Rao, C. M., Arora, D. S., & Mudgal, J. (2023) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-023-10064-z · Cited by 47

Recent advances in multitarget-directed ligands targeting G-protein-coupled receptors

Ma, H., Huang, B., & Zhang, Y. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.07.004 · Cited by 43

Efficacy, acceptability and side-effects of oral versus long-acting- injectables antipsychotics: Systematic review and network meta-analysis

Wang, D., Schneider-Thoma, J., Siafis, S., Qin, M., Wu, H., Zhu, Y., Davis, J. M., Priller, J., & Leucht, S. (2024) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2024.03.003 · Cited by 44

Advances in the characterization of negative affect caused by acute and protracted opioid withdrawal using animal models

Ozdemir, D., Allain, F., Kieffer, B. L., & Darcq, E. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109524 · Cited by 45

Antidepressants in Alzheimer’s Disease: A Focus on the Role of Mirtazapine

Correia, A. S., & Vale, N. (2021) · Pharmaceuticals · doi:10.3390/ph14090930 · Cited by 42

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S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains

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The microbiota–gut–brain axis in mental and neurodegenerative disorders: opportunities for prevention and intervention

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Serotonin in depression and Alzheimer’s disease: Focus on SSRI’s beneficial effects

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Role of 5-HT1A receptors in the ventral hippocampus in the regulation of anxiety- and panic-related defensive behaviors in rats

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The serotonergic system dysfunction in diabetes mellitus

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Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity

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Mood and microbes: a comprehensive review of intestinal microbiota’s impact on depression

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Neuromodulator regulation and emotions: insights from the crosstalk of cell signaling

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Complex Role of the Serotonin Receptors in Depression: Implications for Treatment

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Multiple serotonergic paths to antidepressant efficacy

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Depression and treatment response: dynamic interplay of signaling pathways and altered neural processes

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