CoChat
Sign Up
Cited by 79Helminth infection and controlMollusks and Parasites StudiesParasites and Host Interactions

Larvicidal effect of imidacloprid/moxidectin spot-on solution in dogs experimentally inoculated with Angiostrongylus vasorum

Open access
Schnyder, M., Fahrion, A., Ossent, P., Kohler, L., Webster, P., Heine, J., Deplazes, P.·2009·Veterinary Parasitology
DOI 10.1016/j.vetpar.2009.09.004
Open this paper in CoChat — free accountOpen PDF

Abstract

A controlled, randomized, blinded dose confirmation study was conducted to evaluate the larvicidal efficacy and safety of imidacloprid 10 mg/kg/moxidectin 2.5 mg/kg body weight spot-on solution in dogs experimentally inoculated with 200 infective third stage larvae (L3) of Angiostrongylus vasorum. Twenty-four adult dogs were randomly allocated to three study groups of 8 dogs each. Animals in group 1 were treated 4 days post-inoculation (dpi), those in group 2 at 32 dpi, and the dogs in group 3 were left untreated. All dogs were euthanized and necropsied 56-59 dpi. In order to determine the worm burdens in the arterial lung vessels a method of reverse lung perfusion with phosphate buffered solution after inhibition of coagulation with heparin was applied. In the control group, excretion of first stage larvae (L1) of A. vasorum started 47-55 dpi and all dogs excreted L1 at least on one sample day before euthanasia (0.1-32.5 larvae per gram of faeces). A mean of 99 (SD 42.8) adult parasites were recovered in the post-mortem examinations in these eight control dogs. In contrast, no L1 at all were found in the faeces of dogs of groups 1 and 2, nor were any adult parasites detected at necropsy. Respiratory symptoms were observed in dogs of groups 2 and 3. Pathological findings in the lungs correlated with the treatment groups: in the animals of group 1, no or minimal lesions were found, while in all those of group 2 dispersed patterns of pale pink, slightly raised and consolidated foci were present in all lung lobes. In contrast, the lungs of the dogs from group 3 were severely affected: large confluent areas were hardened, raised and discoloured, with frequent haemorrhagic patches. Pneumonia, thrombi and parasites were histologically confirmed. The lung lymph nodes were regularly enlarged. Hence, imidacloprid/moxidectin spot-on effectively eliminated fourth stage larvae (L4) and immature adult A. vasorum in experimentally infected dogs and prevented patent infections. The earlier an infected dog was treated, the less severe were the pathological lesions observed in the lungs.

Integrity signals

Registry

Crossref · 10.1016/j.vetpar.2009.09.004

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Monthly-based use of imidacloprid 10%/moxidectin 2.5% spot-on potentially prevents or minimizes establishment of adult A. vasorum, severe cardiopulmonary tissue damage, and clinical onset of the disease.

    “A monthly-based use of this topical spot-on potentially prevents or, at least, minimizes the establishment of adult A. vasorum, the severe cardiopulmonary tissue damage caused by the parasite and the clinical onset of the disease [136].”

    From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [136]

  • A single topical application of imidacloprid 10%/moxidectin 2.5% is 100% effective in eliminating fourth stage larvae (L4) and pre-adults of A. vasorum, thus preventing patent infections.

    “A single topical application is 100% effective in the elimination of fourth stage larvae (L4) and pre-adults of the parasite, thus preventing patent infections.”

    From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [136]

  • A spot-on containing imidacloprid 10%/moxidectin 2.5% has effective and safe larvicidal activity in dogs experimentally infected with A. vasorum.

    “A spot-on containing imidacloprid 10%/moxidectin 2.5% can be used for preventing canine angiostrongylosis for its effective and safe larvicidal activity in dogs experimentally infected with A. vasorum.”

    From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [136]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Schnyder, M., Fahrion, A., Ossent, P., Kohler, L., Webster, P., Heine, J., & Deplazes, P.
Affiliations
  • University of Zurich (CH)
  • University of Copenhagen (DK)
Corresponding author
Schnyder, M.
ORCID
Venue
Veterinary Parasitology
Publisher
Elsevier BV
Published
2009-12
Volume
166
Issue
3-4
Pages
326-332
ISSN
0304-4017 (ISSN-L)
DOI
10.1016/j.vetpar.2009.09.004
OpenAlex
W2008791967
Cited by
79
References
28
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 8 · 2012: 5
FWCI
10.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Veterinary Parasitology (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich)
Topics
  • Health Sciences › Veterinary › Small Animals › Helminth infection and control
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Keywords
Angiostrongylus vasorum, canine angiostrongylosis, imidacloprid, moxidectin, spot-on formulation, larvicidal efficacy, experimental infection, fourth-stage larvae, lung pathology
MeSH terms
Neonicotinoids, Angiostrongylus, Animals, Blood Vessels, Dog Diseases, Dogs, Female, Imidazoles, Larva, Lung, Male, Nitro Compounds, Random Allocation, Strongylida Infections, Macrolides

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review