Effects of poly(L-lactide-ε-caprolactone) and magnesium hydroxide additives on physico-mechanical properties and degradation of poly(L-lactic acid)
Open accessAbstract
Background: Biodegradable poly(L-lactic acid) (PLLA) is one of the most widely used polymer in biomedical devices, but it still has limitations such as inherent brittleness and acidic degradation products. In this work, PLLA blends with poly(L-lactide-ε-caprolactone) (PLCL) and Mg(OH) 2 were prepared by the thermal processing to improve their physico-mechanical and thermal properties. In addition, the neutralizing effect of Mg(OH) 2 was evaluated by degradation study. Results: The elongation of PLLA remarkably increased from 3 to 164.4 % and the glass transition temperature (T g ) of PLLA was slightly reduced from 61 to 52 °C by adding PLCL additive. Mg(OH) 2 in polymeric matrix not only improved the molecular weight reduction and mechanical strength of PLLA, but also neutralized the acidic byproducts generated during polyester degradation. Conclusions: Therefore, the results demonstrated that the presence of PLCL and Mg(OH) 2 additives in PLLA matrix could prevent the thermal decomposition and control degradation behavior of polyester.
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Blends of PLLA with PLCL show improved miscibility compared with PLLA/PCL blends.
“blends of PLLA with poly( L -lactide-coε -caprolactone) (PLCL) have been developed and show improved miscibility [25-27]”
From Tuning structural relaxations, mechanical properties, and degradation timescale of PLLA during hydrolytic degradation by blending with PLCL-PEG (2019) · cites this paper as [27]
The Methods section describes fabricating PLLA/PLCL blends as a homogeneous mixture, supporting that such blends were developed. The Results and Discussion section examines their mechanical and thermal properties, but our copy does not compare their miscibility with PLLA/PCL blends or establish improved miscibility. (LLM, conf=0.84)
Experimental — accuracy not yet measuredHigher humidity accelerates PLCL degradation, thereby reducing its mechanical strength.
“In addition, humidity also has an effect on the mechanical properties of PLCL, and higher humidity accelerates PLCL degradation, thereby reducing its mechanical strength [62].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [62]
The Methods > Degradation test section describes immersing PLLA and PLLA/PLCL blends in phosphate-buffered saline, while Results and Discussion > PLLA/PLCL blends links lower tensile strength to adding PLCL. Neither section addresses humidity or shows that higher humidity accelerates PLCL degradation and thereby reduces its mechanical strength. Searches for humidity, moisture, and wet conditions found no passage establishing that relationship. (LLM, conf=0.76)
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- Authors
- Kang, E. Y., Lih, E., Kim, I. H., Joung, Y. K., & Han, D. K.
- Affiliations
- Korea University (KR)
- Korea Institute of Science and Technology (KR)
- Corresponding author
- Han, Dong Keun
- Venue
- Biomaterials Research
- Published
- 2016-03-15
- Volume
- 20
- Issue
- 1
- Pages
- 7-7
- ISSN
- 1226-4601 (ISSN-L)
- 2055-7124
- PMC
- PMC4791761
- OpenAlex
- W2302349352
- Cited by
- 38
- References
- 35
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 2 · 2016: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Biomaterials Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Science, ICT and Future Planning (2014M3C1A3056052, 2014M3A9D3033887)
- Ministry of Trade, Industry and Energy (10048019)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Keywords
- poly(L-lactic acid), magnesium hydroxide, polymer blends, biodegradable polymers, mechanical properties, glass transition temperature, thermal degradation, acidic degradation products, neutralization, molecular weight reduction, biomedical polymers
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