Cited by 411Gut microbiota and healthOral microbiology and periodontitis researchGastrointestinal motility and disorders

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(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease

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Buford, Thomas W.·2017·Microbiome

DOI 10.1186/s40168-017-0296-0PMC PMC5512975

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Abstract

Chronic inflammation represents one of the most consistent biologic features of aging. However, the precise etiology of persistent low-grade increases in inflammation remains unclear. Recent evidence suggests that the gut microbiome may play a key role in age-related inflammation. Indeed, several studies have indicated that older adults display an altered composition of the gut microbiota, and early evidence indicates that this dysbiosis is associated with the presence of several key circulating inflammatory analytes. The present review summarizes knowledge on age-related inflammation and discusses how potential relationships with gut dysbiosis may lead to novel treatment strategies in the future."The pattern of disease is an expression of the response of man to his total environment (physical, biological, and social); this response is, therefore, determined by anything that affects man himself or his environment." - Rene Dubos, 1961.

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Fig. 1 Number of PubMed citations by year using the search term “aging and inflammation”CC BY · PubMed Central

Fig. 2 a Prominent health conditions with both biologic age and chronic inflammation as central risk factors. b Prominent health conditions with evidence linking them to gut dysbiosis. Note the similarities between the conditions associated with aging and inflammation and those associated with gut dysbiosisCC BY · PubMed Central

Fig. 3 Simplified schematic outlining the potential relationships among health risk factors, gut dysbiosis, inflammation, and age-related disease—as well as potential interventions for attenuating gut-associated inflammationCC BY · PubMed Central

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Authors: Buford, T. W.
Affiliations: University of Alabama at Birmingham (US)
Corresponding author: Buford, Thomas W.
ORCID: Buford, Thomas W.
Venue: Microbiome
Publisher: Springer Science and Business Media LLC
Published: 2017-07-14
Volume: 5
Issue: 1
Pages: 80-80
ISSN: 2049-2618 (ISSN-L)
DOI: 10.1186/s40168-017-0296-0
PMC: PMC5512975
OpenAlex: W2734566898
Cited by: 409
References: 133
Citations by year: 2026: 21 · 2025: 37 · 2024: 53 · 2023: 45 · 2022: 60 · 2021: 74 · 2020: 47 · 2019: 40 · 2018: 24 · 2017: 8
FWCI: 3.07
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Microbiome (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: National Institute on Aging (P30AG028740)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: gut microbiota, age-related inflammation, aging, gut dysbiosis, older adults, low-grade inflammation, circulating inflammatory biomarkers, microbiota-targeted therapy
MeSH terms: Gastrointestinal Microbiome, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Animals, Diet, Feces, Female, Health, Humans, Inflammation, Male, Middle Aged, Mice, Dysbiosis

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(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease

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