Lamination of microfibrous PLGA fabric by electrospinning a layer of collagen-hydroxyapatite composite nanofibers for bone tissue engineering
Open accessAbstract
BACKGROUND: To mimic the muscle inspired cells adhesion through proteins secretion, the lamination of collagen-hydroxyapatite nanorod (nHA) composite nanofibers has been carried out successfully on polydopamine (PDA)-coated microfibrous polylactide-co-glycolide (PLGA) fabrics. The lamination of collagen-hydroxyapatite composite nanofibers on polydopamine-coated microfibrous PLGA fabrics was carried through electrospinning the solution of collagen containing L-glutamic acid-grafted hydroxyapatite nanorods (nHA-GA) at a flow rate of 1.5 mL/h and an applied voltage of 15 kV. RESULTS: In comparison to pristine PLGA, dopamine-coated PLGA and collagen-hydroxyapatite composite nanofiber lamination has produced more wettable surfaces and surface wettability is found to higher with dopamine-coated PLGA fabrics then pristine PLGA. The SEM micrographs have clearly indicated that the lamination of polydopamine-coated PLGA fabric with collagen-hydroxyapatite composite nanofibers has shown increased adhesion of MC3T3E1 cells in comparison to pristine PLGA fabrics. CONCLUSION: The results of these studies have clearly demonstrated that collagen-nHA composites fibers may be used to create bioactive 3D scaffolds using PLGA as an architectural support agent.
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High interaction between the composite and MSCs can subsequently help in bone regeneration.
“The interaction between the [99] | composite and the MSCs was high | which can subsequently help in | bone regeneration.”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [99]
The Results and discussion section reports enhanced adhesion and proliferation of MC3T3-E1 cells on the collagen–hydroxyapatite composite scaffolds, and the Conclusions describe their potential for bone tissue engineering (pages not provided). The study does not establish high interaction with MSCs specifically or demonstrate bone regeneration. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe interaction between the composite and the MSCs was high.
“The interaction between the [99] | composite and the MSCs was high | which can subsequently help in | bone regeneration.”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [99]
The Results and discussion section reports increased cell adhesion on the collagen–hydroxyapatite composite scaffolds, supporting the claim of strong cell interaction. However, the tested cells were MC3T3-E1 cells, not MSCs; the paper does not establish the claimed interaction with MSCs. (LLM, conf=0.88)
Experimental — accuracy not yet measured
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Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration.
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- Authors
- Kwon, G.-W., Gupta, K. C., Jung, K.-H., & Kang, I.-K.
- Affiliations
- Kyungpook National University (KR)
- Indian Institute of Technology Roorkee (IN)
- Daegu Catholic University (KR)
- Corresponding author
- Gupta, Kailash Chandra
- Kang, Inn-Kyu
- Venue
- Biomaterials Research
- Published
- 2017-06-13
- Volume
- 21
- Issue
- 1
- Pages
- 11-11
- ISSN
- 1226-4601 (ISSN-L)
- 2055-7124
- PMC
- PMC5470256
- OpenAlex
- W2626822636
- Cited by
- 33
- References
- 41
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 6
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Biomaterials Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Education, Science and Technology (2016R1D1A1A9918166)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- hydroxyapatite nanorods, polydopamine coating, bone tissue engineering, wettability, cell adhesion
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