Cited by 1,902Immune cells in cancerImmune Response and InflammationPhagocytosis and Immune Regulation

The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.

The many faces of macrophage activation

Mosser, David M·2003·Journal of Leukocyte Biology

Open this paper in CoChat — free account

Abstract

Journal of Leukocyte Biology considers manuscripts of original investigations focusing on the origins, developmental biology, biochemistry and functions of granulocytes, lymphocytes, mononuclear phagocytes, and other cells involved in host defense. These include full-length papers on original research, rapid communications of new discoveries, letters, commentaries, and invited reviews.

Integrity signals

Registry

Crossref · 10.1189/jlb.0602325

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

NITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,245
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287
Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation
Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation.
Huynh, M.-L. N., Fadok, V., & Henson, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci11638 · Cited by 1,333
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation
Huynh, M.-L. N., Fadok, V. A., & Henson, P. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0211638 · Cited by 957
Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l -Arginine Metabolism
Hesse, M., Modolell, M., Flamme, A. C. L., Schito, M. L., Fuentes, J. M., Cheever, A. W., Pearce, E. J., & Wynn, T. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6533 · Cited by 723
Other Functions, Other Genes
Goerdt, S., & Orfanos, C. E. (1999) · Immunity · doi:10.1016/s1074-7613(00)80014-x · Cited by 678
Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines
Modolell, M., Corraliza, I. M., Link, F., Soler, G., & Eichmann, K. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250436 · Cited by 554
Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis
Ehrt, S., Schnappinger, D., Bekiranov, S., Drenkow, J., Shi, S., Gingeras, T., Gaasterland, T., Schoolnik, G. K., & Nathan, C. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.8.1123 · Cited by 467
Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts
Song, E., Ouyang, N., Hörbelt, M., Antus, B., Wang, M., & Exton, M. S. (2000) · Cellular Immunology · doi:10.1006/cimm.2000.1687 · Cited by 447

Flagged first, then by citations

Show all 38 references

1 of the 38 references couldn’t be matched to a known paper.

Sorted by citations

Items 401–500 of 1,002

Delineation of Diverse Macrophage Activation Programs in Response to Intracellular Parasites and Cytokines
Zhang, S., Kim, C. C., Batra, S., McKerrow, J. H., & Loke, P. (2010) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000648 · Cited by 99
Inhibition of Macrophage Nuclear Factor-κB Leads to a Dominant Anti-Inflammatory Phenotype that Attenuates Glomerular Inflammation in Vivo
Wilson, H. M., Chettibi, S., Jobin, C., Walbaum, D., Rees, A. J., & Kluth, D. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62950-1 · Cited by 99
DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis
Turnbull, I. R., McDunn, J. E., Takai, T., Townsend, R. R., Cobb, J. P., & Colonna, M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050986 · Cited by 99
SiglecF(HI) Marks Late‐Stage Neutrophils of the Infarcted Heart: A Single‐Cell Transcriptomic Analysis of Neutrophil Diversification
Calcagno, D. M., Zhang, C., Toomu, A., Huang, K., Ninh, V. K., Miyamoto, S., Aguirre, A. D., Fu, Z., Brown, J. H., & King, K. R. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.019019 · Cited by 99
Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis
Shaker, M. E., Ashamallah, S. A., & Houssen, M. E. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2013.12.007 · Cited by 97
Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs
Jia, X., Yu, F., Wang, J., Iwanowycz, S., Saaoud, F., Wang, Y., Hu, J., Wang, Q., & Fan, D. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3164-7 · Cited by 100
Molecular features of macrophage activation
Schultze, J. L., & Schmidt, S. V. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2016.03.009 · Cited by 97
Iron‐load exacerbates the severity of atherosclerosis via inducing inflammation and enhancing the glycolysis in macrophages
Hu, X., Cai, X., Ma, R., Fu, W., Zhang, C., & Du, X. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28518 · Cited by 100
Selective inhibition and augmentation of alternative macrophage activation by progesterone
Menzies, F. M., Henriquez, F. L., Alexander, J. K., & Roberts, C. W. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03488.x · Cited by 100
Toxoplasma gondii Pneumonia in Immunocompetent Subjects: Case Report and Review
Leal, F. E., Cavazzana, C. L., de Andrade, H. F., Galisteo, A. J., de Mendonça, J. S., & Kallas, E. G. (2007) · Clinical Infectious Diseases · doi:10.1086/511871 · Cited by 97
Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice
Latta, C. H., Sudduth, T. L., Weekman, E. M., Brothers, H. M., Abner, E. L., Popa, G. J., Mendenhall, M. D., Gonzalez-Oregon, F., Braun, K. J., & Wilcock, D. M. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0243-6 · Cited by 96
Oncolytic vesicular stomatitis virus expressing interferon-σ has enhanced therapeutic activity
Bourgeois‐Daigneault, M., Roy, D. G., Falls, T. J., Twumasi‐Boateng, K., St-Germain, L. E., Marguerie, M., Garcia, V., Selman, M., Jennings, V. A., Pettigrew, J. L., et al. (2016) · Molecular Therapy — Oncolytics · doi:10.1038/mto.2016.1 · Cited by 96
Phytoconstituents as modulators of NF-κB signalling: Investigating therapeutic potential for diabetic wound healing
Yadav, J. P., Verma, A., Pathak, P., Dwivedi, A. R., Singh, A. K., Kumar, P., Khalilullah, H., Jaremko, M., Emwas, A.-H., & Patel, D. K. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117058 · Cited by 100
IL-4/IL-13-Dependent Alternative Activation of Macrophages but Not Microglial Cells Is Associated with Uncontrolled Cerebral Cryptococcosis
Stenzel, W., Müller, U., Köhler, G., Heppner, F. L., Blessing, M., McKenzie, A. N. J., Brombacher, F., & Alber, G. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080598 · Cited by 96
The Role of Anti-Inflammatory Agents in Parkinson???s Disease
McGeer, E. G., & McGeer, P. L. (2007) · CNS Drugs · doi:10.2165/00023210-200721100-00001 · Cited by 95
OxInflammatory Responses in the Wound Healing Process: A Systematic Review
Lopes, F. B., Sarandy, M. M., Novaes, R. D., Valacchi, G., & Gonçalves, R. V. (2024) · Antioxidants · doi:10.3390/antiox13070823 · Cited by 107
The Effects of NOS2 Gene Deletion on Mice Expressing Mutated Human AβPP
Colton, C. A., Wilcock, D. M., Wink, D. A., Davis, J., Nostrand, W. E. V., & Vitek, M. P. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15405 · Cited by 92
Activation of the Epidermal Growth Factor Receptor in Macrophages Regulates Cytokine Production and Experimental Colitis
Lü, N., Wang, L., Cao, H., Liu, L., Kaer, L. V., Washington, M. K., Rosen, M. J., Dubé, P. E., Wilson, K. T., Ren, X., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1300133 · Cited by 95
Reversible differentiation of pro- and anti-inflammatory macrophages
Xu, W., Zhao, X., Daha, M. R., & van Kooten, C. (2012) · Molecular Immunology · doi:10.1016/j.molimm.2012.07.005 · Cited by 106
Alternatively Activated and Immunoregulatory Monocytes in Human Filarial Infections
Babu, S., Kumaraswami, V., & Nutman, T. B. (2009) · The Journal of Infectious Diseases · doi:10.1086/599090 · Cited by 95
Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation
Ford, A. Q., Dasgupta, P., MIKHAILENKO, I. A., Smith, E., Noben-Trauth, N., & Keegan, A. D. (2012) · BMC Immunology · doi:10.1186/1471-2172-13-6 · Cited by 94
A Modified Collagen Dressing Induces Transition of Inflammatory to Reparative Phenotype of Wound Macrophages
Das, A., Abas, M., Biswas, N., Banerjee, P., Ghosh, N., Rawat, A. K., Khanna, S., Roy, S., & Sen, C. K. (2019) · Scientific Reports · doi:10.1038/s41598-019-49435-z · Cited by 95
Human Macrophage Regulation Via Interaction With Cardiac Adipose Tissue-Derived Mesenchymal Stromal Cells
Adutler‐Lieber, S., Ben-Mordechai, T., Naftali‐Shani, N., Asher, E., Loberman, D., Raanani, E., & Leor, J. (2012) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248412453875 · Cited by 97
SHIP-deficient, alternatively activated macrophages protect mice during DSS-induced colitis
Weisser, S. B., Brugger, H. K., Voglmaier, N., McLarren, K. W., van Rooijen, N., & Sly, L. M. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0311124 · Cited by 94
Patterns of Gene Expression Reveal a Temporally Orchestrated Wound Healing Response in the Injured Spinal Cord
Velardo, M. J., Bürger, C., Williams, P. R., Baker, H. V., López, M. C., Mareci, T. H., White, T. E., Muzyczka, N., & Reier, P. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3316-04.2004 · Cited by 91
Protective effect of curcumin on TNBS-induced intestinal inflammation is mediated through the JAK/STAT pathway
Zhang, X., Wu, J., Ye, B., Wang, Q., Xie, X., & Shen, H. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1273-z · Cited by 93
Microfluidic-Based Cell Sorting of Francisella tularensis Infected Macrophages Using Optical Forces
Perroud, T. D., Kaiser, J. N., Sy, J. C., Lane, T. W., Branda, C., Singh, A. K., & Patel, K. D. (2008) · Analytical Chemistry · doi:10.1021/ac8007779 · Cited by 93
Alternatively activated macrophages (M2 macrophages) in the skin of patient with localized scleroderma
Higashi‐Kuwata, N., Makino, T., Inoue, Y., Takeya, M., & Ihn, H. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00828.x · Cited by 93
The role of interleukin-10 in the regulation of the systemic inflammatory response following trauma-hemorrhage
Schneider, C. P., Schwacha, M. G., & Chaudry, I. H. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.01.003 · Cited by 93
High‐dose dexamethasone or all‐trans‐retinoic acid restores the balance of macrophages towards M2 in immune thrombocytopenia
Feng, Q., Xu, M., Yu, Y., Hou, Y., Mi, X., Sun, Y., Ma, S., Zuo, X., Shao, L., Hou, M., et al. (2017) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13767 · Cited by 96
Transcriptome Analysis of Murine Macrophages in Response to Infection withStreptococcus pyogenesReveals an Unusual Activation Program
Goldmann, O., von Köckritz‐Blickwede, M., Höltje, C., Chhatwal, G. S., Geffers, R., & Medina, E. (2007) · Infection and Immunity · doi:10.1128/iai.00181-07 · Cited by 94
Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi
Cai, C. W., Blase, J. R., Zhang, X., Eickhoff, C. S., & Hoft, D. F. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005902 · Cited by 94
Classical activation of microglia in CD200-deficient mice is a consequence of blood brain barrier permeability and infiltration of peripheral cells
Denieffe, S., Kelly, R. J., McDonald, C., Lyons, A., & Lynch, M. A. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.07.174 · Cited by 92
Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling
Clementi, A. H., Gaudy, A. M., van Rooijen, N., Pierce, R. H., & Mooney, R. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.08.007 · Cited by 95
Humanized mouse model for assessing the human immune response to xenogeneic and allogeneic decellularized biomaterials
Wang, R. M., Johnson, T. D., He, J., Rong, Z., Wong, M., Nigam, V., Behfar, A., Xu, Y., & Christman, K. L. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.016 · Cited by 90
Macrophage heterogeneity and acute inflammation
Liddiard, K., Rosas, M., Davies, L. C., Jones, S. A., & Taylor, P. R. (2011) · European Journal of Immunology · doi:10.1002/eji.201141743 · Cited by 91
Evaluation of epigallocatechin-3-gallate (EGCG) modified collagen in guided bone regeneration (GBR) surgery and modulation of macrophage phenotype
Chu, C., Wang, Y., Wang, Y., Yang, R., Liu, L., Rung, S., Xiang, L., Wu, Y., Du, S., Man, Y., et al. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.01.083 · Cited by 90
Proinflammatory cytokine and chemokine modulation byStreptococcus suisin a whole-blood culture system
Segura, M., Vanier, G., Al-Numani, D., Lacouture, S., Olivier, M., & Gottschalk, M. G. (2006) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2006.00067.x · Cited by 91
Sequential expression of macrophage anti-microbial/inflammatory and wound healing markers following innate, alternative and classical activation
Menzies, F. M., Henriquez, F. L., Alexander, J., & Roberts, C. W. (2010) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2009.04086.x · Cited by 90
Reshaping of Human Macrophage Polarization through Modulation of Glucose Catabolic Pathways
Izquierdo, E., Cuevas, V. D., Fernández‐Arroyo, S., Riera-Borrull, M., Orta‐Zavalza, E., Joven, J., Rial, E., Corbí, A. L., & Escribese, M. M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403045 · Cited by 91
The Survival Condition and Immunoregulatory Function of Adipose Stromal Vascular Fraction (SVF) in the Early Stage of Nonvascularized Adipose Transplantation
Dong, Z., Peng, Z., Chang, Q., & Lu, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080364 · Cited by 90
Heterogeneity across the murine small and large intestine
Bowcutt, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15216 · Cited by 96
Human MICL (CLEC12A) is differentially glycosylated and is down‐regulated following cellular activation
Marshall, A. S. J., Willment, J. A., Pyż, E., Dennehy, K. M., Reid, D. M., Dri, P., Gordon, S., Wong, S. Y. C., & Brown, G. D. (2006) · European Journal of Immunology · doi:10.1002/eji.200535628 · Cited by 89
Macrophages and the kidney
Wilson, H. M., Walbaum, D., & Rees, A. J. (2004) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200405000-00004 · Cited by 89
TLR9 and MyD88 Are Crucial for the Development of Protective Immunity to Malaria
Gowda, K., Wu, X., & Gowda, D. C. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102143 · Cited by 90
Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization
Sherry, C. L., Kim, S. S., Dilger, R. N., Bauer, L. L., Moon, M. L., Tapping, R. I., Fahey, G. C., Jr., Tappenden, K. A., & Freund, G. G. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.01.015 · Cited by 88
Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis
Anderson, R., Franch, À., Castell, M., Pérez-Cano, F. J., Bräuer, R., Pohlers, D., Gajda, M. R., Siskos, A., Κάτσιλα, Θ., Tamvakopoulos, C., et al. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3089 · Cited by 88
Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury
Alizadeh, A., & Karimi‐Abdolrezaee, S. (2016) · The Journal of Physiology · doi:10.1113/jp270895 · Cited by 93
“Tissue-repairing” blood-derived macrophages are essential for healing of the injured spinal cord: From skin-activated macrophages to infiltrating blood-derived cells?
Schwartz, M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.01.010 · Cited by 88
Inflammation, Immunity, and amyotrophic lateral sclerosis: I. Etiology and pathology
Lyon, M. S., Wosiski‐Kuhn, M., Gillespie, R., Caress, J. B., & Milligan, C. (2018) · Muscle & Nerve · doi:10.1002/mus.26289 · Cited by 94
Vitamin D receptor signaling contributes to susceptibility to infection with Leishmania major
Ehrchen, J. M., Helming, L., Varga, G., Pasche, B., Loser, K., Gunzer, M., Sunderkötter, C. H., Sorg, C., Roth, J., & Lengeling, A. (2007) · The FASEB Journal · doi:10.1096/fj.06-7261com · Cited by 88
B Cell–deficient Mice Display Markedly Enhanced Resistance to the Intracellular Bacterium Brucella abortus
Goenka, R., Parent, M. A., Elzer, P. H., & Baldwin, C. L. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq171 · Cited by 87
Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer
Brady, N. J., Chuntova, P., & Schwertfeger, K. L. (2016) · Mediators of Inflammation · doi:10.1155/2016/4549676 · Cited by 93
The divergent roles of macrophages in solid organ transplantation
Salehi, S., & Reed, E. F. (2015) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000209 · Cited by 89
In Vivo Optical Imaging of Cellular Inflammatory Response in Granuloma Formation Using Fluorescence-Labeled Macrophages
Eisenblätter, M., Ehrchen, J. M., Varga, G., Sunderkötter, C. H., Heindel, W. L., Roth, J., Bremer, C., & Wall, A. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.060707 · Cited by 87
Arginase in Parasitic Infections: Macrophage Activation, Immunosuppression, and Intracellular Signals
Stempin, C. C., Dulgerian, L. R., Garrido, V. V., & Cerbán, F. M. (2009) · BioMed Research International · doi:10.1155/2010/683485 · Cited by 89
The biological basis of severe outcomes inAnaplasma phagocytophiluminfection
Dumler, J. S. (2011) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2011.00909.x · Cited by 86
The Isolation and Characterization of Murine Macrophages
Gonçalves, R., & Mosser, D. M. (2015) · Current Protocols in Immunology · doi:10.1002/0471142735.im1401s111 · Cited by 84
Self-citation
Macrophages in Hepatitis B and Hepatitis C Virus Infections
Heydtmann, M. (2008) · Journal of Virology · doi:10.1128/jvi.00996-08 · Cited by 87
New Insights into the Immunological Changes in IL-10-Deficient Mice during the Course of Spontaneous Inflammation in the Gut Mucosa
Gomes-Santos, A. C., Moreira, T. G., de Castro, A. B., Horta, B. C., Lemos, L., Cruz, D. N., Guimarães, M. A. F., Cara, D. C., McCafferty, D., & Faria, A. M. C. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/560817 · Cited by 85
Decursinol Angelate Inhibits LPS-Induced Macrophage Polarization through Modulation of the NFκB and MAPK Signaling Pathways
Islam, S. U., Lee, J., Shehzad, A., Ahn, E., Lee, Y. J., & Lee, Y. K. (2018) · Molecules · doi:10.3390/molecules23081880 · Cited by 84
Elevation in Body Temperature to Fever Range Enhances and Prolongs Subsequent Responsiveness of Macrophages to Endotoxin Challenge
Lee, C.-T., Zhong, L., Mace, T. A., & Repasky, E. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030077 · Cited by 84
Liver Involvement in the Histiocytic Disorders of Childhood
Jaffe, R. (2004) · Pediatric and Developmental Pathology · doi:10.1007/s10024-003-9876-z · Cited by 84
Immune Inhibitory Ligand CD200 Induction by TLRs and NLRs Limits Macrophage Activation to Protect the Host from Meningococcal Septicemia
Mukhopadhyay, S., Plüddemann, A., Hoe, J. C., Williams, K. J., Varin, A., Makepeace, K., Aknin, M.-L. R., Bowdish, D. M. E., Smale, S. T., Barclay, A. N., et al. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.08.005 · Cited by 83
Magnetic Resonance Imaging of Human Brain Macrophage Infiltration
Petry, K. G., Boiziau, C., Dousset, V., & Brochet, B. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.005 · Cited by 84
Human Cytomegalovirus Interleukin-10 Polarizes Monocytes toward a Deactivated M2c Phenotype To Repress Host Immune Responses
Avdic, S., Cao, J. Z., McSharry, B. P., Clancy, L. E., Brown, R., Steain, M. C., Gottlieb, D. J., Abendroth, A., & Slobedman, B. (2013) · Journal of Virology · doi:10.1128/jvi.00912-13 · Cited by 84
Multinucleated giant cell formation exhibits features of phagocytosis with participation of the endoplasmic reticulum
McNally, A. K., & Anderson, J. M. (2005) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2005.06.008 · Cited by 80
Orthologs of macrophage migration inhibitory factor from parasitic nematodes
Vermeire, J. J., Cho, Y., Lolis, E., Bucala, R., & Cappello, M. (2008) · Trends in Parasitology · doi:10.1016/j.pt.2008.04.007 · Cited by 95
The Temporal and Spatial Distribution of Macrophage Subpopulations During Arteriogenesis
Troidl, C., Jung, G., Troidl, K., Hoffmann, J., Möllmann, H., NEF, H. M., Schaper, W. K. A., Hamm, C. W., & Schmitz-Rixen, T. (2012) · Current Vascular Pharmacology · doi:10.2174/1570161111309010005 · Cited by 86
Expression of Calcium-Binding Proteins MRP8 and MRP14 in Inflammatory Muscle Diseases
Seeliger, S., Vogl, T., Engels, I. H., Schröder, J. M., Sorg, C., Sunderkötter, C. H., & Roth, J. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63454-2 · Cited by 82
Human Cytomegalovirus Infection of M1 and M2 Macrophages Triggers Inflammation and Autologous T-Cell Proliferation
Bayer, C., Varani, S., Wang, L., Walther, P., Zhou, S., Straschewski, S., Bachem, M. G., Söderberg‐Nauclér, C., Mertens, T., & Frascaroli, G. (2012) · Journal of Virology · doi:10.1128/jvi.01585-12 · Cited by 82
Macrophage Polarization Modulates FcγR- and CD13-Mediated Phagocytosis and Reactive Oxygen Species Production, Independently of Receptor Membrane Expression
Mendoza-Coronel, E., & Ortega, E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00303 · Cited by 83
Impact of age-related neuroglial cell responses on hippocampal deterioration
Ojo, J. O., Rezaie, P., Gabbott, P. L. A., & Stewart, M. G. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00057 · Cited by 83
Renal macrophages and NLRP3 inflammasomes in kidney diseases and therapeutics
Islamuddin, M., & Qin, X.-B. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01996-3 · Cited by 81
T CELLS ARE POTENT EARLY MEDIATORS OF THE HOST RESPONSE TO SEPSIS
Kasten, K. R., Tschöp, J., Adediran, S., Hildeman, D. A., & Caldwell, C. C. (2010) · Shock · doi:10.1097/shk.0b013e3181e14c2e · Cited by 82
Sustained Antigen-Specific Antitumor Recall Response Mediated by Gene-Modified CD4+ T Helper-1 and CD8+ T Cells
Moeller, M., Kershaw, M. H., Cameron, R., Westwood, J. A., Trapani, J. A., Smyth, M. J., & Darcy, P. K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1141 · Cited by 82
Making cold malignant pleural effusions hot: driving novel immunotherapies
Murthy, P., Ekeke, C. N., Russell, K. L., Butler, S. C., Wang, Y., Luketich, J. D., Soloff, A. C., Dhupar, R., & Lotze, M. T. (2019) · OncoImmunology · doi:10.1080/2162402x.2018.1554969 · Cited by 81
Adaptive Cellular Immunity against African Swine Fever Virus Infections
Schäfer, A., Franzoni, G., Netherton, C. L., Hartmann, L., Blome, S., & Blohm, U. (2022) · Pathogens · doi:10.3390/pathogens11020274 · Cited by 86
Myelin‐phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype
van Rossum, D., Hilbert, S., Straßenburg, S., Hanisch, U., & Brück, W. (2008) · Glia · doi:10.1002/glia.20611 · Cited by 66
A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways
Ivashkiv, L. B. (2008) · Nature reviews. Immunology · doi:10.1038/nri2396 · Cited by 81
Novel Program of Macrophage Gene Expression Induced by Phagocytosis ofLeishmania chagasi
Rodríguez, N. E., Chang, H. K., & Wilson, M. E. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2111-2122.2004 · Cited by 80
Regulated expression of platelet factor 4 in human monocytes—role of PARs as a quantitatively important monocyte activation pathway
Schaffner, A., Rhyn, P., Schoedon, G., & Schaer, D. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0105024 · Cited by 80
Formyl Peptide Receptor-Like 2 Is Expressed and Functional in Plasmacytoid Dendritic Cells, Tissue-Specific Macrophage Subpopulations, and Eosinophils
Devosse, T., Guillabert, A., D’Haene, N., Berton, A., de Nadaı̈, P., Noel, S., Brait, M., Franssen, J., Sozzani, S., Salmon, I. J., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803128 · Cited by 80
Cytosolic Phospholipase A2 Translocates to Forming Phagosomes during Phagocytosis of Zymosan in Macrophages
Girotti, M., Evans, J. H., Burke, D., & Leslie, C. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313867200 · Cited by 80
Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling
Dickensheets, H. L., Vazquez, N., Sheikh, F. G., Gingras, S., Murray, P. J., Ryan, J. J., & Donnelly, R. P. (2006) · Genes and Immunity · doi:10.1038/sj.gene.6364352 · Cited by 84
Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction
Shi, C.-J., Washington, M., Chaturvedi, R., Drosos, Y., Revetta, F. L., Weaver, C. J., Buzhardt, E., Yull, F. E., Blackwell, T. S., Sosa-Pineda, B., et al. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.10 · Cited by 74
Characterization of the interaction of African swine fever virus with monocytes and derived macrophage subsets
Franzoni, G., Graham, S. P., Giudici, S. D., Bonelli, P., Pilo, G., Anfossi, A. G., Pittau, M., Nicolussi, P., Laddomada, A., & Oggiano, A. (2016) · Veterinary Microbiology · doi:10.1016/j.vetmic.2016.12.010 · Cited by 79
High glucose induces a priming effect in macrophages and exacerbates the production of pro-inflammatory cytokines after a challenge
Grosick, R. L., Alvarado-Vazquez, P. A., Messersmith, A., & Romero-Sandoval, E. A. (2018) · Journal of Pain Research · doi:10.2147/jpr.s164493 · Cited by 82
Host Response to Biomaterials for Cartilage Tissue Engineering: Key to Remodeling
Fu, W. E., Liu, S., Chen, M., Tian, G., Zha, K., Yang, Z., Jiang, S., Li, M., Sui, X., Chen, Z., et al. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.664592 · Cited by 78
Omega-6 docosapentaenoic acid-derived resolvins and 17-hydroxydocosahexaenoic acid modulate macrophage function and alleviate experimental colitis
Chiu, C., Gomolka, B., Dierkes, C., Huang, N. R., Schroeder, M., Purschke, M., Manstein, D., Dangi, B., & Weylandt, K. H. (2012) · Inflammation Research · doi:10.1007/s00011-012-0489-8 · Cited by 79
Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment
Olsson, A., Nakhlé, J., Sundstedt, A., Plas, P., Bauchet, A.-L., Pierron, V., Bruetschy, L., Deronic, A., Törngren, M., Liberg, D., et al. (2015) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-015-0098-5 · Cited by 78
Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10)
Comi, M., Avancini, D., de Sio, F. R. S., Villa, M., Uyeda, M. J., Floris, M., Tomasoni, D., Bulfone, A., Roncarolo, M. G., & Gregori, S. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0218-0 · Cited by 83
Reactive Hemophagocytic Syndrome in Adult-Onset Still Disease
Bae, C.-B., Jung, J., Kim, H., & Suh, C. (2015) · Medicine · doi:10.1097/md.0000000000000451 · Cited by 78
From phagocyte diversity and activation to probiotics: Back to Metchnikoff
Mantovani, A. (2008) · European Journal of Immunology · doi:10.1002/eji.200838918 · Cited by 78
Is neuroinflammation in the injured spinal cord different than in the brain? Examining intrinsic differences between the brain and spinal cord
Zhang, B., & Gensel, J. C. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.04.007 · Cited by 81
Guanylate‐binding protein 5 is a marker of interferon‐γ‐induced classically activated macrophages
Fujiwara, Y., Hizukuri, Y., Yamashiro, K., Makita, N., Ohnishi, K., Takeya, M., Komohara, Y., & Hayashi, Y. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.59 · Cited by 78
Atherosclerosis and Coronary Artery Disease
Zaromitidou, M., Siasos, G., Παπαγεωργίου, Ν., Oikonomou, E. K., & Tousoulis, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803312-8.00002-1 · Cited by 82
The innate immune system contributes to tissue‐engineered vascular graft performance
Hibino, N., Mejias, D., Pietris, N., Dean, E. W., Yi, T., Best, C. A., Shinoka, T., & Breuer, C. K. (2015) · The FASEB Journal · doi:10.1096/fj.14-268334 · Cited by 77
In vivo administration of ligands for chicken toll-like receptors 4 and 21 induces the expression of immune system genes in the spleen
Paul, M. S., Mallick, A. I., Haq, K., Orouji, S., Abdul-Careem, M. F., & Sharif, S. (2011) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2011.09.004 · Cited by 77
Phospholipase C β3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice
Wang, Z., Liu, B., Wang, P., Dong, X., Fernandez-Hernando, C. F., Zhong, L., Hla, T., Li, Z., Claffey, K. P., Smith, J. D., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33139 · Cited by 79

Authors: Mosser, D. M.
Affiliations: University of Maryland, College Park (US)
Corresponding author: Mosser, David M
ORCID: Mosser, David M
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2003-02-01
Volume: 73
Issue: 2
Pages: 209-212
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.0602325
OpenAlex: W2016293419
Cited by: 1,902
References: 38
Citations by year: 2026: 16 · 2025: 30 · 2024: 57 · 2023: 42 · 2022: 67 · 2021: 76 · 2020: 68 · 2019: 81 · 2018: 65 · 2017: 92 · 2016: 115 · 2015: 111 · 2014: 139 · 2013: 129 · 2012: 133
FWCI: 5.27
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: macrophage activation, macrophages, mononuclear phagocytes, host defense, granulocytes, lymphocytes, cell development
MeSH terms: Animals, Humans, Interferon-gamma, Macrophage Activation, Macrophages, Interleukin-4, Interleukin-10

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The many faces of macrophage activation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks