Cited by 411Gut microbiota and healthOral microbiology and periodontitis researchGastrointestinal motility and disorders

The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.

(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease

Open access
Buford, Thomas W.·2017·Microbiome

Abstract

Chronic inflammation represents one of the most consistent biologic features of aging. However, the precise etiology of persistent low-grade increases in inflammation remains unclear. Recent evidence suggests that the gut microbiome may play a key role in age-related inflammation. Indeed, several studies have indicated that older adults display an altered composition of the gut microbiota, and early evidence indicates that this dysbiosis is associated with the presence of several key circulating inflammatory analytes. The present review summarizes knowledge on age-related inflammation and discusses how potential relationships with gut dysbiosis may lead to novel treatment strategies in the future."The pattern of disease is an expression of the response of man to his total environment (physical, biological, and social); this response is, therefore, determined by anything that affects man himself or his environment." - Rene Dubos, 1961.

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Crossref · 10.1186/s40168-017-0296-0

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Fig. 1 Number of PubMed citations by year using the search term “aging and inflammation”
Fig. 1 Number of PubMed citations by year using the search term “aging and inflammation”CC BY · PubMed Central
Fig. 2 a Prominent health conditions with both biologic age and chronic inflammation as central risk factors. b Prominent health conditions with evidence linking them to gut dysbiosis. Note the similarities between the conditions associated with aging and inflammation and those associated with gut dysbiosis
Fig. 2 a Prominent health conditions with both biologic age and chronic inflammation as central risk factors. b Prominent health conditions with evidence linking them to gut dysbiosis. Note the similarities between the conditions associated with aging and inflammation and those associated with gut dysbiosisCC BY · PubMed Central
Fig. 3 Simplified schematic outlining the potential relationships among health risk factors, gut dysbiosis, inflammation, and age-related disease—as well as potential interventions for attenuating gut-associated inflammation
Fig. 3 Simplified schematic outlining the potential relationships among health risk factors, gut dysbiosis, inflammation, and age-related disease—as well as potential interventions for attenuating gut-associated inflammationCC BY · PubMed Central

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Metadata

Authors
Buford, T. W.
Affiliations
University of Alabama at Birmingham (US)
Corresponding author
Buford, Thomas W.
Venue
Microbiome
Published
2017-07-14
Volume
5
Issue
1
Pages
80-80
ISSN
2049-2618 (ISSN-L)
OpenAlex
W2734566898
Cited by
409
References
133
Citations by year
2026: 21 · 2025: 37 · 2024: 53 · 2023: 45 · 2022: 60 · 2021: 74 · 2020: 47 · 2019: 40 · 2018: 24 · 2017: 8
FWCI
3.07
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Microbiome (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Institute on Aging (P30AG028740)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut microbiota, age-related inflammation, aging, gut dysbiosis, older adults, low-grade inflammation, circulating inflammatory biomarkers, microbiota-targeted therapy
MeSH terms
Gastrointestinal Microbiome, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Animals, Diet, Feces, Female, Health, Humans, Inflammation, Male, Middle Aged, Mice, Dysbiosis

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