The many faces of macrophage activation

NITRIC OXIDE AND MACROPHAGE FUNCTION

MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,245

M-1/M-2 Macrophages and the Th1/Th2 Paradigm

Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287

Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation

Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation.

Huynh, M.-L. N., Fadok, V., & Henson, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci11638 · Cited by 1,333

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation

Huynh, M.-L. N., Fadok, V. A., & Henson, P. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0211638 · Cited by 957

Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l -Arginine Metabolism

Hesse, M., Modolell, M., Flamme, A. C. L., Schito, M. L., Fuentes, J. M., Cheever, A. W., Pearce, E. J., & Wynn, T. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6533 · Cited by 723

Other Functions, Other Genes

Goerdt, S., & Orfanos, C. E. (1999) · Immunity · doi:10.1016/s1074-7613(00)80014-x · Cited by 678

Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines

Modolell, M., Corraliza, I. M., Link, F., Soler, G., & Eichmann, K. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250436 · Cited by 554

Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis

Ehrt, S., Schnappinger, D., Bekiranov, S., Drenkow, J., Shi, S., Gingeras, T., Gaasterland, T., Schoolnik, G. K., & Nathan, C. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.8.1123 · Cited by 467

Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts

Song, E., Ouyang, N., Hörbelt, M., Antus, B., Wang, M., & Exton, M. S. (2000) · Cellular Immunology · doi:10.1006/cimm.2000.1687 · Cited by 447

Increased both PD–L1 and PD–L2 expressions on monocytes of patients with hepatocellular carcinoma was associated with a poor prognosis

Yasuoka, H., Asai, A., Ohama, H., Tsuchimoto, Y., Fukunishi, S., & Higuchi, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-67497-2 · Cited by 38

The Role of Escherichia coli Shiga Toxins in STEC Colonization of Cattle

Menge, C. (2020) · Toxins · doi:10.3390/toxins12090607 · Cited by 42

PPARγ Cistrome Repression during Activation of Lung Monocyte-Macrophages in Severe COVID-19

Desterke, C., Turhan, A. G., Griscelli, A. B., & Griscelli, F. (2020) · iScience · doi:10.1016/j.isci.2020.101611 · Cited by 38

The State of the Art and Prospects for Osteoimmunomodulatory Biomaterials

Negrescu, A. M., & Cîmpean, A. (2021) · Materials · doi:10.3390/ma14061357 · Cited by 42

Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp

Pacheco, C. M. S., Flores, G. V. A., González, K., Gomes, C. M. D. C., Passero, L., Tomokane, T. Y., Sosa-Ochoa, W. H., Zúniga, C., Calzada, J., Saldaña, A., et al. (2021) · Journal of Immunological Research · doi:10.1155/2021/5596876 · Cited by 28

Tissue Engineering Chamber Promotes Adipose Tissue Regeneration in Adipose Tissue Engineering Models Through Induced Aseptic Inflammation

Peng, Z., Dong, Z., Chang, Q., Zhan, W., Zeng, Z., Zhang, S., & Lu, F. (2014) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2013.0431 · Cited by 38

The Upper and Lower Respiratory Tracts Differ in Their Requirement of IFN-γ and IL-4 in Controlling Respiratory Mycoplasma Infection and Disease

Woolard, M. D., Hodge, L. M., Jones, H. P., Schoeb, T. R., & Simecka, J. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6875 · Cited by 38

Macrophage Activation Associated with Chronic Murine Cytomegalovirus Infection Results in More Severe Experimental Choroidal Neovascularization

Cousins, S. W., Espinosa‐Heidmann, D. G., Miller, D. M., Pereira‐Simon, S., Hernandez, E. P., Chien, H., Meier-Jewett, C. L., & Dix, R. D. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002671 · Cited by 40

The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion

Hucke, S., Herold, M. V. B., Liebmann, M., Freise, N., Lindner, M., Fleck, A.-K., Zenker, S., Thiebes, S., Fernández‐Orth, J., Buck, D., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1593-6 · Cited by 39

Single-cell transcriptional atlas of tumor-associated macrophages in breast cancer

Zhang, Y., Zhong, F., & Liu, L. (2024) · Breast Cancer Research · doi:10.1186/s13058-024-01887-6 · Cited by 43

Respiratory syncytial virus infection is associated with an altered innate immunity and a heightened pro-inflammatory response in the lungs of preterm lambs

Sow, F. B., Gallup, J. M., Krishnan, S., Patera, A. C., Suzich, J., & Ackermann, M. R. (2011) · Respiratory Research · doi:10.1186/1465-9921-12-106 · Cited by 37

Tumor-Cell Co-Culture Induced Alternative Activation of Macrophages Is Modulated by Interferons In Vitro

Müller-Quernheim, U. C., Potthast, L., Müller–Quernheim, J., & Zissel, G. (2012) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0020 · Cited by 37

Temporal profile of M1 and M2 responses in the hippocampus following early 24 h of neurotrauma

Ansari, M. A. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.06.062 · Cited by 39

Therapeutic Benefits of Induced Pluripotent Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension

Huang, W.-C., Ke, M.-W., Cheng, C., Chiou, S., Wann, S.-R., Shu, C., Chiou, K.-R., Tseng, C.-J., Pan, H., Mar, G.-Y., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0142476 · Cited by 37

Interaction of Mycoplasma gallisepticum with Chicken Tracheal Epithelial Cells Contributes to Macrophage Chemotaxis and Activation

Majumder, S., & Silbart, L. K. (2015) · Infection and Immunity · doi:10.1128/iai.01113-15 · Cited by 37

Hematopoietic stem cell loss and hematopoietic failure in severe aplastic anemia is driven by macrophages and aberrant podoplanin expression

Mccabe, A., Smith, J. N. P., Costello, A., Maloney, J., Katikaneni, D., & MacNamara, K. (2018) · Haematologica · doi:10.3324/haematol.2018.189449 · Cited by 36

Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response

Costantini, T. W., Chan, T. W., Cohen, O., Langness, S. M., Treadwell, S., Williams, E. C., Eliceiri, B. P., & Baird, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821853116 · Cited by 37

General Model of Inflammation

Herald, M. C. (2009) · Bulletin of Mathematical Biology · doi:10.1007/s11538-009-9468-9 · Cited by 37

Protective Effect of Intravitreal Injection of Vasoactive Intestinal Peptide–Loaded Liposomes on Experimental Autoimmune Uveoretinitis

Camelo, S., Lajavardi, L., Bochot, A., Thillaye-Goldenberg, B., Naud, M., Brunel, N., Besson-Lescure, B., Klein, C., Fattal, E., Béhar‐Cohen, F., et al. (2009) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2008.0074 · Cited by 37

Macrophage-mediated neuroprotection and neurogenesis in the olfactory epithelium

Borders, A. S., Hersh, M. A., Getchell, M. L., van Rooijen, N., Cohen, D. A., Stromberg, A. J., & Getchell, T. V. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00008.2007 · Cited by 39

NK Cells in Gamma-Interferon-Deficient Mice Suppress Lung Innate Immunity againstMycoplasmaspp

Woolard, M. D., Hudig, D., Tabor‐Simecka, L., Ivey, J. A., & Simecka, J. W. (2005) · Infection and Immunity · doi:10.1128/iai.73.10.6742-6751.2005 · Cited by 37

The influence of harpagoside and harpagide on TNFα-secretion and cell adhesion molecule mRNA-expression in IFNγ/LPS-stimulated THP-1 cells

Schopohl, P., Grüneberg, P., & Melzig, M. F. (2016) · Fitoterapia · doi:10.1016/j.fitote.2016.03.005 · Cited by 37

The Role of Macrophages in Tumor Development

van der Bij, G. J., Oosterling, S. J., Meijer, S., Beelen, R. H. J., & van Egmond, M. (2005) · Analytical Cellular Pathology · doi:10.1155/2005/719412 · Cited by 37

Salmonella enterica Infection Stimulates Macrophages to Hemophagocytose

Pilonieta, M. C., Moreland, S. M., English, C. N., & Detweiler, C. S. (2014) · mBio · doi:10.1128/mbio.02211-14 · Cited by 35

Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury

Wang, B.-J., Chen, Y., Chang, H.-H., Chen, R.-J., Wang, Y., & Lee, Y. (2024) · Particle and Fibre Toxicology · doi:10.1186/s12989-024-00571-z · Cited by 38

Enterococcus faecalis translocation in mice with severe burn injury: a pathogenic role of CCL2 and alternatively activated macrophages (M2aMϕ and M2cMϕ)

Shigematsu, K., Asai, A., Kobayashi, M., Herndon, D. N., & Suzuki, F. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0409235 · Cited by 36

Diabetic Wounds Exhibit Decreased Ym1 and Arginase Expression with Increased Expression of IL-17 and IL-20

Finley, P. J., DeClue, C. E., Sell, S. A., DeBartolo, J. M., & Shornick, L. P. (2015) · Advances in Wound Care · doi:10.1089/wound.2015.0676 · Cited by 36

Perturbed Bone Marrow Monocyte Development Following Burn Injury and Sepsis Promote Hyporesponsive Monocytes

Muthu, K., He, L.-K., Melstrom, K. A., Szilágyi, A., Gamelli, R. L., & Shankar, R. (2008) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e31815fa499 · Cited by 36

Onionin A, a sulfur‐containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells

Fujiwara, Y., Horlad, H., Shiraishi, D., Tsuboki, J., Kudo, R., Ikeda, T., Nohara, T., Takeya, M., & Komohara, Y. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500995 · Cited by 36

Super-Enhancer Induced IL-20RA Promotes Proliferation/Metastasis and Immune Evasion in Colorectal Cancer

Yu, D., Yang, X. N., Lin, J., Cao, Z., Lu, C., Yang, Z., Zheng, M., Pan, R., & Cai, W. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.724655 · Cited by 38

Comparison of how ambient PMcand PM2.5influence the inflammatory potential

Ferguson, M., Migliaccio, C., & Ward, T. J. (2013) · Inhalation Toxicology · doi:10.3109/08958378.2013.847993 · Cited by 36

Storage xyloglucans: Potent macrophages activators

do Rosário, M. M. T., Kangussu-Marcolino, M. M., do Amaral, A. E., Noleto, G. R., & Petkowicz, C. L. D. O. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.09.024 · Cited by 36

Methylsulfonylmethane modulates apoptosis of LPS/IFN-γ-activated RAW 264.7 macrophage-like cells by targeting p53, Bax, Bcl-2, cytochrome c and PARP proteins

Karabay, A. Z., Aktan, F., Sunguroğlu, A., & Büyükbingöl, Z. (2014) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2014.956752 · Cited by 36

Differential Response of Mono Mac 6, BEAS-2B, and Jurkat Cells to Indoor Dust

Riechelmann, H., Deutschle, T., Grabow, A., Heinzow, B., Butte, W., & Reiter, R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9874 · Cited by 36

Induction of an anti-inflammatory human monocyte subtype is a unique property of glucocorticoids, but can be modified by IL-6 and IL-10

Tsianakas, A., Varga, G., Barczyk, K., Bode, G., Nippe, N., Kran, N., Roth, J., Luger, T. A., Ehrchen, J. M., & Sunderkötter, C. H. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.10.002 · Cited by 36

Granulin Exacerbates Lupus Nephritis via Enhancing Macrophage M2b Polarization

Chen, X., Wen, Z., Xu, W., & Xiong, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065542 · Cited by 34

Monocyte/macrophage cytokine activity regulates vascular smooth muscle cell function within a degradable polyurethane scaffold

Battiston, K. G., Ouyang, B., Labow, R. S., Simmons, C. A., & Santerre, J. P. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.12.022 · Cited by 36

Immunomodulatory activity of selenium exopolysaccharide produced byLactococcus lactissubsp.Lactis

Pan, D., Liu, J., Zeng, X., Liu, L., Li, H., & Guo, Y. (2014) · Food and Agricultural Immunology · doi:10.1080/09540105.2014.894000 · Cited by 36

p47phox Deficiency Induces Macrophage Dysfunction Resulting in Progressive Crystalline Macrophage Pneumonia

Liu, Q., Cheng, L., Liang, Y., Zhu, N., Wood, A., Changpriroa, C. M., Ward, J. M., & Jackson, S. H. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080555 · Cited by 35

Preterm delivery predicted by soluble CD163 and CRP in women with symptoms of preterm delivery

Vogel, I., Grove, J., Thorsen, P., Moestrup, S. K., Uldbjerg, N., & Møller, H. J. (2005) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2005.00557.x · Cited by 36

Delayed growth of EL4 lymphoma in SR‐A‐deficient mice is due to upregulation of nitric oxide and interferon‐γ production by tumor‐associated macrophages

Komohara, Y., Takemura, K., Lei, X., Sakashita, N., Harada, M., Suzuki, H., Kodama, T., & Takeya, M. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01296.x · Cited by 36

Targeting Interactions between Fibroblasts and Macrophages to Treat Cardiac Fibrosis

Yang, B., Qiao, Y., Dong, Y., & Meng, Q. (2024) · Cells · doi:10.3390/cells13090764 · Cited by 39

Role of purinergic signalling in neuro-immune cells and adult neural progenitors

Fumagalli, M. (2011) · Frontiers in bioscience · doi:10.2741/3856 · Cited by 37

Phenotypic Variation in Myocardial Macrophage Populations Suggests a Role for Macrophage Activation in SIV-Associated Cardiac Disease

Yearley, J. H., Pearson, C. B., Shannon, R. P., & Mansfield, K. G. (2007) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2006.0211 · Cited by 35

Increased Disease Severity of Parasite-Infected TLR2−/−Mice Is Correlated with Decreased Central Nervous System Inflammation and Reduced Numbers of Cells with Alternatively Activated Macrophage Phenotypes in a Murine Model of Neurocysticercosis

Gundra, U. M., Mishra, B. B., Wong, K., & Teale, J. M. (2011) · Infection and Immunity · doi:10.1128/iai.00920-10 · Cited by 36

Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages

Rex, J., Albrecht, U., Ehlting, C., Thomas, M., Zanger, U. M., Sawodny, O., Häussinger, D., Ederer, M., Feuer, R., & Bode, J. G. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005018 · Cited by 33

Tofacitinib ameliorates atherosclerosis and reduces foam cell formation in apoE deficient mice

Wang, Z., Wang, S., Wang, Z., Yun, T., Wang, C., & Wang, H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.020 · Cited by 35

The Association between Modulating Inflammatory Cytokines and Constipation of Geriatrics in Iran

Mokhtare, M., Alimoradzadeh, R., Agah, S., Mirmiranpour, H., & Khodabandehloo, N. (2017) · Middle East Journal of Digestive Diseases · doi:10.15171/mejdd.2017.78 · Cited by 35

Targeting RAGE as a potential therapeutic approach to Duchenne muscular dystrophy

Sagheddu, R., Chiappalupi, S., Salvadori, L., Riuzzi, F., Donato, R., & Sorci, G. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy288 · Cited by 34

Role of p90RSK in Kidney and Other Diseases

Lin, L., White, S. A., & Hu, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040972 · Cited by 34

Delivery of Interleukin 4 from a Titanium Substrate Coated with Graphene Oxide for Enhanced Osseointegration by Regulating Macrophage Polarization

Li, Q., Liang, B., Wang, F., & Wang, Z. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01011 · Cited by 35

Non-coding RNA derived from extracellular vesicles in cancer immune escape: Biological functions and potential clinical applications

Huang, M., Peng, X., Yang, L., Yang, S., Li, X., Tang, S., Li, B., Jin, H., Wu, B., Liu, J., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.11.005 · Cited by 35

Butyrylcholinesterase genotype and gender influence Alzheimer's disease phenotype

Lane, R. M., & He, Y. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.12.005 · Cited by 35

Long-lasting reactive changes observed in microglia in the striatal and substantia nigral of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Yasuda, Y. U., Shinagawa, R., Yamada, M., Mori, T. A., Tateishi, N., & Fujita, S. (2006) · Brain Research · doi:10.1016/j.brainres.2006.12.054 · Cited by 35

Inhaled IL-10 reduces biotrauma and mortality in a model of ventilator-induced lung injury

Hoegl, S., Boost, K. A., Czerwonka, H., Dolfen, A., Scheiermann, P., Mühl, H., Zwißler, B., & Hofstetter, C. (2008) · Respiratory Medicine · doi:10.1016/j.rmed.2008.09.020 · Cited by 35

The Increase in Mannose Receptor Recycling Favors Arginase Induction and Trypanosoma Cruzi Survival in Macrophages

Garrido, V. V., Dulgerian, L. R., Stempin, C. C., & Cerbán, F. M. (2011) · International Journal of Biological Sciences · doi:10.7150/ijbs.7.1257 · Cited by 35

The central role of macrophages in trypanosomiasis-associated anemia: rationale for therapeutical approaches

Stijlemans, B., Vankrunkelsven, A., Caljon, G., Bockstal, V., Guilliams, M., Bosschaerts, T., Beschin, A., Raes, G., Magez, S., & Baetselier, P. (2010) · Endocrine, Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153010790827966 · Cited by 35

Antiphospholipid antibodies and atherosclerosis

Nicolo, D., & Monestier, M. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.02.016 · Cited by 35

Bacterial Metabolite Reuterin Attenuated LPS-Induced Oxidative Stress and Inflammation Response in HD11 Macrophages

Xu, Y., Ding, X., Wang, Y., Li, D., Xie, L., Liang, S., Zhang, Y., Li, W., Fu, A., & Zhan, X. (2022) · Antioxidants · doi:10.3390/antiox11091662 · Cited by 34

Harnessing anti-inflammatory pathways and macrophage nano delivery to treat inflammatory and fibrotic disorders

Zaid, A. K. M. A., & Ariel, A. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115204 · Cited by 35

Asymmetric dimethylarginine regulates the lipopolysaccharide-induced nitric oxide production in macrophages by suppressing the activation of NF-kappaB and iNOS expression

Pekarová, M., Kubala, L., Martiskova, H., Binó, L., Twarógová, M., Klinke, A., Rudolph, T. K., Kuchtová, Z., Kolářová, H., Ambrožová, G., et al. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.05.001 · Cited by 34

Propranolol as a modulator of M2b monocytes in severely burned patients

Kobayashi, M., Jeschke, M. G., Asai, A., Kogiso, M., Yoshida, S., Herndon, D. N., & Suzuki, F. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1010553 · Cited by 34

CD13 Regulates Anchorage and Differentiation of the Skeletal Muscle Satellite Stem Cell Population in Ischemic Injury

Rahman, M., Ghosh, M., Subramani, J., Fong, G., Carlson, M. E., & Shapiro, L. H. (2013) · Stem Cells · doi:10.1002/stem.1610 · Cited by 34

Immunomodulatory Potential of Chitosan-graft-poly(ε-caprolactone) Copolymers toward the Polarization of Bone-Marrow-Derived Macrophages

Papadimitriou, L., Kaliva, M., Vamvakaki, M., & Chatzinikolaidou, Μ. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00440 · Cited by 34

Host defense peptide LEAP-2 contributes to monocyte/macrophage polarization in barbel steed (Hemibarbus labeo)

Chen, J., Lv, Y., Dai, Q., Hu, Z., Liu, Z., & Li, J.-H. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.01.015 · Cited by 34

Nonglutaraldehyde crosslinked bioprosthetic heart valves based on 2-isocyanatoethyl methacrylate crosslinked porcine pericardium with improved properties of stability, cytocompatibility and anti-calcification

Zheng, C.-S., Ding, K., Huang, X.-Y., Li, M., Wu, B., Lei, Y., & Wang, Y.-B. (2021) · Composites Part B: Engineering · doi:10.1016/j.compositesb.2021.109504 · Cited by 26

Methanolic Phoenix dactylifera L. Extract Ameliorates Cisplatin-Induced Hepatic Injury in Male Rats

El-Hak, H. N. G., Mahmoud, H. S., Ahmed, E., Elnegris, H. M., Aldayel, T. S., Abdelrazek, H. M. A., Soliman, M. T. A., & Menyawi, M. A. I. E. (2022) · Nutrients · doi:10.3390/nu14051025 · Cited by 34

Cytokine storm and targeted therapy in hemophagocytic lymphohistiocytosis

Zhang, H., Yang, S., Fu, Y., Chen, M.-C., Yang, C.-H., Yang, M., Liu, X.-D., He, Q., Jiang, H., & Zhao, M. (2022) · Immunologic Research · doi:10.1007/s12026-022-09285-w · Cited by 35

Effect of Laser Phototherapy on the Release of TNF- α and MMP-1 by Endodontic Sealer–Stimulated Macrophages

Sousa, L. R., Cavalcanti, B. N., & Marques, M. M. (2009) · Photomedicine and Laser Surgery · doi:10.1089/pho.2007.2220 · Cited by 34

Primed Mesenchymal Stem Cells Alter and Improve Rat Medial Collateral Ligament Healing

Saether, E. E., Chamberlain, C. S., Aktas, E., Leiferman, E. M., Brickson, S. L., & Vanderby, R. (2016) · Stem Cell Reviews and Reports · doi:10.1007/s12015-015-9633-5 · Cited by 34

SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis

Alston, C. I., & Dix, R. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00732 · Cited by 34

Adoptive transfer of dendritic cells from allergic mice induces specific immunoglobulin E antibody in naïve recipients in absence of antigen challenge without altering the T helper 1/T helper 2 balance

Chambers, S. J., Bertelli, E., Winterbone, M. S., Regoli, M., Man, A., & Nicoletti, C. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01846.x · Cited by 34

Immunogenicity and anti-fecundity effect of nanoparticle coated glutathione S-transferase (SjGST) DNA vaccine against murine Schistosoma japonicum infection

Mbanefo, E. C., Kumagai, T., Kodama, Y., Kurosaki, T., Furushima‐Shimogawara, R., Chérif, M. S., Mizukami, S., Kikuchi, M., Huy, N. T., Ohta, N., et al. (2015) · Parasitology International · doi:10.1016/j.parint.2015.01.005 · Cited by 33

Epithelial and Mesenchymal Cells in the Bovine Colonic Mucosa Differ in Their Responsiveness toEscherichia coliShiga Toxin 1

Stamm, I., Mohr, M., Bridger, P. S., Schröpfer, E., König, M., Stoffregen, W. C., Dean-Nystrom, E. A., Baljer, G., & Menge, C. (2008) · Infection and Immunity · doi:10.1128/iai.00553-08 · Cited by 33

Screening for Potential Adjuvants Administered by the Pulmonary Route for Tuberculosis Vaccines

Wang, C., Muttil, P., Lu, D., Beltran-Torres, A. A., Garcia‐Contreras, L., & Hickey, A. J. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9089-0 · Cited by 33

Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD)

Salemi, J., Obregon, D. F., Cobb, A., Reed, S., Sadic, E., Jin, J., Fernandez, F., Tan, J., & Giunta, B. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-3 · Cited by 28

The metabolomic signature of hematologic malignancies

Allegra, A., Innao, V., Gerace, D. G., Bianco, O., & Musolino, C. (2016) · Leukemia Research · doi:10.1016/j.leukres.2016.08.002 · Cited by 32

Characterization of immunostimulatory pectic polysaccharide isolated from leaves of Diospyros kaki Thumb . (Persimmon)

Shin, M.-S., Lee, H., Hong, H., & Shin, K. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.07.025 · Cited by 33

Microarray and bioinformatics analyses of gene expression profiles in BALB/c murine macrophage polarization

Li, J., Li, X., Zhang, Y., Zhang, M., Tang, Z., & Lv, K. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7511 · Cited by 33

Monocyte-derived and M1 macrophages from ankylosing spondylitis patients released higher TNF-α and expressed more IL1B in response to BzATP than macrophages from healthy subjects

Akhtari, M., Zargar, S. J., Vojdanian, M., Jamshidi, A., & Mahmoudi, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-96262-2 · Cited by 33

The characteristics of regulatory macrophages and their roles in transplantation

Zhang, F., Zhang, J., Cao, P., Sun, Z., & Wang, W. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107322 · Cited by 32

Differential gene expression analysis in human monocyte-derived macrophages: Impact of cigarette smoke on host defence

Doyle, I., Ratcliffe, M., Walding, A., Bon, E. V., Dymond, M., Tomlinson, W., Tilley, D., Shelton, P. A., & Dougall, I. G. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.11.008 · Cited by 33

Different responses of macrophages in retinal ganglion cell survival after acute ocular hypertension in rats with different autoimmune backgrounds

Huang, Y., Li, Z., van Rooijen, N., Wang, N., Pang, C. P., & Cui, Q. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2007.07.020 · Cited by 33

The Linker for Activation of B Cells (LAB)/Non-T Cell Activation Linker (NTAL) Regulates Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Signaling and Macrophage Inflammatory Responses Independently of the Linker for Activation of T Cells

Whittaker, G. C., Orr, S. J., Quigley, L., Hughes, L., Francischetti, I. M. B., Zhang, W., & McVicar, D. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.038398 · Cited by 33

Direct Effects of Activin A on the Activation of Mouse Macrophage RAW264.7 Cells

Ge, J., Wang, Y., Feng, Y., Liu, H., Cui, X., Chen, F., Tai, G., & Liu, Z. (2009) · Cellular and Molecular Immunology · doi:10.1038/cmi.2009.18 · Cited by 33

Self-Assembled Cationic Biodegradable Nanoparticles from pH-Responsive Amino-Acid-Based Poly(Ester Urea Urethane)s and Their Application As a Drug Delivery Vehicle

He, M., Potuck, A., Kohn, J. C., Fung, K., Reinhart‐King, C. A., & Chu, C. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b01449 · Cited by 33

A twist in anti-inflammation: Annexin 1 acts via the lipoxin A4 receptor

Gavins, F. N. E., Sawmynaden, P., Chatterjee, B. E., & Perretti, M. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.05.008 · Cited by 33

Porcine Macrophage Markers and Populations: An Update

Álvarez, B., Revilla, C., Poderoso, T., Ezquerra, Á., & Domínguez, J. (2023) · Cells · doi:10.3390/cells12162103 · Cited by 35

The scene of lung pathology during PRRSV-1 infection

Ruedas‐Torres, I., Sánchez‐Carvajal, J. M., Salguero, F. J., Pallarés, F. J., Carrasco, L., Mateu, E., Gómez-Laguna, J., & Rodríguez-Gómez, I. M. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1330990 · Cited by 33

Stromal vascular fraction ( SVF ) cells enhance long‐term survival of autologous fat grafting through the facilitation of M2 macrophages

Dong, Z., Fu, R., Liu, L., & Lu, F. (2013) · Cell Biology International · doi:10.1002/cbin.10099 · Cited by 32

Intracellular microbes and haemophagocytosis

Silva‐Herzog, E., & Detweiler, C. S. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01192.x · Cited by 31

Alterations in macrophages and monocytes from tumor-bearing mice: evidence of local and systemic immune impairment

Torroella‐Kouri, M., Rodríguez, D., & Caso, R. (2013) · Immunologic Research · doi:10.1007/s12026-013-8438-3 · Cited by 33

Characterization of In vitro Generated Human Polarized Macrophages

Iqbal, S., & Kumar, A. (2015) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000380 · Cited by 32

Synchrotron microbeam radiotherapy evokes a different early tumor immunomodulatory response to conventional radiotherapy in EMT6.5 mammary tumors

Yang, Y., Swierczak, A., Ibahim, M. J., Paiva, P., Cann, L. M., Stevenson, A. W., Crosbie, J. C., Anderson, R. L., & Rogers, P. A. W. (2019) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2019.01.006 · Cited by 35

Preparation of collagen/chitosan microspheres for 3D macrophage proliferation in vitro

Wang, D., Wang, M., Wang, A., Li, J., Li, X., Jian, H., Bai, S., & Yin, J. (2019) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2019.04.007 · Cited by 31

MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages

Babicky, M. L., Harper, M. M., Chakedis, J. M., Cazes, A., Mose, E. S., Jaquish, D. V., French, R. P., Childers, B. G., Alakus, H., Schmid, M. C., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0811-9 · Cited by 32

Salvianolic acid B inhibits RAW264.7 cell polarization towards the M1 phenotype by inhibiting NF-κB and Akt/mTOR pathway activation

Zou, T., Gao, S., Yu, Z., Zhang, F., Yao, L., Xu, M., Li, J., Wu, Z., Huang, Y., & Wang, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-18246-0 · Cited by 36

Adipose Tissue Remodeling in Obesity: An Overview of the Actions of Thyroid Hormones and Their Derivatives

Petito, G., Cioffi, F., Magnacca, N., de Lange, P., Senese, R., & Lanni, A. (2023) · Pharmaceuticals · doi:10.3390/ph16040572 · Cited by 35

Clinical Experience with Autologous M2 Macrophages in Children with Severe Cerebral Palsy

Chernykh, E. R., Kafanova, M. Y., Shevela, Е. Y., Иванович, С. С., Adonina, E. I., Sakhno, L. V., Ostanin, A. A., & Kozlov, V. V. (2014) · Cell Transplantation · doi:10.3727/096368914x684925 · Cited by 33

Evaluation of the phenotype pattern of macrophages isolated from malignant and non-malignant pleural effusions

Kaczmarek, M., Nowicka, A., Kozłowska, M., Żurawski, J., Batura‐Gabryel, H., & Sikora, J. (2011) · Tumor Biology · doi:10.1007/s13277-011-0214-1 · Cited by 32

Alternative activation of macrophages: immune function and cellular biology

Varin, A., & Gordon, S. (2009) · Immunobiology · doi:10.1016/j.imbio.2008.11.009 · Cited by 361

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

Dyken, S. J. V., & Locksley, R. M. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095906 · Cited by 743

Receptor Is Associated with Alternative Macrophage Activation

Hamann, J. (2015)

Alternative activation of macrophages

Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189

The Alternatively Activated Human—Redux

Scott, A. L. (2009) · The Journal of Infectious Diseases · doi:10.1086/599091 · Cited by 2