BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses
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Brain Derived Neurotrophic Factor (BDNF) signalling contributes to the formation, maturation and plasticity of Central Nervous System (CNS) synapses. Acute exposure of cultured brain circuits to BDNF leads to up-regulation of glutamatergic neuro-transmission, by the accurate tuning of pre and post synaptic features, leading to structural and functional synaptic changes. Chronic BDNF treatment has been comparatively less investigated, besides it may represent a therapeutic option to obtain rescue of post-injury alterations of synaptic networks. In this study, we used a paradigm of BDNF long-term (4 days) incubation to assess in hippocampal neurons in culture, the ability of such a treatment to alter synapses. By patch clamp recordings we describe the augmented function of excitatory neurotransmission and we further explore by live imaging the presynaptic changes brought about by long-term BDNF. In our study, exogenous long-term BDNF exposure of post-natal neurons did not affect inhibitory neurotransmission. We further compare, by genetic manipulations of cultured neurons and BDNF release, intracellular overexpression of this neurotrophin at the same developmental age. We describe for the first-time differences in synaptic modulation by BDNF with respect to exogenous or intracellular release paradigms. Such a finding holds the potential of influencing the design of future therapeutic strategies.
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Microglia play a crucial role in the modulation of synaptic plasticity.
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- Authors
- Rauti, R., Cellot, G., D’Andrea, P., Colliva, A., Scaini, D., Tongiorgi, E., & Ballerini, L.
- Affiliations
- Scuola Internazionale Superiore di Studi Avanzati (IT)
- University of Trieste (IT)
- Corresponding author
- Tongiorgi, Enrico
- Ballerini, Laura
- ORCID
- Venue
- Molecular Brain
- Published
- 2020-03-17
- Volume
- 13
- Issue
- 1
- Pages
- 43-43
- ISSN
- 1756-6606 (ISSN-L)
- PMC
- PMC7079446
- OpenAlex
- W3012145538
- Cited by
- 78
- References
- 103
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 11 · 2023: 14 · 2022: 16 · 2021: 4 · 2020: 5
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Molecular Brain (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion, cc-by)
- SDL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion, cc-by)
- Funders
- FIRB (No. RBFR08MZSP)
- FRA UniTS (pr 2013)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- brain-derived neurotrophic factor, BDNF signalling, hippocampal neurons, synaptic plasticity, excitatory neurotransmission, inhibitory neurotransmission, presynaptic modulation, glutamatergic synapses, cultured neurons
- MeSH terms
- Animals, Cells, Cultured, Extracellular Space, Hippocampus, Neurons, Synapses, Glutamic Acid, Brain-Derived Neurotrophic Factor, Receptor, trkB, Intracellular Space, Vesicular Inhibitory Amino Acid Transport Proteins, Rats
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