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Cited by 171Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and related disorders

The DOI matches its Crossref record; 307 of the 308 references it cites were found in a registry or an index.

Circadian disruption and sleep disorders in neurodegeneration

Open access
Shen, Yun, Lv, Qian-kun, Xie, Wei-ye, Gong, Si-yi, Zhuang, Sheng, Liu, Jun-yi, Mao, Cheng-jie, Liu, Chun-feng·2023·Translational Neurodegeneration
DOI 10.1186/s40035-023-00340-6PMC PMC9926748
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Abstract

Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions of circadian rhythms and sleep cycles and neurodegenerative diseases. Circadian disruption and sleep disorders aggravate neurodegeneration and neurodegenerative diseases can in turn disrupt circadian rhythms and sleep. Importantly, circadian disruption and various sleep disorders can increase the risk of neurodegenerative diseases. Thus, harnessing the circadian biology findings from preclinical and translational research in neurodegenerative diseases is of importance for reducing risk of neurodegeneration and improving symptoms and quality of life of individuals with neurodegenerative disorders via approaches that normalize circadian in the context of precision medicine. In this review, we discuss the implications of circadian disruption and sleep disorders in neurodegenerative diseases by summarizing evidence from both human and animal studies, focusing on the bidirectional links of sleep and circadian rhythms with prevalent forms of neurodegeneration. These findings provide valuable insights into the pathogenesis of neurodegenerative diseases and suggest a promising role of circadian-based interventions.

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Crossref · 10.1186/s40035-023-00340-6

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Fig. 1 Key neuroanatomical pathways of the circadian system. (1) SCN indirectly regulates melatonin release from the pineal gland by projecting light signals to PVN. (2) DMH receives light signals from SCN and then projects them to LC and VLPO, which in turn regulates sleep/awake activity. (3) SCN regulates thermoregulation and aggressive tendency by DMH through SPZ or not through SPZ. DMH dorsomedial hypothalamic nucleus; SPZ subparaventricular zone;
Fig. 1 Key neuroanatomical pathways of the circadian system. (1) SCN indirectly regulates melatonin release from the pineal gland by projecting light signals to PVN. (2) DMH receives light signals from SCN and then projects them to LC and VLPO, which in turn regulates sleep/awake activity. (3) SCN regulates thermoregulation and aggressive tendency by DMH through SPZ or not through SPZ. DMH dorsomedial hypothalamic nucleus; SPZ subparaventricular zone;CC BY · PubMed Central
Fig. 2 Schema of the circadian clock system—the transcription-translation feedback loops. The circadian clock consists of a network of TTFL that generates endogenous circadian rhythm. TTFL includes two loops: (1) The first loop of TTFL begins with BMAL1:CLOCK complex translocating into the nucleus, activating transcription of target genes containing E-box cis-regulatory enhancer sequences in their promoter regions, such as PER and CRY. The CRY and PER are then transferred to the nucleus and interact with CLOCK:BMAL1 complex to inhibit their own transcription. The decrease of PER and CRY protein levels reduces the suppression of BMAL1:CLOCK activity, which allows for the establishment of a new oscillatory cycle. (2) In the second loop, the REV-ERBα/β repressor and the RORα/β activator proteins co-maintain the periodic expression of BMAL1
Fig. 2 Schema of the circadian clock system—the transcription-translation feedback loops. The circadian clock consists of a network of TTFL that generates endogenous circadian rhythm. TTFL includes two loops: (1) The first loop of TTFL begins with BMAL1:CLOCK complex translocating into the nucleus, activating transcription of target genes containing E-box cis-regulatory enhancer sequences in their promoter regions, such as PER and CRY. The CRY and PER are then transferred to the nucleus and interact with CLOCK:BMAL1 complex to inhibit their own transcription. The decrease of PER and CRY protein levels reduces the suppression of BMAL1:CLOCK activity, which allows for the establishment of a new oscillatory cycle. (2) In the second loop, the REV-ERBα/β repressor and the RORα/β activator proteins co-maintain the periodic expression of BMAL1CC BY · PubMed Central
Fig. 3 Circadian dysfunctions in neurodegeneration. Circadian dysfunctions in neurodegeneration can be classified into three categories: behavioral, physiologic, and molecular alterations. There are bi-directional relationships of circadian rhythm and sleep disorder with neurodegeneration
Fig. 3 Circadian dysfunctions in neurodegeneration. Circadian dysfunctions in neurodegeneration can be classified into three categories: behavioral, physiologic, and molecular alterations. There are bi-directional relationships of circadian rhythm and sleep disorder with neurodegenerationCC BY · PubMed Central
Fig. 4 Management of circadian disruption and sleep disorders in patients with neurodegenerative diseases in four steps. About circadian disruption, chronopharmacological methods which combine both pharmacological and non-pharmacological approaches can be considered
Fig. 4 Management of circadian disruption and sleep disorders in patients with neurodegenerative diseases in four steps. About circadian disruption, chronopharmacological methods which combine both pharmacological and non-pharmacological approaches can be consideredCC BY · PubMed Central

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Metadata

Authors
Shen, Y., Lv, Q.-K., Xie, W.-Y., Gong, S.-Y., Zhuang, S., Liu, J.-Y., Mao, C.-J., & Liu, C.-F.
Affiliations
  • Second Affiliated Hospital of Soochow University (CN)
  • Soochow University (CN)
Corresponding author
Liu, Chun-feng
ORCID
Venue
Translational Neurodegeneration
Publisher
Springer Science and Business Media LLC
Published
2023-02-13
Volume
12
Issue
1
Pages
8-8
ISSN
2047-9158 (ISSN-L)
DOI
10.1186/s40035-023-00340-6
PMC
PMC9926748
OpenAlex
W4320483859
Cited by
171
References
308
Citations by year
2026: 50 · 2025: 71 · 2024: 35 · 2023: 15
FWCI
6.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Translational Neurodegeneration (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (82071420)
  • Discipline Construction Program of the Second Affiliated Hospital of Soochow University (XKTJ-XK202001)
  • Suzhou Medical and Health Technology Innovation Project (SKJY2021090)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
circadian rhythm disruption, circadian rhythm, sleep disorders, neurodegenerative diseases, precision medicine, neurodegeneration pathogenesis
MeSH terms
Animals, Circadian Rhythm, Humans, Quality of Life, Sleep, Sleep Wake Disorders, Neurodegenerative Diseases

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