Pulmonary arterial response to Angiostrongylus vasorum in naturally infected dogs: Echocardiographic findings in two cases
Open accessAbstract
BACKGROUND: Angiostrongylus vasorum is a nematode living in the pulmonary arteries of canids. Infected dogs develop severe pulmonary lesions which can potentially lead to pulmonary hypertension (PH). However, reports of PH in natural infected dogs are scant. One of the possible causes of the low prevalence of PH in A. vasorum-infected dogs could be the establishment of large diameter intrapulmonary arteriovenous anastomoses (IPAVAs), which attenuate pulmonary vascular resistance, thus reducing the pulmonary arterial pressure. The present report describes the pulmonary arterial pressure (PAP) response to A. vasorum natural infection in two dogs, assessed by echocardiography and by the saline contrast echocardiographic test (SCE). RESULTS: Both dogs showed clinical signs of respiratory disease. At presentation, case 1 did not show echocardiographic signs of PH and the SCE test was positive proving the presence of IPAVAs. However, at the follow-up visit, despite A. vasorum infection resolution, the same dog showed PH and the SCE test resulted negative, which ruled out the presence of IPAVAs. Case 2 suffered from severe pulmonary arterial hypertension and right-side congestive heart failure since the day of presentation. Saline contrast echocardiography was negative both at the time of presentation and at the follow-up visit. CONCLUSIONS: In the two cases described above, the PH was not associated with IPAVAs. During A. vasorum infection, IPAVAs recruitment mechanism is able to contrast the rise of PAP until a certain level. It probably represents an initial escape mechanism of PH that, over time, exhausts its compensatory capacities allowing PAP to rise and to be detectable on echocardiography.
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In dogs, Angiostrongylus vasorum cannot be seen in echocardiography.
“In dogs, Angiostrongylus vasorum cannot be seen in echocardiography”
From First Autochthonous Infection of a Cat with Dirofilaria immitis in Austria (2021) · cites this paper as [30]
It seems unlikely that A. chabaudi can be seen in echocardiography.
“so it also seems unlikely that A. chabaudi can be seen in echocardiography [30].”
From First Autochthonous Infection of a Cat with Dirofilaria immitis in Austria (2021) · cites this paper as [30]
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Cites
Recommendations for Standards in Transthoracic Two-Dimensional Echocardiography in the Dog and Cat
Thomas, W. P., Gaber, C. E., Jacobs, G. J., et al. (1993) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.1993.tb01015.x · Cited by 1,032 · see citing works
Canine and feline cardiopulmonary parasitic nematodes in Europe: emerging and underestimated
Traversa, D., Di Cesare, A., & Conboy, G. (2010) · Parasites & Vectors · doi:10.1186/1756-3305-3-62 · Cited by 351 · see citing works
Bonagura, J. D., & Miller, M. W. (1989) · Echocardiography · doi:10.1111/j.1540-8175.1989.tb00304.x · Cited by 321 · see citing works
Nematode parasites of domestic animals and of man
Levine, N. D. (1980) · Medical Entomology and Zoology · Cited by 286 · see citing works
Exercise-induced intrapulmonary arteriovenous shunting in healthy humans
Eldridge, M. W., Dempsey, J. A., Haverkamp, H. C., Lovering, A. T., & Hokanson, J. S. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00137.2004 · Cited by 239 · see citing works
Canine pulmonary angiostrongylosis: An update
Koch, J., & Willesen, J. L. (2008) · The Veterinary Journal · doi:10.1016/j.tvjl.2007.11.014 · Cited by 224 · see citing works
Niden, A. H., & Aviado, D. M. (1956) · Circulation Research · doi:10.1161/01.res.4.1.67 · Cited by 202 · see citing works
Pulmonary Hypertension in Dogs: Diagnosis and Therapy
Kellihan, H. B., & Stepien, R. L. (2010) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2010.03.011 · Cited by 160 · see citing works
Why do the lungs clear ultrasonic contrast?
Meltzer, R. S., Tickner, E. G., & Popp, R. L. (1980) · Ultrasound in Medicine & Biology · doi:10.1016/0301-5629(80)90022-8 · Cited by 152 · see citing works
Lovering, A. T., Romer, L. M., Haverkamp, H. C., et al. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00208.2007 · Cited by 149 · see citing works
Canine pulmonary angiostrongylosis: The influence of climate on parasite distribution
Morgan, E. R., Jefferies, R., Krajewski, M., Ward, P., & Shaw, S. E. (2009) · Parasitology International · doi:10.1016/j.parint.2009.08.003 · Cited by 149 · see citing works
Gastrointestinal parasites of shepherd and hunting dogs in the Serres Prefecture, Northern Greece
Papazahariadou, M., Founta, A., Papadopoulos, E., Chliounakis, S., Antoniadou-Sotiriadou, K., & Theodorides, Y. (2007) · Veterinary Parasitology · doi:10.1016/j.vetpar.2007.05.013 · Cited by 146 · see citing works
Serres, F. J., Chetboul, V., Gouni, V., et al. (2007) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2007.tb01950.x · Cited by 132 · see citing works
Serres, F. J., Chetboul, V., Gouni, V., et al. (2007) · Journal of Veterinary Internal Medicine · doi:10.1892/07-064.1 · Cited by 118 · see citing works
Skjærpe, T., & Hatle, L. (1986) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a062126 · Cited by 116 · see citing works
Willesen, J. L., Kristensen, A. T., Jensen, A. L., Heine, J., & Koch, J. (2007) · Veterinary Parasitology · doi:10.1016/j.vetpar.2007.05.001 · Cited by 105 · see citing works
Visser, L. C., Im, M. K., Johnson, L. R., et al. (2016) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.13911 · Cited by 104 · see citing works
Weese, J. S., DaCosta, T., Button, L., Goth, K., Ethier, M., & Boehnke, K. (2004) · Journal of Veterinary Internal Medicine · doi:10.1892/0891-6640(2004)18 · Cited by 103 · see citing works
Schnyder, M., Fahrion, A. S., Riond, B., Ossent, P., Webster, P., Kranjc, A., Glaus, T. M., & Deplazes, P. (2010) · Parasitology Research · doi:10.1007/s00436-010-2021-9 · Cited by 94 · see citing works
Natural Infections of Angiostrongylus vasorum and Crenosoma vulpis in Dogs in Germany (2007–2009)
Barutzki, D., & Schaper, R. (2009) · Parasitology Research · doi:10.1007/s00436-009-1494-x · Cited by 93 · see citing works
Direct demonstration of 25- and 50-μm arteriovenous pathways in healthy human and baboon lungs
Lovering, A. T., Stickland, M. K., Kelso, A. J., et al. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01024.2006 · Cited by 86 · see citing works
Hypoxia-induced intrapulmonary arteriovenous shunting at rest in healthy humans
Laurie, S. S., Yang, X., Elliott, J. E., Beasley, K. M., & Lovering, A. T. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00150.2010 · Cited by 85 · see citing works
Canine and Feline Infections by Cardiopulmonary Nematodes in Central and Southern Italy
Di Cesare, A., Castagna, G., Meloni, S., Milillo, P., Latrofa, S., Otranto, D., & Traversa, D. (2011) · Parasitology Research · doi:10.1007/s00436-011-2405-5 · Cited by 82 · see citing works
Schnyder, M., & Deplazes, P. (2012) · Parasites & Vectors · doi:10.1186/1756-3305-5-258 · Cited by 80 · see citing works
Schnyder, M., Fahrion, A., Ossent, P., Kohler, L., Webster, P., Heine, J., & Deplazes, P. (2009) · Veterinary Parasitology · doi:10.1016/j.vetpar.2009.09.004 · Cited by 79 · see citing works
Identification of first‐stage larvae of metastrongyles from dogs
McGarry, J. W., & Morgan, E. R. (2009) · Veterinary Record · doi:10.1136/vr.165.9.258 · Cited by 76 · see citing works
Intracranial haemorrhage associated with Angiostrongylus vasorum infection in three dogs
GAROSI, L. S., Platt, S. R., McConnell, J. F., et al. (2005) · Journal of Small Animal Practice · doi:10.1111/j.1748-5827.2005.tb00300.x · Cited by 74 · see citing works
Sigrist, N. E., Hofer‐Inteeworn, N., Schefer, R. J., Kümmerle‐Fraune, C., Schnyder, M., & Kutter, A. P. N. (2017) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.14723 · Cited by 69 · see citing works
Bourque, A. C., Conboy, G. A., Miller, L., & Whitney, H. G. (2008) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/104063870802000103 · Cited by 66 · see citing works
Occurrence of fatal canine Angiostrongylus vasorum infection in Italy.
Traversa, D., Torbidone, A., Malatesta, D., & Guglielmini, C. (2008) · Veterinary parasitology · doi:10.1016/j.vetpar.2007.12.009 · Cited by 65 · see citing works
Guardone, L., Schnyder, M., Macchioni, F., Deplazes, P., & Magi, M. (2013) · Veterinary Parasitology · doi:10.1016/j.vetpar.2012.10.016 · Cited by 56 · see citing works
Gredal, H., Willesen, J. L., Jensen, H. E., et al. (2011) · Acta veterinaria Scandinavica · doi:10.1186/1751-0147-53-43 · Cited by 51 · see citing works
Autochthonous Angiostrongylus vasorum infection in dogs in The Netherlands
van Doorn, D. C. K., van de Sande, A. H., Nijsse, E. R., Eysker, M., & Ploeger, H. W. (2009) · Veterinary Parasitology · doi:10.1016/j.vetpar.2009.02.019 · Cited by 50 · see citing works
Traversa, D., Di Cesare, A., Meloni, S., Frangipane di Regalbono, A., Milillo, P., Pampurini, F., & Venco, L. (2013) · Parasitology Research · doi:10.1007/s00436-013-3412-5 · Cited by 50 · see citing works
Coagulation status in dogs with naturally occurringAngiostrongylus vasoruminfection
Adamantos, S. E., Waters, S., & Boag, A. K. (2015) · Journal of Small Animal Practice · doi:10.1111/jsap.12370 · Cited by 50 · see citing works
New insights on metastrongyloid lungworms infecting cats of Sardinia, Italy
Tamponi, C., Varcasia, A., Brianti, E., et al. (2014) · Veterinary Parasitology · doi:10.1016/j.vetpar.2014.04.001 · Cited by 48 · see citing works
Self-citationAngiostrongylus chabaudi Biocca, 1957: a new parasite for domestic cats?
Varcasia, A., Tamponi, C., Brianti, E., et al. (2014) · Parasites & Vectors · doi:10.1186/s13071-014-0588-1 · Cited by 46 · see citing works
Self-citationOtranto, D., Varcasia, A., Solinas, C., Scala, A., Brianti, E., Dantas‐Torres, F., Annoscia, G., Martin, C., Mutafchiev, Y., & Bain, O. (2013) · Parasites & Vectors · doi:10.1186/1756-3305-6-132 · Cited by 41 · see citing works
Self-citationNorris, H. C., Mangum, T. S., Duke, J. W., et al. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01125.2013 · Cited by 38 · see citing works
Twenty-Four-Hour Ambulatory Electrocardiography in Normal Cats
Ware, W. A. (1999) · Journal of Veterinary Internal Medicine · doi:10.1892/0891-6640(1999)013 · Cited by 36 · see citing works
Severe pulmonary arterial hypertension due to Angiostrongylosus vasorum in a dog.
Nicolle, A. P., Chetboul, V., Tessier‐Vetzel, D., Sampedrano, C. C., Aletti, E., & Pouchelon, J. (2006) · Europe PMC (PubMed Central) · Cited by 35 · see citing works
Intrapulmonary arteriovenous shunt: Diagnosis by saline contrast bubbles in the pulmonary veins
Gudavalli, A., Kalaria, V. G., Chen, X., et al. (2002) · Journal of the American Society of Echocardiography · doi:10.1067/mje.2002.121435 · Cited by 34 · see citing works
Kranjc, A., Schnyder, M., Dennler, M., Fahrion, A. S., Makara, M., Ossent, P., Morgan, J. M., Deplazes, P., & Glaus, T. M. (2010) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2010.0529.x · Cited by 29 · see citing works
Borgeat, K., Sudunagunta, S., Kaye, B. M., et al. (2014) · Journal of Small Animal Practice · doi:10.1111/jsap.12309 · Cited by 29 · see citing works
Angiostrongylus vasorum: epidemiological, clinical and histopathological insights
Rinaldi, L., Cortese, L., Meomartino, L., Pagano, T. B., Pepe, P., Cringoli, G., & Papparella, S. (2014) · BMC Veterinary Research · doi:10.1186/s12917-014-0236-1 · Cited by 27 · see citing works
Matos, J. N., Schnyder, M., Bektas, R. N., et al. (2012) · Journal of Veterinary Cardiology · doi:10.1016/j.jvc.2012.01.014 · Cited by 20 · see citing works
New insights onto cardiopulmonary nematodes of dogs in Sardinia, Italy
Pipia, A. P., Varcasia, A., Tosciri, G., Seu, S., Manunta, M. L., Mura, M. C., Sanna, G., Tamponi, C., Brianti, E., & Scala, A. (2014) · Parasitology Research · doi:10.1007/s00436-014-3794-z · Cited by 19 · see citing works
Self-citationMarshall, R. J., WANG, Y., Semler, H. J., et al. (1961) · Circulation Research · doi:10.1161/01.res.9.1.53 · Cited by 19 · see citing works
Glaus, M. T., Schnyder, M., Dennler, M., et al. (2010) · Schweizer Archiv für Tierheilkunde · doi:10.1024/0036-7281/a000076 · Cited by 18 · see citing works
Matos, J. N., Malbon, A. J., Dennler, M., et al. (2016) · Journal of Veterinary Cardiology · doi:10.1016/j.jvc.2015.10.008 · Cited by 16 · see citing works
Coia, M., Hammond, G., Chan, D. L., et al. (2017) · Veterinary Radiology & Ultrasound · doi:10.1111/vru.12505 · Cited by 15 · see citing works
Santa, D. D., Citi, S., Marchetti, V., et al. (2002) · CINECA IRIS Institutial research information system (University of Pisa) · Cited by 11 · see citing works
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First Autochthonous Infection of a Cat with Dirofilaria immitis in Austria
Kulmer, L.-M., Unterköfler, M. S., Fuehrer, H.-P., Janovska, V., Pagac, M., Svoboda, M., Venco, L., & Leschnik, M. (2021) · Pathogens · doi:10.3390/pathogens10091104 · Cited by 21 · see citing works
- Authors
- Corda, A., Carta, S., Varcasia, A., Tamponi, C., Evangelisti, M. A., Scala, A., & Pinna Parpaglia, M. L.
- Affiliations
- University of Sassari (IT)
- Corresponding author
- Varcasia, Antonio
- ORCID
- Venue
- Parasites & Vectors
- Published
- 2019-06-04
- Volume
- 12
- Issue
- 1
- Pages
- 286-286
- ISSN
- 1756-3305 (ISSN-L)
- PMC
- PMC6549332
- OpenAlex
- W2948507184
- Cited by
- 13
- References
- 52
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 1
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Parasites & Vectors (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UnissResearch (Università degli Studi di Sassari) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Università degli Studi di Sassari
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Keywords
- Angiostrongylus vasorum, canine angiostrongylosis, pulmonary arterial hypertension, pulmonary artery pressure, saline contrast echocardiography, right-sided congestive heart failure, compensatory mechanisms, dogs
- MeSH terms
- Angiostrongylus, Animals, Dog Diseases, Dogs, Echocardiography, Female, Hypertension, Pulmonary, Pulmonary Artery, Strongylida Infections, Arterial Pressure
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