Cited by 347Tryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

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The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes

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Beumer, Wouter, Gibney, Sinead M, Drexhage, Roosmarijn C, Pont-Lezica, Lorena, Doorduin, Janine, Klein, Hans C, Steiner, Johann, Connor, Thomas J, Harkin, Andrew, Versnel, Marjan A, Drexhage, Hemmo A·2012·Journal of Leukocyte Biology

DOI 10.1189/jlb.0212100

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Abstract

This review describes a key role for mononuclear phagocytes in the pathogenesis of major psychiatric disorders. There is accumulating evidence for activation of microglia (histopathology and PET scans) and circulating monocytes (enhanced gene expression of immune genes, an overproduction of monocyte/macrophage-related cytokines) in patients with bipolar disorder, major depressive disorder, and schizophrenia. These data are strengthened by observations in animal models, such as the MIA models, the chronic stress models, and the NOD mouse model. In these animal models of depressive-, anxiety-, and schizophrenia-like behavior, similar activations of microglia and circulating monocytes can be found. These animal models also make in-depth pathogenic studies possible and show that microglia activation impacts neuronal development and function in brain areas congruent with the altered depressive and schizophrenia-like behaviors.

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Schubart, C. D., Sommer, I. E., Fusar‐Poli, P., de Witte, L. D., Kahn, R. S., & Boks, M. P. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.11.002 · Cited by 105
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Breier, A. F., Liffick, E., Hummer, T. A., Vohs, J. L., Yang, Z., Mehdiyoun, N. F., Visco, A. C., Metzler, E., Zhang, Y., & Francis, M. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.03.012 · Cited by 99
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Landek‐Salgado, M. A., Faust, T. E., & Sawa, A. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.141 · Cited by 95
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Kern, S., Skoog, I., Börjesson-Hanson, A., Blennow, K., Zetterberg, H., Östling, S., Kern, J., Gudmundsson, P., Marlow, T., Rosengren, L., et al. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.05.006 · Cited by 94
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DiSabato, D. J., Nemeth, D. P., Liu, X., Witcher, K. G., O’Neil, S. M., Oliver, B., Bray, C. E., Sheridan, J. F., Godbout, J. P., & Quan, N. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0788-3 · Cited by 93
Microglia: dismantling and rebuilding circuits after acute neurological injury
Ziebell, J. M., Adelson, P. D., & Lifshitz, J. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-014-9539-y · Cited by 84
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Rahimian, R., Wakid, M., O’Leary, L. A., & Mechawar, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.023 · Cited by 96
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Mazza, M. G., Tringali, A. G. M., Rossetti, A., Botti, R. E., & Clerici, M. (2019) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2019.02.003 · Cited by 89
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Haarman, B. C. M., Burger, H., Doorduin, J., Renken, R. J., Sibeijn‐Kuiper, A., Marsman, J.-B. C., de Vries, E. F. J., de Groot, J. C., Drexhage, H. A., Mendes, R., et al. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.004 · Cited by 87
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Hughes, M. M., Connor, T. J., & Harkin, A. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw001 · Cited by 91
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Morris, G., Puri, B. K., OLIVE, L. S., Carvalho, A. F., Berk, M., Walder, K. R., Gustad, L. T., & Maes, M. H. J. (2020) · BMC Medicine · doi:10.1186/s12916-020-01749-w · Cited by 88
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Aas, M., Dieset, I., Hope, S., Hoseth, E. Z., Mørch, R. H., Reponen, E. J., Steen, N. E., Laskemoen, J. F., Ueland, T., Aukrust, P., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.005 · Cited by 84
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Lawson, M. A., McCusker, R. H., & Kelley, K. W. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-54 · Cited by 80
Repeated social defeat-induced neuroinflammation, anxiety-like behavior and resistance to fear extinction were attenuated by the cannabinoid receptor agonist WIN55,212-2
Lisboa, S. F. D. S., Niraula, A., Resstel, L. B. M., Guimarães, F. S., Godbout, J. P., & Sheridan, J. F. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0064-2 · Cited by 81
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Poletti, S., de Wit, H., Mazza, E. B., Wijkhuijs, A. J. M., Locatelli, C., Aggio, V., Colombo, C., Benedetti, F., & Drexhage, H. A. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.12.020 · Cited by 79
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Corrigan, M., O’Rourke, A. M., Moran, B., Fletcher, J. M., & Harkin, A. (2023) · Neuronal Signaling · doi:10.1042/ns20220054 · Cited by 81
Cannabidiol prevents haloperidol-induced vacuos chewing movements and inflammatory changes in mice via PPARγ receptors
Sonego, A. B., Prado, D. D. S., do Vale, G. T., Sepulveda-Diaz, J. E., Cunha, T. M., Tirapelli, C. R., Bel, E. A. D., Raisman‐Vozari, R., & Guimarães, F. S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.09.014 · Cited by 79
The effect of minocycline on amelioration of cognitive deficits and pro-inflammatory cytokines levels in patients with schizophrenia
Zhang, L., Zheng, H., Wu, R., Kosten, T. R., Zhang, X., & Zhao, J. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.08.005 · Cited by 75
Clinical characteristics of inflammation-associated depression: monocyte gene expression is age-related in major depressive disorder
Grosse, L., Carvalho, L. A., Wijkhuijs, A. J. M., Bellingrath, S., Ruland, T., Ambrée, O., Alferink, J., Ehring, T., Drexhage, H. A., & Arolt, V. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.08.004 · Cited by 71
Neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and mean platelet volume as systemic inflammatory markers in different states of bipolar disorder
Inanli, I., Aydin, M., Çaliskan, A. M., & Eren, I. (2019) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2019.1640789 · Cited by 69
Pyrroloquinoline Quinone (PQQ) Inhibits Lipopolysaccharide Induced Inflammation in Part via Downregulated NF-κB and p38/JNK Activation in Microglial and Attenuates Microglia Activation in Lipopolysaccharide Treatment Mice
Yang, C., Yu, L., Kong, L., Ma, R., Zhang, J., Zhu, Q., Zhu, J., & Hao, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109502 · Cited by 70
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Authors: Beumer, W., Gibney, S. M., Drexhage, R. C., Pont-Lezica, L., Doorduin, J., Klein, H. C., Steiner, J., Connor, T. J., Harkin, A., Versnel, M. A., & Drexhage, H. A.
Affiliations: Erasmus MC (NL)
Trinity College Dublin (IE)
Institut de Biologie de lˈEcole Normale Supérieure , INSERM, Paris, France
University Medical Center Groningen (NL)
Department of Psychiatry, University of Magdeburg, Magdeburg , Germany
Corresponding author: Beumer, Wouter
ORCID: Doorduin, Janine
Klein, Hans C
Harkin, Andrew
Versnel, Marjan A
Drexhage, Hemmo A
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2012-11-01
Volume: 92
Issue: 5
Pages: 959-975
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.0212100
OpenAlex: W2134543031
Cited by: 347
References: 242
Citations by year: 2026: 8 · 2025: 23 · 2024: 18 · 2023: 18 · 2022: 27 · 2021: 21 · 2020: 25 · 2019: 22 · 2018: 28 · 2017: 23 · 2016: 36 · 2015: 33 · 2014: 38 · 2013: 22 · 2012: 3
FWCI: 1.99
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: microglial activation, circulating monocytes, mononuclear phagocytes, bipolar disorder, major depressive disorder, schizophrenia, cytokines, chronic stress, NOD mice, neuroinflammation, animal models of psychiatric disorders
MeSH terms: Animals, Mental Disorders, Humans, Monocytes, Microglia

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The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes

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