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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

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A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

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The Classical Complement Cascade Mediates CNS Synapse Elimination

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Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects

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Developmental and neurobehavioral toxicity of 2,2′-methylenebis(6-tert-butyl-4-methylphenol) (antioxidant AO2246) during the early life stage of zebrafish

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Chronic Psychological Distress as an Inducer of Microglial Activation and Leukocyte Recruitment into the Area Postrema

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Immune dysregulation in offspring of a bipolar parent. Altered serum levels of immune growth factors at adolescent age.

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Attenuated inflammatory response of monocyte-derived macrophage from patients with BD: a preliminary report

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Vortioxetine on Cognition in Schizophrenia

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Adenosine Hypothesis of Antipsychotic Drugs Revisited: Pharmacogenomics Variation in Nonacute Schizophrenia

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Inhibition of Microglial GSK3β Activity Is Common to Different Kinds of Antidepressants: A Proposal for an In Vitro Screen to Detect Novel Antidepressant Principles

Kalkman, H. O. (2023) · Biomedicines · doi:10.3390/biomedicines11030806 · Cited by 18

Evidence for an association between inflammatory markers and suicide: a cohort study based on 359,849 to 462,747 Taiwanese adults

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HMGB1: Different secretion pathways with pivotal role in epilepsy and major depressive disorder

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Effects of fingolimod, a sphingosine-1-phosphate (S1P) receptor agonist, on white matter microstructure, cognition and symptoms in schizophrenia

Francis, M., Hummer, T. A., Liffick, E., Vohs, J. L., Mehdiyoun, N. F., Visco, A. C., Yang, Z., Kovacs, R. J., Zhang, Y., & Breier, A. F. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00375-7 · Cited by 17

Huntington’s Disease: Pathogenic Mechanisms and Therapeutic Targets

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More dampened monocytic Toll-like receptor 4 response to lipopolysaccharide and its association with cognitive function in Chinese Han first-episode patients with schizophrenia

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In Vivo Microdialysis Sampling of Cytokines from Rat Hippocampus: Comparison of Cannula Implantation Procedures

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Transient anxiety-and depression-like behaviors are linked to the depletion of Foxp3-expressing cells via inflammasome in the brain

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LPS-induced cortical kynurenic acid and neurogranin-NFAT signaling is associated with deficits in stimulus processing during Pavlovian conditioning

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Reduced plasma Fetuin-A is a promising biomarker of depression in the elderly

Fanelli, G., Benedetti, F., Wang, S., Lee, S.-J., Jun, T., Masand, P. S., Patkar, A. A., Han, C., Serretti, A., Pae, C., et al. (2019) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-019-01090-1 · Cited by 16

Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia

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Conventional and new immunotherapies for immune system dysregulation in postpartum mood disorders: comparisons to immune system dysregulations in bipolar disorder, major depression, and postpartum autoimmune thyroid disease

Drexhage, H. A., Bergink, V., Poletti, S., Benedetti, F., & Osborne, L. M. (2024) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2024.2420053 · Cited by 16

Electroconvulsive seizures (ECS) do not prevent LPS-induced behavioral alterations and microglial activation

van Buel, E. M., Bosker, F. J., van Drunen, J., Strijker, J., Douwenga, W., Klein, H. C., & Eisel, U. L. M. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0454-x · Cited by 17

Neuroinflammation and excitatory symptoms in bipolar disorder

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Monocyte/HDL Cholesterol Ratios as a New Inflammatory Marker in Patients with Schizophrenia

Kılıç, N., Tasci, G., Yılmaz, S., Öner, P., & Korkmaz, S. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13020276 · Cited by 15

Inducible Nitric Oxide Synthase Inhibition in the Medial Prefrontal Cortex Attenuates the Anxiogenic-Like Effect of Acute Restraint Stress via CB1 Receptors

Coelho, A. A., Vila-Verde, C., Sartim, A. G., Uliana, D. L., Braga, L. A., Guimarães, F. S., & Lisboa, S. F. D. S. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.923177 · Cited by 15

Biomarkers of stress resilience: A review

Paribello, P., Branchi, I., Viglione, A., Mancini, G. F., Morena, M., Campolongo, P., & Manchia, M. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104052 · Cited by 17

Blood Vessels and Perivascular Phagocytes of Prefrontal White and Gray Matter in Suicide

Schnieder, T. P., Qin, I. D. Z., Trencevsja-Ivanovska, I., Rosoklija, G. B., Stankov, A., Pavlovski, G., Mann, J. J., & Dwork, A. J. (2018) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nly103 · Cited by 15

Old and New Biomarkers for Infection, Inflammation, and Autoimmunity in Treatment-Resistant Affective and Schizophrenic Spectrum Disorders

Scheiber, C., Schulz, T., Schneider, J. M., Bechter, K., & Schneider, E. M. (2022) · Pharmaceuticals · doi:10.3390/ph15030299 · Cited by 15

cRGD mediated liposomes enhanced antidepressant-like effects of edaravone in rats

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Reduction in serum IL-1β, IL-6, and IL-18 levels and Beck Depression Inventory-II score by combined sertraline and ketoprofen administration in major depressive disorder: A clinical trial

Al‐Hakeim, H. K., Twayej, A. J., & Al-Dujaili, A. H. (2018) · Neurology Psychiatry and Brain Research · doi:10.1016/j.npbr.2018.10.001 · Cited by 16

Monocyte–Lymphocyte Ratio and Dysglycemia: A Retrospective, Cross-Sectional Study of the Saudi Population

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The causal relationship between immune cell traits and schizophrenia: a Mendelian randomization analysis

Du, J., Baranova, A. V., Zhang, G., & Zhang, F. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1452214 · Cited by 14

Neurokinin (NK)-1 receptor expression in monocytes from bipolar disorder patients: A pilot study

Amoruso, A., Bardelli, C., Cattaneo, C. I., Fresu, L. G., Manzetti, E., & Brunelleschi, S. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.03.013 · Cited by 14

Metabolic syndrome following a first episode of psychosis: results of a 1-year longitudinal study conducted in metropolitan Lisbon, Portugal

Coentre, R. M., Levy, P., Góis, C., & Figueira, M. L. (2022) · Journal of International Medical Research · doi:10.1177/03000605221106703 · Cited by 13

Association of total peripheral inflammation with lower frontal and temporal lobe volumes in early-stage bipolar disorder: A proof-of-concept study.

Bond, D., Andreazza, A., Torres, I., Honer, W., Lam, R. W., & Yatham, L. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.044 · Cited by 11

Aspects of the immune system that impact brain function

Bondy, S. C. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577167 · Cited by 14

Differential Macrophage Responses in Affective Versus Non-Affective First-Episode Psychosis Patients

Hughes, H. K., Mills-Ko, E., Yang, H. T., Lesh, T. A., Carter, C. S., & Ashwood, P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.583351 · Cited by 13

Exaggerated Increases in Microglia Proliferation, Brain Inflammatory Response and Sickness Behaviour upon Lipopolysaccharide Stimulation in Non-Obese Diabetic Mice

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Pharmacotherapy of schizophrenia: immunological aspects and potential role of immunotherapy

Chauhan, P., Kaur, G., Prasad, R., & Singh, H. (2021) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2021.1994857 · Cited by 12

Treat the brain and treat the periphery: toward a holistic approach to major depressive disorder

Zheng, X., Zhang, X., Wang, G., & Hao, H. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.03.015 · Cited by 12

Differential expression of brain immune genes and schizophrenia-related behavior in C57BL/6N and DBA/2J female mice

Ma, L., Kulesskaya, N., Võikar, V., & Tian, L. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.01.001 · Cited by 12

Does CRP predict outcome in bipolar disorder in regular outpatient care?

Balukova, S. M., Haarman, B. C. M., der Lek, R. F. R., & Schoevers, R. A. (2016) · International Journal of Bipolar Disorders · doi:10.1186/s40345-016-0055-3 · Cited by 12

From the immune system to mood disorders especially induced by Toxoplasma gondii: CD4+ T cell as a bridge

Wang, Q., Zhong, Y., Chen, N., & Chen, J. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1078984 · Cited by 12

Total and Differential White Blood Cell Counts, Cocaine, and Marijuana Use in Patients With Schizophrenia

Goetz, R. L., & Miller, B. J. (2019) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000001019 · Cited by 11

Antiviral treatment in schizophrenia: a randomized pilot PET study on the effects of valaciclovir on neuroinflammation

Jonker, I., Doorduin, J., Knegtering, H., Hag, E. V., Dierckx, R., de Vries, E. F. J., Schoevers, R. A., & Klein, H. C. (2023) · Psychological Medicine · doi:10.1017/s0033291723000430 · Cited by 11

Inflammation and Mental Health Disorders: Immunomodulation as a Potential Therapy for Psychiatric Conditions

Safari, H., & Mashayekhan, S. (2023) · Current Pharmaceutical Design · doi:10.2174/0113816128251883231031054700 · Cited by 11

Comparison of monocyte gene expression among patients with neurocysticercosis-associated epilepsy, Idiopathic Epilepsy and idiopathic headaches in India

Prabhakaran, V., Drevets, D. A., Govindan, R., Manoj, J., Anderson, M. P., Hanas, J. S., Rajshekhar, V., Oommen, A. M., & Carabin, H. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005664 · Cited by 10

Splicing landscape of the eight collaborative cross founder strains

ZHENG, C. L., Wilmot, B., Walter, N. A. R., Oberbeck, D. L., Kawane, S., Searles, R. P., McWeeney, S. K., & HITZEMANN, R. J. (2015) · BMC Genomics · doi:10.1186/s12864-015-1267-0 · Cited by 10

Allergen Induces Depression-like Behavior in Association with Altered Prefrontal-hippocampal Circuit in Male Rats

Dehdar, K., Salimi, M., Tabasi, F., Dehghan, S., Sumiyoshi, A., Garousi, M., Jamaati, H., Javan, M., & Raoufy, M. R. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.05.034 · Cited by 9

Cocaine perturbs neurodevelopment and increases neuroinflammation in a prenatal cerebral organoid model

Davis, J. L., Kennedy, C., McMahon, C. L., Keegan, L., Clerkin, S., Treacy, N. J., Hoban, A. E., Kelly, Y., Brougham, D. F., Crean, J. K. G., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03315-5 · Cited by 9

Serum neurofilament light as a potential marker of illness duration in bipolar disorder

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Purification of cells from fresh human brain tissue: primary human glial cells

Mizee, M. R., van der Poel, M., & Huitinga, I. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63639-3.00019-0 · Cited by 10

Development and validation of a nomogram based on lymphocyte subsets to distinguish bipolar depression from major depressive disorder

Su, L., Shuai, Y., Mou, S., Shen, Y., Shen, X., Shen, Z., & Zhang, X. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1017888 · Cited by 9

Disentangling the Genetic Landscape of Peripartum Depression: A Multi-Polygenic Machine Learning Approach on an Italian Sample

Harrington, Y. A., Fortaner-Uyà, L., Paolini, M., Poletti, S., Lorenzi, C., Spadini, S., Melloni, E. M. T., Agnoletto, E., Zanardi, R., Colombo, C., et al. (2024) · Genes · doi:10.3390/genes15121517 · Cited by 8

Effect of probiotics on C-reactive protein levels in schizophrenia: Evidence from a systematic review and meta-analysis

Romero‐Ferreiro, V., Fernandez, L. G., Fernández, J. M. B., Romero, C., González-Soltero, R., la Fuente, M. D., Álvarez-Mon, M. Á., Wynn, R., & Rodríguez–Jiménez, R. (2025) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2025.103126 · Cited by 9

Influence of the inflammasome complex on psychiatric disorders: clinical and preclinical studies

Kwon, S., & Cheon, S. Y. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.2005027 · Cited by 9

Plasma soluble suppression of tumorigenicity 2 and depression after acute ischemic stroke

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Targeting neurotransmitter-mediated inflammatory mechanisms of psychiatric drugs to mitigate the double burden of multimorbidity and polypharmacy

Matt, S. M. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100353 · Cited by 8

Multi-frequency electromagnetic radiation induces anxiety in mice via inflammation in the cerebral cortex

Jing, X., Li, M.-H., Li-hui, Z., Qian, W., Xueli, W., Xuelong, Z., Li, Z., Dong, G., & Changzhen, W. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-33447-y · Cited by 7

Psychosomatic - psychotherapeutic treatment of stress-related disorders impacts the sphingolipid metabolism towards increased sphingosine and sphingosine-1-phosphate levels

Werner, F., Schumacher, F., Mühle, C., Adler, W., Schug, C., Schäflein, E., Morawa, E., Kleuser, B., Kornhuber, J., Erim, Y., et al. (2025) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-025-01985-2 · Cited by 7

Translocator protein ligand, YL-IPA08, attenuates lipopolysaccharide-induced depression-like behavior by promoting neural regeneration

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The Interaction of Inflammatory Markers and Alcohol-Use on Cognitive Function in Korean Male Firefighters

Yun, J.-A., Jeong, K. S., Ahn, Y., Han, Y., & Choi, K. (2021) · Psychiatry Investigation · doi:10.30773/pi.2020.0101 · Cited by 8

Comments on the ambiguity of selected surface markers, signaling pathways and omics profiles hampering the identification of myeloid-derived suppressor cells

Lutz, M. B., & Eckert, I. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104347 · Cited by 7

Serum Galectin‐1, Galectin‐9, and YKL‐40 levels in bipolar disorder and their relationship with cognitive functions

Selahaddin, E., Demir, B., Şahin, Ş. K., Tayşi, S., Ulusal, H., Elboğa, G., & Altındağ, A. (2024) · Brain and Behavior · doi:10.1002/brb3.3421 · Cited by 6

Genetic Variations within Metalloproteinases Impact on the Prophylaxis of Depressive Phases in Bipolar Patients

Drago, A., Monti, B., Ronchi, D. D., & Serretti, A. (2014) · Neuropsychobiology · doi:10.1159/000356971 · Cited by 8

Role of the IL-6-Receptor expression in CD14+ monocytes in modulating sleep in patients with bipolar disorder

Ritter, P. S., Brandt, M., Schrempf, W., Brezan, F., Krupka, A., Storch, A., Sauer, C., Pfennig, A., Bauer, M., & Soltmann, B. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.06.037 · Cited by 7

Granulocyte-macrophage colony-stimulating factor-triggered innate immune tolerance against chronic stress-induced behavioral abnormalities in mice

Chen, Z., Liu, H., Ye, Y., Chen, D., Lu, Q., Lu, X., & Huang, C. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108924 · Cited by 6

Onset age moderates the associations between neutrophil-to-lymphocyte ratio and clinical symptoms in first-episode patients with schizophrenia

Wang, K., Liu, S., Huang, D. F., Guan, X., Chen, N., Xiu, M., Liu, D., & Huang, Y. (2024) · Schizophrenia · doi:10.1038/s41537-024-00522-9 · Cited by 6

Rodent Models of Stress-Induced Depression: The Link Between Stress and Immune System Related Changes

McGuinness, B. W., & Harkin, A. (2015) · Current topics in neurotoxicity · doi:10.1007/978-3-319-13602-8_3 · Cited by 7

Neuroglia in anxiety disorders

Bonomi, R. E., Pietrzak, R. H., & Cosgrove, K. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19102-2.00008-9 · Cited by 5

Analysis of selected polymorphisms in FOXP3 gene in a cohort of Egyptian patients with schizophrenia

Mostafa, M., Fathy, A. A., Elwasify, M., & Abdelsalam, M. (2022) · Journal of Genetic Engineering and Biotechnology · doi:10.1186/s43141-022-00371-y · Cited by 5

Severe fatigue as symptom of long COVID is characterized by increased expression of inflammatory genes in monocytes, increased serum pro-inflammatory cytokines, and increased CD8+ T-lymphocytes: A putative dysregulation of the immune-brain axis, the coagulation process, and auto-inflammation to explain the diversity of long COVID symptomsPreprint

Berentschot, J. C., Drexhage, H. A., Mersha, D. G. A., Wijkhuijs, A. J. M., GeurtsvanKessel, C. H., Koopmans, M., Voermans, J. J. C., Heijenbrok‐Kal, M. H., Bek, L. M., Ribbers, G. M., et al. (2022) · medRxiv · doi:10.1101/2022.09.15.22279970 · Cited by 5

THSG counteracts microglial glycolytic reprogramming and neuronal necroptosis both in vivo and in vitro under conditions of neuroinflammation

Guo, Z., Zhong, S.-J., Bai, J.-P., Lang, X.-Y., Cao, M., Hu, Y., Qin, X., & Sun, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-05994-y · Cited by 4

Profiling of activated monocyte populations in autism and associations with increased severity and comorbid behaviors

Breece, E., Moreno, R. J., Azzam, Y. W., Rogers, S. J., & Ashwood, P. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.12.151 · Cited by 4

Preventive and Therapeutic Effects of Intracerebroventricular Administration of Maresin-1 on Lipopolysaccharide-Induced Depression-Like Behaviors in Mice

Deyama, S., Kaneda, K., & Minami, M. (2025) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b24-00743 · Cited by 4

Serum Interleukin-1β and tumor necrosis factor–α in first-episode drug-naive and chronic schizophrenia patients: Associated with cognitive deficits

Zhang, L., Liu, F., Zheng, H., Wu, R., & Zhao, J. (2021) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2021.102605 · Cited by 4

The role of HMGB1 in neuroinflammation and tissue repair: A potential therapeutic target for depression?

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Neurogliovascular alterations in brain pathologies across lifespan

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