A pilot randomised controlled trial of an Internet-based cognitive behavioural therapy self-management programme (MS Invigor8) for multiple sclerosis fatigue
Abstract
The majority of people affected by Multiple Sclerosis (paMS) experience severe and disabling fatigue. A recent randomised controlled trial (RCT) showed that cognitive behaviour therapy with a clinical psychologist was an effective treatment for MS fatigue. An Internet-based version of this intervention, MS Invigor8, was developed for the current study using agile design and input from paMS. MS Invigor8 includes eight tailored, interactive sessions. The aim was to test the feasibility and potential efficacy and cost-effectiveness of the programme in a pilot RCT. 40 patients were randomised to MS Invigor8 (n=23) or standard care (n=17). The MS Invigor8 group accessed sessions over 8-10 weeks and received up to three 30-60min telephone support sessions. Participants completed online standardised questionnaires assessing fatigue, mood, quality of life and service use at baseline and 10 weeks follow-up. Large between group treatment effects were found for the primary outcomes of fatigue severity (d=1.19) and impact (d=1.02). The MS Invigor8 group also reported significantly greater improvements in anxiety, depression and quality-adjusted life years. These data suggest that Internet-based CBT may be a clinically and cost-effective treatment for MS fatigue. A larger RCT with longer term follow-up is warranted.
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Several studies have demonstrated that online CBT-based fatigue management programs are a cost-effective and accessible treatment option for pwMS.
“Several studies have demonstrated that online CBT-based fatigue management programs are a cost-effective and accessible treatment option for pwMS (Pottgen et al., 2018;Moss-Morris et al., 2012;van den Akker et al., 2017).”
From Neuropsychology intervention for managing invisible symptoms of MS (NIMIS-MS) group: A pilot effectiveness and acceptability study (2024) · cites this paper as Moss-Morris et al., 2012
CCBT has been used for 25 different clinical disorders, not only mental health conditions.
“Furthermore, CCBT has been used for 25 different clinical disorders [27], not only mental health conditions [59-62].”
From Computerized cognitive behavior therapy for anxiety and depression in rural areas:a systematic review (2015) · cites this paper as [59]
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The importance of fatigue cognitions in chronic hepatitis C infection
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Behavioral Interventions in Multiple Sclerosis.
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Self-citationThe emotional disorders associated with multiple sclerosis.
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- Authors
- Moss-Morris, R., McCrone, P., Yardley, L., van Kessel, K., Wills, G., & Dennison, L.
- Affiliations
- Guy's Hospital (GB)
- King's College London (GB)
- University of Southampton (GB)
- Corresponding author
- Moss-Morris, Rona
- Venue
- Behaviour Research and Therapy
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 50
- Issue
- 6
- Pages
- 415-421
- ISSN
- 0005-7967 (ISSN-L)
- OpenAlex
- W2068642589
- Cited by
- 209
- References
- 28
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 12 · 2023: 12 · 2022: 11 · 2021: 28 · 2020: 18 · 2019: 16 · 2018: 17 · 2017: 14 · 2016: 18 · 2015: 15 · 2014: 18 · 2013: 3 · 2012: 1
- FWCI
- 16.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behaviour Research and Therapy (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Multiple Sclerosis Society
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- multiple sclerosis, fatigue, cognitive behavioral therapy, online intervention, self-management program, feasibility, cost-effectiveness, anxiety, depression, quality of life, telephone support
- MeSH terms
- Adult, Cost-Benefit Analysis, Fatigue, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Patient Compliance, Pilot Projects, Quality of Life, Self Care, Cognitive Behavioral Therapy, Treatment Outcome, Patient Satisfaction, Remote Consultation, Internet
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