The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease
Open accessAbstract
Chronic inflammation represents one of the most consistent biologic features of aging. However, the precise etiology of persistent low-grade increases in inflammation remains unclear. Recent evidence suggests that the gut microbiome may play a key role in age-related inflammation. Indeed, several studies have indicated that older adults display an altered composition of the gut microbiota, and early evidence indicates that this dysbiosis is associated with the presence of several key circulating inflammatory analytes. The present review summarizes knowledge on age-related inflammation and discusses how potential relationships with gut dysbiosis may lead to novel treatment strategies in the future."The pattern of disease is an expression of the response of man to his total environment (physical, biological, and social); this response is, therefore, determined by anything that affects man himself or his environment." - Rene Dubos, 1961.
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“A recent study has shown that intestinal-barrier permeability increases during ageing, leading to higher levels of endotoxins, including LPS, in ageing tissues58,59.”
From Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages (2020) · cites this paper as [58]
In the citing paper
“Gradual changes in microbiota composition have been observed as normal features of aging, including changes in microbial resilience, stability, and diversity, which are features that occur alongside changes in microglial physiology with age (Zapata and Quagliarello, 2015; Buford, 2017).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Buford, 2017
In the citing paper
“Gradual changes in microbiota composition have been observed as normal features of aging, including changes in microbial resilience, stability, and diversity, which are features that occur alongside changes in microglial physiology with age (Zapata and Quagliarello, 2015; Buford, 2017).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Buford, 2017
In the citing paper
“Similar to neurodevelopmental disorders, this trend suggests that microbiota-driven changes in microglial behavior might have a larger role in the onset or progression of neurodegenerative disorders than previously thought (Buford, 2017).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Buford, 2017
In the citing paper
“In the aged GI tract, compromised epithelial and mucosal cell turnover, integrity, and function [32, 36, 76, 83] can lead to increased epithelial barrier permeability [19, 75, 118, 120]”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [19]
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Cites
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Gut microbiota composition correlates with diet and health in the elderly
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Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267
Yuan, T., Yang, T., Chen, H., Fu, D., Hu, Y., Wang, J., Yuan, Q., Yu, H., Xu, W., & Xie, X. (2018) · Redox Biology · doi:10.1016/j.redox.2018.09.025 · Cited by 766
Gut microbiome and aging: physiological and mechanistic insights
Nagpal, R., Mainali, R., Ahmadi, S., Wang, S., Singh, R., Kavanagh, K., Kitzman, D. W., Kushugulova, A., Marotta, F., & Yadav, H. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-170030 · Cited by 670
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Oscillospira - a candidate for the next-generation probiotics
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Metadata
- Authors
- Buford, T. W.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Buford, Thomas W.
- ORCID
- Buford, Thomas W.
- Venue
- Microbiome
- Published
- 2017-07-14
- Volume
- 5
- Issue
- 1
- Pages
- 80-80
- ISSN
- 2049-2618 (ISSN-L)
- PMC
- PMC5512975
- OpenAlex
- W2734566898
- Cited by
- 409
- References
- 133
- Citations by year
- 2026: 21 · 2025: 37 · 2024: 53 · 2023: 45 · 2022: 60 · 2021: 74 · 2020: 47 · 2019: 40 · 2018: 24 · 2017: 8
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Microbiome (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute on Aging (P30AG028740)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, age-related inflammation, aging, gut dysbiosis, older adults, low-grade inflammation, circulating inflammatory biomarkers, microbiota-targeted therapy
- MeSH terms
- Gastrointestinal Microbiome, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Animals, Diet, Feces, Female, Health, Humans, Inflammation, Male, Middle Aged, Mice, Dysbiosis
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