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The role of 5-HT receptors in depression
Open accessAbstract
Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly prescribed drugs worldwide. In this review, we will discuss the evidence that links serotonin and serotonin receptors to the etiology of depression and the mechanisms underlying response to antidepressant treatment. We will then revisit the role of serotonin in three distinct hypotheses that have been proposed over the last several decades to explain the pathophysiology of depression: the monoamine, neurotrophic, and neurogenic hypotheses. Finally, we will discuss how recent studies into serotonin receptors have implicated specific neural circuitry in mediating the antidepressant response, with a focus being placed on the hippocampus.
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“the effects of serotonin receptors have been linked to antidepressant effects(Yohn et al., 2017)”
From Efficacy, acceptability and side-effects of oral versus long-acting- injectables antipsychotics: Systematic review and network meta-analysis (2024) · cites this paper as Yohn et al., 2017
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Cites
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,588
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889
Evidence-based health policy—lessons from the Global Burden of Disease Study
Murray, C. J. L., & Lopez, A. D. (1996) · Science · doi:10.1126/science.274.5288.740 · Cited by 2,178
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109
ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
Ming, G., & Song, H. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.051804.101459 · Cited by 1,891
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567
Bunney, W. E., Hippius, H., Laakmann, G., & Schmauß, M. (1990) · Springer eBooks · doi:10.1007/978-3-642-74034-3 · Cited by 1,523
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
Autry, A. E., & Monteggia, L. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005108 · Cited by 1,390
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
Chen, Z.-Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C.-J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., et al. (2006) · Science · doi:10.1126/science.1129663 · Cited by 1,340
Amygdala circuitry mediating reversible and bidirectional control of anxiety
Tye, K. M., Prakash, R., Kim, S.-Y., Fenno, L. E., Grosenick, L., Zarabi, H., Thompson, K. R., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2011) · Nature · doi:10.1038/nature09820 · Cited by 1,289
David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267
Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication
Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., & Young, L. T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01083-6 · Cited by 1,164
Mental health: a world of depression
Smith, K. (2014) · Nature · doi:10.1038/515180a · Cited by 1,148
Adult brain neurogenesis and psychiatry: a novel theory of depression
Jacobs, B. L., van Praag, H., & Gage, F. H. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000712 · Cited by 964
Pharmacological profile of antidepressants and related compounds at human monoamine transporters
Tatsumi, M., Groshan, K., Blakely, R. D., & Richelson, E. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01393-9 · Cited by 939
The GABAergic deficit hypothesis of major depressive disorder
Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult
Gross, C. T., Zhuang, X., Stark, K. L., Ramboz, S., Oosting, R. S., Kirby, L. G., Santarelli, L., Beck, S. G., & Hen, R. (2002) · Nature · doi:10.1038/416396a · Cited by 906
VEGF links hippocampal activity with neurogenesis, learning and memory
Cao, L., Jiao, X., Zuzga, D. S., Liu, Y., Fong, D. M., Young, D., & During, M. J. (2004) · Nature Genetics · doi:10.1038/ng1395 · Cited by 850
Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)
Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00169-4 · Cited by 841
Serotonin receptor 1A knockout: An animal model of anxiety-related disorder
Ramboz, S., Oosting, R. S., Amara, D. A., Kung, H. F., Blier, P., Mendelsohn, M. M., Mann, J. J., Brunner, D., & Hen, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14476 · Cited by 831
Molecular biology of 5-HT receptors
Hannon, J., & Hoyer, D. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.020 · Cited by 815
Interaction between BDNF and Serotonin: Role in Mood Disorders
Martinowich, K., & Lu, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301571 · Cited by 793
Sairanen, M., Lucas, G., Ernfors, P., Castrén, M., & Castrén, E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3741-04.2005 · Cited by 763
Lemonde, S., Turecki, G., Bakish, D., Du, L., Hrdina, P. D., Bown, C. D., Sequeira, A., Kushwaha, N., Morris, S. J., Basak, A., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08788.2003 · Cited by 738
The STAR*D project results: A comprehensive review of findings
Warden, D., Rush, A. J., Trivedi, M. H., Fava, M., & Wisniewski, S. R. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0061-3 · Cited by 727
Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus
Kheirbek, M. A., Drew, L. J., Burghardt, N. S., Costantini, D. O., Tannenholz, L., Ahmari, S. E., Zeng, H., Fenton, A. A., & Hen, R. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.038 · Cited by 713
Monoamine Metabolites in CSF and Suicidal Behavior
Träskman, L. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780310031002 · Cited by 692
How widespread is adult neurogenesis in mammals?
Gould, E. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2147 · Cited by 687
Essential role of brain-derived neurotrophic factor in adult hippocampal function
Monteggia, L. M., Barrot, M., Powell, C. M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R. W., & Nestler, E. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402141101 · Cited by 685
Monoamine neurocircuitry in depression and strategies for new treatments
Hamon, M., & Blier, P. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.04.009 · Cited by 674
Role of neurotrophic factors in depression
CASTREN, E., VOIKAR, V, & RANTAMAKI, T. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.08.009 · Cited by 667
TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
Li, Y., Luikart, B. W., Birnbaum, S., Chen, J., Kwon, C.-H., Kernie, S. G., Bassel-Duby, R., & Parada, L. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.023 · Cited by 634
Comorbid depression and anxiety spectrum disorders
Gorman, J. M. (1996) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1996)4:4 · Cited by 629
Karege, F., Vaudan, G., Schwald, M., Perroud, N., & La Harpe, R. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.020 · Cited by 600
Wang, J.-W., David, D. J., Monckton, J. E., Battaglia, F., & Hen, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3632-07.2008 · Cited by 550
Opioid receptors: Distinct roles in mood disorders
Lutz, P.-E., & Kieffer, B. L. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.11.002 · Cited by 542
Mechanism of action of serotonin selective reuptake inhibitors
Stahl, S. M. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00221-3 · Cited by 540
Banasr, M., Héry, M., Printemps, R., & Daszuta, A. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300320 · Cited by 539
Glowinski, J., & Axelrod, J. (1964) · Nature · doi:10.1038/2041318a0 · Cited by 512
Monteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502
Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression
Bagot, R. C., Parise, E. M., Peña, C. J., Zhang, H.-X., Maze, I., Chaudhury, D., Persaud, B., Cachope, R., Bolaños-Guzmán, C. A., Cheer, J. F., et al. (2015) · Nature Communications · doi:10.1038/ncomms8062 · Cited by 491
Verhagen, M., van der Meij, A., van Deurzen, P. A. M., Janzing, J. G. E., Arias-Vásquez, A., Buitelaar, J. K., & Franke, B. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.109 · Cited by 470
Padilla-Coreano, N., Bolkan, S. S., Pierce, G. M., Blackman, D. R., Hardin, W. D., Garcia-Garcia, A. L., Spellman, T. J., & Gordon, J. A. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.011 · Cited by 463
Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala
Marcinkiewcz, C. A., Mazzone, C. M., D’Agostino, G., Halladay, L. R., Hardaway, J. A., DiBerto, J. F., Navarro, M., Burnham, N., Cristiano, C., Dorrier, C. E., et al. (2016) · Nature · doi:10.1038/nature19318 · Cited by 456 · cited 7×
“showed that 5-HT release from the dorsal raphe nucleus enhances fear and anxiety through activation of 5-HT2CRs on a subpopulation of corticotropin-releasing factor (CRF) neurons in the bed nucleus of the stria terminalis (BNST) [86].”
BackgroundInfluential5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants
Richardson-Jones, J. W., Craige, C. P., Guiard, B. P., Stephen, A., Metzger, K. L., Kung, H. F., Gardier, A. M., Dranovsky, A., David, D. J., Beck, S. G., et al. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.003 · Cited by 450
VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants
Warner-Schmidt, J. L., & Duman, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610282104 · Cited by 438
Furey, M. L., & Drevets, W. C. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.10.1121 · Cited by 417
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression
Airan, R. D., Meltzer, L. A., Roy, M., Gong, Y., Chen, H., & Deisseroth, K. (2007) · Science · doi:10.1126/science.1144400 · Cited by 396
Akiskal, H. S., & McKinney, W. T. (1973) · Science · doi:10.1126/science.182.4107.20 · Cited by 389 · cited 1×
“of monoamines, can induce depression in a subset of patients [14, 15].”
BackgroundSignaling in Adult Neurogenesis
Suh, H., Deng, W., & Gage, F. H. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113256 · Cited by 388
The current state of the neurogenic theory of depression and anxiety
Miller, B. R., & Hen, R. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.08.012 · Cited by 386
Lira, A., Zhou, M., Castanon, N., Ansorge, M. S., Gordon, J. A., Francis, J. H., Bradley-Moore, M., Lira, J., Underwood, M. D., Arango, V., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00696-6 · Cited by 385
Fear erasure in mice requires synergy between antidepressant drugs and extinction training
Karpova, N. N., Pickenhagen, A., Lindholm, J., Tiraboschi, E., Kulesskaya, N., Ágústsdóttir, A., Antila, H., Popova, D., Akamine, Y., Sullivan, R., et al. (2011) · Science · doi:10.1126/science.1214592 · Cited by 382
Löo, H., Hale, A. S., & haenen, H. D. (2002) · International Clinical Psychopharmacology · doi:10.1097/00004850-200209000-00004 · Cited by 366
Serotonin4 (5-HT4) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action
Lucas, G., Rymar, V. V., Du, J., Mnie‐Filali, O., Bisgaard, C. F., Manta, S., Lambás‐Señas, L., Wiborg, O., Haddjeri, N., Piñeyro, G., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.041 · Cited by 366
Duman, R. S., & Li, N. (2012) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2011.0357 · Cited by 362
Boldrini, M., Santiago, A. N., Hen, R., Dwork, A. J., Rosoklija, G. B., Tamir, H., Arango, V., & John Mann, J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.5 · Cited by 361
5-HT4Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice
Liu, M., Kuan, Y., Wang, J., Hen, R., & Gershon, M. D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1145-09.2009 · Cited by 358
Parsey, R. V., Oquendo, M. A., Ogden, R. T., Olvet, D. M., Simpson, N. R., Huang, Y., Heertum, R. L. V., Arango, V., & Mann, J. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.016 · Cited by 353
Holmes, A., Murphy, D. L., & Crawley, J. N. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.09.003 · Cited by 348
Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects
Hoshaw, B. A., Malberg, J. E., & Lucki, I. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.007 · Cited by 348
Serotonin and Hippocampal Neurogenesis
Gould, E. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00045-7 · Cited by 331
Sen, S., Nesse, R. M., Stoltenberg, S. F., Li, S., Gleiberman, L., Chakravarti, A., Weder, A. B., & Burmeister, M. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300053 · Cited by 331
Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue
Ross, S. B., & Rényi, A. L. (1969) · European Journal of Pharmacology · doi:10.1016/0014-2999(69)90091-0 · Cited by 320
Lower Serotonin Transporter Binding Potential in the Human Brain During Major Depressive Episodes
Parsey, R. V., Hastings, R., Oquendo, M. A., Huang, Y., Simpson, N. R., Arcement, J., Huang, Y. H., Ogden, R. T., Heertum, R. L. V., Arango, V., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.52 · Cited by 316
Adult‐born hippocampal neurons promote cognitive flexibility in mice
Burghardt, N. S., Park, E. H., Hen, R., & Fenton, A. A. (2012) · Hippocampus · doi:10.1002/hipo.22013 · Cited by 311
Poor replication of candidate genes for major depressive disorder using genome-wide association data
Bosker, F. J., Hartman, C. A., Nolte, I. M., Prins, B. P., Terpstra, P., Posthuma, D., van Veen, T., Willemsen, G., DeRijk, R. H., de Geus, E. J., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.38 · Cited by 309
Rantamäki, T., Hendolin, P., Kankaanpää, A., Mijatovic, J., Piepponen, P., Domenici, E., Chao, M. V., Männistö, P. T., & Castrén, E. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301345 · Cited by 305
Placebo-controlled trial of agomelatine in the treatment of major depressive disorder
Kennedy, S. H., & Emsley, R. A. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.09.002 · Cited by 300
Neurotransmitters and Suicidal Behavior
Åsberg, M. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52359.x · Cited by 290
Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo
Abbas, A. I., Hedlund, P. B., Huang, X., Tran, T. B., Meltzer, H. Y., & Roth, B. L. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1521-8 · Cited by 289
Placidi, G. P. A., Oquendo, M. A., Malone, K. M., Huang, Y.-Y., Ellis, S. P., & Mann, J. J. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01170-2 · Cited by 288
5-HT1A Receptors, Gene Repression, and Depression: Guilt by Association
Albert, P. R., & Lemonde, S. (2004) · The Neuroscientist · doi:10.1177/1073858404267382 · Cited by 284
5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern
Hedlund, P. B., Huitron-Resendiz, S., Henriksen, S. J., & Sutcliffe, J. G. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.012 · Cited by 281
The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor
Samuels, B. A., Nautiyal, K. M., Kruegel, A. C., Levinstein, M. R., Magalong, V. M., Gassaway, M. M., Grinnell, S. G., Han, J., Ansonoff, M. A., Pintar, J. E., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.60 · Cited by 279
Pothuizen, H. H. J., Zhang, W., Jongen‐Rêlo, A. L., Feldon, J., & Yee, B. K. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03170.x · Cited by 274
Association of a functional BDNF polymorphism and anxiety-related personality traits
Lang, U. E., Hellweg, R., Kalus, P., Bajbouj, M., Lenzen, K. P., Sander, T., Kunz, D., & Gallinat, J. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2137-7 · Cited by 274
Role of Somatodendritic 5‐HT Autoreceptors in Modulating 5‐HT Neurotransmission a
Blier, P., Piñeyro, G., Mansari, M. E., Bergeron, R., & de Montigny, C. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10192.x · Cited by 273
Effect of Agomelatine in the Chronic Mild Stress Model of Depression in the Rat
Papp, M., Gruca, P., Boyer, P., & Mocaër, E. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300091 · Cited by 273
Olié, J., & Kasper, S. F. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707007766 · Cited by 261
Garcia‐García, Á. L., Newman‐Tancredi, A., & Leonardo, E. D. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3389-x · Cited by 260
Niswender, C. M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00223-2 · Cited by 256
Hwang, J., Tsai, S., Hong, C., Yang, C.-H., Lirng, J., & Yang, Y.-M. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.013 · Cited by 253
The role of serotonin receptor subtypes in treating depression: a review of animal studies
Carr, G. V., & Lucki, I. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2097-z · Cited by 244
Wesołowska, A., Nikiforuk, A., Stachowicz, K., & Tatarczynska, E. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.04.017 · Cited by 230
Guscott, M. R., Bristow, L. J., Hadingham, K. L., Rosahl, T. W., Beer, M. S., Stanton, J. A., Bromidge, F. A., Owens, A. P., Huscroft, I. T., Myers, J., et al. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.11.015 · Cited by 229
Implications of adult hippocampal neurogenesis in antidepressant action
Malberg, J. E. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0422 · Cited by 217
Reversal of hippocampal neuronal maturation by serotonergic antidepressants
Kobayashi, K., Ikeda, Y., Sakai, A., Yamasaki, N., Haneda, E., Miyakawa, T., & Suzuki, H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912690107 · Cited by 212
A clinical and pharmacodynamic evaluation of iproniazid as a psychic energizer.
Loomer, H. P., SAUNDERS, J. C., & Kline, N. S. (1957) · PubMed · Cited by 205
5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response
Samuels, B. A., Anacker, C., Hu, A., Levinstein, M. R., Pickenhagen, A., Tsetsenis, T., Madroñal, N., Donaldson, Z. R., Drew, L. J., Dranovsky, A., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4116 · Cited by 200
Fujioka, T., Fujioka, A., & Duman, R. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1065.03.2004 · Cited by 194
Richardson-Jones, J. W., Craige, C. P., Nguyen, T. H., Kung, H. F., Gardier, A. M., Dranovsky, A., David, D. J., Guiard, B. P., Beck, S. G., Hen, R., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5836-10.2011 · Cited by 192
Adult neurogenesis modifies excitability of the dentate gyrus
Ikrar, T., Guo, N., He, K., Besnard, A., Levinson, S., Hill, A., Lee, H.-K., Hen, R., Xu, X., & Sahay, A. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00204 · Cited by 192
An open trial of fluoxetine in the treatment of panic attacks.
Gorman, J. M., Liebowitz, M. R., Fyer, A. J., Goetz, D. M., Campeas, R. B., Fyer, M. R., Davies, S. O., & Klein, D. F. (1987) · PubMed · Cited by 192
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus
Lacefield, C. O., Itskov, V., Reardon, T., Hen, R., & Gordon, J. A. (2012) · Hippocampus · doi:10.1002/hipo.20860 · Cited by 188
Jacobsen, J. P. R., Medvedev, I. O., & Caron, M. G. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0109 · Cited by 186
Invited review: the evolution of antidepressant mechanisms
Slattery, D. A., Hudson, A. L., & Nutt, D. (2004) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2004.00195.x · Cited by 185
Burghardt, N. S., Bush, D. E. A., McEwen, B. S., & LeDoux, J. E. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.023 · Cited by 179
Compan, V., Zhou, M., Grailhe, R., Gazzara, R. A., Martin, R., Gingrich, J. A., Dumuis, A., Brunner, D., Bockaert, J., & Hen, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2806-03.2004 · Cited by 177
Massart, R., Mongeau, R., & Lanfumey, L. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0212 · Cited by 177
An Open Trial of Fluoxetine in the Treatment of Panic Attacks
GORMAN, J. M., LIEBOWITZ, M. R., FYER, A. J., GOETZ, D., CAMPEAS, R. B., FYER, M. R., DAVIES, S. O., & KLEIN, D. F. (1987) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198710000-00007 · Cited by 175
Lanfumey, L., & Hamon, M. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043482570 · Cited by 173
Mößner, R., Daniel, S., Albert, D., Heils, A., Okladnova, O., Schmitt, A. G., & Lesch, K. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(99)00122-9 · Cited by 172
Bonaventure, P., Kelly, L., Aluisio, L. E., Shelton, J. E., Lord, B., Galici, R., Miller, K. L., Atack, J. R., Lovenberg, T. W., & Dugovic, C. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.119404 · Cited by 170
Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons
Drew, L. J., Kheirbek, M. A., Luna, V. M., Denny, C. A., Cloidt, M. A., Wu, M. V., Jain, S., Scharfman, H. E., & Hen, R. (2016) · Hippocampus · doi:10.1002/hipo.22557 · Cited by 169
Mendez‐David, I., David, D. J. P., Darcet, F., Wu, M. V., Kerdine‐Römer, S., Gardier, A. M., & Hen, R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.332 · Cited by 168
Effects of Antidepressants on 5-HT7 Receptor Regulation in the Rat Hypothalamus
Mullins, U. L. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00041-x · Cited by 166
Newman‐Tancredi, A., & Kleven, M. S. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2247-y · Cited by 164
Biochemical and Behavioral Evidence for Antidepressant-Like Effects of 5-HT6Receptor Stimulation
Svenningsson, P., Tzavara, E. T., Qi, H., Carruthers, R., Witkin, J. M., Nomikos, G. G., & Greengard, P. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3110-06.2007 · Cited by 160
Fournier, N. M., & Duman, R. S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.022 · Cited by 159
Kappa-opioid ligands in the study and treatment of mood disorders
Carlezon, W. A., Béguin, C., Knoll, A. T., & Cohen, B. M. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.05.008 · Cited by 156
VEGF as a potential target for therapeutic intervention in depression
Warner‐Schmidt, J. L., & Duman, R. S. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.013 · Cited by 156
Wesołowska, A., & Nikiforuk, A. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.01.007 · Cited by 154
Greene, J., Banasr, M., Lee, B., Warner-Schmidt, J., & Duman, R. S. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.68 · Cited by 143
Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety
Rainer, Q., Xia, L., Guilloux, J., Gabriel, C., Mocaër, E., Hen, R., Enhamre, E., Gardier, A. M., & David, D. J. P. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000356 · Cited by 139
Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor
Laplante, P., Diorio, J., & Meaney, M. J. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00550-3 · Cited by 135
Novelty-Suppressed Feeding in the Mouse
Samuels, B. A., & Hen, R. (2011) · Neuromethods · doi:10.1007/978-1-61779-313-4_7 · Cited by 131
Potential role of the 5-HT6 receptor in depression and anxiety: an overview of preclinical data
Wesołowska, A. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70315-7 · Cited by 128
Borroto‐Escuela, D. O., Romero‐Fernandez, W., Mudò, G., Pérez‐Alea, M., Ciruela, F., Tarakanov, A. O., Narváez, M., Liberto, V. D., Agnati, L. F., Belluardo, N., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.012 · Cited by 126
Antidepressant-like effects of intracerebroventricular FGF2 in rats
Turner, C. A., Gula, E. L., Taylor, L. P., Watson, S. J., & Akil, H. (2008) · Brain Research · doi:10.1016/j.brainres.2008.05.088 · Cited by 125
Serotonin receptor expression along the dorsal–ventral axis of mouse hippocampus
Tanaka, K. F., Samuels, B. A., & Hen, R. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0038 · Cited by 124
A common C-1018G polymorphism in the human 5-HT1A receptor gene
Wu, S., & Comings, D. E. (1999) · Psychiatric Genetics · doi:10.1097/00041444-199906000-00010 · Cited by 122
Baumeister, A. A., Hawkins, M. F., & Uzelac, S. (2003) · Journal of the History of the Neurosciences · doi:10.1076/jhin.12.2.207.15535 · Cited by 121
Wesołowska, A., Nikiforuk, A., & Stachowicz, K. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.09.064 · Cited by 112
Neurotrophins as Mediators of Drug Effects on Mood, Addiction, and Neuroprotection
Ċastrén, E. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:3:289 · Cited by 109
Pascual-Brazo, J., Castro, E., Díaz, Á., Valdizán, E. M., Pilar-Cuéllar, F., Vidal, R., Treceño, B., & Pazos, Á. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000782 · Cited by 106
Functional implications of hypothalamic neurogenesis in the adult mammalian brain
Lee, D. A., & Blackshaw, S. (2012) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2012.07.003 · Cited by 105
Kishi, T., Yoshimura, R., Fukuo, Y., Okochi, T., Matsunaga, S., Umene‐Nakano, W., Nakamura, J., Serretti, A., Correll, C. U., Kane, J. M., et al. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0337-4 · Cited by 101
The 5-HT1B Receptor: A Novel Target for the Pathophysiology of Depression (Supplementary Tables)
Ruf, B. M., & Bhagwagar, Z. (2009) · Current Drug Targets · doi:10.2174/138945009789735192 · Cited by 100
Beck, S. G., Choi, K. C., & List, T. J. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10347-9 · Cited by 98
Modeling treatment-resistant depression
Samuels, B. A., Leonardo, E. D., Gadient, R. A., Williams, A., Zhou, J., David, D. J. P., Gardier, A. M., Wong, E. H. F., & Hen, R. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.017 · Cited by 96
The Main Features of Central 5-HT1A Receptors
Hamon, M. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60921-3_9 · Cited by 95
Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression
Anttila, S., Huuhka, K., Huuhka, M., Rontu, R., Hurme, M., Leinonen, E. V. J., & Lehtimäki, T. J. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0705-9 · Cited by 95
Citalopram reduces social interaction in rats by activation of serotonin (5-HT)2C receptors
Dekeyne, A., Denorme, B., Monneyron, S., & Millan, M. J. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00268-3 · Cited by 95
Fluoxetine-Induced Cortical Adult Neurogenesis
Ohira, K., Takeuchi, R., Shoji, H., & Miyakawa, T. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.2 · Cited by 93
ska, E. T., ska, A. K. O., Stachowicz, K., & Chojnacka-Wójcik, E. (2004) · Behavioural Pharmacology · doi:10.1097/00008877-200412000-00001 · Cited by 91
Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats
Carr, G. V., Schechter, L. E., & Lucki, I. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1798-7 · Cited by 90
Ohira, K., Takeuchi, R., Iwanaga, T., & Miyakawa, T. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-43 · Cited by 90
Iga, J., Ueno, S., Yamauchi, K., Numata, S., Tayoshi‐Shibuya, S., Kinouchi, S., Nakataki, M., Song, H., Hokoishi, K., Tanabe, H., et al. (2007) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30520 · Cited by 87
Rosel, P., Arranz, B., Urretavizcaya, M., Oros, M., San, L., & Navarro, M. A. (2004) · Neuropsychobiology · doi:10.1159/000077365 · Cited by 84
Adaptive changes in serotonin neurons of the raphe nuclei in 5‐HT4 receptor knock‐out mouse
Conductier, G., Dusticier, N., Lucas, G., Côté, F., Debonnel, G., Daszuta, A., Dumuis, A., Nieoullon, A. L., Hen, R., Bockaert, J., et al. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04943.x · Cited by 83
Czesak, M., François, B. L., Millar, A., Deria, M., Daigle, M., Visvader, J. E., Anisman, H., & Albert, P. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.293027 · Cited by 82
Pindolol augmentation of antidepressant therapy
McAskill, R., Mir, S., & Taylor, D. M. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.173.3.203 · Cited by 81
Ohtsuki, T., Ishiguro, H., Detera‐Wadleigh, S. D., Toyota, T., Shimizu, H., Yamada, K., Yoshitsugu, K., Hattori, E., Yoshikawa, T., & Arinami, T. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001133 · Cited by 80
Acute restraint stress increases 5-HT7 receptor mRNA expression in the rat hippocampus
Yau, J. L. W., Noble, J., & Seckl, J. R. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02054-7 · Cited by 80
5-HT1B mrna regulation in two animal models of altered stress reactivity
Neumaier, J. F., Edwards, E., & Plotsky, P. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01371-3 · Cited by 78
Dow, A. L., Russell, D., & Duman, R. S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5155-04.2005 · Cited by 78
Monoamine depletion studies: implications for antidepressant discontinuation syndrome.
Delgado, P. L. (2006) · PubMed · Cited by 74
Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis
Kishi, T., Tsunoka, T., Ikeda, M., Kawashima, K., Okochi, T., Kitajima, T., Kinoshita, Y., Okumura, T., Yamanouchi, Y., Inada, T., et al. (2009) · Journal of Human Genetics · doi:10.1038/jhg.2009.84 · Cited by 71
Belzung, C., Guisquet, A. M. L., Barreau, S., & Calatayud, F. (2001) · Behavioural Pharmacology · doi:10.1097/00008877-200105000-00001 · Cited by 70
A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors
Nautiyal, K. M., Tritschler, L., Ahmari, S. E., David, D. J. P., Gardier, A. M., & Hen, R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.109 · Cited by 68
Tamburella, A., Micale, V., Navarria, A., & Drago, F. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.07.001 · Cited by 66
The main features of central 5-HT1 receptors.
Hamon, M., Lanfumey, L., Mestikawy, S. E., Boni, C., Miquel, M. C., Bolaños, F. J., Schechter, L. E., & GOZLAN, H. (1989) · HAL · Cited by 65
Wu, M. V., Sahay, A., Duman, R. S., & Hen, R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018978 · Cited by 64
Familial Risk for Major Depression is Associated with Lower Striatal 5-HT4 Receptor Binding
Madsen, K. S., Torstensen, E. W., Holst, K. K., Haahr, M. E., Knorr, U., Frøkjær, V. G., Brandt-Larsen, M., Iversen, P., Fisher, P. M., & Knudsen, G. M. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu034 · Cited by 61
McDevitt, R. A., Hiroi, R., Mackenzie, S. M., Robin, N. C., Cohn, A., Kim, J. J., & Neumaier, J. F. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.029 · Cited by 60
Chenu, F., David, D. J. P., Leroux‐Nicollet, I., Maître, E. L., Gardier, A. M., & Bourin, M. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0852 · Cited by 56
Deuchars, J., Li, Y., Kasparov, S., & Paton, J. F. R. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000207)417:2 · Cited by 54
Imoto, Y., Kira, T., Sukeno, M., Nishitani, N., Nagayasu, K., Nakagawa, T., Kaneko, S., Kobayashi, K., & Segi-Nishida, E. (2015) · Molecular Brain · doi:10.1186/s13041-015-0120-3 · Cited by 53
Neumaier, J. F., Petty, F., Kramer, G. L., Szot, P., & Hamblin, M. W. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00114-x · Cited by 51
FGFR1–5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression
Borroto‐Escuela, D. O., Tarakanov, A. O., & Fuxé, K. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.11.003 · Cited by 50
Relapse of depression after rapid depletion of tryptophan
Leyton, M., Young, S. N., & Benkelfat, C. (1997) · The Lancet · doi:10.1016/s0140-6736(05)61726-6 · Cited by 48
Borroto‐Escuela, D. O., Narváez, M., Pérez‐Alea, M., Tarakanov, A. O., Jimenez‐Beristain, A., Mudò, G., Agnati, L. F., Ciruela, F., Belluardo, N., & Fuxé, K. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.11.112 · Cited by 47
Cryan, J. F., & Lucki, I. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00858-x · Cited by 43
Dawson, L. A., Hughes, Z. A., Starr, K. R., Storey, J. D., Bettelini, L., Bacchi, F., Arban, R., Poffe, A., Melotto, S., Hagan, J. J., et al. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.01.010 · Cited by 42
Tatarczynska, E., Kłodzińska, A., & Chojnacka-Wójcik, E. (2003) · PubMed · Cited by 40
Borroto‐Escuela, D. O., Pérez‐Alea, M., Narváez, M., Tarakanov, A. O., Mudò, G., Jimenez‐Beristain, A., Agnati, L. F., Ciruela, F., Belluardo, N., & Fuxé, K. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.04.133 · Cited by 39
Gage, F. H., Thompson, R. G., & Valdés, J. J. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90297-6 · Cited by 37
5-HT7 receptor activation promotes an increase in TrkB receptor expression and phosphorylation
Samarajeewa, A., Goldemann, L., Vasefi, M., Ahmed, N., Gondora, N., Khanderia, C., Mielke, J. G., & Beazely, M. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00391 · Cited by 37
Gardier, A. M., Trillat, A., Malagié, I., David, D. J. P., Hascoët, M., Colombel, M.-C., Jolliet, P., Jacquot, C., Hen, R., & Bourin, M. (2001) · Comptes Rendus de l Académie des Sciences - Series III - Sciences de la Vie · doi:10.1016/s0764-4469(01)01332-4 · Cited by 37
Tatarczynska, E., Kłodzińska, A., Stachowicz, K., & Chojnacka-Wójcik, E. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.01.008 · Cited by 34
Wesołowska, A., & Nikiforuk, A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.12.013 · Cited by 31
Ganea, K., Menke, A., Schmidt, M. V., Lucae, S., Rammes, G., Liebl, C., Harbich, D., Sterlemann, V., Storch, C., Uhr, M., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.104 · Cited by 31
Serotonin-Influencing Drugs in the Treatment of Panic Disorder
Westenberg, H. G. M., & den Boer, J. A. (2010) · Psychopathology · doi:10.1159/000284628 · Cited by 29
Ding, S., Li, L., & Zhou, F.-M. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00831.2014 · Cited by 20
Ishizuka, T., Goshima, H., Ozawa, A., & Watanabe, Y. (2014) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12224 · Cited by 11
Liu, Y. K., Kelly, M. A., Sexton, T. J., & Neumaier, J. F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.032 · Cited by 10
Research works printed but not linked: 1
- Feighner JP, Boyer WF. Selective serotonin reuptake inhibitors, 2nd edition: advances in basic research and clinical practice. Chichester: Wiley; 1996.
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Metadata
- Authors
- Yohn, C. N., Gergues, M. M., & Samuels, B. A.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Samuels, Benjamin Adam
- Venue
- Molecular Brain
- Published
- 2017-06-24
- Volume
- 10
- Issue
- 1
- Pages
- 28-28
- ISSN
- 1756-6606 (ISSN-L)
- PMC
- PMC5483313
- OpenAlex
- W2695471189
- Cited by
- 485
- References
- 190
- Citations by year
- 2026: 28 · 2025: 53 · 2024: 69 · 2023: 72 · 2022: 60 · 2021: 75 · 2020: 59 · 2019: 38 · 2018: 26 · 2017: 5
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Molecular Brain (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Brain and Behavior Research Foundation (NARSAD Young Investigator)
- National Institute of Mental Health (R01 MH112861)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- depression, serotonin receptors, serotonin, selective serotonin reuptake inhibitors, antidepressant response, monoamine hypothesis, neurotrophic hypothesis, hippocampus, neural circuits, depression pathophysiology
- MeSH terms
- Animals, Depression, Hippocampus, Humans, Models, Biological, Receptors, Serotonin, Serotonin, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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